Biofuels Bioproducts & Biorefining-Biofpr最新文献

{"title":"Atmospheric pressure drying starch aerogel as a drug carrier for enhancing ibuprofen water solubility","authors":"Mina Behruzi,&nbsp;Jafarsadegh Moghaddas,&nbsp;Sina Ramezanian,&nbsp;Akbar Mohammadi","doi":"10.1002/bbb.70172","DOIUrl":"https://doi.org/10.1002/bbb.70172","url":null,"abstract":"<p>One of the main challenges in drug delivery is to enhance the bioavailability of poorly water-soluble drugs using non-toxic nanocarriers such as hydrophilic polymer matrices. Polysaccharide aerogels, such as starch aerogels, are promising drug delivery matrices owing to their biocompatibility, biodegradability, abundant availability, and high surface area for drug loading. In this study, after the synthesis of potato starch aerogels as drug carriers, the characteristics of the prepared samples were investigated by Brunauer-Emmett-Teller (BET), scanning electron microscopy, Fourier transform infrared (FTIR), and X-ray diffraction (XRD) analyses. Starch aerogels were loaded with ibuprofen by adsorption from drug solution using different solvents of ethanol and isopropanol. The drug-loaded aerogels were analyzed by UV, FTIR, and XRD spectroscopy, confirming the drug's structural integrity after loading. Adsorption studies using ethanol and isopropanol revealed that ibuprofen's higher solubility in ethanol led to an approximately 9% increase in drug loading compared with isopropanol. Adsorption equilibrium studies show that the Freundlich model for both ethanol and isopropanol solvents shows a better curve fit with the experimental data, with correlation coefficients of 0.9764 and 0.984, respectively. Owing to the poor dissolution rate of pure ibuprofen, the dissolution rate is improved by loading the drug onto starch aerogel, such that after 240 min, 72 and 66% of the ibuprofen present on the carrier is dissolved when ethanol and isopropanol solvents are used, respectively. Then, the small-volume USP2 device used in this study was built using scaling-down rules, considering the standard USP2 as a design reference. For the first time, the particle image velocimetry (PIV) technique was used to investigate the flow patterns and their effects on the drug release. The instantaneous velocity data shows the presence of eddies and secondary flows in different regions of the tank, and also the dominant flow inside the tank is tangential flow created by the rotation of the blade. These flows are very suitable for micro-mixing. The results of the obtained data show that this drug delivery system can be used as an alternative to the micronization method, which is currently used to achieve rapid drug release.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1861-1881"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic synthesis of acylglycerides from agroindustrial residues: process design and simplified techno-economic assessment","authors":"Ronaldo Rodrigues de Sousa,&nbsp;Isabelle de Souza Barbosa,&nbsp;Ana Cristina de Araújo Collaço,&nbsp;Denise Maria Guimarães Freire,&nbsp;Viridiana Santana Ferreira-Leitão","doi":"10.1002/bbb.70162","DOIUrl":"https://doi.org/10.1002/bbb.70162","url":null,"abstract":"<p>This study developed an enzymatic process to add value to palm oil fatty acid distillate (PFAD) and glycerol, resulting in the production of monoacylglycerides (MAG) and diacylglycerides (DAG). The biocatalyst loading (Novozym 435) and molar ratio of reagents were evaluated to obtain a suitable reaction condition in terms of space–time yield and catalytic productivity. A conversion of 80.3% was achieved after 4 h at 65 °C with an acid:glycerol molar ratio of 1:1, using 2.5% (wt/wt, total mass) Novozym 435 in a stoppered flask. In a bubble-column reactor prototype, conversion reached 91.8% after 5 h at 70 °C, reducing the biocatalyst loading to 1.5%. The same biocatalyst loading could be reused for 12 cycles, resulting in high catalytic productivity (458.4 g of main product per g of biocatalyst). The data obtained were used in preliminary process design, modeling, and simulation to estimate equipment sizing, capital investment expenditure (CAPEX), and operational expenditure (OPEX) for industrial-scale acylglyceride production from PFAD and glycerol. Preliminary technoeconomic assessment identified scenarios in which enzymatic MAG/DAG production from agroindustrial residues may be economically feasible, with a positive net present value (NPV) and a payback time of under 3 years.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1821-1834"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic lipase B from Candida antarctica (CALB) biocatalyst for integrated valorization of tilapia by-products and biodiesel biorefining","authors":"Rafael Leandro Fernandes Melo,&nbsp;Francisco Simão Neto,&nbsp;Bruno Caio Chaves Fernandes,&nbsp;Paulo Gonçalves de Sousa Junior,&nbsp;Patrick da Silva Sousa,&nbsp;Tiago Melo Freire,&nbsp;Raniere Dantas Valença,&nbsp;Frederico Ribeiro do Carmo,&nbsp;Marcos Reinaldo da Silva,&nbsp;Leonardo Farias Serafim,&nbsp;João Maria Soares,&nbsp;Pierre Basílio Almeida Fechine,&nbsp;José Cleiton Sousa dos Santos","doi":"10.1002/bbb.70164","DOIUrl":"https://doi.org/10.1002/bbb.70164","url":null,"abstract":"<p>The immobilization of lipase B from <i>Candida antarctica</i> (CALB) on an amino-epoxy functionalized magnetic support (Fe₃O₄-PEI-DGEBA) resulted in a highly stable and efficient biocatalyst for biofuel production from tilapia oil. The synthesized support was characterized using scanning electron microscopy, transmission electron microscopy, X-ray fluorescence spectroscopy, Fourier transform infrared (FTIR), thermogravimetric analysis, and vibrating sample magnetometry, confirming the successful immobilization and preservation of the magnetic core. The immobilized CALB exhibited superior catalytic performance, achieving a 97% immobilization yield, remarkable thermal and pH stability, and retaining over 80% activity after 120 days of storage. Additionally, it maintained high esterification efficiency over 10 reuse cycles, demonstrating its industrial applicability. Molecular docking and molecular dynamics simulations revealed that immobilization enhanced CALB's substrate selectivity, favoring long-chain saturated fatty acids through hydrophobic interactions with residues such as Leu140, Ala141, and Val154. Hybrid molecular mechanics and quantum mechanics simulations identified the nucleophilic attack step as the rate-limiting stage of the esterification process, with an energy barrier of 17.5 kcal mol⁻¹, aligning with the enzyme's optimized catalytic efficiency post-immobilization. The biodiesel produced 98.8% conversion efficiency, with key FTIR and nuclear magnetic resonance signals confirming successful esterification. However, its viscosity exceeded ASTM and ANP standards, suggesting the need for blending with lower-viscosity biofuels. These findings highlight Fe₃O₄-PEI-DGEBA@CALB as a promising biocatalyst for sustainable biofuel production, combining high stability, reusability, and efficiency, with potential applications in green chemistry and industrial biocatalysis.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1835-1860"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulating competition in the US bioeconomy to produce hard-to-electrify transportation fuels using limited biomass resources","authors":"Nicholas A. Carlson,&nbsp;Emily K. Newes,&nbsp;Kristen Lu,&nbsp;Eric C. D. Tan","doi":"10.1002/bbb.70166","DOIUrl":"https://doi.org/10.1002/bbb.70166","url":null,"abstract":"<p>This study presents a novel bioeconomy optimization framework, BiOpt, designed to address critical questions regarding the strategic use of limited US biomass resources for biofuel production. By integrating detailed techno-economic analyses, life cycle assessments, and resource assessment data, BiOpt optimizes resource distributions across competing technologies to maximize economic performance and/or minimize greenhouse gas emissions. Using feedstock scenarios from the 2023 Billion Ton Study, the analysis explores optimal biomass allocations across sustainable aviation fuel, diesel, and marine biofuel conversion pathways given varying production targets and policy incentives. Results demonstrate distinct feedstock preferences and pathway utilizations when prioritizing economic returns vs. emissions reductions. For instance, fats, oils, and greases were highly favored in cost-optimized scenarios, while low-carbon feedstocks such as wet waste dominated greenhouse gas-minimized strategies. The findings underscore the pivotal role of policy incentives and technological advances in shaping biofuel supply chains and provide actionable insights for scaling sustainable biofuel production to decarbonize hard-to-electrify sectors. This framework offers a robust tool for policymakers and stakeholders to evaluate biofuel strategies that balance energy output, economic viability, and environmental impact.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1895-1910"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating agro-residue valorization and clean hydrogen production: coconut fiber-based catalysts for NaBH4 hydrolysis","authors":"Isabelly Silveira Freitas,&nbsp;Francisco Izaias da Silva Aires,&nbsp;Dayana Nascimento Dari,&nbsp;Jacob Tchiyeke António Kandjila,&nbsp;Maurício Quintas Salamba,&nbsp;Diego Lomonaco,&nbsp;Monalisa Moura de Oliveira,&nbsp;Pierre Basílio Almeida Fechine,&nbsp;Rafael Leandro Fernandes Melo,&nbsp;Alan Silva de Menezes,&nbsp;Marcos Carlos de Mattos,&nbsp;Leonardo Farias Serafim,&nbsp;Maria Cristiane Martins de Souza,&nbsp;Ada Amelia Sanders Lopes,&nbsp;John Herbert da Silva Felix,&nbsp;Eveline de Abreu Menezes,&nbsp;José Cleiton Sousa dos Santos","doi":"10.1002/bbb.70158","DOIUrl":"https://doi.org/10.1002/bbb.70158","url":null,"abstract":"<p>A novel phosphoric acid-treated green coconut fiber (GCF-C) was developed as a catalyst for hydrogen production from the hydrolysis of sodium borohydride (NaBH₄). Characterization techniques confirmed structural modifications, including X-ray diffraction, scanning electron microscopy, X-ray fluorescence, Fourier transform infrared, and thermogravimetric analysis. The Taguchi method was applied to optimize the conditions, achieving an optimal hydrogen generation rate of 596.67 mLH₂ min⁻¹ g⁻¹ at 60 °C, 300 mg GCF-C, and 750 mg NaBH₄. Kinetic analysis indicated an activation energy (<i>E</i>_a) of 28.95 kJ mol⁻¹ for GCF-C, significantly reducing the energy barrier for the reaction. The GCF-C showed improved performance over untreated GCF, with a hydrogen production rate of 104.17 mLH₂ min⁻¹ g⁻¹. The porous structure of the catalyst, confirmed by scanning electron microscopy, enhanced reactant interaction, and X-ray fluorescence analysis revealed higher phosphorus content, supporting catalytic efficiency. Future work will explore the potential for catalyst reuse and improvements to reduce atmospheric contamination in the reaction setup.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1798-1820"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.70158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green extraction of carotenoids from Spirulina subsalsa and Chlorella vulgaris using natural deep eutectic solvents","authors":"Amira Jacqueline Maldonado-Ortiz,&nbsp;Gregorio Guadalupe Carbajal Arizaga,&nbsp;Rosa María Camacho-Ruiz,&nbsp;José Daniel Padilla-de la Rosa,&nbsp;Sandeep Surendra Panikar,&nbsp;Sanghamitra Khandual","doi":"10.1002/bbb.70173","DOIUrl":"https://doi.org/10.1002/bbb.70173","url":null,"abstract":"<p>Carotenoids from microalgae, including <i>β</i>-carotene, lutein, and astaxanthin, have significant potential for food and healthcare applications due to their antioxidant properties. Increasing demand for these pigments necessitates greener extraction methods. Natural deep eutectic solvents (NADES) have emerged as promising green solvents that could replace conventional organic solvents. This study investigates the extraction and quantification of <i>β</i>-carotene, lutein, and astaxanthin from <i>Chlorella vulgaris</i> and <i>Spirulina subsalsa</i> using a range of NADES to identify efficient, nontoxic solvent extraction methods suitable for functional food development. High-performance liquid chromatography (HPLC) was used for quantification. The lactic acid:1,2-propanediol (LAPo) system showed the highest extraction efficiency for carotenes in both species. <i>β</i>-Carotene extraction reached 73% in <i>C. vulgaris</i> and 97.63% in <i>S. subsalsa</i>. Lutein extraction reached 61% in <i>C. vulgaris</i> and 98% in <i>S. subsalsa</i>. Astaxanthin extraction reached 36% in <i>C. vulgaris</i> and 43% in <i>S. subsalsa</i>. For <i>S. subsalsa</i> strain Z15, NADES performed comparably to traditional solvents. This research highlights the potential of NADES as eco-friendly alternatives for carotene extraction and supports their application in scalable functional food production. Gelatin matrices incorporating microalgal carotenoids were also developed to evaluate color stability and related properties.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1729-1742"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging research directions in nanoparticle-based foam control for bioprocessing: a bibliometric approach","authors":"Antonio Átila Menezes Ferreira,&nbsp;John Hebert da Silva Felix,&nbsp;Thiago Queiroz da Silva,&nbsp;Larissa Oliveira Araújo,&nbsp;Maria Tayane Barroso dos Santos,&nbsp;Larysse Maria Santiago de Castro,&nbsp;José Cleiton Sousa dos Santos","doi":"10.1002/bbb.70170","DOIUrl":"https://doi.org/10.1002/bbb.70170","url":null,"abstract":"<p>Overfoaming remains a critical challenge in industrial bioprocesses, compromising mass transfer, operational stability, and downstream efficiency in bioreactors and wastewater treatment systems. This study provides a bibliometric and scientometric assessment of nanoparticle-enabled foam control to map technological trends and identify research gaps. A total of 118 Web of Science records were analyzed using Bibliometrix and VOSviewer. The literature shows sustained growth after 2005, peaking in 2021, and is dominated by chemistry, materials science, and engineering, underscoring the interdisciplinary nature of the field. Keyword co-occurrence reveals four major research fronts: hybrid nanoparticle–surfactant/oil formulations; interfacial mechanisms (wettability, adsorption, dewetting); stimulus-responsive systems (pH, temperature, CO₂) enabling reversible foam control; and application-driven studies with increasing translation to bioprocessing and biorefinery contexts. Polymeric systems (22.9%), metallic/magnetic nanoparticles (17.8%), carbon nanomaterials (14.4%), silica-based nanoparticles (13.6%), and bioderived nanomaterials (11.0%) emerge as the most investigated platforms, reflecting both performance-driven and sustainability-oriented trajectories. Mechanistic fundamentals (Young–Laplace capillarity, Derjaguin–Landau–Verwey–Overbeek (DLVO)-based disjoining pressure, and bridge–dewetting) are consolidated to support rational design criteria for particulate antifoams. Finally, key barriers – especially toxicity/environmental fate, process compatibility, scalability, and cost – are discussed, highlighting future directions toward bioderived and biodegradable materials, recoverable multifunctional systems, and Industry 4.0-enabled real-time foam monitoring and adaptive control for sustainable bioprocesses.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1708-1728"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bbb.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squalene production from biodiesel-derived crude glycerol as the substrate by Pichia pastoris in batch and fed-batch systems","authors":"R. Srivatsan,&nbsp;Naorem Bela Devi,&nbsp;B. Adhithya,&nbsp;Kannan Pakshirajan","doi":"10.1002/bbb.70171","DOIUrl":"https://doi.org/10.1002/bbb.70171","url":null,"abstract":"<p>This study reports the production of squalene and other value-added metabolites from crude glycerol by the yeast <i>Pichia pastoris</i>. To the best of our knowledge, this is the first study to demonstrate the utilization of crude glycerol for squalene biosynthesis in <i>P. pastoris</i>, with process intensification achieved through fed-batch cultivation in a bioreactor. A maximum squalene titer of 70 mg L⁻¹ was achieved using 1% (v/v) crude glycerol along with 0.2 mg L⁻¹ added terbinafine in mineral salt media. Various biokinetic models, modified-Gompertz, Luedeking-Piret, Aiba, and Andrews models, were applied to understand the kinetics of squalene accumulation by <i>P. pastoris</i>. The Modified-Gompertz model accurately predicted the maximum squalene production, whereas the Aiba and Andrews models described the inhibitory effect caused by crude glycerol. Scale-up experiments performed using a laboratory-scale stirred tank bioreactor demonstrated enhanced squalene accumulation by 1.67-fold under batch operation (117 mg L⁻¹) and by up to 2.94-fold under fed-batch operation (206 mg L⁻¹), relative to the shake flask cultivation study. High-resolution mass spectrometry analysis of the spent media revealed that, in addition to squalene accumulation by the yeast, arabitol, succinic acid, mannitol, benzoic acid, and citric acid were produced as extracellular products from crude glycerol.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1923-1938"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esterification of free fatty acids (C8–C16) from coconut oil for bio-jet fuel precursor production using 12-tungstophosphoric acid supported on niobium pentoxide","authors":"Oscar Goyeneche,&nbsp;Emerson Barrios Mogollón,&nbsp;Glaucio José Gomes,&nbsp;Ana Caroline Raimundini Aranha,&nbsp;Pedro Augusto Arroyo","doi":"10.1002/bbb.70157","DOIUrl":"https://doi.org/10.1002/bbb.70157","url":null,"abstract":"<p>The growing demand for sustainable aviation fuels has driven the exploration of renewable alternatives to reduce dependence on fossil sources and mitigate environmental impacts. This study investigates the hydroesterification of vacuum-distilled fatty acid fractions (150–190 and 195–220 °C at 0.1 bar) from coconut oil using 12-tungstophosphoric acid supported on niobium pentoxide (TPA/Nb₂O₅) as a heterogeneous catalyst. Catalyst characterization <i>via</i> X-ray diffraction and N₂ physisorption revealed a transition to a hexagonal crystalline phase after calcination at 550 °C, with reduced Brunauer–Emmett–Teller surface area owing to structural reorganization at lower temperatures. Temperature-programmed desorption of ammonia analysis confirmed predominant strong acid sites associated with Keggin ions, independent of calcination temperature. Catalytic performance was assessed by varying parameters such as catalyst loading, temperature, reaction time, and ethanol-to-fatty acid molar ratio in the ethyl esterification of distilled fatty acids and lauric acid (C12) as a model compound. Optimal conditions (15 wt% catalyst, 120 °C, 4 h, 1:11 <span>m</span> ratio) yielded 92 and 90% conversions for lauric acid and the 150–190 °C fraction, respectively. However, the 195–220 °C fraction showed lower reactivity owing to reduced C12 content. These findings highlight TPA/Nb₂O₅ as a promising catalyst for producing bio-kerosene from distilled coconut oil fractions, advancing green chemistry in biofuel synthesis.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1781-1797"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic study into levulinic acid production from rice husk in a biorefinery framework","authors":"Carlos R. Ruiz,&nbsp;Andrea N. Pila,&nbsp;Eliana P. Dagnino","doi":"10.1002/bbb.70174","DOIUrl":"https://doi.org/10.1002/bbb.70174","url":null,"abstract":"<p>In the context of growing global demand for chemicals and renewable fuels, levulinic acid (LA) appears as a key platform chemical owing to its ability to be transformed into a wide range of industrial derivatives. This study investigates the chemical conversion of cellulose fraction of rice husk (RH) into LA, focusing on the influence of key reaction parameters and the kinetic behavior of the process within the framework of an integrated biorefinery system. The results of the experimental design indicate that temperature and solid loading are influential factors in the chemical conversion of cellulose fraction of RH to LA, finding an optimal reaction temperature of 167.27 °C and a solid load of 8% w/v. In parallel, it was found that a concentration of 5% v/v sulfuric acid maximizes the efficiency of the process, avoiding undesirable by-products. From a kinetic perspective, the reaction follows a pseudo-first-order model with a kinetic constant of <i>k</i> = 0.0309 min⁻¹, a coefficient of adjustment <i>R</i>² = 0.9892 and an activation energy for the reaction of 46.2 kJ mol⁻¹. These findings contribute to the understanding of the LA production process, thereby enhancing the understanding of the underlying reaction mechanisms for potential future applications.</p>","PeriodicalId":55380,"journal":{"name":"Biofuels Bioproducts & Biorefining-Biofpr","volume":"20 4","pages":"1939-1949"},"PeriodicalIF":3.8,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}