Clinical & Developmental Immunology最新文献_第2页

Dexamethasone preconditioning improves the response of collagen-induced arthritis to treatment with short-term lipopolysaccharide-stimulated collagen-loaded dendritic cells. 地塞米松预处理改善胶原诱导关节炎对短期脂多糖刺激胶原负载树突状细胞治疗的反应。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-05-29 DOI: 10.1155/2013/296031

Corina Peña, David Gárate, Juan Contreras-Levicoy, Octavio Aravena, Diego Catalán, Juan C Aguillón

{"title":"Dexamethasone preconditioning improves the response of collagen-induced arthritis to treatment with short-term lipopolysaccharide-stimulated collagen-loaded dendritic cells.","authors":"Corina Peña, David Gárate, Juan Contreras-Levicoy, Octavio Aravena, Diego Catalán, Juan C Aguillón","doi":"10.1155/2013/296031","DOIUrl":"https://doi.org/10.1155/2013/296031","url":null,"abstract":"Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an injection of lipopolysaccharide-(LPS-) stimulated and CII-loaded DCs on the CIA course. Methods. After CIA induction, mice pretreated with DXM were injected with 4-hour LPS-stimulated DCs loaded with CII (DXM/4hLPS/CII/DCs). Results. Mice injected with DXM/4hLPS/CII/DCs displayed significantly less severe clinical disease compared to animals receiving 4hLPS/CII/DCs alone or those in which only DXM was administered. Cytokine profile evaluation showed that CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups release higher IL-10 levels than those from mice receiving DXM alone or CIA mice. CD4+ T cells from all DC-treated groups showed less IL-17 release when compared to the CIA group. On the contrary, CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups released higher IFN- γ levels than those from CIA group. Conclusion. A combined treatment, including DXM preconditioning followed by an inoculation of short-term LPS-stimulated CII-loaded DCs, provides an improved strategy for attenuating CIA severity. Our results suggest that this benefit is driven by a modulation in the cytokine profile secreted by CD4+ T cells. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"296031"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/296031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31549531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Interleukin-19 in breast cancer. 白细胞介素-19在乳腺癌中的作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-04-22 DOI: 10.1155/2013/294320

Ying-Yin Chen, Chien-Feng Li, Ching-Hua Yeh, Ming-Shi Chang, Chung-Hsi Hsing

引用次数: 27

Interaction among cells of bone, immune system, and solid tumors leads to bone metastases. 骨细胞、免疫系统和实体瘤之间的相互作用导致骨转移。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-04-24 DOI: 10.1155/2013/315024

Ilaria Roato

引用次数: 20

Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain. 在小鼠实验性胶质瘤模型中，通过抗cd25治疗耗用调节性T细胞导致脑内非免疫抑制性骨髓细胞浸润。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-04-23 DOI: 10.1155/2013/952469

Wim Maes, Tina Verschuere, Anaïs Van Hoylandt, Louis Boon, Stefaan Van Gool

引用次数: 41

Collagen XVII: a shared antigen in neurodermatological interactions? 胶原蛋白 XVII：神经性皮肤病相互作用中的共同抗原？

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-26 DOI: 10.1155/2013/240570

Allan Seppänen

引用次数: 40

JC polyomavirus (JCV) and monoclonal antibodies: friends or potential foes? JC多瘤病毒(JCV)和单克隆抗体:朋友还是潜在的敌人?

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-06-25 DOI: 10.1155/2013/967581

Roberta Antonia Diotti, Akira Nakanishi, Nicola Clementi, Nicasio Mancini, Elena Criscuolo, Laura Solforosi, Massimo Clementi

引用次数: 15

The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption. 强直性脊柱炎、克罗恩病、克雷伯氏菌与淀粉摄入量之间的联系。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-05-27 DOI: 10.1155/2013/872632

Taha Rashid, Clyde Wilson, Alan Ebringer

{"title":"The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.","authors":"Taha Rashid, Clyde Wilson, Alan Ebringer","doi":"10.1155/2013/872632","DOIUrl":"10.1155/2013/872632","url":null,"abstract":"Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the Klebsiella microbes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiella antibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"872632"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31610975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the immune system in Huntington's disease. 免疫系统在亨廷顿氏症中的作用。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-15 DOI: 10.1155/2013/541259

Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A Linker

{"title":"The role of the immune system in Huntington's disease.","authors":"Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A Linker","doi":"10.1155/2013/541259","DOIUrl":"10.1155/2013/541259","url":null,"abstract":"Huntington's disease (HD) is characterized by a progressive course of disease until death 15-20 years after the first symptoms occur and is caused by a mutation with expanded CAG repeats in the huntingtin (htt) protein. Mutant htt (mhtt) in the striatum is assumed to be the main reason for neurodegeneration. Knowledge about pathophysiology has rapidly improved discussing influences of excitotoxicity, mitochondrial damage, free radicals, and inflammatory mechanisms. Both innate and adaptive immune systems may play an important role in HD. Activation of microglia with expression of proinflammatory cytokines, impaired migration of macrophages, and deposition of complement factors in the striatum indicate an activation of the innate immune system. As part of the adaptive immune system, dendritic cells (DCs) prime T-cell responses secreting inflammatory mediators. In HD, DCs may contain mhtt which brings the adaptive immune system into the focus of interest. These data underline an increasing interest in the peripheral immune system for pathomechanisms of HD. It is still unclear if neuroinflammation is a reactive process or if there is an active influence on disease progression. Further understanding the influence of inflammation in HD using mouse models may open various avenues for promising therapeutic approaches aiming at slowing disease progression or forestalling onset of disease. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"541259"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LPS-induced inflammation potentiates the IL-1β-mediated reduction of LH secretion from the anterior pituitary explants. LPS诱导的炎症增强了IL-1β介导的垂体前叶LH分泌减少。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-17 DOI: 10.1155/2013/926937

Andrzej Przemysław Herman, Agata Krawczyńska, Joanna Bochenek, Elżbieta Dobek, Anna Herman, Dorota Tomaszewska-Zaremba

{"title":"LPS-induced inflammation potentiates the IL-1β-mediated reduction of LH secretion from the anterior pituitary explants.","authors":"Andrzej Przemysław Herman, Agata Krawczyńska, Joanna Bochenek, Elżbieta Dobek, Anna Herman, Dorota Tomaszewska-Zaremba","doi":"10.1155/2013/926937","DOIUrl":"10.1155/2013/926937","url":null,"abstract":"Acting at the level of the brain, interleukin- (IL-)1 β is considered to be one of the most potent downregulators of reproduction processes during immune/inflammatory challenge. IL-1 β suppresses gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus resulting in the inhibition of the luteinizing hormone (LH) release from the anterior pituitary (AP). However, the presence of IL-1 β receptors in the AP suggests the possible direct action of this cytokine on LH secretion. The study was designed to determine the effect of IL-1 β on the LH secretion from the AP explants collected from saline and LPS-treated ewes in the follicular phase. It was found that IL-1 β suppressed (P ≤ 0.01) GnRH-stimulated LH release and LH β gene expression in AP explants in both groups. However, IL-1 β action was more potent in the explants collected from LPS-treated animals. Pituitaries from LPS-treated animals were characterized by increased (P ≤ 0.01) IL-1 type I receptor and decreased (P ≤ 0.01) GnRH receptor gene expression level compared to the saline-treated group. IL-1 β also affected the GnRH-R gene expression in explants collected from LPS-treated animals. Our results show that direct action of IL-1 β on the pituitary gonadotropes could be one of the reasons of the reproductive processes disorders accompanying an inflammatory state. ","PeriodicalId":55254,"journal":{"name":"Clinical & Developmental Immunology","volume":"2013 ","pages":"926937"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homeostatic T cell proliferation after islet transplantation. 胰岛移植后稳态T细胞增殖。

Clinical & Developmental Immunology Pub Date : 2013-01-01 Epub Date: 2013-07-22 DOI: 10.1155/2013/217934

Paolo Monti, Lorenzo Piemonti

引用次数: 17