Clinical & Developmental Immunology最新文献_第5页

Molecular pathogenesis of B-cell posttransplant lymphoproliferative disorder: what do we know so far? b细胞移植后淋巴细胞增生性疾病的分子发病机制:目前我们知道些什么?

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-04-14 DOI: 10.1155/2013/150835

J Morscio, D Dierickx, T Tousseyn

{"title":"Molecular pathogenesis of B-cell posttransplant lymphoproliferative disorder: what do we know so far?","authors":"J Morscio, D Dierickx, T Tousseyn","doi":"10.1155/2013/150835","DOIUrl":"10.1155/2013/150835","url":null,"abstract":"Posttransplant lymphoproliferative disorder (PTLD) is a potentially fatal disease that arises in 2%-10% of solid organ and hematopoietic stem cell transplants and is most frequently of B-cell origin. This very heterogeneous disorder ranges from benign lymphoproliferations to malignant lymphomas, and despite the clear association with Epstein-Barr Virus (EBV) infection, its etiology is still obscure. Although a number of risk factors have been identified (EBV serostatus, graft type, and immunosuppressive regimen), it is currently not possible to predict which transplant patient will eventually develop PTLD. Genetic studies have linked translocations (involving C-MYC, IGH, BCL-2), various copy number variations, DNA mutations (PIM1, PAX5, C-MYC, RhoH/TTF), and polymorphisms in both the host (IFN-gamma, IL-10, TGF-beta, HLA) and the EBV genome to B-cell PTLD development. Furthermore, the tumor microenvironment seems to play an important role in the course of disease representing a local niche that can allow antitumor immune responses even in an immunocompromised host. Taken together, B-cell PTLD pathogenesis is very complex due to the interplay of many different (patient-dependent) factors and requires thorough molecular analysis for the development of novel tailored therapies. This review aims at giving a global overview of the currently known parameters that contribute to the development of B-cell PTLD.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"150835"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/150835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31537022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 91

The correlations of disease activity, socioeconomic status, quality of life, and depression/anxiety in Chinese patients with systemic lupus erythematosus. 中国系统性红斑狼疮患者疾病活动度、社会经济地位、生活质量和抑郁/焦虑的相关性

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-20 DOI: 10.1155/2013/270878

Biyu Shen, Wei Tan, Guijuan Feng, Yan He, Jinwei Liu, Weijun Chen, Xiaoqin Huang, Zhanyun Da, Xujuan Xu, Hong Liu, Zhifeng Gu

{"title":"The correlations of disease activity, socioeconomic status, quality of life, and depression/anxiety in Chinese patients with systemic lupus erythematosus.","authors":"Biyu Shen, Wei Tan, Guijuan Feng, Yan He, Jinwei Liu, Weijun Chen, Xiaoqin Huang, Zhanyun Da, Xujuan Xu, Hong Liu, Zhifeng Gu","doi":"10.1155/2013/270878","DOIUrl":"https://doi.org/10.1155/2013/270878","url":null,"abstract":"The prevalence of psychological problems is frequent in systemic lupus erythematosus (SLE) patients and appears to be increasing. The current study investigated the relationship among disease parameters, quality of life, and the psychological status in Chinese patients with SLE. A self-report survey design was administered to 170 SLE patients and 210 healthy individuals using the Self-Rating Anxiety Scale, the Self-Rating Depression Scale, and the Short Form 36 health survey (SF-36). Our results showed that 20.3% SLE patients had anxiety, and 32.9% had depression, which were significantly higher than the control group (7.1%, 14.3%, resp.). And there were significant correlations among socioeconomic status (SES), disease activity, and anxiety/depression in SLE patients. Meanwhile, SF-36 analysis results revealed that VT, PF, and RP scales were the most powerful predictors of anxiety of SLE patients, and SLEDAI, VT, PF, SF, and RE domains were significantly accounted for anxiety. In summary, there were significant relationships among disease parameters, quality of life, and anxiety/depression in Chinese SLE patients. Therefore, it is necessary to have psychiatric and psychological evaluations and formulate an integrated approach for managing mental health in Chinese lupus patients, especially those who have high disease activity, low SES, and poor quality of life. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"270878"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/270878","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31589159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 67

Dextromethorphan inhibits activations and functions in dendritic cells. 右美沙芬抑制树突状细胞的激活和功能。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-05-28 DOI: 10.1155/2013/125643

Der-Yuan Chen, Pei-Shan Song, Jau-Shyong Hong, Ching-Liang Chu, I-Horng Pan, Yi-Ming Chen, Ching-Hsiung Lin, Sheng-Hao Lin, Chi-Chen Lin

{"title":"Dextromethorphan inhibits activations and functions in dendritic cells.","authors":"Der-Yuan Chen, Pei-Shan Song, Jau-Shyong Hong, Ching-Liang Chu, I-Horng Pan, Yi-Ming Chen, Ching-Hsiung Lin, Sheng-Hao Lin, Chi-Chen Lin","doi":"10.1155/2013/125643","DOIUrl":"https://doi.org/10.1155/2013/125643","url":null,"abstract":"Dendritic cells (DCs) play an important role in connecting innate and adaptive immunity. Thus, DCs have been regarded as a major target for the development of immunomodulators. In this study, we examined the effect of dextromethorphan (DXM), a common cough suppressant with a high safety profile, on the activation and function of DCs. In the presence of DXM, the LPS-induced expression of the costimulatory molecules in murine bone marrow-derived dendritic cells (BMDCs) was significantly suppressed. In addition, DXM treatment reduced the production of reactive oxygen species (ROS), proinflammatory cytokines, and chemokines in maturing BMDCs that were activated by LPS. Therefore, DXM abrogated the ability of LPS-stimulated DCs to induce Ag-specific T-cell activation, as determined by their decreased proliferation and IFN- γ secretion in mixed leukocyte cultures. Moreover, the inhibition of LPS-induced MAPK activation and NF- κ B translocation may contribute to the suppressive effect of DXM on BMDCs. Remarkably, DXM decreased the LPS-induced surface expression of CD80, CD83, and HLA-DR and the secretion of IL-6 and IL-12 in human monocyte-derived dendritic cells (MDDCs). These findings provide a new insight into the impact of DXM treatment on DCs and suggest that DXM has the potential to be used in treating DC-related acute and chronic diseases.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"125643"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/125643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31610974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Altered immune regulation in type 1 diabetes. 1型糖尿病的免疫调节改变。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-08-21 DOI: 10.1155/2013/254874

András Zóka, Györgyi Műzes, Anikó Somogyi, Tímea Varga, Barbara Szémán, Zahra Al-Aissa, Orsolya Hadarits, Gábor Firneisz

{"title":"Altered immune regulation in type 1 diabetes.","authors":"András Zóka, Györgyi Műzes, Anikó Somogyi, Tímea Varga, Barbara Szémán, Zahra Al-Aissa, Orsolya Hadarits, Gábor Firneisz","doi":"10.1155/2013/254874","DOIUrl":"https://doi.org/10.1155/2013/254874","url":null,"abstract":"Research in genetics and immunology was going on separate strands for a long time. Type 1 diabetes mellitus might not be characterized with a single pathogenetic factor. It develops when a susceptible individual is exposed to potential triggers in a given sequence and timeframe that eventually disarranges the fine-tuned immune mechanisms that keep autoimmunity under control in health. Genomewide association studies have helped to understand the congenital susceptibility, and hand-in-hand with the immunological research novel paths of immune dysregulation were described in central tolerance, apoptotic pathways, or peripheral tolerance mediated by regulatory T-cells. Epigenetic factors are contributing to the immune dysregulation. The interplay between genetic susceptibility and potential triggers is likely to play a role at a very early age and gradually results in the loss of balanced autotolerance and subsequently in the development of the clinical disease. Genetic susceptibility, the impaired elimination of apoptotic β -cell remnants, altered immune regulatory functions, and environmental factors such as viral infections determine the outcome. Autoreactivity might exist under physiologic conditions and when the integrity of the complex regulatory process is damaged the disease might develop. We summarized the immune regulatory mechanisms that might have a crucial role in disease pathology and development. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"254874"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/254874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31910370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. 用CB2激动剂JWH-133治疗可降低高胆固醇血症小鼠勃起功能障碍相关的组织学特征。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-11-03 DOI: 10.1155/2013/263846

Rodrigo Araujo Fraga-Silva, Fabiana Pereira Costa-Fraga, Fabrizio Montecucco, Younouss Faye, Silvia Quintao Savergnini, Sébastien Lenglet, François Mach, Sabine Steffens, Nikolaos Stergiopulos, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

{"title":"Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice.","authors":"Rodrigo Araujo Fraga-Silva, Fabiana Pereira Costa-Fraga, Fabrizio Montecucco, Younouss Faye, Silvia Quintao Savergnini, Sébastien Lenglet, François Mach, Sabine Steffens, Nikolaos Stergiopulos, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva","doi":"10.1155/2013/263846","DOIUrl":"https://doi.org/10.1155/2013/263846","url":null,"abstract":"Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. The cannabinoid system might regulate peripheral mechanisms of sexual function; however, its role is still poorly understood. We investigated the effects of CB2 activation on oxidative stress and fibrosis within the corpus cavernosum of hypercholesterolemic mice. Apolipoprotein-E-knockout mice were fed with a western-type diet for 11 weeks and treated with JWH-133 (selective CB2 agonist) or vehicle during the last 3 weeks. CB2 receptor expression, total collagen content, and reactive oxygen species (ROS) production within the penis were assessed. In vitro corpus cavernosum strips preparation was performed to evaluate the nitric oxide (NO) bioavailability. CB2 protein expression was shown in cavernosal endothelial and smooth muscle cells of wild type and hypercholesterolemic mice. Treatment with JWH-133 reduced ROS production and NADPH-oxidase expression in hypercholesterolemic mice penis. Furthermore, JWH-133 increased endothelial NO synthase expression in the corpus cavernosum and augmented NO bioavailability. The decrease in oxidative stress levels was accompanied with a reduction in corpus cavernosum collagen content. In summary, CB2 activation decreased histological features, which were associated with erectile dysfunction in hypercholesterolemic mice. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"263846"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/263846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31925541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Persistent suppression of type 1 diabetes by a multicomponent vaccine containing a cholera toxin B subunit-autoantigen fusion protein and complete Freund's adjuvant. 含有霍乱毒素B亚单位-自身抗原融合蛋白和完全弗氏佐剂的多组分疫苗对1型糖尿病的持续抑制

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-11-11 DOI: 10.1155/2013/578786

Béla Dénes, István Fodor, William H R Langridge

引用次数: 11

Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE⁻/⁻ mice. toll样受体4在lps -挑战ApoE中狼疮肺损伤和动脉粥样硬化中的作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-09-15 DOI: 10.1155/2013/476856

Jing-qin Ni, Qiufang Ouyang, Ling Lin, Ziyang Huang, Huixia Lu, Xiaoqing Chen, Huili Lin, Zhenhua Wang, Dongming Xu, Yun Zhang

{"title":"Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE⁻/⁻ mice.","authors":"Jing-qin Ni, Qiufang Ouyang, Ling Lin, Ziyang Huang, Huixia Lu, Xiaoqing Chen, Huili Lin, Zhenhua Wang, Dongming Xu, Yun Zhang","doi":"10.1155/2013/476856","DOIUrl":"https://doi.org/10.1155/2013/476856","url":null,"abstract":"To investigate the pathologic mechanisms of toll-like receptor 4 (TLR4) in lung injury and atherosclerosis, ApoE⁻/⁻ or wild-type mice were intraperitoneally administered saline, lipopolysaccharides (LPS), or LPS plus TAK-242 (TLR4 inhibitor), respectively, twice a week for 4 weeks. Serum autoantibody of antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), and cytokines of interferon-gamma (IFN-γ), tumor necrosis factor (TNF-α ), and interleukin-1 (IL-1β) were assessed by ELISA. Hematoxylin and eosin (HE) and Perl's stains for lung pathomorphology as well as HE staining for atherosclerosis were employed. TLR4 in macrophages was detected by double immunofluorescent staining. While protein expressions of TLR4, nuclear factor-kappa B p65 (NF-κB p65), and B cell activating factor belonging to the TNF family (BAFF) were examined by immunohistochemistry. We found that serum autoantibody (ANA and anti-dsDNA), cytokines (IFN-γ, TNF-α, IL-1β), lung inflammation, and intima-media thickness in brachiocephalic artery were obviously increased after LPS challenge in both genotypes, but to a lesser extent in wild-type strains. And those alterations were alleviated by coadministration of LPS and TAK-242. Mechanistically, upregulation of TLR4, NF-κb, and BAFF was involved. We concluded that TLR4/NF-κb/BAFF in macrophages might be a possible common autoimmune pathway that caused lung injury and atherosclerosis. TLR4 signal will be a therapeutic target in atherosclerosis and immune-mediated lung injury.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"476856"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/476856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Notch signaling and T-helper cells in EAE/MS. 缺口信号和t辅助细胞在EAE/MS中的作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-11-14 DOI: 10.1155/2013/570731

Ribal Bassil, William Orent, Wassim Elyaman

引用次数: 16

Helicobacter pylori infection and light chain gammopathy. 幽门螺杆菌感染及轻链γ -病变。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-02 DOI: 10.1155/2013/348562

José A Girón, Shawn L Shah

{"title":"Helicobacter pylori infection and light chain gammopathy.","authors":"José A Girón, Shawn L Shah","doi":"10.1155/2013/348562","DOIUrl":"https://doi.org/10.1155/2013/348562","url":null,"abstract":"Objective: Helicobacter pylori provokes a host of immune alterations upon colonizing the gastric mucosa.Design: We report 22 individuals with confirmed Helicobacter pylori infection who were also managed for the concurrent elevation of immunoglobulin free light chain (kappa and lambda) levels.Result: Of the 22 patients, 15 patients (68.2%) had elevated free light chain levels: 6 patients (40%) had only kappa chain elevation, 2 patients (13.3%) had only lambda chain elevation, and 7 patients (46.7%) had both kappa and lambda chain elevation. Twenty out of the 22 patients (90.9%) were microbiologically confirmed cured with 3 patients being lost to follow-up for repeat levels. Of the 3 patients who were lost to follow-up, 1 patient had only kappa chain elevation, 1 patient had only lambda chain elevation, and 1 patient had both kappa and lambda chain elevation. For those who were cured (19 patients), 5 patients with kappa elevation had normalized values, 4 patients with lambda elevation had normalized values, and 2 patients with combined kappa and lambda elevation had normalized values. For 6 out of the 19 patients, the light chain levels remained elevated.Conclusion: We speculate that the Helicobacter pylori infection disrupts the immunoglobulin system with potential implications being discussed below.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"348562"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/348562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31976594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The effect of perioperative immunonutrition on the phagocytic activity of blood platelets in advanced gastric cancer patients. 围手术期免疫营养对晚期胃癌患者血小板吞噬活性的影响。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-12-01 DOI: 10.1155/2013/435672

Zbigniew Kamocki, Joanna Matowicka-Karna, Mariusz Gryko, Konrad Zareba, Boguslaw Kedra, Halina Kemona

{"title":"The effect of perioperative immunonutrition on the phagocytic activity of blood platelets in advanced gastric cancer patients.","authors":"Zbigniew Kamocki, Joanna Matowicka-Karna, Mariusz Gryko, Konrad Zareba, Boguslaw Kedra, Halina Kemona","doi":"10.1155/2013/435672","DOIUrl":"https://doi.org/10.1155/2013/435672","url":null,"abstract":"Background and aims: Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer.Methods: 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I--TPN, II--oral arginine, peripheral TPN, III--TPN preoperatively, and IV--without nutrition. The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag).Results: The percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I--1.136-1.237, P = NS, and 1.007-1.1, P = NS, respectively, II--1.111-1.25, P < 0.05, and 1.011-1.083, P < 0.05, III--1.112-1.186, P = NS, and 0.962-1.042, P = NS, and IV--1.085-0.96, P = NS, and 1.023-1.04, P = NS.Conclusions: The phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired. Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets. This trial is registered with Clinicaltrials.gov--NCT01704664.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"435672"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/435672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31976595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9