Bratislava Medical Journal-Bratislavske Lekarske Listy最新文献

{"title":"Human milk oligosaccharide associated with the firmicutes-to-bacteroidetes ratio among stunted infants in Malang, Indonesia.","authors":"Annisa Annisa, Sanarto Santoso, Lilik Zuhriyah, Dian Handayani","doi":"10.4149/BLL_2024_94","DOIUrl":"https://doi.org/10.4149/BLL_2024_94","url":null,"abstract":"<p><strong>Background: </strong>Human milk oligosaccharide (HMO) is a unique component of breastmilk. To date, no study has investigated the correlation between HMO and infant nutritional status particularly through the lens of gut microbiota. Therefore, our study aims to investigate the relationships between 2'-Fucosyllactose (2'-FL) in HMO and Firmicutes/Bacteroidetes (F/B) ratio among stunted infants.</p><p><strong>Methods: </strong>A case-control study was conducted among 103 mother-infant pairs in Malang City, Indonesia. The quantification of 2'-FL HMO was assessed using High-Performance Liquid Chromatography (HPLC). The F/B ratio was analyzed with real-time poly-chain reaction (RT-PCR). For bivariate analysis, we employed the Spearman correlation and Mann‒Whitney tests, while for multivariate analysis, we utilized multiple linear regression.</p><p><strong>Results: </strong>The findings showed that the stunted nutritional status was detected in 49 out of 103 infants. In this group, 40.81% of mothers of infants with a stunted nutritional status had a secretor-positive status, while all mothers of infants with appropriate nutritional status tested positive for the secretor status (100%). However, the association between maternal secretor status and infant nutritional status was not statistically significant (p>0.05). The average levels of 2'-FL HMO in breast milk were lower in the group with stunted infants compared to non-stunted infants (1.21 mg/L vs 1.40 mg/L). The regression analysis revealed a significant association of 2'-FL HMO levels with the presence of Bacteroidetes and value of the F/B ratio (p>0.05).</p><p><strong>Conclusions: </strong>The breast milk component 2'-FL HMO significantly influences the gut microbiota of stunted infants. Future research aimed at elucidating the mechanisms by which 2'-FL HMO modulates infant gut microbiota should consider not only concentration and specific bacterial taxa but also intake levels (Tab. 2, Fig. 1, Ref. 37). Text in PDF www.elis.sk Keywords: 2'-fucosyllactose, human milk, oligosaccharide, firmicutes, bacteroidetes, stunting, infant.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming emergency triage: A preliminary, scenario-based cross-sectional study comparing artificial intelligence models and clinical expertise for enhanced accuracy.","authors":"Suna Eraybar, Evren Dal, Mevlut Okan Aydin, Maruf Begenen","doi":"10.4149/BLL_2024_114","DOIUrl":"https://doi.org/10.4149/BLL_2024_114","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines triage judgments in emergency settings and compares the outcomes of artificial intelligence models for healthcare professionals. It discusses the disparities in precision rates between subjective evaluations by health professionals with objective assessments of AI systems.</p><p><strong>Material and method: </strong>For the analysis of the efficacy of emergency triage; 50 virtual patient scenarios had been created. Emergency medicine residents and other healthcare providers who had triage education were tasked with categorizing triage levels for virtual patient scenarios. Also artificial intelligence systems, tasked for resolving the same scenarios. All of them were asked to use three color-coded triage of the Republic of Turkey Ministry of Health. The answer keys were created by consensus of the researchers. In addition, Emergency medicine specialists were asked to evaluate the acuity level of each scenario in order to perform sub-analyses.</p><p><strong>Results: </strong>The study consisted of 86 healthcare professionals, comprising 31 Emergency medicine residents (26.5%), 1 paramedic (0.9%), 5 emergency health technicians (4.3%), and 80 nurses (68.4%). Google Bard AI and OpenAI Chat GPT v.3.5 were used as artificial intelligence systems. The responses compared with the answer key to determine each groups efficacy. As planned the responses from healthcare professionals were analyzed individually for acuity level of scenarios. Emergency medicine residents and other groups of healthcare providers had significantly higher numbers of correct answers compared to Google Bard and Chat GPT (n=30.7 vs n=25.5). There was no significant difference between ChatGPT and Bard for low and high acuity scenarios (p=0.821)CONCLUSION: AI models can examine extensive data sets and make more accurate and quicker triage judgments with sophisticated algorithms. However, in this study, we found that the triage ability of artificial intelligence is not as sufficient as humans. A more efficient triage system can be developed by integrating artificial intelligence with human input, rather than solely relying on technology (Tab. 4, Ref. 41). Text in PDF www.elis.sk Keywords: emergency triage, AI applications, health technology, artificial intelligence, emergency management.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Comparison of second-generation cryoballoon ablation and quantitative radiofrequency ablation guided by ablation index for atrial fibrillation.","authors":"Qin-Dan Yan,&nbsp;Ke-Zeng Gong,&nbsp;Xue-Hai Chen,&nbsp;Jian-Hua Chen,&nbsp;Zhe Xu,&nbsp;Wei-Wei Wang,&nbsp;Fei-Long Zhang","doi":"10.4149/BLL_2023_023","DOIUrl":"https://doi.org/10.4149/BLL_2023_023","url":null,"abstract":"<p><p>Ahead of Print article withdrawn by publisher.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9097156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity and heart rate adjustments of diabetic people during isometric contraction.","authors":"Pauline Romualdo Cogo, Angélica Cristiane DA Cruz Britto, Eduardo Federighi Baisi Chagas, Pedro Henrique Rodrigues, Cristiano Sales DA Silva, Robison José Quitério","doi":"10.4149/BLL_2022_146","DOIUrl":"10.4149/BLL_2022_146","url":null,"abstract":"<p><strong>Ntroduction: </strong>Type 2 Diabetes Mellitus (DM2) can lead to autonomic nervous system dysfunction and heart rate variability (HRV) is often used to assess this system both during rest and during physical exercise.</p><p><strong>Objective: </strong>To evaluate the autonomic modulation at rest and the responses of heart rate and parasympathetic indices of individuals with DM2 to isometric handgrip exercise.</p><p><strong>Method: </strong>The sample consisted of individuals of both sexes; over 40 years, divided into groups, with and without DM2 diagnosis. The collection of resting HRV was performed for 20 minutes in the supine position, and 256 points were selected for symbolic and linear analysis. The individuals performed isometric contraction for one minute with intensities of 10, 20, 30, 40 and 50 % of the maximum contraction, using the parasympathetic indexes RMSSD and SD1 for analysis.</p><p><strong>Results: </strong>Linear and symbolic indices of HRV at rest and those obtained during exercise were similar (p-value>0.05). No association was found between the indices at rest and the responses to exercise, with a slight delay in the response of diabetics in HR and parasympathetic indices being identified.</p><p><strong>Conclusion: </strong>There was no difference between the groups in the modulation of rest or in the parasympathetic adjustments of the exercise (Tab. 4, Ref. 32).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10468429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D insufficiency is not associated with thyroid autoimmunity in Slovak women with Hashimoto´s disease.","authors":"Lenka Filipova,&nbsp;Zora Lazurova,&nbsp;Pavol Fulop,&nbsp;Ivica Lazurova","doi":"10.4149/BLL_2023_029","DOIUrl":"https://doi.org/10.4149/BLL_2023_029","url":null,"abstract":"<p><p>The role of vitamin D (VD) in the etiopathogenesis of autoimmune diseases (AI) is extensively studied. However, its association with autoimmune thyroid disease (AITD) is still controversial. AIM of this study was to assess the relationship between the vitamin D status and thyroid autoimmunity in Slovak premenopausal women with newly diagnosed AITD.</p><p><strong>Subjects and methods: </strong>This prospective case-control study included 57 women with AITD and 41 age- and BMI-matched controls. All subjects were examined for summer and winter serum 25(OH)D, thyroid autoantibodies (a-TPO, a-TG), freeT4 and TSH concentrations. Thyroid volume was measured by ultrasound.</p><p><strong>Results: </strong>There were no significant differences in serum 25(OH)D between AITD and control groups. No significant correlation between 25(OH)D and thyroid autoantibodies was found either in the whole cohort or in AITD women. The prevalence of vitamin D insufficiency was 60.31 % in AITD women and 52.5 % in the control group. No significant association between VD and thyroid autoantibodies, thyroid hormones and thyroid volume was detected in this study.</p><p><strong>Conclusion: </strong>Authors conclude that VD insufficiency is common in Slovak premenopausal women independently of the presence of AITD. Vitamin D insufficiency is not associated with thyroid autoimmunity in patients with early diagnosis of AITD (Tab. 3, Ref. 31). Text in PDF www.elis.sk Keywords: vitamin D, autoimmune thyroid disease, thyroid autoantibodies.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil‑to‑lymphocyte ratio as a marker of inflammation in restless legs syndrome during pregnancy.","authors":"Mustafa Karadeniz,&nbsp;Merve Hazal Ser,&nbsp;Mecbure Nalbantoglu,&nbsp;Feray Bolukbasi Tumay,&nbsp;Nevin Yilmaz,&nbsp;Serdar Acikgoz,&nbsp;Gulcin Benbir Senel","doi":"10.4149/BLL_2023_006","DOIUrl":"https://doi.org/10.4149/BLL_2023_006","url":null,"abstract":"PURPOSE The pregnancy is accepted as an independent risk factor for restless legs syndrome/Willis-Ekbom disease (RLS/WED). The neutrophil-to-lymphocyte ratio (NLR) was recently reported in the pathophysiology of RLS/WED. In this report, we investigated the relationship between the presence of RLS/WED and the levels of NLR in pregnancy. METHODS We included 268 pregnant women attending routine prenatal visits; 148 women had RLS/WED, and 120 women without RLS/WED were the control group. A pre-formed questionnaire was administered to all participants regarding demographic characteristics, habitual behaviors, detailed medical history and questions about RLS/WED including disease duration, severity, and family history. Laboratory investigations were performed in all participants regarding the complete blood count, NLR, fasting blood glucose, blood urea nitrogen, creatinine, ferritin, and total iron binding capacity. RESULTS NLR was significantly higher in pregnant women with RLS/WED as compared to those without it (3.9±0.9 versus 3.5±1.1, p=0.039). Smoking was also significantly more common in pregnant women with RLS/WED (p=0.022). NLR significantly increased as the gestational period progressed, even after the adjustments for age, BMI, and smoking (p=0.035). Higher NLR in pregnant women with RLS/WED was especially prominent in the 3rd trimester, although the difference was not significant. CONCLUSION These results may suggest that an increased inflammation demonstrated by the increased NLR, may, in part, play a role in higher prevalence of RLS/WED in pregnancy, especially in late gestational weeks (Tab. 2, Fig. 1, Ref. 34). Text in PDF www.elis.sk Keywords: neutrophil-to-lymphocyte ratio, restless legs syndrome/Willis-Ekbom disease, pregnancy, inflammation.","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10348527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult cardiac surgery report 2021: The annual report from the Registry of the National Institute of Cardiovascular Diseases.","authors":"Michal Hulman,&nbsp;Panagiotis Artemiou,&nbsp;Branislav Bezak,&nbsp;Vladan Hudec,&nbsp;Ivan Glonek,&nbsp;Martin Bena,&nbsp;Rudolf Jurco Md,&nbsp;Mikulas Kiss,&nbsp;Marian Jancar,&nbsp;Matej Ondrusek,&nbsp;Rastislav Cikrai,&nbsp;Ruben Charchoglhyan,&nbsp;Andrej Domonkos,&nbsp;Maria Zembery,&nbsp;Ivo Gasparovic","doi":"10.4149/BLL_2023_027","DOIUrl":"https://doi.org/10.4149/BLL_2023_027","url":null,"abstract":"<p><strong>Introduction: </strong>Based on a longtime voluntary registry founded by the Ministry of Healthcare of the Slovak Republic in 2012 and endorsed by the National Institute of Cardiovascular Diseases, well-defined data of all adult cardiac surgery procedures performed during the year 2021 are analyzed.</p><p><strong>Material and method: </strong>For this period, data on 947 procedures were submitted to the registry.</p><p><strong>Results: </strong>The unadjusted in-hospital survival rate for the 352 isolated coronary artery bypass grafting procedures including urgent and emergency procedures (relationship on-/off pump 3.8 : 1) was 96.3 %. For 331 isolated heart valve procedures (33 transcatheter interventions), it was 95.5 %. Concerning ventricular assist devices, 19 implantations were registered. In 2021 the number of isolated heart transplantations was 16, which is a decrease by 38.5 % as compared to the previous year.</p><p><strong>Conclusion: </strong>These annually registered data are collected from voluntary public reporting and accumulate actual information on nearly all heart procedures carried out in the National Institute of Cardiovascular Diseases. These data capture advancements in heart medicine and represent the basis for quality management. In addition, the registry demonstrates that the provision of cardiac surgery in Slovakia is up to date, appropriate, and nationwide patient treatment is guaranteed all the time (Tab. 14, Fig. 2, Ref. 5). Text in PDF www.elis.sk Keywords: heart valve surgery, outcomes, coronary artery bypass grafting, aortic surgery, heart transplantation.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10750218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A report on accessory renal arteries incidence in Slovak adults: Cadaveric study and surgical correlation.","authors":"Janka Vecanova,&nbsp;Natalia Hvizdosova,&nbsp;Ingrid Hodorova","doi":"10.4149/BLL_2023_088","DOIUrl":"https://doi.org/10.4149/BLL_2023_088","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to evaluate renal arterial variations in Slovak context.</p><p><strong>Methods: </strong>Forty cadavers (80 formalin-fixed cadaveric kidneys) were included in the study. The accessory renal arteries (ARAs) were evaluated on the basis of point of origin, termination in the kidney (superior pole, hilum, inferior pole), and symmetry.</p><p><strong>Results: </strong>The incidence of ARAs was detected in 20 % (8/40) of the cadavers. Double renal arteries were observed in 9 (11.25 %, n = 80) of kidneys. Among 8 cadavers with ARAs, the unilateral presence of ARA was found in 7 cadavers and bilateral presence in 1 cadaver. Among 9 ARAs, polar artery was the most common anomaly seen in 7 (78 %) kidneys (inferior polar artery 5, superior polar artery 2) followed by the hilar artery in 2 kidneys.</p><p><strong>Conclusions: </strong>This is the first cadaveric study on the incidence and morphology of ARAs in Slovakia. The study has shown that the variations in renal arterial anatomy are a frequent finding (20 % of cadavers) while all of the described variants have significant implications for a variety of surgical procedures in the retroperitoneal space. The variations in renal arteries should be considered an integral part of anatomy teaching as they point to the diverse clinical reality of anatomy (Tab. 1, Fig. 1, Ref. 35). Text in PDF www.elis.sk Keywords: renal artery, variation, polar artery, double renal artery, cadaver.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9784862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astroglial differentiation of fibronectin‑positive human \"glia-like\" cells.","authors":"Ivana Sivakova,&nbsp;Peter Mraz,&nbsp;Anna Perzelova","doi":"10.4149/BLL_2023_066","DOIUrl":"https://doi.org/10.4149/BLL_2023_066","url":null,"abstract":"<p><strong>Objectives: </strong>Fibronectin (Fn) is a glycoprotein of extracellular matrix produced by a variety of mesenchymal and neoplastic cell types.</p><p><strong>Background: </strong>In adult brain tissue, Fn is restricted to blood vessels. However, adult human brain cultures are almost entirely comprised of flat or spindle‑shaped Fn-positive cells usually referred to as \"glia-like\" cells. Since Fn is primarily present in fibroblasts, these cultures may be considered to be of non-glial origin.</p><p><strong>Methods: </strong>Cells gained by long-term culturing of adult human brain tissue derived from brain biopsies obtained from 12 patients with non-malignant diagnoses were examined by immunofluorescence methods.</p><p><strong>Results: </strong>Primary cultures contained GFAP-/Vim+/Fn+ \"glia-like\" cells (95-98 %) and GFAP+/Vim+/Fn- astrocytes (0.1 %) which disappeared by passage number 3. The formation of cell processes and enlargement of cell bodies was observed in 9 of 12 cultures with decreased cell growth during passages 12 to 17. It is remarkable that during this period, all \"glia-like\" cells became GFAP+/Vim+/Fn+.</p><p><strong>Conclusion: </strong>Herein, we confirm our previously published hypothesis about the origin of adult human \"glia-like\" cells, which we consider to be precursor cells scattered through the brain cortex and subcortical white matter. Cultures were comprised entirely of GFAP-/Fn+ \"glia-like\" cells and showed morphological and immunochemical astroglial differentiation with spontaneously decelerated growth during prolonged passaging. We propose that the adult human brain tissue contains a \"dormant population\" of undefined glial precursor cells. Under culture, these cells show to have a high proliferative capacity and different stages of cell dedifferentiation (Fig. 2, Ref. 21).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9777589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lipid parameters with insulin resistance in the Kazakh population.","authors":"Aizhan Shakhanova,&nbsp;Nurlan Aukenov,&nbsp;Alma Nurtazina,&nbsp;Alida Kasskabayeva,&nbsp;Meruyert Massabayeva,&nbsp;Dana Kenzhebayeva","doi":"10.4149/BLL_2023_094","DOIUrl":"https://doi.org/10.4149/BLL_2023_094","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) is a consequence of chronic adipose tissue inflammation and underlies the pathogenesis of several diseases, such as type 2 diabetes mellitus, cardiovascular diseases and metabolic syndrome. In this study, we examined the association between dyslipidaemia and IR; directly comparing conventional lipid ratios and apoB/apoA1 ratios for strength and independence as risk factors for IR in a Kazakh population.</p><p><strong>Methods: </strong>The design of this study was a case-control study. There were 507 participants in the study. We examined each participant's plasma total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, apolipoprotein B, and apolipoprotein A1. IR was determined using an IR homeostasis model assessment (HOMA-IR). To assess the risk of an atherogenic blood lipid profile, atherogenicity coefficients were calculated: Bad cholesterol to good cholesterol ratio ((TC-HDL)/HDL); TG to HDL ratio (TRG/HDL); apoB to apoA1 ratio (apoB/apoA1).</p><p><strong>Results: </strong>In this study, high waist circumference and BMI were more common in men. The group with IR had significantly higher waist circumference (cm) (p = 0.0001) and BMI (kg/m2) (p = 0.04) than the group without IR. The risk of IR was significantly associated with the apoB/apoA1 ratio (p = 0.03). Analysis of the association between HOMA-IR and apoB/apoA1 ratio increased the risk of IR at apoB/apoA1 ratios of 0.71 to 0.85 and above 0.86 by a factor of 1.93 and 1.84, respectively. HOMA-IR levels were weakly significantly correlated with TG levels (rS = 0.3; p = 0.0001) and very weakly positively correlated with apoB levels (rS = 0.1; p = 0.002) and apoB/apoA1 (rS = 0.1; p = 0.001), there was a weak negative correlation with apoA1 levels (rS = -0.1; p = 0.02). Logistic regression analysis showed that the risk of developing IR was significantly lower in men than in women, adjusted OR (95% CI) = 0.75 (0.49-1.0) p = 0.02.</p><p><strong>Conclusion: </strong>In our study, IR was more common in Kazakh women than in Kazakh men. IR was also associated with apoB and TG levels. Thus, we suggest that analysis of TG, apoB and apoB/apoA1 ratio may be recommended as early predictors of IR risk in the Kazakh population (Tab. 3, Ref. 22). Text in PDF www.elis.sk Keywords: insulin resistance, dyslipidaemia, apolipoproteins, triglycerides, lipids.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9793766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}