Biomedical Papers-Olomouc最新文献_第3页

Fetal magnetic resonance imaging in the confirmation of congenital anomalies found on routine mid-trimester ultrasound. 胎儿磁共振成像用于确认常规中期超声检查发现的先天性畸形。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-11-01 Epub Date: 2024-03-04 DOI: 10.5507/bp.2024.008

Ishraq Dhaifalah, Marek Godava, Jana Havalova, Pavla Hanzlikova, Kamila Michalkova, Lenka Bakaj Zbrozkova, Jakub Civrny, Howard Cuckle

{"title":"Fetal magnetic resonance imaging in the confirmation of congenital anomalies found on routine mid-trimester ultrasound.","authors":"Ishraq Dhaifalah, Marek Godava, Jana Havalova, Pavla Hanzlikova, Kamila Michalkova, Lenka Bakaj Zbrozkova, Jakub Civrny, Howard Cuckle","doi":"10.5507/bp.2024.008","DOIUrl":"10.5507/bp.2024.008","url":null,"abstract":"Objective: To determine the added value of fetal magnetic resonance imaging (MRI) when clarifying a suspected anomaly detected by mid-trimester scan.Methods: Women attending two centers of fetal medicine between January 2017 and December 2021 were identified. The centers carried out routine mid-trimester ultrasound scans to detect fetal anomalies. Those with a suspected anomaly which required further clarification were referred for fetal magnetic resonance imaging (MRI). The medical records of all referred women were examined to determine the anomalies found at scan, MRI and termination of pregnancy or delivery. A total of 9571 women had a routine mid-trimester scan and an anomaly was either diagnosed or suspected in 449 (4.7%); an MRI examination was made in 76 cases (0.79%).Results: MRI confirmed the presence of an abnormality in 61 referrals (80%) and failed to yield a result in one case. Outcome information was available for 69 cases: the MRI confirmation rate was 89% (48/54) in those with abnormal outcome and 40% (6/15) if the outcome was normal, P.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":"326-331"},"PeriodicalIF":0.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of simple training protocol in patients after mild traumatic brain injury. 对轻度脑外伤患者进行简单训练的安全性和有效性。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-11-01 Epub Date: 2023-05-04 DOI: 10.5507/bp.2023.013

Martina Martinikova, Robert Ruzinak, Petra Hnilicova, Michal Bittsansky, Marian Grendar, Lucia Babalova, Pavol Skacik, Ema Kantorova, Vladimir Nosal, Monika Turcanova Koprusakova, Jozef Sivak, Jana Sivakova, Zuzana Biringerova, Branislav Kolarovszki, Kamil Zelenak, Egon Kurca, Stefan Sivak

{"title":"Safety and efficacy of simple training protocol in patients after mild traumatic brain injury.","authors":"Martina Martinikova, Robert Ruzinak, Petra Hnilicova, Michal Bittsansky, Marian Grendar, Lucia Babalova, Pavol Skacik, Ema Kantorova, Vladimir Nosal, Monika Turcanova Koprusakova, Jozef Sivak, Jana Sivakova, Zuzana Biringerova, Branislav Kolarovszki, Kamil Zelenak, Egon Kurca, Stefan Sivak","doi":"10.5507/bp.2023.013","DOIUrl":"10.5507/bp.2023.013","url":null,"abstract":"Aims: Mild Traumatic Brain Injury (mTBI) is the most common type of craniocerebral injury. Proper management appears to be a key factor in preventing post-concussion syndrome. The aim of this prospective study was to evaluate the effect and safety of selected training protocol in patients after mTBI.Methods: This was a prospective study that included 25 patients with mTBI and 25 matched healthy controls. Assessments were performed in two sessions and included a post-concussion symptoms questionnaire, battery of neurocognitive tests, and magnetic resonance with tractography. Participants were divided into two groups: a passive subgroup with no specific recommendations and an active subgroup with simple physical and cognitive training.Results: The training program with slightly higher initial physical and cognitive loads was well tolerated and was harmless according to the noninferiority test. The tractography showed overall temporal posttraumatic changes in the brain. The predictive model was able to distinguish between patients and controls in the first (AUC=0.807) and second (AUC=0.652) sessions. In general, tractography had an overall predictive dominance of measures.Conclusion: The results from our study objectively point to the safety of our chosen training protocol, simultaneously with the signs of slight benefits in specific cognitive domains. The study also showed the capability of machine learning and predictive models in mTBI patient recognition.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":"295-303"},"PeriodicalIF":0.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9425630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute pancreatitis as a risk factor of chronic pancreatitis and pancreatic cancer. An overview. 急性胰腺炎是慢性胰腺炎和胰腺癌的风险因素。综述。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.5507/bp.2024.023

David Solil, Petr Dite, Michal Senkyrik, Martina Bojkova, Bohuslav Kianicka

引用次数: 0

Serum neurofilament light chain in response to probiotics in bi-center, double-blind, randomized, placebo-controlled clinical trial (CleverAge Biota). 在双中心、双盲、随机、安慰剂对照临床试验（CleverAge Biota）中，血清神经丝轻链对益生菌的反应。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-10-14 DOI: 10.5507/bp.2024.032

Lenka Fialova, Ales Bartos, Marta Kalousova, Libuse Noskova, Miroslava Zelenkova, Michaela Slukova, Tomas Zima

{"title":"Serum neurofilament light chain in response to probiotics in bi-center, double-blind, randomized, placebo-controlled clinical trial (CleverAge Biota).","authors":"Lenka Fialova, Ales Bartos, Marta Kalousova, Libuse Noskova, Miroslava Zelenkova, Michaela Slukova, Tomas Zima","doi":"10.5507/bp.2024.032","DOIUrl":"https://doi.org/10.5507/bp.2024.032","url":null,"abstract":"Background and aims: Neurodegenerative disorders affecting the brain and spinal cord are caused by a large number of factors. More recently, imbalances in gut microbiota are found to be one factor linked directly to neurological dysfunction. Probiotics prevent cognitive decline. For the first time, the effect of probiotics was assessed by monitoring the concentrations of the neurodegeneration biomarker neurofilament light chains (NfL) in a well-defined group of community-dwelling individuals. The aim of this study was to determine whether administration of our new probiotics could reduce NfL concentrations.Methods: The serum NfL concentrations were measured in total of 190 serum samples of 85 older community-dwelling individuals. The participants were randomly divided into two groups: the PROPLA group and the PLAPRO group. Individuals in the PROPLA group started with a three-month use of probiotics and continued with a three-month use of placebo while the order was reversed in the PLAPRO group. The participants underwent detailed examinations at three time points: at baseline, in three and six months. The serum NfL concentrations were determined using ultrasensitive single-molecule array (SIMOA) assay.Results: Longitudinal comparisons of NfL concentrations between samplings at different time points in the PROPLA and PLAPRO groups showed no statistically significant differences. Baseline NfL concentrations at the beginning of the study and in the succeeding samplings were not significantly different for the two groups in cross-sectional comparisons.Conclusions: Serum NfL concentrations were not influenced by the three-month use of probiotics.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers. 庆大霉素肾毒性导致的急性肾损伤和作为生物标志物的特异性 miRNA。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-10-11 DOI: 10.5507/bp.2024.031

Viktor Klementa, Nadezda Petejova, Pavel Horak, Ester Kurasova, Josef Zadrazil

{"title":"Acute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers.","authors":"Viktor Klementa, Nadezda Petejova, Pavel Horak, Ester Kurasova, Josef Zadrazil","doi":"10.5507/bp.2024.031","DOIUrl":"https://doi.org/10.5507/bp.2024.031","url":null,"abstract":"Acute kidney injury (AKI) due to gentamicin nephrotoxicity is a significant concern in clinical medicine, particularly in patients receiving prolonged or high-dose gentamicin therapy. Gentamicin is an aminoglycoside antibiotic frequently used in the treatment of a range of bacterial infections. However, its use is associated with nephrotoxicity which can manifest as AKI. Due to this, it is crucial to diagnose promptly and manage treatment effectively. Ongoing studies are therefore focusing on non-protein-coding RNAs as potential biomarkers for AKI. Numerous microRNAs (miRNAs) have been implicated in gentamicin-induced nephrotoxicity and AKI. They participate in pathways associated with inflammation, cell death, and oxidative stress and each of these factors play critical roles in the development of gentamicin-induced kidney injury. Research studies have demonstrated changes in the expression levels of these miRNAs in response to gentamicin exposure both in vitro and in in vivo models, as well as in human clinical trials involving patients receiving gentamicin therapy. The dysregulation of these miRNAs correlates with the severity of kidney injury and may serve as sensitive biomarkers for early detection and monitoring of AKI induced by gentamicin.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal insufficiency - causes and laboratory diagnosis. 肾上腺功能不全--病因和实验室诊断。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-10-07 DOI: 10.5507/bp.2024.033

Tomas Brutvan, Jana Jezkova, Marcela Kotasova, Michal Krsek

引用次数: 0

The role of Fetuin-A and Leucine-rich α-2-glycoprotein in the diagnosis of prostate cancer - a pilot study. Fetuin-A和富亮氨酸α-2-糖蛋白在前列腺癌诊断中的作用--一项试点研究。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-09-27 DOI: 10.5507/bp.2024.028

Alena Sorokac Kubolkova, Gabriel Varga, Miroslava Benovska, Lenka Kovacova, Michal Fedorko

{"title":"The role of Fetuin-A and Leucine-rich α-2-glycoprotein in the diagnosis of prostate cancer - a pilot study.","authors":"Alena Sorokac Kubolkova, Gabriel Varga, Miroslava Benovska, Lenka Kovacova, Michal Fedorko","doi":"10.5507/bp.2024.028","DOIUrl":"https://doi.org/10.5507/bp.2024.028","url":null,"abstract":"Background: Prostate cancer (PC) is one of the most frequently diagnosed non-skin solid cancers and is a leading cause of cancer-related death and the incidence increasing. Early diagnosis of the disease improves the outcomes. There is an urgent need for new biomarkers with greater discriminative precision for diagnosis, risk-stratification and treatment. The aim of our study was to evaluate the diagnostic and prognostic potential of Fetuin-A and LRG1 in patients with PC.Methods: Serum levels of Fetuin-A and LRG1 were compared in patients with PC (n=46), a control group 1 including young, healthy subjects (n=26) and control group 2 including patients with negative prostate biopsy (n=46). In PC patients, the levels of both biomarkers were compared in subgroups with different tumour characteristics.Results: We demonstrated a statistically significant higher concentrations of Fetuin-A in PC patients compared to control group 2 (439 mg/L vs. 372 mg/L), P<0.001. No statistically significant difference was found between PC patients and control group 1, nor for LRG1 levels between the three groups. In PC patients, higher serum levels of LRG1 were found in M1 patients compared to M0 (98 mg/L vs. 42 mg/L), P=0.059.Conclusion: Fetuin-A levels are significantly higher in patients with prostate cancer than in patients without malignancy but LRG1 levels do not differ between patients with PC and controls.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrence. 经皮经胸针活检肺部病变是一种安全的方法，胸膜复发的风险非常低。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-09-27 DOI: 10.5507/bp.2024.030

Martin Svaton, David Havel, Marcela Buresova, Jan Baxa, Petr Hosek

{"title":"Percutaneous transthoracic needle biopsy of lung lesions is a safe method associated with a very low risk of pleural recurrence.","authors":"Martin Svaton, David Havel, Marcela Buresova, Jan Baxa, Petr Hosek","doi":"10.5507/bp.2024.030","DOIUrl":"https://doi.org/10.5507/bp.2024.030","url":null,"abstract":"Aim: Percutaneous transthoracic needle biopsy (PTNB), an alternative to bronchoscopic confirmation of lung lesions, is today being associated with a risk of pneumothorax and hemorrhage. Further, there are no data on the possible risk of malignant disease spreading to the pleura at the site of the PTNB. Previous studies have dealt with this risk in stage I non-small cell lung cancer only. The aim of this study was thus to assess the risk of pleural recurrence for all types of lung lesions. Secondary objectives included assessment of diagnostic yield and safety with respect to the incidence of pneumothorax and hemorrhage.Methods: Clinical data of all patients from the University Hospital in Pilsen who had undergone PTNB of lung lesions between 1.1.2018 and 31.12.2022 were included in this retrospective study.Results: Following PTNB, ipsilateral pleural effusion occurred in 4.8% of patients without prior pleural infiltration. The effusion was confirmed as malignant in one patient (0.7%). Diagnostic yield of the method was 86.6%. We recorded pneumothorax or hemorrhage in the lung parenchyma or pleural space requiring medical intervention in 3.4% and 1.1% of patients, respectively.Conclusion: In our study, percutaneous transthoracic needle biopsy of lung lesions showed high sensitivity and low degree of acute complications requiring an invasive solution. The risk of pleural recurrence after a biopsy was very low. Consequently, we continue to consider this method to be an alternative to bronchoscopy biopsies.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary ventriculitis caused by Streptococcus intermedius - a rare case and challenge with uncertain clinical outcome. Case report. 中间链球菌引起的原发性脑室炎--一个罕见病例和临床结果不确定的挑战。病例报告。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-09-27 DOI: 10.5507/bp.2024.029

Stefan Trnka, Premysl Stejskal, Jakub Jablonsky, David Krahulik, Eva Cechakova, Lumir Hrabalek

{"title":"Primary ventriculitis caused by Streptococcus intermedius - a rare case and challenge with uncertain clinical outcome. Case report.","authors":"Stefan Trnka, Premysl Stejskal, Jakub Jablonsky, David Krahulik, Eva Cechakova, Lumir Hrabalek","doi":"10.5507/bp.2024.029","DOIUrl":"https://doi.org/10.5507/bp.2024.029","url":null,"abstract":"Aims: To present a case of primary ventriculitis in a 53-year-old patient caused by Streptococcus intermedius, emphasizing the rarity of the condition and the challenges in achieving clinical improvement despite targeted therapy.Methods: The patient underwent clinical evaluation, including CT and MRI imaging, as well as CSF analysis. Empirical antibiotic therapy was initiated with cefotaxime and metronidazole, followed by targeted therapy based on CSF culture results. External ventricular drainage was performed surgically.Results: No predisposing factors were identified in the patient. Initial imaging showed no acute changes, but follow-up imaging revealed significant ventricular inflammation. CSF analysis confirmed the presence of Streptococcus intermedius. Despite early and targeted antibiotic therapy, and surgical intervention, the patient's clinical condition did not improve.Conclusion: This case highlights the rarity of primary ventriculitis caused by Streptococcus intermedius and the challenges in managing it. The lack of clinical improvement despite prompt and targeted treatment underscores the need for further research to develop more effective therapeutic strategies for such infections.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonographic signs as predictors of metastatic involvement in the axillary lymph nodes in breast cancer patients: from minimal changes to the appearance of the pathological lymph node. A retrospective analysis. 预测乳腺癌患者腋窝淋巴结转移的超声波征象：从最小变化到病理淋巴结的出现。回顾性分析。

IF 0.7 4区医学

Biomedical Papers-Olomouc Pub Date : 2024-09-01 Epub Date: 2023-03-10 DOI: 10.5507/bp.2023.009

Lucia Veverkova, Marketa Koleckova, Katherine Vomackova, Nora Zlamalova, Lubica Lowova

{"title":"Ultrasonographic signs as predictors of metastatic involvement in the axillary lymph nodes in breast cancer patients: from minimal changes to the appearance of the pathological lymph node. A retrospective analysis.","authors":"Lucia Veverkova, Marketa Koleckova, Katherine Vomackova, Nora Zlamalova, Lubica Lowova","doi":"10.5507/bp.2023.009","DOIUrl":"10.5507/bp.2023.009","url":null,"abstract":"Introduction: The aim of this study was to retrospectively analyse the ultrasound findings in the axillary lymph nodes in breast cancer patients with morphological changes that required biopsy. In most cases the morphological changes were minimal.Materials and methods: Between January 2014 and September 2019 examination of axillary lymph nodes with subsequent core-biopsy was performed in 185 breast cancer patients at the Department of Radiology. Lymph node metastases were detected in 145 cases, while in the remaining 40 cases benign changes or normal lymph node (LN) histology was observed. Ultrasound morphological characteristics and the sensitivity and specificity were evaluated retrospectively. Seven ultrasound characteristics were evaluated - diffuse cortical thickening, focal cortical thickening, absence of the hilum, cortical non-homogeneities, L/T ratio (longitudinal to transverse axis), type of vascularization and perinodal oedema.Results and conclusion: It is a diagnostic challenge to recognize metastases in the lymph nodes with minimal morphological changes. The most specific signs are non-homogeneities in the cortex of the lymph node as well as the absence of fat hilum and perinodal oedema. Metastases are significantly more frequent in LNs with a lower L/T ratio, in LNs with perinodal oedema and with a peripheral type of vascularization. Biopsy of these lymph nodes is necessary to confirm or exclude metastases, especially if it affects the type of treatment.","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":"216-222"},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0