Clinical & Developmental Immunology最新文献_第6页

Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia. 雷帕霉素联合小剂量强的松治疗慢性免疫性血小板减少症的疗效。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-02 DOI: 10.1155/2013/548085

Jiaming Li, Zhaoyue Wang, Lan Dai, Lijuan Cao, Jian Su, Mingqing Zhu, Ziqiang Yu, Xia Bai, Changgeng Ruan

{"title":"Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia.","authors":"Jiaming Li, Zhaoyue Wang, Lan Dai, Lijuan Cao, Jian Su, Mingqing Zhu, Ziqiang Yu, Xia Bai, Changgeng Ruan","doi":"10.1155/2013/548085","DOIUrl":"https://doi.org/10.1155/2013/548085","url":null,"abstract":"We conducted this randomized trial to investigate the efficacy and safety of rapamycin treatment in adults with chronic immune thrombocytopenia (ITP). Eighty-eight patients were separated into the control (cyclosporine A plus prednisone) and experimental (rapamycin plus prednisone) groups. The CD4⁺CD25⁺CD127(low) regulatory T (Treg) cells level, Foxp3 mRNA expression, and the relevant cytokines levels were measured before and after treatment. The overall response (OR) was similar in both groups (experimental group versus control group: 58% versus 62%, P = 0.70). However, sustained response (SR) was more pronounced in the experimental group than in the control group (68% versus 39%, P < 0.05). Both groups showed similar incidence of adverse events (7% versus 11%, P = 0.51). As expected, the low pretreatment baseline level of Treg cells was seen in all patients (P < 0.001); however, the experimental group experienced a significant rise in Treg cell level, and there was a strong correlation between the levels of Treg cells and TGF-beta after the treatment. In addition, the upregulation maintained a stable level during the follow-up phase. Thus, rapamycin plus low dose prednisone could provide a new promising option for therapy of ITP.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"548085"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/548085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31976596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

T cell vaccination inhibits Th1/Th17/Tfh frequencies and production of autoantibodies in collagen-induced arthritis. T细胞接种抑制Th1/Th17/Tfh频率和胶原诱导关节炎自身抗体的产生。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-02 DOI: 10.1155/2013/967301

Shan Li, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, Guangjie Chen

{"title":"T cell vaccination inhibits Th1/Th17/Tfh frequencies and production of autoantibodies in collagen-induced arthritis.","authors":"Shan Li, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, Guangjie Chen","doi":"10.1155/2013/967301","DOIUrl":"https://doi.org/10.1155/2013/967301","url":null,"abstract":"The aim of this study is to determine whether the regulatory role of T cell vaccination (TCV) is through inhibition of Th1/Th17/Tfh and production of autoantibodies on collagen-induced arthritis (CIA). First, CIA mice were treated with TCV. After disease onset, the incidence and severity of change in joint histopathology were evaluated. Mice in the TCV-treated group showed less disease severity and less infiltration of inflammatory cells in the joint sections. TCV decreased the frequencies of Th1/Th17/Tfh cells and related cytokines. Reduction of IL-21 may be associated with both Tfh and Th17, which further influence B cell and T cell responses. In addition, inhibition of Th1/Th17/Tfh frequencies led to the reduced expression of T-bet, ROR α , ROR γ t, and Bcl6. Lastly, the proliferation of type-II-collagen-(CII-) specific T cells and the production of anti-CII antibodies were inhibited in the TCV-treated group. The results provide novel evidence that the therapeutic effects of TCV on CIA are associated with the inhibition of Th1/Th17/Tfh frequencies and autoantibodies production. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"967301"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/967301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31976598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interleukin-17: a promoter in colorectal cancer progression. 白介素-17:结直肠癌进展的启动子。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-07 DOI: 10.1155/2013/436307

Dang Wu, Pin Wu, Qi Huang, Yang Liu, Jun Ye, Jian Huang

引用次数: 102

Persistence of Th17/Tc17 cell expression upon smoking cessation in mice with cigarette smoke-induced emphysema. 吸烟致肺气肿小鼠戒烟后Th17/Tc17细胞表达的持续性

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-29 DOI: 10.1155/2013/350727

Min-Chao Duan, Hai-Juan Tang, Xiao-Ning Zhong, Ying Huang

{"title":"Persistence of Th17/Tc17 cell expression upon smoking cessation in mice with cigarette smoke-induced emphysema.","authors":"Min-Chao Duan, Hai-Juan Tang, Xiao-Ning Zhong, Ying Huang","doi":"10.1155/2013/350727","DOIUrl":"10.1155/2013/350727","url":null,"abstract":"Th17 and Tc17 cells may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), a disease caused predominantly by cigarette smoking. Smoking cessation is the only intervention in the management of COPD. However, even after cessation, the airway inflammation may be present. In the current study, mice were exposed to room air or cigarette smoke for 24 weeks or 24 weeks followed by 12 weeks of cessation. Morphological changes were evaluated by mean linear intercepts (Lm) and destructive index (DI). The frequencies of CD8(+)IL-17(+)(Tc17) and CD4(+)IL-17(+)(Th17) cells, the mRNA levels of ROR gamma and IL-17, and the levels of IL-8, TNF-alpha, and IFN-gamma in lungs or bronchoalveolar lavage fluid of mice were assayed. Here we demonstrated that alveolar enlargement and destruction induced by cigarette smoke exposure were irreversible and that cigarette smokeenhanced these T-cell subsets, and related cytokines were not significantly reduced after smoking cessation. In addition, the frequencies of Th17 and Tc17 cells in lungs of smoke-exposed mice and cessation mice were positively correlated with emphysematous lesions. More important, the frequencies of Tc17 cells were much higher than Th17 cells, and there was a significantly positive correlation between Th17 and Tc17. These results suggested that Th17/Tc17 infiltration in lungs may play a critical role in sustaining lung inflammation in emphysema. Blocking the abnormally increased numbers of Tc17 and Th17 cells may be a reasonable therapeutic strategy for emphysema. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"350727"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/350727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32084460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Baicalin inhibits IL-17-mediated joint inflammation in murine adjuvant-induced arthritis. 黄芩苷抑制il -17介导的小鼠佐剂性关节炎的关节炎症。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-12 DOI: 10.1155/2013/268065

Xue Yang, Ji Yang, Hejian Zou

引用次数: 55

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. 与 T-helper 17 相关的细胞因子 IL-17、IL-22 和 IL-23 在炎症性疾病中的关键作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-14 DOI: 10.1155/2013/968549

Ning Qu, Mingli Xu, Izuru Mizoguchi, Jun-ichi Furusawa, Kotaro Kaneko, Kazunori Watanabe, Junichiro Mizuguchi, Masahiro Itoh, Yutaka Kawakami, Takayuki Yoshimoto

引用次数: 154

Platelets and inflammatory markers in patients with gastric cancer. 胃癌患者的血小板和炎症标志物。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-03-10 DOI: 10.1155/2013/401623

Joanna Matowicka-Karna, Zbigniew Kamocki, Beata Polińska, Joanna Osada, Halina Kemona

{"title":"Platelets and inflammatory markers in patients with gastric cancer.","authors":"Joanna Matowicka-Karna, Zbigniew Kamocki, Beata Polińska, Joanna Osada, Halina Kemona","doi":"10.1155/2013/401623","DOIUrl":"10.1155/2013/401623","url":null,"abstract":"The aim of the study was to assess the contribution of platelets and inflammatory markers in gastric cancer. We studied 50 patients. Taking into consideration the advancement of gastric cancer, patients were divided into 3 groups. Group (E)--13 patients with early gastric cancer, group (A)--18 patients with regionally advanced cancer, and group (M)--19 patients with metastatic cancer. The determinations were performed twice prior to surgery and after surgery. In patients with gastric cancer, there is an increase in IL-6 and IL-23 compared with the healthy group. The highest values of IL-6 were obtained in early cancer (more than 8-fold increase), which seems to confirm the presence of acute inflammation. The lowest value of both of these cytokines was obtained in patients with metastatic cancer. In all patients, regardless of tumor stage, there was an increase in the concentration of CRP. An increase of PLT, higher proportion of the percentage of large platelets (LPLT), and increased mean platelet volume (MPV) were observed in the process of disease development. A positive correlation between MPV and LPLT and the accompanying decrease in the concentration of proinflammatory cytokines indicates the presence of an existing relationship between the platelet morphological parameters and the inflammation process in the development of gastric cancer.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":" ","pages":"401623"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/401623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40242411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis. 类风湿关节炎患者外周血单个核细胞和成纤维细胞样滑膜细胞microRNA-155表达上调。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-17 DOI: 10.1155/2013/296139

Li Long, Ping Yu, Yanying Liu, Shiyao Wang, Ru Li, Jinxia Shi, Xiaoping Zhang, Yanmei Li, Xiaolin Sun, Bin Zhou, Liufu Cui, Zhanguo Li

{"title":"Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis.","authors":"Li Long, Ping Yu, Yanying Liu, Shiyao Wang, Ru Li, Jinxia Shi, Xiaoping Zhang, Yanmei Li, Xiaolin Sun, Bin Zhou, Liufu Cui, Zhanguo Li","doi":"10.1155/2013/296139","DOIUrl":"https://doi.org/10.1155/2013/296139","url":null,"abstract":"Objective: This study was to screen for the miRNAs differently expressed in peripheral blood mononuclear cells (PBMC) of RA, to further identify the expression of miR-155 in RA PBMC and fibroblast-like synoviocytes (FLS), and to evaluate the function of miR-155 in RA-FLS.Methods: Microarray was used to screen for differentially expressed miRNAs in RA PBMC. miR-155 expression in PBMC and FLS of RA were identified by real-time PCR. Enforced overexpression and downexpression of miR-155 were used to investigate the function of miR-155 in RA-FLS. Expression of IKBKE which was previously identified as the actual target of miR-155 was examined by Western blot and real-time PCR in RA-FLS.Results: miR-155 levels were increased in both PBMC and FLS of RA and could be induced by TNF- α . Upregulation of miR-155 decreased MMP-3 levels and suppressed proliferation and invasion of RA-FLS. Inverse relationship between the expressions of miR-155 and the MMPs production-related protein IKBKE was found.Conclusion: An inflammatory milieu may alter miRNA expression profiles in rheumatoid arthritis. miR-155 is upregulated in RA-FLS, and it may be a protective factor against the inflammatory effect in part by attenuating expression of IKBKE.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":" ","pages":"296139"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/296139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40259859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 93

Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata. 自身免疫性脱发病斑秃发病机制的研究进展。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-18 DOI: 10.1155/2013/348546

Taisuke Ito

引用次数: 101

Clinical characteristics of Nocardia infection in patients with rheumatic diseases. 风湿病患者诺卡菌感染的临床特点。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-19 DOI: 10.1155/2013/818654

Mieko Yamagata, Koichi Hirose, Kei Ikeda, Hiroshi Nakajima

引用次数: 9