Cell Communication and Adhesion最新文献_第4页

N-cadherin/catenin complex as a master regulator of intercalated disc function. n -钙粘蛋白/连环蛋白复合物作为嵌入盘功能的主要调节因子。

Cell Communication and Adhesion Pub Date : 2014-06-01 Epub Date: 2014-04-28 DOI: 10.3109/15419061.2014.908853

Alexia Vite, Glenn L Radice

{"title":"N-cadherin/catenin complex as a master regulator of intercalated disc function.","authors":"Alexia Vite, Glenn L Radice","doi":"10.3109/15419061.2014.908853","DOIUrl":"https://doi.org/10.3109/15419061.2014.908853","url":null,"abstract":"Abstract Intercellular adhesive junctions are essential for maintaining the physical integrity of tissues; this is particularly true for the heart that is under constant mechanical load. The correct functionality of the heart is dependent on the electrical and mechanical coordination of its constituent cardiomyocytes. The intercalated disc (ID) structure located at the termini of the rod-shaped adult cardiomyocyte contains various junctional proteins responsible for the integration of structural information and cell–cell communication. According to the classical description, the ID consists of three distinct junctional complexes: adherens junction (AJ), desmosome (Des), and gap junction (GJ) that work together to mediate mechanical and electrical coupling of cardiomyocytes. However, recent morphological and molecular studies indicate that AJ and Des components are capable of mixing together resulting in a “hybrid adhering junction” or “area composita.” This review summarizes recent progress in understanding the in vivo function(s) of AJ components in cardiac homeostasis and disease.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 3","pages":"169-79"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.908853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32292046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Engineering cardiac cell junctions in vitro to study the intercalated disc. 体外工程化心脏细胞连接研究嵌入椎间盘。

Cell Communication and Adhesion Pub Date : 2014-06-01 Epub Date: 2014-04-23 DOI: 10.3109/15419061.2014.905931

Megan L McCain, Thomas Desplantez, André G Kléber

引用次数: 6

Bringing law and order to the cytoskeleton and cell junctions: an interview with Werner Franke. 给细胞骨架和细胞连接带来法律和秩序:对维尔纳·弗兰克的采访。

Cell Communication and Adhesion Pub Date : 2014-06-01 DOI: 10.3109/15419061.2014.914786

Werner Franke, Pamela Cowin

{"title":"Bringing law and order to the cytoskeleton and cell junctions: an interview with Werner Franke.","authors":"Werner Franke, Pamela Cowin","doi":"10.3109/15419061.2014.914786","DOIUrl":"https://doi.org/10.3109/15419061.2014.914786","url":null,"abstract":"PC: Where were you born? WWF: I was born on Jan 31, 1940 during the fi rst weeks of the World War 2, in Paderborn, the place of a thousand springs, one of the oldest cities in Germany, an important place, a King’s palace or Pfalz in the days of Charlemagne. I attended the local high school, the gymnasium, as we call it, one of the oldest schools in Germany that was donated by Pope Leo the 3 rd and of course had a theological focus. In 799 AD he had been thrown out of Rome and came to Charlemagne in Paderborn. They returned to Rome to reinstate him and in return Pope Leo gave Charlemagne two things: fi rst the title: Heiliges R ö misches Reich Deutscher Nation (Holy Roman Empire of the German Nation) and second, the school, which was founded in 806 AD. PC: What was the major factor infl uencing you to go into science? WWF: I and my classmate and sports club friend Theo Plesser were reading science books and doing experiments together on the side in school. He then studied physics and went on to become a Professor at the Max Planck Institute in Dortmund. Initially, I too leaned towards physics. But during my studies in Heidelberg I realized it was then still technically impossible to answer the questions that I had in mind, so I switched to biological applications of physics. As you know I am fascinated by optics. I did my University Diploma in four areas: botany, zoology, chemistry and I particularly enjoyed physics.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 3","pages":"103-7"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2014.914786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32364451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Force measurement tools to explore cadherin mechanotransduction. 力测量工具探讨钙粘蛋白的机械转导。

Cell Communication and Adhesion Pub Date : 2014-06-01 Epub Date: 2014-04-23 DOI: 10.3109/15419061.2014.905929

Sarah C Stapleton, Anant Chopra, Christopher S Chen

引用次数: 17

150th anniversary series: desmosomes in physiology and disease. 150周年纪念系列:生理和疾病中的桥粒。

Cell Communication and Adhesion Pub Date : 2014-04-01 Epub Date: 2014-02-07 DOI: 10.3109/15419061.2013.863281

Nicola Cirillo

引用次数: 11

Contribution of the α8 integrin chain to the expression of extracellular matrix components. α8整合素链对细胞外基质成分表达的贡献。

Cell Communication and Adhesion Pub Date : 2014-04-01 Epub Date: 2014-01-24 DOI: 10.3109/15419061.2013.876012

Gudrun Volkert, Angelika Jahn, Christina Dinkel, Fabian Fahlbusch, Christina Zürn, Karl F Hilgers, Wolfgang Rascher, Andrea Hartner, Ines Marek

{"title":"Contribution of the α8 integrin chain to the expression of extracellular matrix components.","authors":"Gudrun Volkert, Angelika Jahn, Christina Dinkel, Fabian Fahlbusch, Christina Zürn, Karl F Hilgers, Wolfgang Rascher, Andrea Hartner, Ines Marek","doi":"10.3109/15419061.2013.876012","DOIUrl":"https://doi.org/10.3109/15419061.2013.876012","url":null,"abstract":"In the kidney, the α8 integrin chain (itga8) is expressed in mesenchymal cells and is upregulated in fibrotic disease. We hypothesized that itga8 mediates a profibrotic phenotype of renal cells by promoting extracellular matrix and cytokine expression. Genetic itga8 deficiency caused complex changes in matrix expression patterns in mesangial and smooth-muscle cells, with the only concordant effect in both cell types being a reduction of collagen III expression. Silencing of itga8 with siRNA led to a decline of matrix turnover with repression of matrix metalloproteinases and reduction of matrix production. In contrast, de novo expression of itga8 in tubular epithelial cells resulted in reduced collagen synthesis. Overexpression of itga8 in fibroblasts did not change the expression of matrix molecules or regulators of matrix turnover. Thus, the influence of itga8 on the expression of matrix components was not uniform and celltype dependent. Itga8 seems unlikely to exert overall profibrotic effects in renal cells.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 2","pages":"89-98"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.876012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32059485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases. 结合动物模型和体外组织模型阐明桥粒蛋白在疾病中的作用。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876015

Maranke I Koster, Jason Dinella, Jiangli Chen, Charlene O'Shea, Peter J Koch

{"title":"Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases.","authors":"Maranke I Koster, Jason Dinella, Jiangli Chen, Charlene O'Shea, Peter J Koch","doi":"10.3109/15419061.2013.876015","DOIUrl":"https://doi.org/10.3109/15419061.2013.876015","url":null,"abstract":"Desmosomes are intercellular junctions that provide tissues with structural stability. These junctions might also act as signaling centers that transmit environmental clues to the cell, thereby affecting cell differentiation, migration, and proliferation. The importance of desmosomes is underscored by devastating skin and heart diseases caused by mutations in desmosomal genes. Recent observations suggest that abnormal desmosomal protein expression might indirectly contribute to skin disorders previously not linked to these proteins. For example, it has been postulated that reduced desmosomal protein expression occurs in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC), a skin fragility disorder caused by mutations in the transcription factor TP63. Currently, it is not clear how these changes in desmosomal gene expression contribute to AEC. We will discuss new approaches that combine in vitro and in vivo models to elucidate the role of desmosomal gene deregulation in human skin diseases such as AEC.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.876015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32058278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

When rare illuminates common: how cardiocutaneous syndromes transformed our perspective on arrhythmogenic cardiomyopathy. 当罕见阐明常见:心皮肤综合征如何改变我们对心律失常性心肌病的看法。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876415

Srijita Sen-Chowdhry, William J McKenna

引用次数: 7

Highlights from special issue: junctional targets of skin and heart diseases. 特刊亮点:皮肤和心脏疾病的结合点。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2014.876847

Mario Delmar, Kathleen Green, Pamela Cowin

引用次数: 1

Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. 心律失常性心肌病中细胞-细胞连接的重塑。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876016

Angeliki Asimaki, Jeffrey E Saffitz

引用次数: 18