Depression and Anxiety最新文献

{"title":"Depressive Symptoms and Cognitive Function in Older Adults: A Cross-Lagged Network Analysis","authors":"He-Li Sun,&nbsp;Pan Chen,&nbsp;Wei Bai,&nbsp;Qinge Zhang,&nbsp;Sha Sha,&nbsp;Zhaohui Su,&nbsp;Teris Cheung,&nbsp;Gabor S. Ungvari,&nbsp;Todd Jackson,&nbsp;Yuan Feng,&nbsp;Yu-Tao Xiang","doi":"10.1155/2024/6166775","DOIUrl":"https://doi.org/10.1155/2024/6166775","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Depressive symptoms commonly co-occur with cognitive decline in older adults. However, prospective interrelationships between different cognitive function domains and depressive symptoms are not well understood. This study evaluated prospective interrelationships between depressive symptoms and cognitive functioning components among individuals aged 50 years or older from a perspective of network analysis.</p>\u0000 <p><b>Method:</b> Longitudinal data from the English Longitudinal Study of Aging were analyzed. Depressive symptoms were measured with the eight-item Center for Epidemiologic Studies Short–Depression Scale. Cognitive functions assessed included memory, orientation, and executive function. Contemporaneous network analyses were conducted using mixed graphical model, while a temporal network model was assessed using cross-lagged panel network model. To identify important predictors and outcomes, centrality indices, including expected influence, out-expected influence, and in-expected influence, were calculated.</p>\u0000 <p><b>Results:</b> A total of 6,433 older adults were included in the network analysis. Baseline “Not enjoy life” (CESD-6) was negatively associated with executive function at the follow-up assessment. Moreover, improvements in “Everything was an effort” (CESD-2) and “Loneliness” (CESD-5) were related to less future decline of executive function and memory ability. Furthermore, analyses suggested targeting “Lack of happiness” (CESD-4) could be useful in reducing the co-occurrence of depression and cognitive decline among older adults.</p>\u0000 <p><b>Conclusions:</b> This network analysis study highlighted dynamic interrelationships between depressive symptoms and cognitive decline in older adults. Findings suggest that interventions targeting specific depressive symptoms may have the potential to alleviate declines in executive function and memory for this population.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6166775","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Plasma Homocysteine Levels Between Early-Onset and Late-Onset Depression","authors":"Tianle Wang,&nbsp;Qiang Wang,&nbsp;Huarong Zhou,&nbsp;Xiaomei Zhong,&nbsp;Ying-Chun Dai,&nbsp;Jiubo Zhao,&nbsp;Zezhi Li,&nbsp;Yuping Ning","doi":"10.1155/2024/7919736","DOIUrl":"https://doi.org/10.1155/2024/7919736","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Elevated homocysteine levels and late-life depression are risk factors for cognitive decline: a comparative study highlighted the association of late-onset depression (LOD) with more significant cognitive deficits and brain pathology than early-onset depression (EOD). Limited research has explored the possible interaction between homocysteine levels and their correlation with cognitive performance in patients with EOD and LOD.</p>\u0000 <p><b>Methods:</b> Fifty-seven individuals with EOD, 56 with LOD, and 89 matched healthy controls (HC) were recruited. Global cognition, memory, execution, language, attention, visuospatial skills, and plasma homocysteine levels were examined.</p>\u0000 <p><b>Results:</b> Compared with HC and patients with EOD, patients with LOD had higher plasma homocysteine levels (<i>p</i> &lt; 0.05), with no significant difference between HC and patients with EOD (<i>p</i> &gt; 0.05). Furthermore, homocysteine levels and diagnosis groups showed significant main effects on depression and cognition, with no significant interaction effects being observed. Additionally, plasma homocysteine levels were negatively correlated with global cognition, attention, visuospatial skills, and executive function in patients with LOD (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusions:</b> Compared with HC and patients with EOD, elevated homocysteine levels in patients with LOD were independently associated with cognitive performance. The potential therapeutic efficacy of homocysteine-lowering B-vitamin supplementation could be explored as a viable intervention to mitigate the documented debilitating effects of cognitive deficits in this population.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7919736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OnabotulinumtoxinA in Resistant Depression: A Randomized Trial Comparing Two Facial Injection Sites (OnaDEP Study)","authors":"Caroline Ceolato-Martin,&nbsp;Claire Chevallier-Collins,&nbsp;Jean-Pierre Clément,&nbsp;Eric Charles,&nbsp;Aurélie Lacroix,&nbsp;Danièle Ranoux","doi":"10.1155/2024/1177925","DOIUrl":"https://doi.org/10.1155/2024/1177925","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> OnabotulinumtoxinA (OnaA) injection in glabella area appears to be a promising treatment for major depression. However, one major concern of placebo-controlled studies on botulinum toxin injections is to ensure adequate blinding.</p>\u0000 <p><b>Patients and Methods:</b> In this context, all subjects of this trial received the active product (OnaA). After randomization, 58 patients with resistant major depressive disorder (MDD) received OnaA either in the glabella area (<i>N</i> = 29) or in the crow’s feet area (<i>N</i> = 29). Subjects were blinded to the supposedly effective area against resistant depression and the examiner was not aware of the injected area. The primary outcome measure was the proportion of responders (50% or greater decrease in MADRS [Montgomery and Asberg Depression Rating Scale] score from baseline) in glabella group versus crow’s feet group at week 6 after the OnaA injection.</p>\u0000 <p><b>Results:</b> The number of responders was significantly higher in the glabella group than in the crow’s feet group with 13 responders out of 29 patients (44.8%) in the glabella group and five out of 28 patients (17.9%) in the crow’s feet group (<i>p</i> = 0.029). The rate of psychomotor agitation as measured by item 9 of the Hamilton Depression Rating Scale (HAM-D), associated with a shorter span of psychiatric disorder, was a potent positive predictive factor of positive response to treatment.</p>\u0000 <p><b>Conclusion:</b> We conclude that OnaA injected in the glabella muscles is an effective and well-tolerated treatment for MDD. We suggest that patients with a high score at item 9 of the HAM-D might be a subgroup of best responders. We assume that OnaA may act as a modulator of the activity of the primary sensorimotor cortex and then of the amygdala.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03484754</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1177925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of 2-Year Trajectory of Post-Traumatic Stress Disorder Following Physical Injury","authors":"Jae-Min Kim,&nbsp;Ju-Wan Kim,&nbsp;Hee-Ju Kang,&nbsp;Ye-Jin Kim,&nbsp;Hyunseok Jang,&nbsp;Jung-Chul Kim,&nbsp;Sung-Wan Kim,&nbsp;Il-Seon Shin,&nbsp;Robert Stewart","doi":"10.1155/2024/5570405","DOIUrl":"https://doi.org/10.1155/2024/5570405","url":null,"abstract":"<div>\u0000 <p><i>Objectives</i>. This study investigated post-traumatic stress disorder (PTSD) trajectories and their predictors over a 2-year period, in individuals recovering from physical injuries. <i>Materials and Methods</i>. Between June 2015 and January 2021, 1,142 patients from a South Korean University Hospital Trauma Center underwent baseline evaluations, including PTSD-related measures and sociodemographic characteristics. They were subsequently followed up for PTSD using the Clinician-Administered PTSD Scale at 3, 6, 12, and 24 months. The analyzed sample consisted of 1,014 patients who were followed up at least once after the baseline and 3-month evaluations. Latent class growth analysis and logistic regression models were used. <i>Results</i>. Five distinctive trajectories were identified: resilient, worsening/recovery, worsening, recovery, and chronic groups. The worsening/recovery trajectory was associated with previous traumatic events and traffic-related injuries, while the worsening trajectory was linked to higher education and elevated depressive symptoms. The recovery trajectory was characterized by female sex, childhood abuse, traffic-related injuries, dissociative subtype, and higher levels of anxiety and depressive symptoms. The chronic trajectory was predicted by the dissociative subtype and heightened anxiety symptoms. <i>Conclusion</i>. These findings highlighted the heterogeneity of PTSD symptom development and, thus, the importance of considering individual characteristics when assessing and addressing PTSD following physical injuries.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5570405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission or Persistence? A Prediction Tool to Identify Women at Risk for Long-Term Depressive Symptoms Postpartum","authors":"Karin Gidén,&nbsp;Richelle Duque Björvang,&nbsp;Richard Aubrey White,&nbsp;Lisa Vinnerljung,&nbsp;Stavros I Iliadis,&nbsp;Alkistis Skalkidou,&nbsp;Emma Fransson","doi":"10.1155/2024/7734542","DOIUrl":"https://doi.org/10.1155/2024/7734542","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Peripartum depression is a common complication with potential long-term adverse effects on the woman and her family. Approximately 30%–50% of newly delivered women experience prolonged depressive symptoms at 6–12 months postpartum. Early detection may facilitate preventive and treatment interventions. <i>Aim</i>. To investigate correlates for and create a tool for predicting long-term symptomatology in women experiencing depressive symptoms at 6 weeks postpartum. <i>Materials and Methods</i>. Data from the Biology, Affect, Stress, Imaging, and Cognition study was used, to identify women who scored high (≥12) on the Edinburgh Postnatal Depression Scale (EPDS) at 6 weeks postpartum (<i>n</i> = 697). Further, we collected data from medical records and included 40 variables based on earlier studies and clinical experience. A total of 654 women were included. Elastic net linear regression analysis was performed to identify predictors of continued symptoms at 6 months postpartum. An equation predicting the EPDS score at 6 months postpartum based on weighted variables was developed. <i>Results</i>. High education level and sleep for more than 6 hr per night in pregnancy week 17 were protective factors. Parity, pregnancy complications, stressful events, attention deficit hyperactivity disorder/attention deficit disorder, history of depression, depressive symptoms, and anxiety during pregnancy were predictive factors of prolonged depressive symptoms. A prediction tool with area under curve 0.73 and positive predictive value of 79%–83% depending on chosen EPDS cutoff was developed for clinical use. <i>Conclusions</i>. Our prediction tool offers a method to identify women at risk for persisting depressive symptoms postnatally, based on their significant depressive symptoms during the first weeks after delivery. Screening in order to identify these women can already start in the antenatal setting.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7734542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Nonpharmacological Interventions for Improving the Mental Health and Other Psychosocial Outcomes of Parents with Perinatal Loss: A Systematic Review and Meta-Analysis","authors":"Si Ni Li,&nbsp;Li Yang,&nbsp;Qing Yu Wang,&nbsp;Si Pan,&nbsp;Mei Hui Xiao,&nbsp;Jiao Xie","doi":"10.1155/2024/2181544","DOIUrl":"https://doi.org/10.1155/2024/2181544","url":null,"abstract":"<div>\u0000 <p>The objective of this study was to assess the effectiveness of nonpharmacological interventions in enhancing the mental health and psychosocial outcomes of parents who have experienced perinatal loss, in comparison to active/inactive control groups. It also sought to identify the characteristics and components of effective interventions in the included studies. A comprehensive search was conducted across seven databases from January 2008 to December 2023. The analysis included randomized controlled trials (RCTs) published in English journals and dissertations that reported at least one mental health outcome postintervention for parents with perinatal loss. Twenty-one RCTs were included. The findings demonstrated significant improvements of nonpharmacological interventions in the grief, posttraumatic stress disorder, depression, anxiety, and perceived social support of parents with perinatal loss, with moderate-to-high certainty of evidence. Optimal characteristics of nonpharmacological interventions for parents with perinatal loss were identified to inform future studies, including the intervention approaches (cognitive-based interventions), delivery modalities (face-to-face), and formats (individual-based), and a recommended number of sessions of four or fewer. To validate these findings and explore the process of nonpharmacological interventions in improving health outcomes for parents with perinatal loss from diverse backgrounds, further rigorous RCTs with larger sample sizes and longer follow-up periods are required.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2181544","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Epidemiology of Depression in Working-Age Individuals, 1990–2019","authors":"Jin-shuai Yang,&nbsp;Lu-yu Zhang,&nbsp;Cheng-hao Yang,&nbsp;Xin-yu Li,&nbsp;Zhi-qiang Li","doi":"10.1155/2024/4747449","DOIUrl":"https://doi.org/10.1155/2024/4747449","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Depression is a disorder that can have a serious impact on functioning and quality of life. Understanding the global, regional, and national epidemiology of depression in working-age populations (15–49 years) is important for informing mental health policies and services. However, up-to-date data have been lacking, especially in developing regions. <i>Methods</i>. This study delved into the prevalence of depression among individuals in the working-age group, specifically those between 15 and 49 years, by analyzing data from the 2019 Global Burden of Disease, Injuries, and Risk Factors Study (GBD). The comprehensive analysis aimed to determine the age-standardized prevalence, incidence, and disability-adjusted life years (DALYs) associated with depression across diverse groups. It considered factors such as geographical regions, age brackets, genders, and sociodemographic indices, spanning a time frame from 1990 to 2019. <i>Results</i>. Globally, the estimated prevalent cases, incident cases, and DALYs for depression increased from 1990 to 2019. Regionally, certain regions like Central Latin America saw rapid increases in age-standardized prevalence and incidence rates over time. By sociodemographic regions, all tiers witnessed rises in incident cases, with high sociodemographic index (SDI) areas having the greatest burden in 2019. Nationally, countries such as India, China, and the United States had the highest total prevalence and incidence in 2019, while nations like Yemen and Angola reported exceptionally high age-standardized rates (ASRs). Peak prevalence risk occurred in the mid-to-late 40s age range. Period effects showed declining risks over time. Earlier birth cohorts, especially before the mid-1960s, faced higher risks than more recent generations. Population growth rather than epidemiological changes appeared to drive increases in disease burden. <i>Conclusion</i>. From 1990 to 2019, the overall trend of depression burden in working-age individuals presents regional and national variations and differs by age, sex, period, and cohort.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/4747449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Physical Activity on the Development of Postpartum Depression","authors":"Marija Rovcanin,&nbsp;Ana Tomic,&nbsp;Sandra Sipetic Grujicic,&nbsp;Svetlana Jankovic,&nbsp;Bojana Ivic,&nbsp;Milan Lackovic,&nbsp;Maja Lackovic,&nbsp;Isidora Vujcic","doi":"10.1155/2024/6539734","DOIUrl":"https://doi.org/10.1155/2024/6539734","url":null,"abstract":"<div>\u0000 <p>Although the benefits of physical activity (PA) on mental well-being are well established, the vulnerability of women during pregnancy and the postpartum period poses challenges in studying the effects of PA on postpartum depression (PPD). This study investigated the association between total and domain-specific PA levels during pregnancy and postpartum depressive symptoms. The study included 105 healthy pregnant women whose PA status was evaluated by the Serbian version of the Physical Activity Questionnaire during Pregnancy (PPAQ-SRB) and their postpartum mental health by the Edinburgh Postnatal Depression Scale. Multivariable logistic regression was used to explore the independent relationship between PPAQ-SRB scores and the prediction of the PPD symptom occurrence. Our analysis revealed that the development of PPD symptomatology was associated with a lower “Total PPAQ-SRB score” (odds ratio (OR) 0.81; 95% confidence interval (CI) [0.70–0.93]; <i>p</i> = 0.03) and “Total Activity score” (OR 0.82; 95% CI [0.71–0.93]; <i>p</i> = 0.03) as well as lower scores of light-intensity PA (OR 0.81; 95% CI [0.69–0.96]; <i>p</i> = 0.013), moderate-intensity PA (OR 0.82; 95% CI [0.71–0.94]; <i>p</i> = 0.005), “Household/care” (OR 0.85; 95% CI [0.73–0.98]; <i>p</i> = 0.028), and “Occupational” activities (OR 0.80; 95% CI [0.78–0.95]; <i>p</i> = 0.012). Lower levels of light-to-moderate-intensity household and occupational activities appeared to increase the risk of PPD, indicating the importance of circumstances under which PA is performed. Hence, our findings indicate that PA during pregnancy can mitigate mood disorders in postpartum mothers. Moreover, reduced participation in light-to-moderate-intensity household and occupational activities seemed to increase the risk of PPD.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6539734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Influence of Depression on the Occupational Performance of People Diagnosed with Multiple Sclerosis and Its Impact on Caregiver Burden","authors":"Sergio Rodríguez Menéndez,&nbsp;Marta Perez-de-Heredia-Torres,&nbsp;David Jaraba Berné,&nbsp;Manuel Menéndez González,&nbsp;Rosa Mª Martínez-Piédrola","doi":"10.1155/2024/7549306","DOIUrl":"https://doi.org/10.1155/2024/7549306","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. One of the most common symptoms in multiple sclerosis (MS) is depression, which causes disruption to daily participation. MS as a degenerative disease causes caregiver strain. The aim of this study is to analyze the influence of depression on the occupational performance of people with MS and to study whether these aspects influence caregiver strain. <i>Materials and Methods</i>. A descriptive cross-sectional observational study was carried out. A total of 124 people with a diagnosis of multiple sclerosis were assessed and administered the Beck Depression Inventory-II, the Canadian Occupational Performance Measure, and the Zarit Caregiver Burden Scale. <i>Results</i>. MS type influences performance, involvement, and caregiver burden. High levels of depression are associated with low levels of participation and performance. The types of MS with the highest caregiver burden are relapsing–remitting and secondary progressive. <i>Conclusions</i>. The type of MS negatively influences occupational performance. Depression and occupational performance are related to caregiver strain. The greater the depressive symptoms, the worse the performance, and the more caregiver strain.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7549306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Levels and Depressive Symptoms during Pregnancy: A Prospective Pregnancy Cohort Study","authors":"Vilja Seppälä,&nbsp;Soile Tuovinen,&nbsp;Marius Lahti-Pulkkinen,&nbsp;Polina Girchenko,&nbsp;Sture Andersson,&nbsp;Katri Räikkönen,&nbsp;Kati Heinonen","doi":"10.1155/2024/1788167","DOIUrl":"https://doi.org/10.1155/2024/1788167","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. Depressive symptoms during pregnancy increase the risk for adverse outcomes in women and children. Lower vitamin D levels are suggested to be associated with higher depressive symptoms in nonpregnant populations. We studied if the level of or change in serum of 25-hydroxyvitamin D (25(OH)D) concentration was associated with the levels of depressive symptoms during pregnancy. <i>Methods</i>. The participants of this prospective longitudinal study came from the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study. The analytic sample comprised 307 women (mean age = 32.5 (range 20.3–44.3)) who reported depressive symptoms concurrently with serum 25(OH)D measurements at a median of 13.0, 19.3, and 27.0 gestational weeks. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Linear and mixed-model regression analyses were used to study the associations. <i>Results</i>. The 25(OH)D levels were not associated with depressive symptoms cross-sectionally (<i>p</i> values &gt; 0.58) or across the three assessment points during pregnancy (<i>B</i> = −0.05; 95% CI, −0.12, 0.01; and <i>p</i> = 0.12). Yet, a higher increase in 25(OH)D during pregnancy was associated with lower levels of depressive symptoms (<i>B</i> = −1.41; 95% CI, −2.75, −0.07; and <i>p</i> = 0.04) but not after adjusting for covariates (<i>p</i> = 0.08). <i>Conclusions</i>. The 25(OH)D levels and depressive symptoms were not associated among pregnant women throughout the pregnancy. However, there is a need for randomized controlled trials to fully exclude the possibility of vitamin D supplementation in the prevention of depression during pregnancy.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1788167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}