力测量工具探讨钙粘蛋白的机械转导。

Q2 Biochemistry, Genetics and Molecular Biology

Cell Communication and Adhesion Pub Date : 2014-06-01 Epub Date: 2014-04-23 DOI:10.3109/15419061.2014.905929

Sarah C Stapleton, Anant Chopra, Christopher S Chen

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引用次数: 17

摘要

细胞-细胞粘附作用于细胞间的机械偶联，在发育、疾病和体内平衡过程中允许力在细胞间的远距离传递。最近的研究表明，这种接触也在将机械信号转导成多种对组织功能重要的细胞行为中发挥作用。因此，通过黏附分子来理解细胞的机械调节已经成为人们关注的焦点。这篇综述将重点介绍现有的和新兴的技术和模型，这些技术和模型允许探索基于钙粘蛋白的粘连作为机械转导的位点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Force measurement tools to explore cadherin mechanotransduction.

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Force measurement tools to explore cadherin mechanotransduction.

Cell-cell adhesions serve to mechanically couple cells, allowing for long-range transmission of forces across cells in development, disease, and homeostasis. Recent work has shown that such contacts also play a role in transducing mechanical cues into a wide variety of cellular behaviors important to tissue function. As such, understanding the mechanical regulation of cells through their adhesion molecules has become a point of intense focus. This review will highlight the existing and emerging technologies and models that allow for exploration of cadherin-based adhesions as sites of mechanotransduction.

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来源期刊

Cell Communication and Adhesion 生物-生化与分子生物学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation Cell Communication and Adhesion is an international Open Access journal which provides a central forum for research on mechanisms underlying cellular signalling and adhesion. The journal provides a single source of information concerning all forms of cellular communication, cell junctions, adhesion molecules and families of receptors from diverse biological systems. The journal welcomes submission of original research articles, reviews, short communications and conference reports.