Bratislava Medical Journal-Bratislavske Lekarske Listy最新文献

{"title":"Human milk oligosaccharide associated with the firmicutes-to-bacteroidetes ratio among stunted infants in Malang, Indonesia.","authors":"Annisa Annisa, Sanarto Santoso, Lilik Zuhriyah, Dian Handayani","doi":"10.4149/BLL_2024_94","DOIUrl":"https://doi.org/10.4149/BLL_2024_94","url":null,"abstract":"<p><strong>Background: </strong>Human milk oligosaccharide (HMO) is a unique component of breastmilk. To date, no study has investigated the correlation between HMO and infant nutritional status particularly through the lens of gut microbiota. Therefore, our study aims to investigate the relationships between 2'-Fucosyllactose (2'-FL) in HMO and Firmicutes/Bacteroidetes (F/B) ratio among stunted infants.</p><p><strong>Methods: </strong>A case-control study was conducted among 103 mother-infant pairs in Malang City, Indonesia. The quantification of 2'-FL HMO was assessed using High-Performance Liquid Chromatography (HPLC). The F/B ratio was analyzed with real-time poly-chain reaction (RT-PCR). For bivariate analysis, we employed the Spearman correlation and Mann‒Whitney tests, while for multivariate analysis, we utilized multiple linear regression.</p><p><strong>Results: </strong>The findings showed that the stunted nutritional status was detected in 49 out of 103 infants. In this group, 40.81% of mothers of infants with a stunted nutritional status had a secretor-positive status, while all mothers of infants with appropriate nutritional status tested positive for the secretor status (100%). However, the association between maternal secretor status and infant nutritional status was not statistically significant (p>0.05). The average levels of 2'-FL HMO in breast milk were lower in the group with stunted infants compared to non-stunted infants (1.21 mg/L vs 1.40 mg/L). The regression analysis revealed a significant association of 2'-FL HMO levels with the presence of Bacteroidetes and value of the F/B ratio (p>0.05).</p><p><strong>Conclusions: </strong>The breast milk component 2'-FL HMO significantly influences the gut microbiota of stunted infants. Future research aimed at elucidating the mechanisms by which 2'-FL HMO modulates infant gut microbiota should consider not only concentration and specific bacterial taxa but also intake levels (Tab. 2, Fig. 1, Ref. 37). Text in PDF www.elis.sk Keywords: 2'-fucosyllactose, human milk, oligosaccharide, firmicutes, bacteroidetes, stunting, infant.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 10","pages":"605-611"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming emergency triage: A preliminary, scenario-based cross-sectional study comparing artificial intelligence models and clinical expertise for enhanced accuracy.","authors":"Suna Eraybar, Evren Dal, Mevlut Okan Aydin, Maruf Begenen","doi":"10.4149/BLL_2024_114","DOIUrl":"https://doi.org/10.4149/BLL_2024_114","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines triage judgments in emergency settings and compares the outcomes of artificial intelligence models for healthcare professionals. It discusses the disparities in precision rates between subjective evaluations by health professionals with objective assessments of AI systems.</p><p><strong>Material and method: </strong>For the analysis of the efficacy of emergency triage; 50 virtual patient scenarios had been created. Emergency medicine residents and other healthcare providers who had triage education were tasked with categorizing triage levels for virtual patient scenarios. Also artificial intelligence systems, tasked for resolving the same scenarios. All of them were asked to use three color-coded triage of the Republic of Turkey Ministry of Health. The answer keys were created by consensus of the researchers. In addition, Emergency medicine specialists were asked to evaluate the acuity level of each scenario in order to perform sub-analyses.</p><p><strong>Results: </strong>The study consisted of 86 healthcare professionals, comprising 31 Emergency medicine residents (26.5%), 1 paramedic (0.9%), 5 emergency health technicians (4.3%), and 80 nurses (68.4%). Google Bard AI and OpenAI Chat GPT v.3.5 were used as artificial intelligence systems. The responses compared with the answer key to determine each groups efficacy. As planned the responses from healthcare professionals were analyzed individually for acuity level of scenarios. Emergency medicine residents and other groups of healthcare providers had significantly higher numbers of correct answers compared to Google Bard and Chat GPT (n=30.7 vs n=25.5). There was no significant difference between ChatGPT and Bard for low and high acuity scenarios (p=0.821)CONCLUSION: AI models can examine extensive data sets and make more accurate and quicker triage judgments with sophisticated algorithms. However, in this study, we found that the triage ability of artificial intelligence is not as sufficient as humans. A more efficient triage system can be developed by integrating artificial intelligence with human input, rather than solely relying on technology (Tab. 4, Ref. 41). Text in PDF www.elis.sk Keywords: emergency triage, AI applications, health technology, artificial intelligence, emergency management.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 11","pages":"738-743"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year prognosis of patients with acute myocardial infarction and out-of-hospital cardiac arrest.","authors":"Daniel Alusik, Andrej Corba, Jan Kmec, Ignac Kubica, Lubomira Romanova, Peter Gal, Martin Studencan","doi":"10.4149/BLL_2024_66","DOIUrl":"https://doi.org/10.4149/BLL_2024_66","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the mortality and prognosis of acute myocardial infarction (AMI) patients with out-of-hospital cardiac arrest (OHCA) initially admitted to Department of Anesthesiology and Intensive Care in comparison with patients initially admitted to Cardiac Centre (CC).</p><p><strong>Background: </strong>Global acute coronary syndrome (ACS) registries often omit patients with OHCA initially admitted to anaesthesiology and intensive care units. This exclusion may lead to underestimated mortality rates in patients following acute MI worldwide.</p><p><strong>Methods: </strong>A retrospective analysis was conducted in patients admitted in 2014 to the (Department of Anesthesiology and Intensive Care) at a single center, J.A. Reiman Teaching Hospital in Presov, Slovakia. Survival rates were evaluated in-hospital, at 30 days, and annually over a five-year period. Patients with STEMI and NSTEMI were analyzed separately, particularly during the early in-hospital phase.</p><p><strong>Results: </strong>In the OHCA group, 52% of STEMI patients experienced in-hospital mortality, whereas the CC group reported only 3% mortality. The total hospital mortality for STEMI patients was 6.69%. Among NSTEMI patients in the OHCA group, in-hospital mortality reached 50%, compared to 4.33% in the CC group. The total center mortality for all NSTEMI patients was 6.09%.</p><p><strong>Conclusion: </strong>Although the short-term prognosis for MI patients with OHCA is unfavorable, with a 30-day mortality rate of 54.9%, for those who survive the initial 30 days following cardiac arrest and are successfully discharged from the hospital, the long-term prognosis aligns with MI patients without OHCA. In light of these findings, the inclusion of all patients with MI (from both OHCA and CC groups) in global ACS registries could significantly raise in-hospital and 30-day mortality rates (Tab. 3, Fig. 4, Ref. 21).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 7","pages":"429-434"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 incentive payments for long-term care workers.","authors":"Irina Bocharova, Alexander Rymanov","doi":"10.4149/BLL_2024_95","DOIUrl":"https://doi.org/10.4149/BLL_2024_95","url":null,"abstract":"<p><strong>Objective: </strong>Amid the COVID-19 pandemic in the Russian Federation, social care providers received incentives such as bonuses and welfare payments. The study examines the association between COVID-19 pandemic indicators and distribution of incentives to care providers in Russia.</p><p><strong>Methods: </strong>To test the hypotheses, regression analysis is employed.</p><p><strong>Results: </strong>Hypothesis H1, regarding the correlation between the COVID-19 case rate in a specific region of the Russian Federation and the actual monetary amount of bonus payments compensating for challenging working conditions of care workers in that region is supported. Hypotheses H2-H3, regarding the relationship between the COVID-19 cases/recovery rate and the monetary amount of special welfare payments to care workers distributed across the country during a given calendar month are also supported. Hypothesis H4, pertaining to the relationship between the Fiscal Year End and the monetary amount of special welfare payments distributed throughout the country to care providers during a given calendar month, is likewise supported.</p><p><strong>Conclusion: </strong>There is a correlation between payments to social care providers and coronavirus pandemic indicators (Tab. 5, Ref. 31). Text in PDF www.elis.sk Keywords: welfare payment, bonus, care providers.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 10","pages":"612-616"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lengthening of the percutaneous implant in the surgical treatment of Th-L ankylosed spine fractures: 4 segment fixation versus 5 to 8 segment fixation.","authors":"Juraj Svac, Peter Stranak, Tomas Hrin, Lumir Hrabalek, Roman Alberty, Radoslav Zamborsky, Miroslav Kilian","doi":"10.4149/BLL_2024_129","DOIUrl":"https://doi.org/10.4149/BLL_2024_129","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Fractures of thoracolumbar spine in the field of ankylosing diseases such as ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) can by surgically treated with miniinvasive posterior transpedicular fixation. The exact length of implant is the subject of several studies. In our study, we retrospectively evaluated the treatment of B3 fractures of the ankylosed thoracolumbar spine with use a shorter versus longer implant, always with 8 screws.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 46 patients were included in the study (36 men and 10 women). Sixteen patients had AS and 30 patients had DISH. Patients treated between 2018 and 2022 with minimally invasive dorsal transpedicular fixation using 8 transpedicular screws were included in this study. We compared two groups where the first consisted of patients operated on with fixation of a maximum of 4 segments and the second group of patients consisted of patients in whom longer stabilization was used, at least 5 to 8 segments, with skipping of some vertebra between screws. We compared the effect of fixation length on reduction and retention before surgery, after surgery, and after 6 and 12 months. We evaluated the effect of reduction and retention on the basis of differences in the measurement of the Cobb angle and the angle, which we called \"vege\", which was formed by dislocation of the fracture. Furthermore, we monitored demographic data, the length of surgery, the number of complications, the number of concomitant injuries, the presence of a neurological deficit, and the result was assessed by the AO Spine PROST questionnaire.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the entire group of 46 patients, the difference in the \"vege\" angle was significant (p&lt;0.001). When comparing the reduction between the groups with short and longer fixation, the difference was not significant (p=0.829). The difference of the Cobb angle before and after the surgery in the comparison between the two groups did not show a statistically significant difference (p=0.434). Measurements of the Cobb angle bisegmentally after 6 and 12 months showed a progressive change in terms of kyphotization, which was smaller in the group with longer fixation, this difference was not statistically significant (p=0.709). Complete reduction was achieved in the group with short fixation vs 75% vs 63.3% with longer fixation (p-0.739). At the check-up after 6 months, all incomplete intraoperative reductions were spontaneously reduced.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Based on this study, we could conclude that both used constructions are comparable in terms of treatment results. It can be observed that longer fixation is more resistant to kyphotization at 6 and 12 months, but we would need a larger group of patients to confirm this hypothesis. In all incomplete reduced fractures through the surgery, complete reduction after verticalization occurred within 6 months in both groups. The angle","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 12","pages":"844-850"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer epidemiology in Slovakia.","authors":"Ludmila Kutakova, Maria Reckova, Alexandra Brazinova","doi":"10.4149/BLL_2024_127","DOIUrl":"https://doi.org/10.4149/BLL_2024_127","url":null,"abstract":"<p><p>Slovakia, in accordance with a global trend, is experiencing an increasing cancer burden. Development and assessment of preventive and healthcare interventions are informed by cancer epidemiology.This study presents the current epidemiological situation and trends for three prevalent malignancies: breast, colorectal, and cervical cancer in the Slovakia. Population-based screening programs for these cancers have recently been reinforced.Breast cancer is the most common newly diagnosed cancer and also the most common cause of death of all cancer in women. Cervical cancer is the second most common cancer in women with decreasing mortality. Colorectal cancer belongs to the cancer diseases with highest incidence and mortality in both the male and female populations, with the majority of cases diagnosed in later stages. Despite progress in specific areas of cancer care, Slovakia acknowledges the need for further improvements. Enhancing cancer screening uptake presents a crucial area for advancement (Fig. 7, Ref. 19). Keywords: epidemiology, Slovakia, breast cancer, colorectal cancer, cervical cancer.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 12","pages":"829-834"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of nutritional support in patients with neoplasms of the hepatopancreatoduodenal zone as a component of intensive therapy in the postoperative period.","authors":"Sherzad Kurbanalievich Davanov, Natalia Nikolaevna Vasilyeva, Svetlana Vladimirovna Plyassovskaya, Xenia Eduardovna Mkhitaryan, Gulmira Alievna Zhanalina, Svetlana Ivanovna Rogova, Vladimir Nikolaevich Priz, Gulnur Zhanibekovna Toktibayeva, Dinara Serikovna Aubakirova","doi":"10.4149/BLL_2024_126","DOIUrl":"https://doi.org/10.4149/BLL_2024_126","url":null,"abstract":"<p><strong>Background: </strong>A pressing concern involves the efficient and intensive treatment of complications arising from malignant tumors in the hepatopancreatoduodenal region. This matter is closely tied to rectifying energy deficits, addressing insufficient body weight, and restoring proper metabolic processes. This is particularly crucial post-surgery, as the process is hindered by significant hypercatabolism, heightened nutritional requirements, and the presence of intoxication syndrome.</p><p><strong>Objective: </strong>To consider the features of nutritional support in patients with tumors of the hepatopancreatoduodenal zone in the early postoperative period.</p><p><strong>Methods: </strong>An investigation was carried out on 91 individuals aged 18 years and older who were afflicted with malignant tumors situated in the hepatopancreatoduodenal area. These patients were categorized into three distinct groups, each receiving a different form of nutritional assistance.The assessment encompassed various aspects of the patients' nutritional well-being, including outcomes from the screening protocol, body mass index, basal metabolic rate, and critical laboratory measurements such as blood lymphocyte count, total protein level, total bilirubin concentration, as well as ALaT and ASaT levels.</p><p><strong>Results: </strong>Under the provision of parenteral nutritional support, as per the applied screening protocols, a span of 10 to 12 days saw 17 patients sustaining a \"normal\" nutritional state, while 14 patients experienced a condition of \"moderate malnutrition.\" Notably, one patient (3.2%) demonstrated a regression from the status of \"severe malnutrition.\"In the mixed nutrition group, within the same 10 to 12-day timeframe post-operation, there was a rise in the prevalence of patients classified as having \"moderate malnutrition\" according to the SGA and NRI scales by 10% and 6.7%, respectively. Remarkably, all indicators pointing to \"severe malnutrition\" were entirely eliminated as assessed by the mentioned nutritional evaluation scales (p<0.005).</p><p><strong>Conclusion: </strong>A notable degree of effectiveness in stabilizing and upholding the nutritional condition of patients was attainable within the isolated parenteral nutrition group. This achievement was realized by elevating the count of patients classified under \"moderate\" and \"normal\" nutritional statuses, and concurrently diminishing the number of patients experiencing severe and moderate nutritional insufficiency, respectively.The mixed type of nutritional support in this case can be considered with a high degree of probability as an alternative replacement for parenteral nutrition, due to the statically similar indicators of the nutritional status of patients achieved in this study (Fig. 4, Ref. 12).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"125 12","pages":"823-828"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Comparison of second-generation cryoballoon ablation and quantitative radiofrequency ablation guided by ablation index for atrial fibrillation.","authors":"Qin-Dan Yan,&nbsp;Ke-Zeng Gong,&nbsp;Xue-Hai Chen,&nbsp;Jian-Hua Chen,&nbsp;Zhe Xu,&nbsp;Wei-Wei Wang,&nbsp;Fei-Long Zhang","doi":"10.4149/BLL_2023_023","DOIUrl":"https://doi.org/10.4149/BLL_2023_023","url":null,"abstract":"<p><p>Ahead of Print article withdrawn by publisher.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9097156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity and heart rate adjustments of diabetic people during isometric contraction.","authors":"Pauline Romualdo Cogo, Angélica Cristiane DA Cruz Britto, Eduardo Federighi Baisi Chagas, Pedro Henrique Rodrigues, Cristiano Sales DA Silva, Robison José Quitério","doi":"10.4149/BLL_2022_146","DOIUrl":"10.4149/BLL_2022_146","url":null,"abstract":"<p><strong>Ntroduction: </strong>Type 2 Diabetes Mellitus (DM2) can lead to autonomic nervous system dysfunction and heart rate variability (HRV) is often used to assess this system both during rest and during physical exercise.</p><p><strong>Objective: </strong>To evaluate the autonomic modulation at rest and the responses of heart rate and parasympathetic indices of individuals with DM2 to isometric handgrip exercise.</p><p><strong>Method: </strong>The sample consisted of individuals of both sexes; over 40 years, divided into groups, with and without DM2 diagnosis. The collection of resting HRV was performed for 20 minutes in the supine position, and 256 points were selected for symbolic and linear analysis. The individuals performed isometric contraction for one minute with intensities of 10, 20, 30, 40 and 50 % of the maximum contraction, using the parasympathetic indexes RMSSD and SD1 for analysis.</p><p><strong>Results: </strong>Linear and symbolic indices of HRV at rest and those obtained during exercise were similar (p-value>0.05). No association was found between the indices at rest and the responses to exercise, with a slight delay in the response of diabetics in HR and parasympathetic indices being identified.</p><p><strong>Conclusion: </strong>There was no difference between the groups in the modulation of rest or in the parasympathetic adjustments of the exercise (Tab. 4, Ref. 32).</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10468429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D insufficiency is not associated with thyroid autoimmunity in Slovak women with Hashimoto´s disease.","authors":"Lenka Filipova,&nbsp;Zora Lazurova,&nbsp;Pavol Fulop,&nbsp;Ivica Lazurova","doi":"10.4149/BLL_2023_029","DOIUrl":"https://doi.org/10.4149/BLL_2023_029","url":null,"abstract":"<p><p>The role of vitamin D (VD) in the etiopathogenesis of autoimmune diseases (AI) is extensively studied. However, its association with autoimmune thyroid disease (AITD) is still controversial. AIM of this study was to assess the relationship between the vitamin D status and thyroid autoimmunity in Slovak premenopausal women with newly diagnosed AITD.</p><p><strong>Subjects and methods: </strong>This prospective case-control study included 57 women with AITD and 41 age- and BMI-matched controls. All subjects were examined for summer and winter serum 25(OH)D, thyroid autoantibodies (a-TPO, a-TG), freeT4 and TSH concentrations. Thyroid volume was measured by ultrasound.</p><p><strong>Results: </strong>There were no significant differences in serum 25(OH)D between AITD and control groups. No significant correlation between 25(OH)D and thyroid autoantibodies was found either in the whole cohort or in AITD women. The prevalence of vitamin D insufficiency was 60.31 % in AITD women and 52.5 % in the control group. No significant association between VD and thyroid autoantibodies, thyroid hormones and thyroid volume was detected in this study.</p><p><strong>Conclusion: </strong>Authors conclude that VD insufficiency is common in Slovak premenopausal women independently of the presence of AITD. Vitamin D insufficiency is not associated with thyroid autoimmunity in patients with early diagnosis of AITD (Tab. 3, Ref. 31). Text in PDF www.elis.sk Keywords: vitamin D, autoimmune thyroid disease, thyroid autoantibodies.</p>","PeriodicalId":55328,"journal":{"name":"Bratislava Medical Journal-Bratislavske Lekarske Listy","volume":"124 3","pages":"182-186"},"PeriodicalIF":1.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}