Cell Communication and Adhesion最新文献_第5页

Desmosomal cadherins and signaling: lessons from autoimmune disease. 桥粒体钙粘蛋白和信号:来自自身免疫性疾病的教训。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.877000

Volker Spindler, Jens Waschke

{"title":"Desmosomal cadherins and signaling: lessons from autoimmune disease.","authors":"Volker Spindler, Jens Waschke","doi":"10.3109/15419061.2013.877000","DOIUrl":"https://doi.org/10.3109/15419061.2013.877000","url":null,"abstract":"Autoantibodies from patients suffering from the autoimmune blistering skin disease pemphigus can be applied as tools to study desmosomal adhesion. These autoantibodies targeting the desmosomal cadherins desmoglein (Dsg) 1 and Dsg3 cause disruption of desmosomes and loss of intercellular cohesion. Although pemphigus autoantibodies were initially proposed to sterically hinder desmosomes, many groups have shown that they activate signaling pathways which cause disruption of desmosomes and loss of intercellular cohesion by uncoupling the desmosomal plaque from the intermediate filament cytoskeleton and/or by interfering with desmosome turnover. These studies demonstrate that desmogleins serve as receptor molecules to transmit outside-in signaling and demonstrate that desmosomal cadherins have functions in addition to their adhesive properties. Two central molecules regulating cytoskeletal anchorage and desmosome turnover are p38MAPK and PKC. As cytoskeletal uncoupling in turn enhances Dsg3 depletion from desmosomes, both mechanisms reinforce one another in a vicious cycle that compromise the integrity and number of desmosomes.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 1","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.877000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32058280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Plakophilins in desmosomal adhesion and signaling. 亲血小板蛋白在桥粒黏附和信号传导中的作用。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876017

Mechthild Hatzfeld, Annika Wolf, René Keil

{"title":"Plakophilins in desmosomal adhesion and signaling.","authors":"Mechthild Hatzfeld, Annika Wolf, René Keil","doi":"10.3109/15419061.2013.876017","DOIUrl":"https://doi.org/10.3109/15419061.2013.876017","url":null,"abstract":"The regulation of adhesion and growth is important for epithelial function and dysfunction. β-catenin (armadillo in Drosophila) is the prototype of a multifunctional molecule that regulates cell adhesion via adherens junctions and cell signaling via LEF/TCF transcription factors. Desmosomal armadillo proteins comprise plakoglobin and the plakophilins 1, 2, and 3. These proteins are essential for building up the desmosome and linking the desmosomal cadherins to keratin filaments. High expression of plakophilins in desmosomes correlates with strong intercellular cohesion and is essential for tissue integrity under mechanical stress. However, like β-catenin, these proteins have diverse non-desmosomal functions, for example, in regulating actin organization, protein synthesis, and growth control. In line with these functions, their de-regulated expression with up- as well as down-regulation has been connected to cancer and metastasis. Now, recent evidence sheds light on the post-translational regulation and provides an explanation for how de-regulation of plakophilins can contribute to cancer.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 1","pages":"25-42"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.876017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32060467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Desmosomal adhesion in vivo. 体内桥粒黏附。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876018

Mohamed Berika, David Garrod

引用次数: 28

Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. 到插入椎间盘的贩运高速公路:解锁连接蛋白43定位特异性的新见解。

Cell Communication and Adhesion Pub Date : 2014-02-01 DOI: 10.3109/15419061.2013.876014

Shan-Shan Zhang, Robin M Shaw

{"title":"Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization.","authors":"Shan-Shan Zhang, Robin M Shaw","doi":"10.3109/15419061.2013.876014","DOIUrl":"https://doi.org/10.3109/15419061.2013.876014","url":null,"abstract":"With each heartbeat, billions of cardiomyocytes work in concert to propagate the electrical excitation needed to effectively circulate blood. Regulated expression and timely delivery of connexin proteins to form gap junctions at the specialized cell-cell contact region, known as the intercalated disc, is essential to ventricular cardiomyocyte coupling. We focus this review on several regulatory mechanisms that have been recently found to govern the lifecycle of connexin 43 (Cx43), the short-lived and most abundantly expressed connexin in cardiac ventricular muscle. The Cx43 lifecycle begins with gene expression, followed by oligomerization into hexameric channels, and then cytoskeletal-based transport toward the disc region. Once delivered, hemichannels interact with resident disc proteins and are organized to effect intercellular coupling. We highlight recent studies exploring regulation of Cx43 localization to the intercalated disc, with emphasis on alternatively translated Cx43 isoforms and cytoskeletal transport machinery that together regulate Cx43 gap junction coupling between cardiomyocytes.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"21 1","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.876014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32058279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions. 空间模式:在e -钙粘蛋白连接处协调粘附和肌动球蛋白收缩。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-08 DOI: 10.3109/15419061.2013.856889

Selwin Kaixiang Wu, Alpha S Yap

引用次数: 34

A century of cell adhesion: from the blastomere to the clinic part 1: conceptual and experimental foundations and the pre-molecular era. 一个世纪的细胞粘附:从卵裂球到临床第一部分:概念和实验基础和前分子时代。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-19 DOI: 10.3109/15419061.2013.858713

Gerald B Grunwald

引用次数: 5

Structural and functional diversity of desmosomes. 桥粒的结构和功能多样性。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-08 DOI: 10.3109/15419061.2013.855204

Robert M Harmon, Kathleen J Green

引用次数: 42

Signaling and mechanical roles of E-cadherin. e -钙粘蛋白的信号传导和机械作用。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-08 DOI: 10.3109/15419061.2013.854778

Tanay Bhatt, Abrar Rizvi, Surya Prakash Rao Batta, Sunny Kataria, Colin Jamora

{"title":"Signaling and mechanical roles of E-cadherin.","authors":"Tanay Bhatt, Abrar Rizvi, Surya Prakash Rao Batta, Sunny Kataria, Colin Jamora","doi":"10.3109/15419061.2013.854778","DOIUrl":"https://doi.org/10.3109/15419061.2013.854778","url":null,"abstract":"The epithelium comprises an important tissue that lines the internal and external surfaces of metazoan organs. In order to organize sheets of epithelial cells into three-dimensional tissues, it requires the coordination of basic cellular processes such as polarity, adhesion, growth, and differentiation. Moreover, as a primary barrier to the external environment, epithelial tissues are often subjected to physical forces and damage. This critical barrier function dictates that these fundamental cellular processes are continually operational in order to maintain tissue homeostasis in the face of almost constant trauma and stress. A protein that is largely responsible for the organization and maintenance of epithelial tissues is the transmembrane protein, E-cadherin, found at the surface of epithelial cells. Though originally investigated for its essential role in mediating intercellular cohesion, its impact on a wide array of physiological processes underscores its fundamental contributions to tissue development and its perturbation in a variety of common diseases.","PeriodicalId":55269,"journal":{"name":"Cell Communication and Adhesion","volume":"20 6","pages":"189-99"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/15419061.2013.854778","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31846226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Leaders in cell adhesion: an interview with Richard Hynes, pioneer of cell-matrix interactions. Interview by Pamela Cowin. 细胞粘附的领导者:采访细胞-基质相互作用的先驱理查德·海因斯。帕梅拉·考文采访。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-25 DOI: 10.3109/15419061.2013.857662

Richard Hynes

引用次数: 1

Highlighting young investigators: guest editor Ramanuj DasGupta. Ram DasGupta: pushing the boundaries of β-catenin signaling and drug development. 特邀编辑拉马努杰·达斯古普塔(Ramanuj DasGupta)。Ram DasGupta:推动β-连环蛋白信号和药物开发的边界。

Cell Communication and Adhesion Pub Date : 2013-12-01 Epub Date: 2013-11-25 DOI: 10.3109/15419061.2013.858134

Pamela Cowin

引用次数: 1