复发性多发性硬化症患者体内维生素 D 受体相关长非编码 RNA 的表达分析。

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_018

Mahdis Rahimi Naiini, Kolsoum Saeidi, Arezoo Azarian, Kiana Bahramzadeh, Mahdieh Nazari-Robati

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引用次数: 0

摘要

背景：维生素 D 是一种神经活性类固醇，通过维生素 D 受体（VDR）发挥其生物功能。VDR 基因与某些长非编码 RNA（lncRNA）相互作用。本研究旨在评估复发缓解型多发性硬化症（RRMS）患者体内 VDR 基因以及 HOTAIR、H19、MALAT1 和 P21 lncRNAs 的表达水平：研究对象为 38 名 RRMS 患者和 38 名健康人。方法：该研究以38名RRMS患者和38名健康人为对象，测定了外周血中VDR和部分lncRNAs的表达水平以及血浆中维生素D的表达水平：结果发现，与对照组相比，RRMS 组 lncRNA H19 的表达量明显增加。H19基因表达的接收者操作特征曲线（ROC）分析显示诊断值为0.699（95% CI：0.575-0.823）。在多发性硬化症患者中，VDR与lncRNA HOTAIR（r = 0.446，p = 0.008）、H19（r = 0.351，p = 0.042）、MALAT1（r = 0.464，p = 0.006）和P21（r = 0.512，p = 0.002）之间存在正相关：本研究结果表明，lncRNA H19可作为多发性硬化症诊断的潜在生物标志物（表4，图1，参考文献34）。

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Expression analysis of vitamin D receptor-associated long noncoding RNAs in patients with relapsing-remitting multiple sclerosis.

Background: Vitamin D is a neuroactive steroid that carries out its biological functions through the vitamin D receptor (VDR). The VDR gene interacts with certain long noncoding RNAs (lncRNAs). The present study is aimed at evaluating the expression levels of the VDR gene as well as those of HOTAIR, H19, MALAT1, and P21 lncRNAs in patients with relapsing-remitting multiple sclerosis (RRMS).

Methods: This research was conducted on 38 RRMS patients and 38 healthy individuals. The expression levels of VDR and selected lncRNAs in peripheral blood as well as those of vitamin D in the plasma were measured.

Results: The results revealed a significant increase in the expression of lncRNA H19 in the RRMS group compared to the control group. The analysis of the receiver operating characteristic (ROC) curve for H19 gene expression demonstrated a diagnostic value of 0.699 (95% CI: 0.575-0.823). Positive correlations were detected between VDR and lncRNA HOTAIR (r = 0.446, p = 0.008), H19 (r = 0.351, p = 0.042), MALAT1 (r = 0.464, p = 0.006), and P21 (r = 0.512, p = 0.002) in MS patients.

Conclusion: The findings of this study suggest that lncRNA H19 could serve as a potential biomarker for MS diagnosis (Tab. 4, Fig. 1, Ref. 34).

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.