Fungal Genetics and Biology最新文献

{"title":"Himalayan mountains imposing a barrier on gene flow of wheat yellow rust pathogen in the bordering regions of Pakistan and China","authors":"Muhammad Awais ,&nbsp;Jie Zhao ,&nbsp;Xiangrui Cheng ,&nbsp;Abdul Ghaffar Khoso ,&nbsp;Meng Ju ,&nbsp;Zia Ur Rehman ,&nbsp;Aamir Iqbal ,&nbsp;Muhammad Rameez Khan ,&nbsp;Wen Chen ,&nbsp;Maxinzhi Liu ,&nbsp;Xinyao Ma ,&nbsp;Lin Wang ,&nbsp;Wei Liu ,&nbsp;Zhimin Du ,&nbsp;Mudi Sun ,&nbsp;Gensheng Zhang ,&nbsp;Zhensheng Kang ,&nbsp;Sajid Ali","doi":"10.1016/j.fgb.2022.103753","DOIUrl":"10.1016/j.fgb.2022.103753","url":null,"abstract":"<div><p>The wheat yellow rust pathogen has been shown to be diverse and potentially originated in the Himalayan region. Although Himalayan populations of Pakistan, Nepal and Bhutan have been previously compared, little is known about the relative divergence and diversity in <em>Puccinia striiformis</em> populations in the bordering regions of Pakistan and China. To assess the relative diversity and divergence in these regions of Pakistan (Gilgit-Baltistan, Hazara and Azad Jammu Kashmir) and China (Xinjiang, Qinghai, Tibet, Sichuan, Guizhou and Yunnan), a total of 1245 samples were genotyped using 17 microsatellite SSR markers. A clear divergence was observed between the bordering regions of Pakistan and China (<em>F_ST</em> = 0.28) without any resampling of genetic groups and multilocus genotypes across two sides of the Himalayan mountains. The closest subpopulations across the two countries were Xinjiang and Gilgit-Baltistan (<em>Nei’s</em> distance = 0.147), which were close geographically. A very high diversity and recombinant population structure was observed in both populations, though slightly higher in China (Genotypic diversity = 0.970; r¯d = 0.000) than in Pakistan (Genotypic diversity = 0.902; r¯d = 0.065). The distribution of genetic groups and resampling of MLGs revealed more gene flow across Yunnan, Guizhou and Sichuan regions in China, while between Hazara and Azad-Jammu Kashmir in Pakistan. The lack of gene flow between Pakistan and China populations is due to geographical barriers and a large patch of land without wheat. The information on the relative diversity and divergence in different geographical zones of the pathogen center of diversity and neighboring region should be considered in resistant wheat deployment while considering the invasion potential of the pathogen at regional and global contexts.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10517432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the polyketide synthase gene responsible for the synthesis of tanzawaic acids in Penicillium steckii IBWF104-06","authors":"Azahara Bernal ,&nbsp;Stefan Jacob ,&nbsp;Karsten Andresen ,&nbsp;Alexander Yemelin ,&nbsp;Holger Hartmann ,&nbsp;Luis Antelo ,&nbsp;Eckhard Thines","doi":"10.1016/j.fgb.2022.103750","DOIUrl":"10.1016/j.fgb.2022.103750","url":null,"abstract":"<div><p>Microorganisms have been used as biological control agents (BCAs) in agriculture for a long time, but their importance has increased dramatically over the last few years.</p><p>The <em>Penicillium steckii</em> IBWF104-06 strain has presented strong BCA activity in greenhouse experiments performed against phytopathogenic fungi and oomycetes. <em>P. steckii</em> strains generally produce different antifungal tanzawaic acids; interesting compounds known to be catalyzed by polyketide synthetases in other fungi.</p><p>Since the decalin structure is characteristic for tanzawaic acids, two polyketide synthase genes (<em>PsPKS1</em> and <em>PsPKS2</em>) were selected for further analysis, which have similarity in sequence and gene cluster structure with genes that are known to be responsible for the biosynthesis of decalin-containing compounds.</p><p>Subsequently, gene-inactivation mutants of both <em>PsPKS1</em> and <em>PsPKS2</em> have been generated. It was found, that the <em>ΔPspks1</em> mutant cannot produce tanzawaic acids any more, whereas reintegration of the original <em>PsPKS1</em> gene into the genome of <em>ΔPspks1</em> reestablished tanzawaic acid production. The mutant <em>ΔPspks<span>2</span></em> is not altered in tanzawaic acids production.</p><p>Interestingly, both mutants <em>ΔPsPKS1</em> and <em>ΔPsPKS2</em> still display strong BCA activity, indicating that the mechanism of action is not related to the production of tanzawaic acids.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10530541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprospecting of the probiotic potential of yeasts isolated from a wine environment","authors":"Silvia Cristina Vergara Alvarez ,&nbsp;María José Leiva Alaniz ,&nbsp;María Victoria Mestre Furlani ,&nbsp;Fabio Vazquez ,&nbsp;Pamela Mancha Agresti ,&nbsp;María Cristina Nally ,&nbsp;Yolanda Paola Maturano","doi":"10.1016/j.fgb.2022.103767","DOIUrl":"10.1016/j.fgb.2022.103767","url":null,"abstract":"<div><p>Autochthonous yeasts of oenological origin are adapted to highly stressful and selective environments, which makes them potential candidates for probiotics. The objective of the present study was to explore the probiotic potential of 96 native yeasts of oenological origin, their biosafety, resistance to gastrointestinal tract conditions and adhesion properties. Regarding biosafety, 66 isolates shown negative hemolytic activity, negative urease activity and susceptibility to 3 or more antifungals. After the gastrointestinal resistance test, 15 isolates were selected that showed growth at different temperatures, tolerance to low pH and the presence of bile salts in in vitro tests. In general, survival after simulated conditions of the gastrointestinal tract was high and more restrictive was the duodenal. The results of the adhesion properties showed highly variable hydrophobicity and a high percentage of autoaggregation at 24 h. The maximum production of biofilm was detected in the <em>Pichia</em> strains. Of a total of 96 yeast strains, 15 non-<em>Saccharomyces</em> yeasts presented suitable properties as probiotic candidates. The native winemaking strains performed better than the reference probiotic strain, <em>Saccharomyces cerevisiae</em> var. <em>boulardii</em> CNCM I-745, which reaffirms that these strains are promising probiotic candidates and further studies are necessary to confirm their probiosis.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Papiliotrema laurentii UFV-1 strains with improved acetic acid tolerance selected by adaptive laboratory evolution","authors":"E.L.M. Almeida ,&nbsp;R.Z. Ventorim ,&nbsp;M.A.M. Ferreira ,&nbsp;M.D. Costa ,&nbsp;H.C. Mantovani ,&nbsp;W.B. Silveira","doi":"10.1016/j.fgb.2022.103765","DOIUrl":"10.1016/j.fgb.2022.103765","url":null,"abstract":"<div><p>The production of yeast oil from lignocellulosic biomasses is impaired by inhibitors formed during the pretreatment step, mainly acetic acid. Herein, we applied Adaptive Laboratory Evolution (ALE) to select three Acetic acid Tolerant Strains (ATS) of <em>P. laurentii</em><span> UFV-1. Different phenotypes emerged alongside evolution. The ATS II presented trade-offs in the absence of acetic acid, suggesting that it displays a specialized phenotype of tolerance to growth on organic acids. On the other hand, ATS I and ATS III presented phenotypes associated with the behavior of generalists. ATS I was considered the most promising evolved strain as it displayed the oleaginous phenotype in all conditions tested. Thus, we applied whole-genome sequencing to detect the mutations that emerged in this strain during the ALE. We found alterations in genes encoding proteins involved in different cellular functions, including multidrug resistance<span> (MDR) transporters, energy metabolism, detoxification, coenzyme<span><span> recycling, and cell envelope remodeling. To evaluate acetic acid stress responses, both parental and ATS I strains were cultivated in chemostat mode in the absence and presence of acetic acid. In contrast to ATS I, the parental strain presented alterations in the cell envelope and cell size under acetic acid stress conditions. Furthermore, the parental strain and the ATS I presented differences regarding acetic acid assimilation. Contrary to the parental strain, the ATS I displayed an increase in </span>unsaturated fatty acid content irrespective of acetic acid stress, which might be related to improved tolerance to acetic acid. Altogether, these results provided insights into the mechanisms involved with the acetic acid tolerance displayed by ATS I and the responses of </span></span></span><em>P. laurentii</em> to this stressful condition.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative transcriptomics of growth metabolism and virulence reveal distinct morphogenic profiles of yeast-like cells and hyphae of the fungus Metarhizium rileyi","authors":"Natasha Sant́Anna Iwanicki ,&nbsp;Italo Delalibera Júnior ,&nbsp;Lana L.B. de Carvalho ,&nbsp;Jørgen Eilenberg ,&nbsp;Henrik H. De Fine Licht","doi":"10.1016/j.fgb.2022.103766","DOIUrl":"10.1016/j.fgb.2022.103766","url":null,"abstract":"<div><p><em>Metarhizium rileyi</em> <!-->is an entomopathogenic fungus with a narrow host range which distinguishes it from other <em>Metarhizium<!--> </em>species with broad host ranges. This species is also unique because the initial yeast-like growth on solid media is only observed in liquid culture in other <em>Metharizium</em> species. A lack of knowledge about the metabolism and genetic signatures of <em>M. rileyi</em> <!-->during this yeast-like phase on solid and in liquid media is a bottleneck for its large-scale production as a commercial biocontrol agent.<!--> <!-->In this study we<!--> <!-->found that <em>M. rileyi</em> <!-->yeast-like cells produced on solid medium infected and killed the important insect pest <em>Spodoptera frugiperda</em> with comparable efficiency as yeast-like cells grown in liquid medium. Secondly, we used comparative transcriptomic analysis to investigate the<!--> <!-->active genes and genomic signatures of the <em>M. rileyi</em> yeast-like morphotypes produced on solid and in liquid media. Yeast-like cells grown in liquid medium had upregulated genes relating specifically to signal transduction and<!--> <!-->particular membrane transporters. Thirdly, we compared the transcriptomic profiles of yeast-like phases of <em>M. rileyi</em> with those of <em>M. anisopliae</em>. The yeast-like phase of <em>M. rileyi</em> grown on solid medium upregulated unique genes not found in other<!--> <em>Metarhizium</em> <!-->species including specific membrane proteins and several virulence factors. Orthologous genes associated with heat shock protein, iron permease, membrane proteins and key virulence traits (e.g. collagen-like protein Mcl1) were upregulated in both species. Comparative transcriptome analyses of gene expression showed more differences than similarities between <em>M. anisopliae</em> and <em>M. rileyi</em> yeast-like cells.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10516973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"bHLH transcription factor EcdR controls conidia production, pigmentation and virulence in Aspergillus fumigatus","authors":"Cong He ,&nbsp;Qian Wei ,&nbsp;Jie Xu ,&nbsp;Renhui Cai ,&nbsp;Qingtao Kong ,&nbsp;Peiying Chen ,&nbsp;Ling Lu ,&nbsp;Hong Sang","doi":"10.1016/j.fgb.2022.103751","DOIUrl":"10.1016/j.fgb.2022.103751","url":null,"abstract":"<div><p>Invasive <em>Aspergillus fumigatus</em> infection is a disease with high morbidity and mortality rates. Abnormalities in sporulation and pigmentation can significantly alter the pathogenicity of <em>A. fumigatus</em>, thus the mechanisms of conidiation and pigment biosynthesis have gained increasing attention. In <em>Aspergillus oryzae</em>, a novel predicted bHLH protein-encoding gene, <em>ecdR</em>, plays a role in asexual development, and its ortholog has also been characterized in <em>A. nidulans</em>. Herein, we determined its role in <em>A. fumigatus</em> by testing whether <em>ecdR</em> deletion affects asexual development, melanin synthesis, and regulation of virulence in this fungus. Our study shows that EcdR controls conidia and melanin production in <em>A. fumigatus</em>. In addition, we found that virulence in the Δ<em>ecdR</em> strain was significantly reduced in the infection model of immunodeficiency mice.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA interstrand crosslink repair by XPF-ERCC1 homologue confers ultraviolet resistance in Neurospora crassa","authors":"Kotaro Tsukada,&nbsp;Shin Hatakeyama,&nbsp;Shuuitsu Tanaka","doi":"10.1016/j.fgb.2022.103752","DOIUrl":"10.1016/j.fgb.2022.103752","url":null,"abstract":"<div><p>Ultraviolet (UV) light is a mutagen that causes DNA damage. Some UV-sensitive <em>Neurospora crassa</em> strains have been reported to exhibit a partial photoreactivation defect (PPD) phenotype, and the possible cause of this has been unknown for more than half a century. In this study, in the process of elucidating the possible causes of a PPD phenotype, we discovered that the XPF homologue MUS-38 is involved in repairing the UV-induced DNA interstrand crosslink (ICL) in <em>N. crassa</em>. Furthermore, the sensitivity of the <em>Δmus-38</em> and <em>Δmus-44</em> strains to ICL agents was significantly higher than that of other nucleotide excision repair (NER)-related gene knockout (KO) strains, indicating that the MUS-38/MUS-44 complex is involved in an NER-independent ICL repair mechanism. Based on reports concerning the mammalian homologues XPF and ERCC1 we obtained separation-of-function mutants defective only in NER in <em>mus-38</em> and <em>mus-44</em>. Additionally, the photoreactivation ability of these mutants was significantly higher than that of the KO strains. These results indicate that the PPD phenotype is caused by a defect in the repair-ability of ICL induced by UV and that an NER-independent ICL repair by MUS-38 and MUS-44 confers resistance to UV in <em>N. crassa</em>.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprospecting of the probiotic potential of yeasts isolated from a wine environment.","authors":"Silvia Cristina Vergara Alvarez, María José Leiva Alaniz, María Victoria Mestre Furlani, F. Vazquez, Pamela Mancha Agresti, María Cristina Nally, Yolanda Paola Maturano","doi":"10.2139/ssrn.4100196","DOIUrl":"https://doi.org/10.2139/ssrn.4100196","url":null,"abstract":"Autochthonous yeasts of oenological origin are adapted to highly stressful and selective environments, which makes them potential candidates for probiotics. The objective of the present study was to explore the probiotic potential of 96 native yeasts of oenological origin, their biosafety, resistance to gastrointestinal tract conditions and adhesion properties. Regarding biosafety, 66 isolates shown negative hemolytic activity, negative urease activity and susceptibility to 3 or more antifungals. After the gastrointestinal resistance test, 15 isolates were selected that showed growth at different temperatures, tolerance to low pH and the presence of bile salts in in vitro tests. In general, survival after simulated conditions of the gastrointestinal tract was high and more restrictive was the duodenal. The results of the adhesion properties showed highly variable hydrophobicity and a high percentage of autoaggregation at 24 h. The maximum production of biofilm was detected in the Pichia strains. Of a total of 96 yeast strains, 15 non-Saccharomyces yeasts presented suitable properties as probiotic candidates. The native winemaking strains performed better than the reference probiotic strain, Saccharomyces cerevisiae var. boulardii CNCM I-745, which reaffirms that these strains are promising probiotic candidates and further studies are necessary to confirm their probiosis.","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83720095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of the manganese lipoxygenase gene family – A mini-review","authors":"Ernst H. Oliw","doi":"10.1016/j.fgb.2022.103746","DOIUrl":"10.1016/j.fgb.2022.103746","url":null,"abstract":"<div><p>Analyses of fungal genomes of escalate from biological and evolutionary investigations. The biochemical analyses of putative enzymes will inevitably lag behind and only a selection will be characterized. Plant-pathogenic fungi secrete manganese-lipoxygenases (MnLOX), which oxidize unsaturated fatty acids to hydroperoxides to support infection. Six MnLOX have been characterized so far including the 3D structures of these enzymes of the Rice blast and the Take-all fungi. The goal was to use this information to evaluate MnLOX-related gene transcripts to find informative specimens for further studies. Phylogenetic analysis, determinants of catalytic activities, and the C-terminal amino acid sequences divided 54 transcripts into three major subfamilies. The six MnLOX belonged to the same “prototype” subfamily with conserved residues in catalytic determinants and C-terminal sequences. The second subfamily retained the secretion mechanism, presumably necessary for uptake of Mn²⁺, but differed in catalytic determinants and by cysteine replacement of an invariant Leu residue for positioning (“clamping”) of fatty acids. The third subfamily contrasted with alanine in the Gly/Ala switch for regiospecific oxidation and a minority contained unprecedented C-terminal sequences or lacked secretion signals. With these exceptions, biochemical analyses of transcripts of the three subfamilies appear to have reasonable prospects to find active enzymes.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087184522000913/pdfft?md5=a5d3cea8ce9794a799380633d27a7126&pid=1-s2.0-S1087184522000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A GATA-type transcription factor SreA affects manganese susceptibility by regulating the expression of iron uptake-related genes","authors":"Pengfei Zhai ,&nbsp;Wenlong Du ,&nbsp;Nanbiao Long ,&nbsp;Ling Lu","doi":"10.1016/j.fgb.2022.103731","DOIUrl":"10.1016/j.fgb.2022.103731","url":null,"abstract":"<div><p>SreA has been identified as a GATA-type transcription factor that represses iron uptake to avoid iron excess during iron sufficiency. However, knowledge about whether SreA also affects the homeostasis of other divalent metal ions is limited. In this study, by screening <em>Aspergillus fumigatus</em> transcription factor deletion mutant libraries, we demonstrate that the <em>sreA</em> deletion mutant shows the greatest tolerance to MnCl₂ among the tested divalent metal ions. Fe and Mn stimuli are able to enhance the expression of SreA with the different time-dependent manner, while the expression of SreA contributes to Mn²⁺ tolerance. Lack of SreA results in abnormally increased expression of a series of siderophore biosynthesis genes and iron transport-related genes, especially under MnCl₂ treatment. Further mechanistic exploration indicated that lack of SreA exacerbates abnormal iron uptake, and iron excess inhibits cellular Mn content; thus, deletion of <em>sreA</em> results in Mn tolerance. Thus, findings in this study have demonstrated a new unexplored function for the transcription factor SreA in regulation of the Mn²⁺ tolerance.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10477798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}