Fungal Genetics and Biology最新文献

{"title":"Candida albicans strains adapted to the mouse gut are resistant to bile salts via a Flo8-dependent mechanism.","authors":"Susana Hidalgo-Vico, Daniel Prieto, Rebeca Alonso-Monge, Elvira Román, Corinne Maufrais, Christophe d'Enfert, Jesús Pla","doi":"10.1016/j.fgb.2024.103939","DOIUrl":"10.1016/j.fgb.2024.103939","url":null,"abstract":"<p><p>Candidaalbicans normally colonizes the human gastrointestinal tract as a commensal. Studying fungal factors involved in colonizing the mammalian gastrointestinal tract requires mouse models with altered microbiota. We have obtained strains of C.albicans through microevolution in the mouse gut for a prolonged period (one year) that display a substantial increase in fitness in this niche. These strains show resistance to bile salts, an increase in their adhesion to the intestinal mucosa, and are unable to filament in response to serum. Genetic analysis revealed some alterations, mainly a triploidy of chr7, a whole chr6 homozygosis, and an SNP in the FLO8 gene (located in the chr6), resulting in a truncated protein version. A wild type FLO8 gene complemented filamentation and bile salt sensitivity but showed an intermediate fitness phenotype in colonization. Alterations in bile salt sensitivity were also evident in bmt mutants, defective in β-mannosylation, and transcriptional targets of Flo8, suggesting a link between the fungal cell wall and mammalian gut colonization via the Flo8 transcriptional regulator.</p>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on the structure and function of Candida albicans drug efflux protein, Cdr1","authors":"Chibuike Ibe,&nbsp;Carolina H. Pohl","doi":"10.1016/j.fgb.2024.103938","DOIUrl":"10.1016/j.fgb.2024.103938","url":null,"abstract":"<div><div><em>Candida albicans</em> is an important human pathogenic yeast, that can become resistant to commonly used antifungal agents, such as azoles. One mechanism of drug resistance is efflux via ATP binding cassette transporters, such as Cdr1. Several studies have investigated the structural organization, binding mechanisms, function and regulation of Cdr1. This review summarizes the findings on the structure and function of Cdr1 and highlights important aspects to consider in future research relating to multidrug ABC transporters.</div></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New simple sequence repeat markers reveal undetected diversity in Spanish and Californian Diplodia sapinea populations","authors":"Laura Vilanova ,&nbsp;Maria Caballol ,&nbsp;Ke Zhang ,&nbsp;Åke Olson ,&nbsp;Irene Barnes ,&nbsp;Michael J. Wingfield ,&nbsp;Jonàs Oliva","doi":"10.1016/j.fgb.2024.103937","DOIUrl":"10.1016/j.fgb.2024.103937","url":null,"abstract":"<div><div><em>Diplodia sapinea</em> is the causal agent of Diplodia shoot blight, an emerging disease affecting pine forests worldwide. The range expansion of this pathogen in northern Europe has been suggested to be partially facilitated by recent warmer conditions. Although <em>D. sapinea</em> has been studied extensively, critical aspects of its infection biology and population structure remain unexplored. In this study, we developed nine simple sequence repeat (SSR) markers mined from <em>D. sapinea</em> genomes to assess the genetic diversity at higher resolution. Isolates from northern Spain, an area formerly regarded as having low genetic diversity and samples from a Californian population that was formerly regarded as clonal, were analysed in the study. In Spain, the nine SSR markers identified 56 genotypes in 285 samples. Isolates from symptomatic shoots, cones and asymptomatic tissues collected from different stands, suggested admixture between local populations. The same genotype tended to dominate within a single cone, and the same genotypes were usually found in both symptomatic and asymptomatic shoot tissues. The nine new SSR markers developed in this study revealed a high level of genetic diversity in both the northern Spanish and northern Californian populations than previously anticipated. Analyses using these nine SSR markers should contribute to a better understanding of the epidemiology, evolution and origin of <em>D. sapinea</em>, a pathogen that is gaining prominence in many parts of the world.</div></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putative APSES family transcription factor mbp1 plays an essential role in regulating cell wall synthesis in the agaricomycete Pleurotus ostreatus","authors":"Hayase Kojima ,&nbsp;Moriyuki Kawauchi ,&nbsp;Yuitsu Otsuka ,&nbsp;Kim Schiphof ,&nbsp;Kenya Tsuji ,&nbsp;Akira Yoshimi ,&nbsp;Chihiro Tanaka ,&nbsp;Shigekazu Yano ,&nbsp;Takehito Nakazawa ,&nbsp;Yoichi Honda","doi":"10.1016/j.fgb.2024.103936","DOIUrl":"10.1016/j.fgb.2024.103936","url":null,"abstract":"<div><div>The clade A APSES family transcription factors (Mbp1, Swi4, and Swi6) contribute to cell wall synthesis regulation in fungi. Herein, evolutionary relationships among these proteins were clarified by phylogenetic analysis using various ascomycetes and basidiomycetes, and then the detailed function of Mbp1 in cell wall synthesis regulation was analyzed in <em>Pleurotus ostreatus</em>. Our phylogenetic analysis revealed that Mbp1 and Swi6 are widely conserved among various fungi, whereas Swi4 is a protein specific for Saccharomycotina. In <em>P. ostreatus</em>, two putative clade A APSES family transcription factors, protein ID 83192 and 134090, were found and identified as Mbp1 and Swi6, respectively. The <em>mbp1</em> gene was then disrupted through homologous recombination using <em>P. ostreatus</em> 20b strain (Δ<em>ku80</em>) as a host to obtain <em>mbp1</em> disruption strains (Δ<em>mbp1</em>). Disruption of <em>mbp1</em> significantly decreased the growth rate and shortened aerial hyphae, suggesting that Mbp1 is involved in mycelial growth, especially aerial hyphal growth. Furthermore, thinner cell walls, decreased relative percentage of β-glucan, and downregulation of all β-glucan synthase genes were observed in Δ<em>mbp1</em> strains. Therefore, Mbp1 plays an essential role in β-glucan synthesis regulation in <em>P. ostreatus</em>. Disruption of <em>mbp1</em> also impacted the expression profiles of chitin synthase genes, septum formation, and sensitivity to a chitin synthesis inhibitor, suggesting that Mbp1 also regulates chitin synthesis. In conclusion, Mbp1 is responsible for normal mycelial growth and regulates β-glucan and chitin synthesis in <em>P. ostreatus</em>. To the best of our knowledge, this is the first report on the detailed function of Mbp1 in cell wall synthesis regulation in fungi.</div></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing fungal extracellular vesicle proteomic profiling through combined analysis of in-solution and in-gel digestion","authors":"Daniel A. Salgado-Bautista ,&nbsp;Eduardo Callegari ,&nbsp;Meritxell Riquelme","doi":"10.1016/j.fgb.2024.103935","DOIUrl":"10.1016/j.fgb.2024.103935","url":null,"abstract":"<div><div>Proteomics offers a powerful tool to identify proteins within diverse microbial organisms, environments, and organelles, including extracellular vesicles (EVs). Fungal EVs are of particular interest due to their roles in cellular development and communication. While several methods exist to isolate EVs from cells, a universally accepted approach for EV protein characterization is lacking. This study investigated in-solution digestion (SD) and in-gel digestion (GD), for characterizing proteins from <em>Neurospora crassa</em> EVs, followed by LC-MS/MS analysis. GD identified three to four-times more proteins than SD while using the same number of unique peptides. Although GD requires a higher amount of starting sample, it offers a more comprehensive protein identification for fungal EVs, potentially preventing the omission of crucial data.</div></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllosticta paracitricarpa is synonymous with the EU quarantine fungus P. citricarpa based on phylogenomic analyses","authors":"Valerie A. van Ingen-Buijs ,&nbsp;Anouk C. van Westerhoven ,&nbsp;Petros Skiadas ,&nbsp;Xander C.L. Zuijdgeest ,&nbsp;Sajeet Haridas ,&nbsp;Christopher Daum ,&nbsp;Kecia Duffy ,&nbsp;Jie Guo ,&nbsp;Hope Hundley ,&nbsp;Kurt LaButti ,&nbsp;Anna Lipzen ,&nbsp;Jasmyn Pangilinan ,&nbsp;Robert Riley ,&nbsp;Jie Wang ,&nbsp;Mi Yan ,&nbsp;Francis Martin ,&nbsp;Kerrie Barry ,&nbsp;Igor V. Grigoriev ,&nbsp;Johannes Z. Groenewald ,&nbsp;Pedro W. Crous ,&nbsp;Michael F. Seidl","doi":"10.1016/j.fgb.2024.103925","DOIUrl":"10.1016/j.fgb.2024.103925","url":null,"abstract":"<div><p><em>Phyllosticta citricarpa</em> is an important citrus-pathogen and a quarantine organism in the European Union. Its recently described relative, <em>P. paracitricarpa</em>, is very closely related and not listed as a quarantine organism. <em>P. paracitricarpa</em> is very difficult to distinguish from <em>P. citricarpa</em>, since its morphological features overlap and the barcoding gene sequences that were originally used to delimit them as distinct species have a low number of species-specific polymorphisms that have subsequently been shown to overlap between the two clades. Therefore, we performed extensive genomic analyses to determine whether the genetic variation between <em>P. citricarpa</em> and <em>P. paracitricarpa</em> strains should be considered to represent infraspecific variation within <em>P. citricarpa</em>, or whether it is indicative of distinct species. Using a phylogenomic analysis with 3,000 single copy ortholog genes and whole-genome comparisons, we determined that the variation between <em>P. citricarpa</em> and <em>P. paracitricarpa</em> can be considered as infraspecies variation within <em>P. citricarpa</em>. We also determined the level of variation in mitochondrial assemblies of several <em>Phyllosticta</em> species and concluded there are only minimal differences between the assemblies of <em>P. citricarpa</em> and <em>P. paracitricarpa</em>. Thus, using several orthogonal approaches, we here demonstrate that variation within the nuclear and mitochondrial genomes of other <em>Phyllosticta</em> species is larger than variation between genomes obtained from <em>P. citricarpa</em> and <em>P. paracitricarpa</em> strains. Thus, <em>P. citricarpa</em> and <em>P. paracitricarpa</em> should be considered as conspecific.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087184524000628/pdfft?md5=551c0118874a22b2fde3b8d86173256b&pid=1-s2.0-S1087184524000628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population genomics of Fusarium graminearum isolates from the Americas","authors":"Upasana Dhakal ,&nbsp;Wei Yue ,&nbsp;John F. Leslie,&nbsp;Christopher Toomajian","doi":"10.1016/j.fgb.2024.103924","DOIUrl":"10.1016/j.fgb.2024.103924","url":null,"abstract":"<div><p>Fusarium head blight (FHB) is a major disease of wheat and barley worldwide and is caused by different species in the genus <em>Fusarium</em>, <em>Fusarium graminearum</em> being the most important. We conducted population genomics analyses using SNPs obtained through genotyping by sequencing of over 500 isolates of <em>F. graminearum</em> from the US Upper Midwest, New York, Louisiana, and Uruguay. PCA and STRUCTURE analyses group our isolates into four previously described populations: NA1, NA2, Southern Louisiana (SLA) and Gulf Coast (GC). Some isolates were not assigned to populations because of mixed ancestry. Population structure was associated with toxin genotype and geographic origin. The NA1, NA2, and SLA populations are differentiated (<em>F_ST</em> 0.385 – 0.551) but the presence of admixed isolates indicates that the populations are not reproductively isolated. Patterns of linkage disequilibrium (LD) decay suggest frequent recombination within populations. <em>Fusarium graminearum</em> populations from the US have great evolutionary potential given the high recombination rate and a large proportion of admixed isolates. The NA1, NA2, and Southern Louisiana (SLA) populations separated from their common ancestral population roughly at the same time in the past and are evolving with moderate levels of subsequent gene flow between them. Genome-wide selection scans in all three populations revealed outlier regions with the strongest signatures of recent positive natural selection. These outlier regions include many genes with unknown function and some genes with known roles in plant–microbe interaction, fungicide/drug resistance, cellular transport and genes that are related to cellular organelles. Only a very small proportion of outlier regions are shared as outliers among the three populations, suggesting unique host-pathogen interactions and environmental adaptation.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087184524000616/pdfft?md5=abdc32c0ab09b219944f197979901205&pid=1-s2.0-S1087184524000616-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential impacts of furfural and acetic acid on the bioenergetics and fermentation performance of Scheffersomyces stipitis","authors":"José J. Saucedo-Gutierrez ,&nbsp;Monserrat Escamilla-García ,&nbsp;Aldo Amaro-Reyes ,&nbsp;Andrés Carrillo-Garmendia ,&nbsp;Luis A. Madrigal-Pérez ,&nbsp;Carlos Regalado-González ,&nbsp;José Á. Granados-Arvizu","doi":"10.1016/j.fgb.2024.103914","DOIUrl":"10.1016/j.fgb.2024.103914","url":null,"abstract":"<div><p>Lignocellulosic material is a leading carbon source for economically viable biotechnological processes; however, compounds such furfural and acetic acid exhibit toxicity to yeasts. Nonetheless, research about the molecular mechanism of furfural and acetic acid toxicity is still scarce in yeasts like <em>Scheffersomyces stipitis</em>. Thus, this study aims to elucidate the impact of furfural and acetic acid on <em>S. stipitis</em> regarding bioenergetic and fermentation parameters. Here, we provide evidence that furfural and acetic acid induce a delay in cell growth and extend the lag phase. The mitochondrial membrane potential decreased in all treatments with no significant differences between inhibitors or concentrations. Interestingly, reactive oxygen species increased when the inhibitor concentrations were from 0.1 to 0.3 % (v/v). The glycolytic flux was not significantly (<em>p</em> &gt; 0.05) altered by acetic acid, but furfural caused different effects. Ethanol production decreased significantly (4.32 g·L^-1 in furfural and 5.06 g·L^-1 in acetic acid) compared to the control (26.3 g·L^-1). In contrast, biomass levels were not significantly different in most treatments compared to the control. This study enhances our understanding of the effects of furfural and acetic acid at the mitochondrial level in a pentose-fermenting yeast like <em>S. stipitis</em>.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Final piece to the Fusarium pigmentation puzzle – Unraveling of the phenalenone biosynthetic pathway responsible for perithecial pigmentation in the Fusarium solani species complex","authors":"Mikkel Rank Nielsen ,&nbsp;Trine Sørensen ,&nbsp;Tobias Bruun Pedersen ,&nbsp;Klaus Ringsborg Westphal ,&nbsp;Lorena Díaz Fernández De Quincoces ,&nbsp;Teis Esben Sondergaard ,&nbsp;Reinhard Wimmer ,&nbsp;Daren W. Brown ,&nbsp;Jens Laurids Sørensen","doi":"10.1016/j.fgb.2024.103912","DOIUrl":"10.1016/j.fgb.2024.103912","url":null,"abstract":"<div><p>The <em>Fusarium solani</em> species complex (FSSC) is comprised of important pathogens of plants and humans. A distinctive feature of FSSC species is perithecial pigmentation. While the dark perithecial pigments of other <em>Fusarium</em> species are derived from fusarubins synthesized by polyketide synthase 3 (PKS3), the perithecial pigments of FSSC are derived from an unknown metabolite synthesized by PKS35. Here, we confirm in FSSC species <em>Fusarium vanettenii</em> that PKS35 (<em>fsnI</em>) is required for perithecial pigment synthesis by deletion analysis and that <em>fsnI</em> is closely related to <em>phnA</em> from <em>Penicillium herquei</em>, as well as <em>duxI from Talaromyces stipentatus</em>, which produce prephenalenone as an early intermediate in herqueinone and duclauxin synthesis respectively. The production of prephenalenone by expression of <em>fsnI</em> in <em>Saccharomyces cerevisiae</em> indicates that it is also an early intermediate in perithecial pigment synthesis. We next identified a conserved cluster of 10 genes flanking <em>fsnI</em> in <em>F. vanettenii</em> that when expressed in <em>F. graminearum</em> led to the production of a novel corymbiferan lactone F as a likely end product of the phenalenone biosynthetic pathway in FSSC.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087184524000495/pdfft?md5=9015af29abe9500f83c7493c0cdf145c&pid=1-s2.0-S1087184524000495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High phenotypic and genotypic plasticity among strains of the mushroom-forming fungus Schizophyllum commune","authors":"Ioana M. Marian ,&nbsp;Ivan D. Valdes ,&nbsp;Richard D. Hayes ,&nbsp;Kurt LaButti ,&nbsp;Kecia Duffy ,&nbsp;Mansi Chovatia ,&nbsp;Jenifer Johnson ,&nbsp;Vivian Ng ,&nbsp;Luis G. Lugones ,&nbsp;Han A.B. Wösten ,&nbsp;Igor V. Grigoriev ,&nbsp;Robin A. Ohm","doi":"10.1016/j.fgb.2024.103913","DOIUrl":"10.1016/j.fgb.2024.103913","url":null,"abstract":"<div><p><em>Schizophyllum commune</em> is a mushroom-forming fungus notable for its distinctive fruiting bodies with split gills. It is used as a model organism to study mushroom development, lignocellulose degradation and mating type loci. It is a hypervariable species with considerable genetic and phenotypic diversity between the strains. In this study, we systematically phenotyped 16 dikaryotic strains for aspects of mushroom development and 18 monokaryotic strains for lignocellulose degradation. There was considerable heterogeneity among the strains regarding these phenotypes. The majority of the strains developed mushrooms with varying morphologies, although some strains only grew vegetatively under the tested conditions. Growth on various carbon sources showed strain-specific profiles. The genomes of seven monokaryotic strains were sequenced and analyzed together with six previously published genome sequences. Moreover, the related species <em>Schizophyllum fasciatum</em> was sequenced. Although there was considerable genetic variation between the genome assemblies, the genes related to mushroom formation and lignocellulose degradation were well conserved. These sequenced genomes, in combination with the high phenotypic diversity, will provide a solid basis for functional genomics analyses of the strains of <em>S. commune</em>.</p></div>","PeriodicalId":55135,"journal":{"name":"Fungal Genetics and Biology","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087184524000501/pdfft?md5=4b9314edeb77dde82d99b95832663019&pid=1-s2.0-S1087184524000501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}