Clinical and Experimental Ophthalmology最新文献

{"title":"Cataract Surgery in the Small Adult Eye: A Review","authors":"Jonathan E. Moore,&nbsp;Richard N. McNeely,&nbsp;Salissou Moutari","doi":"10.1111/ceo.14510","DOIUrl":"10.1111/ceo.14510","url":null,"abstract":"<p>Modern cataract surgery continues to advance, yet intraocular lens (IOL) based surgery in the small adult eye remains challenging. Thorough preoperative assessment and surgical preparation optimise postoperative outcomes in these cases. Advances in IOL power calculation, including artificial intelligence-driven formulas, improve accuracy; however, careful consideration of biometry and IOL power selection is still necessary because inaccuracies can produce significant errors. Limited availability of high-powered IOLs to fully correct high refractive errors may necessitate further intervention. Surgical techniques have evolved to address the unique anatomical challenges of small eyes, improving safety and outcomes. Knowledge of the potential risks inherent in these cases can assist the surgeon in modifying the operative technique accordingly. This review discusses essential preoperative assessments, IOL power selection, surgical techniques, and potential complications, offering guidance for surgeons performing cataract surgery on small adult eyes.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 5","pages":"558-569"},"PeriodicalIF":4.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveal Melanoma Treatment: A Paradigm Shift?","authors":"Gustav Stålhammar","doi":"10.1111/ceo.14496","DOIUrl":"https://doi.org/10.1111/ceo.14496","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 2","pages":"113-115"},"PeriodicalIF":4.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Professional Development","authors":"","doi":"10.1111/ceo.14499","DOIUrl":"https://doi.org/10.1111/ceo.14499","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 2","pages":"221-224"},"PeriodicalIF":4.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Challenge of Managing Paediatric Periorbital Cellulitis","authors":"Kathy Jao,&nbsp;Shuan Dai","doi":"10.1111/ceo.14497","DOIUrl":"https://doi.org/10.1111/ceo.14497","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 2","pages":"116-118"},"PeriodicalIF":4.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Cost New Glaucoma Drainage Device in Indonesia: One Year Follow-Up of 252 Subjects","authors":"Virna Dwi Oktariana Asrory,&nbsp;William H. Morgan","doi":"10.1111/ceo.14509","DOIUrl":"10.1111/ceo.14509","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To evaluate the early efficacy and safety of a new polymethyl methacrylate 200 mm² non-valved glaucoma drainage device (GDD) designed for Indonesian use over a 12 month period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a prospective study following subjects with various forms of refractory glaucoma aged ≥ 7 years old followed for 12 months. The subjects had IOP measurements and biomicroscopy examination preoperatively and at 1, 3, 6 and 12 months timepoints. We noted anti-glaucoma medication use and additional interventions during follow-up. Success was defined as an IOP &gt; 5 and ≤ 21 mmHg on no medications (complete) or medications (qualified).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 252 subjects, 31% (79/252) primary glaucoma and 69% (173/252) secondary glaucoma. All primary glaucoma had previous surgery. The majority of secondary glaucoma was post-vitrectomy and silicone oil insertion 35.6% (62/174). The mean pre-op IOP was 36.8 ± 12.2 mmHg and the 12 months post op IOP was 14.2 ± 6.6 mmHg. The qualified success rate was 89% at 1 year and the complete success was 57%. Mean medication use dropped from 3.5 to 1.3. Certain subtypes (Silicone oil and POAG) appeared to experience greater IOP reduction, however they also had greater preoperative IOP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This new GDD has comparable IOP lowering outcomes compared with other non-valved glaucoma drainage devices during 1 year follow up with similar complication rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 5","pages":"493-501"},"PeriodicalIF":4.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monogenic Retinal Diseases Associated With Genes Encoding Phototransduction Proteins: A Review","authors":"Wendy M. Wong,&nbsp;Omar A. Mahroo","doi":"10.1111/ceo.14511","DOIUrl":"10.1111/ceo.14511","url":null,"abstract":"<p>Phototransduction, the process by which captured photons elicit electrical changes in retinal rod and cone cells, represents the first neuronal step in vision and involves interactions between several highly specialised proteins. Pathogenic variants in genes encoding many of these proteins can give rise to significant vision impairment, accounting for a substantial portion of inherited retinal disease. Such genes include <i>RHO</i>, <i>OPN1LW</i>, <i>OPN1MW</i>, <i>GNAT1</i>, <i>GNAT2</i>, <i>GNB3</i>, <i>PDE6A</i>, <i>PDE6B</i>, <i>PDE6G</i>, <i>PDE6C</i>, <i>PDE6H</i>, <i>CNGA1</i>, <i>CNGB1</i>, <i>CNGA3</i>, <i>CNGB3</i>, <i>GRK1</i>, <i>SAG</i>, <i>ARR3</i>, <i>RGS9</i>, <i>RGS9BP</i>, <i>GUCY2D</i>, <i>GUCA1A</i> and <i>SLC24A1</i>. Many of these conditions have distinct mechanisms and clinical features. They follow several modes of inheritance (including in one case digenic, or tri-allelic, inheritance). Some conditions also entail myopia. Rod and cone phototransduction will be outlined, followed by the discussion of diseases associated with these genes. Some phenotypic features will be highlighted as well as their prevalence in a large genotyped inherited retinal disease cohort.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"260-280"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14511","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Intraocular Lens Exchange Rates in Australia 2003-2022.","authors":"Bobak Bahrami, Carmelo Macri, Adrian Esterman, Michael Goggin, Weng Onn Chan","doi":"10.1111/ceo.14512","DOIUrl":"https://doi.org/10.1111/ceo.14512","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of SLC38A8 and Its Role in Retinal Pathways and Disease","authors":"Chen Weiner,&nbsp;Idan Hecht,&nbsp;Jiri Lindovsky,&nbsp;Marcela Palkova,&nbsp;Michaela Krupkova,&nbsp;Petr Kasparek,&nbsp;Jan Prochazka,&nbsp;Radislav Sedlacek,&nbsp;Alina Kotlyar,&nbsp;Nir Raini,&nbsp;Yonathan Zehavi,&nbsp;Yevgeni Yegorov,&nbsp;Pnina Hilman,&nbsp;Ranin Basel,&nbsp;Ramzia Abu-Hamed,&nbsp;Noam Shomron,&nbsp;Eran Pras","doi":"10.1111/ceo.14504","DOIUrl":"10.1111/ceo.14504","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study investigates the role of the <i>SLC38A8</i> gene. <i>SLC38A8</i> facilitates glutamine influx, which converts to glutamate in the visual pathway. Mutations in <i>SLC38A8</i> are associated with FHONDA syndrome, a subtype of foveal hypoplasia with congenital nystagmus and optic-nerve-decussation defects without pigmentation leading to severe vision loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In vivo and in vitro methods were conducted using retinal cell lines overexpressing <i>SLC38A8</i>, and <i>Slc38a8</i>/<i>Slc38a7</i> gene-edited mice to evaluate visual function and physiological changes. Statistical analyses included two-way ANOVA, multiple regression, and ANCOVA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In vitro, <i>SLC38A8</i> overexpression influenced retinal gene expression, light detection, and visual perception, as well as glutamine and glutamate dynamics. In Y79^SNAT8-OE cells, glutamate levels were significantly higher under light conditions compared to dark conditions at 12 h (3.4 ± 0.16 nmol/μl vs. 3.9 ± 0.17 nmol/μl, <i>p</i> = 0.0011) and 17 h (3.6 ± 0.22 nmol/μl vs. 4.5 ± 0.24 nmol/μl, <i>p</i> = 0.0001), a pattern not observed in control cells. <i>SLC38A8</i> expression also increased significantly (RQ = 2.1 ± 0.11, <i>p</i> &lt; 0.05) in Y79 cells under glutamine deprivation. In vivo, <i>Slc38a8</i>-truncated gene mice exhibited altered testicular morphology, with significantly reduced volume (70.9 ± 5.1 mm³ vs. 85.5 ± 6.7 mm³, <i>p</i> = 0.023), and reduced length (4.8 ± 0.2 mm vs. 5.4 ± 0.4 mm, <i>p</i> = 0.0169), alongside degenerative changes in germinal epithelium, and elevated liver enzyme. Despite normal eye morphology, retinal thickness, and visual evoked potentials, electroretinogram and behavioural tests indicated enhanced scotopic responsiveness with significant increases in a-wave (162.98 ± 14.1 μv vs. 133.9 ± 36.9 μv, <i>p</i> = 1.5e-07) and b-wave amplitudes (274.82 ± 25.2 μv vs. 199.9 ± 56.1 μv, <i>p</i> = 3.02e-09).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings underscore <i>SLC38A8</i> role in retinal function and glutamine-glutamate metabolism, with clinical implications for FHONDA and potential future dietary intervention targeting glutamine or glutamate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 5","pages":"542-557"},"PeriodicalIF":4.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strabismus in Genetic Syndromes: A Review","authors":"Seyda Kilic,&nbsp;Jillian Bove,&nbsp;Bethany Nahri So,&nbsp;Mary C. Whitman","doi":"10.1111/ceo.14507","DOIUrl":"10.1111/ceo.14507","url":null,"abstract":"<div>\u0000 \u0000 <p>Strabismus is a feature of many genetic syndromes, with highly variable penetrance. The congenital cranial dysinnervation disorders (CCDDs) result in paralytic strabismus, with limited eye movements. CCDDs result from either deficits in differentiation of the cranial motor neuron precursors or from abnormal axon guidance of the cranial nerves. Although most individuals with comitant strabismus are otherwise healthy, strabismus is a variable feature of many genetic syndromes, most commonly those associated with intellectual disability. We review 255 genetic syndromes in which strabismus has been described and discuss the variable penetrance. The association with intellectual disability and neurological disorders underscores the likely neurological basis of strabismus, but the variable penetrance emphasises the complexity of strabismus pathophysiology. The syndromes described here mostly result from loss of function or change in function of the responsible genes; one hypothesis is that nonsyndromic strabismus may result from altered expression or regulation of the same genes.</p>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 3","pages":"302-330"},"PeriodicalIF":4.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Kidney Disease and Glaucoma: Is the Case Truly Closed?","authors":"Alan Y. Hsu,&nbsp;Yi-Ching Shao,&nbsp;Chun-Ju Lin,&nbsp;Yi-Yu Tsai","doi":"10.1111/ceo.14506","DOIUrl":"10.1111/ceo.14506","url":null,"abstract":"","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"53 5","pages":"570-571"},"PeriodicalIF":4.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}