Biofuels Bioproducts & Biorefining-Biofpr最新文献

{"title":"Biorefinery potential of Dunaliella (Chlorophyta) for production of value-added compounds","authors":"Yogita Sharma,&nbsp;Gajendra Pal Singh,&nbsp;Chandra Pal Singh","doi":"10.1002/bbb.2635","DOIUrl":"10.1002/bbb.2635","url":null,"abstract":"<p><i>Dunaliella</i> functions as a microscopic bioindustry that can capture atmospheric carbon dioxide and amass it into a range of economically viable compounds. <i>Dunaliella</i>-based biorefineries have emerged as sustainable platforms for fostering a green economy and reducing carbon emissions. <i>Dunaliella</i>-derived value-added compounds are commercially important due to their application in the food, pharmaceutical, cosmeceutical, and nutraceutical sectors. The present study highlights the economic application of different <i>Dunaliella</i> species and the available sustainable technologies for the cultivation, harvesting, and extraction of bioactive compounds that have the potential for commercial scaleup. Their incorporation into biorefinery processes can reduce dependency on energy-intensive and low-yield processes.</p><p>This review briefly discusses the technoeconomic analysis (TEA) of <i>Dunaliella</i>-driven industrial approaches for the optimization of effective yield and determination of final production costs. The major algal biorefineries are operational in countries like Australia, China, India, Israel, Japan, Portugal, Spain and the USA. The authors have comprehensively deliberated different aspects of <i>Dunaliella</i> from physiological to industrial applications, meanwhile underscoring the existing knowledge gaps that impede the success of <i>Dunaliella</i> biorefineries. The current industrial methods being employed for biorefineries are limited to producing individual bioproducts, which may not be fully cost effective, making them less competitive in the global market. However, the analysis carried out can serve as a starting point and can guide stakeholders towards the future direction of <i>Dunaliella</i>-based research and the circular bioeconomy.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1755-1781"},"PeriodicalIF":3.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of hydrothermal liquefaction data for use in machine-learning models","authors":"Geert Haarlemmer,&nbsp;Lucie Matricon,&nbsp;Anne Roubaud","doi":"10.1002/bbb.2637","DOIUrl":"10.1002/bbb.2637","url":null,"abstract":"<p>Hydrothermal liquefaction is a new, sustainable pathway to generate biogenic liquids from organic resources. The technology is compatible with a wide variety of resources such as lignocellulosic resources, organic waste, algae, and sewage sludge. The chemistry is complex and predictions of yields are notoriously difficult. Understanding and modeling of hydrothermal liquefaction is currently mostly based on a simplified biochemical analysis and product yield data. This paper presents a large dataset of 2439 experiments in batch reactors that were extracted from 171 publications in the scientific literature. The data include biochemical composition data such as fiber content and composition, proteins, lipids, carbohydrates, and ash. The experimental conditions are recorded for each experiment as well as the reported yields. The objective of this paper is to make a large database available to the scientific community. This database is analyzed with machine-learning tools. The results show that there is no consensus on the analysis techniques, experimental procedures, and reported data. There are many inconsistencies across the literature that should be improved by the scientific community. Machine-learning tools with a large dataset allow the generation of reliable yield production tools with a large application field. Given the accuracy of the data, the overall precision of prediction in an extrapolation to new results can be expected to be around 10%.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1782-1798"},"PeriodicalIF":3.2,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.2637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141117977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Box–Behnken modeling of biodiesel production from Botryococcus braunii microalgae","authors":"Mohamed A. Hassaan,&nbsp;Nesma I. M. Abdelaziz,&nbsp;Muhammad Altaf Nazir,&nbsp;Muhammad Jamshaid,&nbsp;Mohammed S. Hassouna,&nbsp;Ahmed El Nemr","doi":"10.1002/bbb.2626","DOIUrl":"10.1002/bbb.2626","url":null,"abstract":"<p>This research aimed to model and optimize the growth factors and enhance the lipid yield from <i>Botryococcus braunii</i> microalgae, and to design a system for obtaining biodiesel from these lipids as this does not compromise food security. <i>Botryococcus braunii</i>, grown on a modified Chu-13 medium, reached the stationary phase after 27 days with a maximum cell count of 265 × 10⁴ cells mL⁻¹ after 27 days and maximum biomass yield of 725 mg L⁻¹ after 30 days on modified Chu-13 medium, which was higher than growth on Basal SAG medium. The maximum lipid content (18.47%) and lipid yield (4.46 mg L⁻¹day) were obtained when <i>B. braunii</i> was cultivated on modified Chu-13 medium after 30 days. Gas chromatography (GC) analysis for the lipids indicated that the highest percentages of SFAs (51.03%) and lowest percentages of monounsaturated fatty acids (MUFAs) (36.47%) and polyunsaturated fatty acids (PUFAs) (12.49%) were obtained by culturing <i>B. braunii</i> on modified Chu-13 medium. The effect of different growth parameters (N₂ level, NaHCO₃, and CO₂ concentrations) on growth yield was modeled by using D-optimal design response surface methodology (RSM).</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1321-1354"},"PeriodicalIF":3.2,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140963641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the potential of activated sludge biomass from Nigeria as a feedstock for biodiesel production","authors":"Ifeanyichukwu Edeh,&nbsp;Keniwenimo Emmanuel Ozori,&nbsp;Ezekiel Ngochingo","doi":"10.1002/bbb.2631","DOIUrl":"10.1002/bbb.2631","url":null,"abstract":"<p>Depleting fossil fuel reserves and the effects of greenhouse gases on climate change have led to the investigation of alternative energy sources such as biofuel, including biodiesel and renewable diesel. Unfortunately, the cost of the feedstock exceeds 70% of the total production cost. The current work investigates the potential of utilizing a waste product (activated sludge biomass) from wastewater treatment, as an alternative feedstock for biodiesel production. The activated sludge biomass was pretreated with subcritical water to enhance the lipid yield before extracting the lipid using solvent extraction. The result showed that lipid yield from the activated sludge was 4.73–8.58%. After subcritical water pretreatment with varying residence time, temperature, and biomass loading, the lipid yield increased by 158.04–400%. Gas chromatography–mass spectrometry (GC–MS) analysis of the fatty acid methyl esters (FAME) from the transesterification of the lipid extract using calcined egg shell as a catalyst identified the following lipids: triglyceride, fatty acids, sphingolipid, phospholipid, glycerolipid, glycerophospholipid, steroid, and cholesterol. The predominant lipid was triglyceride, and the high percentage of unsaturated fatty acids, including arachidonic acid (23.54%), eicosadienoic acid (8.37%), and oleic acid (6.23%) suggest that the lipid extract is a potential feedstock for biodiesel production.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1411-1422"},"PeriodicalIF":3.2,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141127010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating new routes: circular economy and innovative use of waste in the olive sector","authors":"M. Dolores La Rubia,&nbsp;Francisco J. Navas-Martos","doi":"10.1002/bbb.2636","DOIUrl":"10.1002/bbb.2636","url":null,"abstract":"&lt;p&gt;In recent years, new business models have emerged based on the principles of the circular economy, which promote different actions such as: (a) the optimization of available resources, (b) the reduction in the consumption of raw materials of nonrenewable origin, and (c) the use of waste for the manufacture of more environmentally friendly materials and products. In comparison with linear production models, in which the goods produced are discarded at the end of their useful life, these new models propose to keep resources in the economic system for much longer to achieve greater optimization. Taking all of the above into account, the commitment to business models aligned with the principles of the circular economy represents a useful opportunity for the olive sector, which annually generates large quantities of waste with strong potential for use.&lt;/p&gt;&lt;p&gt;Nowadays, there are already a wide variety of ways to use waste from the olive sector that are well known, such as energy, composting and animal feed.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Nevertheless, the most innovative alternatives for using this waste are those that could generate new business models that would have a very significant impact on the economy of olive-growing areas. Among these alternatives are the manufacture of biomaterials, bioplastics or bioactive compounds.&lt;/p&gt;&lt;p&gt;In this sense, one of the most innovative and interesting proposals is the use of wood fibers from olive-tree pruning as reinforcement of those polymeric matrices with which plastic parts are manufactured for different industrial sectors such as the automotive industry or the furniture industry (Fig. 1). This way of valorizing olive-tree pruning waste intended for use in the plastic sector has been developed in the framework of the Life-Compolive project to the point of manufacturing polymer-based parts with high added value. The sustainable alternative solutions obtained have resulted in (a) a significant reduction in consumption of fossil-based plastic by incorporating up to 40 wt% of waste, (b) a decrease in the environmental impact of the final products, (c) an innovative alternative management of this waste that gives rise to products with high added value, and (d) new business models based on the circular economy with many competitive advantages given that pruning is an abundant, low-cost, highly available, and highly localized waste. The results of the Life-Compolive project are therefore not only beneficial from an environmental and technical point of view, but also economically and socially.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;This innovative proposal represents a new economic opportunity for the agricultural sector. For the plastic sector, the advantages are even more numerous as they allow plastic consumption to be reduced, addressing environmental and economic issues by reducing pollution and plastic waste. They stimulate innovation in materials, decrease reliance on nonrenewable resources, and contribute to a mult","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 4","pages":"791-792"},"PeriodicalIF":3.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.2636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of antioxidants from pequi leaves on the thermal and oxidative stability of biodiesel","authors":"Ranuir Lucas de Oliveira Irineu,&nbsp;Victor Juan Rodrigues da Silva,&nbsp;Josiane da Rocha Ferreira Nogueira,&nbsp;Thais Cardoso Merlo,&nbsp;Rafael Cardoso Rial","doi":"10.1002/bbb.2629","DOIUrl":"10.1002/bbb.2629","url":null,"abstract":"<p>In this study, the efficacy of antioxidants found in pequi leaves was examined for safeguarding pequi biodiesel (EBP) against oxidation. The results reveal notable achievements. The antioxidant activity of AFP (a pequi leaf antioxidant additive) was assessed at various concentrations, demonstrating that as the concentration of AFP increases, the inhibition percentage significantly rises, reaching a remarkable inhibition of 99.12% at 100 mg L⁻¹, with a calculated IC₅₀ of 25.4 mg L⁻¹. Additionally, the analysis of the AFP composition revealed the presence of terpenes and oxygenated compounds, which are well known for their antioxidant properties. Furthermore, the research emphasized the significance of thermogravimetric analysis in evaluating the thermal stability of additives, identifying critical temperatures at which AFP begins to protect biodiesel against oxidation (247.18°C) and the point at which its effectiveness may diminish (469.19°C). The EBP met quality standards regarding acidity, water content and density, but exhibited slightly lower oxidative stability compared with established standards. The correlation between the thermal degradation of biodiesel and the induction period highlighted the efficacy of AFP in mitigating thermal degradation. Nevertheless, it also indicated that maintaining biodiesel quality requires complementary approaches to minimize degradation over time.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1385-1395"},"PeriodicalIF":3.2,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatic rich biofuel production via catalytic co-pyrolysis of paulownia wood and polypropylene waste","authors":"Esmaeel Balaghi Inaloo,&nbsp;Ahmad Tavasoli","doi":"10.1002/bbb.2628","DOIUrl":"10.1002/bbb.2628","url":null,"abstract":"<p>Thermo-catalytic co-pyrolysis of paulownia wood and polypropylene mixture were carried out in a fixed bed horizontal reactor system. The biochar obtained from pyrolysis of paulownia wood was activated by steam at 700°C. Activated biochar supported magnesium oxide, nickel oxide and cobalt oxide catalysts were prepared by incipient miosture impregnation and were used to upgrade the bio-oil. Catalytic pyrolysis reduced the amount of bio-oil compared with non-catalytic pyrolysis (59.5% of bio-oil). The results indicate that the production of aromatic compounds increased from 40.35% to 65.93, 62.12 and 61.56% using Ni, Co and Mg catalysts, respectively. For all three catalysts, the production of furan compounds decreased. It was found that bio-char based catalysts are suitable for use in the co-pyrolysis process to improvement the biofuel production.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1369-1384"},"PeriodicalIF":3.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fast, reliable, low-cost, and efficient xylan extraction for xylooligosaccharides production","authors":"Kajal Kumari,&nbsp;Sushil Nagar,&nbsp;Sakshi Goyal,&nbsp;Sonu Maan,&nbsp;Vinod Kumar,&nbsp;Neeraj Kharor,&nbsp;Meena Sindhu,&nbsp;Vinay Kumar","doi":"10.1002/bbb.2627","DOIUrl":"10.1002/bbb.2627","url":null,"abstract":"<p>A fast, reliable, low-cost, and efficient method for the recovery of xylan from agro-residue materials is needed to improve the use of xylan in industrial processes. Xylan was extracted from two agrowastes (corncobs and wheat bran) using a cost-effective alkali extraction method. The characteristic band patterns and bending vibrations associated with hemicellulose and beta glycoside linkage could be seen in the corncob-extracted xylan (CCEx) and wheatbran-extracted xylan (WBEx). Scanning electron microscopy (SEM) analysis showed that the extracted xylans consisted of aggregated and nonaggregated particles with irregular morphology and rough surfaces. Particle-size analysis displayed average sizes of 205.6, 210.8, and 794.2 nm for commercial beechwood xylan (Bx), CCEx, and WBEx, respectively. Alkali extraction was performed with different concentrations of NaOH, from 5% to 20%, with a solid–liquid ratio of 1:20. It was found that 82.90 and 76.77% of xylan were extracted from corncob and wheat bran, respectively, which represents a higher yield obtained in a shorter duration in comparison with studies in the literature. The enzymatic hydrolysis of wheat bran and corncob that used 250 IU/mL of <i>Enterobacter hormaechie</i> KS1 xylanase yielded 334.38 and 162.35 mg/g of xylooligosaccharides. Their properties were studied and were found to be very similar to those of commercial xylan. They could reduce costs if applied in industry.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1355-1368"},"PeriodicalIF":3.2,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immobilization of an endophytic Bacillus sp. on Phragmites karka stem for lipase production in the presence of Cassia fistula seeds","authors":"Maria M. Ashraf,&nbsp;Muhammad Sohail,&nbsp;Zainul Abideen,&nbsp;Syed Tariq Ali,&nbsp;Abdullah K. Alanazi","doi":"10.1002/bbb.2630","DOIUrl":"10.1002/bbb.2630","url":null,"abstract":"<p>Endophytic bacteria have not been reported widely for their lipolytic abilities, so they are not used for large-scale lipase production. The purpose of this study was to explore an endophytic bacterium for the production of lipase implementing cost-effective techniques, including the use of <i>Cassia fistula</i> seeds, as a substrate in the production medium and stem pieces of <i>Phragmites karka</i> as the immobilization matrix. The endophytic strain <i>Bacillus</i> sp. E4 was originally isolated from the halophytic plant <i>Arthrocnemum macrostachyum. Bacillus</i> sp. E4 produced 6.05 IU mL⁻¹ lipase in the presence of powdered seeds of <i>Cassia fistula</i> (golden shower tree). Initial trial experiments using a one-factor-at-a-time approach led to an improvement in lipase titers to 10.05 IU mL⁻¹. Consequently, investigations using the Plackett–Burman design suggested the influence of three significant factors – incubation period, inoculum size, and substrate concentration – on lipase production. They were optimized using the Box–Behnken design (BBD). In the response optimization experiment, strain E4 yielded 52.35 IU mL⁻¹ lipase, which was in accordance with the predicted yield and indicated an overall 8.65 fold improvement in lipase production. To investigate the use of free cells, strain E4 was immobilized on the stem pieces of a halophytic plant, <i>Phragmites karka</i>, which was used for the first time as an immobilization matrix. The immobilized cells retained lipase production ability for up to six cycles with the highest yield of 110 IU mL⁻¹, which corresponded to an improvement of more than eighteenfold. Scanning electron micrographs confirmed the colonization of E4 cells in the matrix and demonstrated the utilization of <i>C. fistula</i> seeds. Fourier transform infrared spectroscopy affirmed the utilization of components including fatty acids by the immobilized E4 cells. The study suggests that endophytic bacterial strains could be applied for the production of lipase with the utilization of nontraditional oil sources.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 5","pages":"1396-1410"},"PeriodicalIF":3.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of red mud as a catalyst in the thermocatalytic reforming process","authors":"Hillary O. Onyishi,&nbsp;Johannes Neidel,&nbsp;Robert Daschner,&nbsp;Andreas Apfelbacher,&nbsp;Andreas Hornung","doi":"10.1002/bbb.2618","DOIUrl":"10.1002/bbb.2618","url":null,"abstract":"<p>This work studies red mud, a residue from the processing of bauxite, as a support catalyst in the thermocatalytic reforming (TCR) process, using wood, digestate, and straw as case studies. Thermocatalytic reforming is a thermochemical process for the conversion of biomass into biofuels, combining intermediate pyrolysis and catalytic reforming and resulting in high-quality biofuels. The quantity and quality of the catalyst in the postreformer is vital as it influences the reactions taking place in it. Normally, nonreactive components of the char produced in the process act as the catalyst in the postreformer but adding a support catalyst may improve the products. In this work, red mud is introduced in the process by mixing it with the feedstock in a ratio of 1:3. The results, in comparison with normal TCR experiments on the same feedstock materials, show that the introduction of red mud into the process generally reduces the biochar yield and generally increases the biogas and product water yields, and the bio-oil yield remains constant. Its introduction also increases the hydrogen fraction of the gas and tends to reduce the nitrogen and sulfur content of the products, thus improving their quality. These observations are consistent across feedstock materials and postreformer temperatures. The results therefore suggest that red mud is a good support catalyst for increasing the gas yield, increasing the hydrogen fraction of the gas, and improving the quality of the products from the TCR process.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"18 4","pages":"927-937"},"PeriodicalIF":3.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.2618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}