Heart & Lung最新文献

{"title":"Exercise intolerance, oxidative stress, and irisin in pediatric cystic fibrosis: Can telehealth-based exercise training make a difference?","authors":"Kubra Kilic ,&nbsp;Naciye Vardar-Yagli ,&nbsp;Halime Nayir-Buyuksahin ,&nbsp;Ismail Guzelkas ,&nbsp;Deniz Dogru ,&nbsp;Melda Saglam ,&nbsp;Ebru Calik-Kutukcu ,&nbsp;Deniz Inal-Ince ,&nbsp;Nagehan Emiralioglu ,&nbsp;Ebru Yalcin ,&nbsp;Ugur Ozcelik ,&nbsp;Nural Kiper","doi":"10.1016/j.hrtlng.2024.06.016","DOIUrl":"10.1016/j.hrtlng.2024.06.016","url":null,"abstract":"<div><h3>Background</h3><p>Patients with cystic fibrosis (CF) experience increased oxidative stress. Tele-exercise can be a new method to improve exercise in CF.</p></div><div><h3>Objective</h3><p>This study aimed to investigate the effect of telehealth-based exercise training using different modalities (combined exercise training group, CombG, core stabilization exercise group, SG), in comparison with control group (CG), on exercise capacity, oxidative stress, and irisin in children with CF.</p></div><div><h3>Methods</h3><p>Thirty-nine children with CF (mean age=11.41±2.18 years, mean FEV₁(z-score)=-0.66±1.96) were included in the study. The children were randomly allocated to groups. The CombG and SG performed core stabilization exercises (CS) 3 days per week for 8 weeks. The CombG also performed aerobic exercises 3 days per week in addition to CS. Physical activity (PA) recommendations were provided to the CG. Exercise capacity was evaluated using the Modified Shuttle Test (MST). Oxidative stress was assessed using total antioxidant status (TAS), total oxidant status (TOS), Oxidative Stress Index (OSI), malondialdehyde (MDA), and superoxide dismutase (SOD). The irisin level was also measured.</p></div><div><h3>Results</h3><p>Children's baseline sex, age, BMI, and FEV₁ z-scores were similar (<em>p</em> &gt; 0.05). The MST distance (<em>p</em> = 0.047,np²=0.157) and%MST distance (<em>p</em> = 0.045, np²=0.159) significantly improved in the CombG compared with the SG and CG. Although TAS and SOD decreased over time (<em>p</em> &lt; 0.05), no significant changes were observed for TAS, TOS, OSI, MDA, SOD, and irisin parameters between the groups after training (<em>p</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>Combining aerobic exercise training with core stabilization applied using telehealth improved exercise capacity more than core stabilitation training only or PA recommendations in children with CF.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries","authors":"Denise Battaglini MD, PhD ,&nbsp;Thu-Lan Kelly PhD ,&nbsp;Matthew Griffee MD, PhD ,&nbsp;Jonathon Fanning MD, PhD ,&nbsp;Lavienraj Premraj Ms ,&nbsp;Glenn Whitman MD ,&nbsp;Diego Bastos Porto MD, PhD ,&nbsp;Rakesh Arora MD, PhD ,&nbsp;David Thomson MD, PhD ,&nbsp;Paolo Pelosi MD, FERS, FESAIC ,&nbsp;Nicole M. White PhD ,&nbsp;Gianluigi Li Bassi MD, PhD ,&nbsp;Jacky Suen MD, PhD ,&nbsp;John F. Fraser MD, PhD ,&nbsp;Chiara Robba MD, PhD ,&nbsp;Sung-Min Cho DO, MHS","doi":"10.1016/j.hrtlng.2024.06.015","DOIUrl":"10.1016/j.hrtlng.2024.06.015","url":null,"abstract":"<div><h3>Purpose</h3><p>We aimed to compare the incidence of stroke in low-and middle-income countries (LMICs) versus high-income countries (HICs) in critically ill patients with COVID-19 and its impact on in-hospital mortality.</p></div><div><h3>Methods</h3><p>International observational study conducted in 43 countries. Stroke and mortality incidence rates and rate ratios (IRR) were calculated per admitted days using Poisson regression. Inverse probability weighting (IPW) was used to address the HICs vs. LMICs imbalance for confounders.</p></div><div><h3>Results</h3><p>23,738 patients [20,511(86.4 %) HICs vs. 3,227(13.6 %) LMICs] were included. The incidence stroke/1000 admitted-days was 35.7 (95 %CI = 28.4–44.9) LMICs and 17.6 (95 %CI = 15.8–19.7) HICs; ischemic 9.47 (95 %CI = 6.57–13.7) LMICs, 1.97 (95 %CI = 1.53, 2.55) HICs; hemorrhagic, 7.18 (95 %CI = 4.73–10.9) LMICs, and 2.52 (95 %CI = 2.00–3.16) HICs; unspecified stroke type 11.6 (95 %CI = 7.75–17.3) LMICs, 8.99 (95 %CI = 7.70–10.5) HICs. In regression with IPW, LMICs vs. HICs had IRR = 1.78 (95 %CI = 1.31–2.42, <em>p</em> &lt; 0.001). Patients from LMICs were more likely to die than those from HICs [43.6% vs 29.2 %; Relative Risk (RR) = 2.59 (95 %CI = 2.29–2.93), <em>p</em> &lt; 0.001)]. Patients with stroke were more likely to die than those without stroke [RR = 1.43 (95 %CI = 1.19–1.72), <em>p</em> &lt; 0.001)].</p></div><div><h3>Conclusions</h3><p>Stroke incidence was low in HICs and LMICs although the stroke risk was higher in LMICs. Both LMIC status and stroke increased the risk of death. Improving early diagnosis of stroke and redistribution of healthcare resources should be a priority.</p></div><div><h3>Trial registration</h3><p>ACTRN12620000421932 registered on 30/03/2020.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 and RSV bronchiolitis outcomes","authors":"Donna R. Mendez MD, EdD ,&nbsp;Krishna Paul ,&nbsp;Joan Richardson ,&nbsp;Dietrich Jehle MD","doi":"10.1016/j.hrtlng.2024.06.005","DOIUrl":"https://doi.org/10.1016/j.hrtlng.2024.06.005","url":null,"abstract":"<div><h3>Background</h3><p>Severe acute respiratory syndrome related coronavirus (SARS-CoV-2) bronchiolitis has arisen with the SARS-CoV-2 pandemic. There is a paucity of literature on SARS-CoV-2 bronchiolitis.</p></div><div><h3>Objective</h3><p>The purpose of our paper was to review and compare outcomes in bronchiolitis due to severe acute respiratory syndrome related coronavirus 2 (SARS- CoV-2) and Respiratory Syncytial Virus (RSV). We also performed a subgroup analysis of two disrupted RSV seasons during the pandemic.</p></div><div><h3>Methods</h3><p>This was a retrospective study from a US TriNetX database from March 1, 2020-January 1, 2023. Propensity matching was utilized for confounders.</p></div><div><h3>Results</h3><p>There was a total of 3,592 patients (1,796 in each group) after propensity matching.</p><p>There was an increased risk of oxygen saturation ≤95 % (RR=1.50 95 % CI 1.58–1.94, <em>p</em> = 0.002) and ICU admission (RR=1.44 95 % CI 1.06–1.94, <em>p</em> = 0.02) in those with SARS- CoV-2 but not for oxygen saturation ≤90 % (RR=1.03 95 %CI 0.75–1.42, <em>p</em> = 0.85) or intubation (RR=0.73 95 % CI 0.35–1.47, <em>p</em> = 0.37). There was a decreased risk of a patient with SARS- CoV-2 bronchiolitis being hospitalized (RR=0.65 95 % CI 0.57–0.74, <em>p</em> &lt; 0.0001), respiratory rate ≥60 (RR=0.64 95 % CI 0.48–0.88, <em>p</em> &lt; 0.001) or ≥70 (RR=0.64 95 % CI 0.43–0.96, <em>p</em> = 0.03) when compared to RSV bronchiolitis. Specifically examining SARS- CoV-2 versus RSV bronchiolitis during the delayed RSV seasons, during the first season both infections were not severe, but during the second RSV bronchiolitis season, patients infected with RSV had less risk of ICU admission compared to those infected with SARS- CoV-2.</p></div><div><h3>Conclusion</h3><p>SARS- CoV-2 bronchiolitis patients appeared to have more severe outcomes since the risk of ICU admission was higher for these patients. Also, during the second delayed RSV season, SARS- CoV-2 bronchiolitis was more severe than RSV bronchiolitis.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular complications in the course of COVID-19 - lessons learned and implications for the future care of patients with viral respiratory diseases: Data from a single center retrospective observational study","authors":"Dominika Krogulec ,&nbsp;Carlo Bieńkowski ,&nbsp;Justyna D. Kowalska ,&nbsp;Agnieszka Bednarska ,&nbsp;Beata Wojtycha-Kwaśnica ,&nbsp;Natalia Jurek ,&nbsp;Piotr Ząbek ,&nbsp;Hanna Czeszko-Paprocka ,&nbsp;Monika Mrozińska ,&nbsp;Marcin Paciorek ,&nbsp;Andrzej Pihowicz ,&nbsp;Andrzej Horban","doi":"10.1016/j.hrtlng.2024.06.009","DOIUrl":"10.1016/j.hrtlng.2024.06.009","url":null,"abstract":"<div><h3>Background</h3><p>Factors associated with cardiovascular complications of COVID-19 remain understudied.</p></div><div><h3>Objectives</h3><p>Here we investigate the occurrence and risk factors of arrythmias, myocardial infarction and/or stroke, and thromboembolism in the course of COVID-19.</p></div><div><h3>Methods</h3><p>We have performed an observational study with prospectively designed data collection. Data of patients diagnosed with COVID-19 who were admitted from March 6th 2020 to November 30th 2021 in our Hospital were analyzed. Logistic regression was used to identify variables associated with the odds of early hospital death due to COVID-19.</p></div><div><h3>Results</h3><p>Fourteen-point three percent of 1964 patients had cardiovascular complications, 6.36 % arrhythmias, 5.5 % thromboembolic events and 2.39 % myocardial infarction and/or stroke. Factors independently increasing the odds of arrhythmia were older age (OR=1.49 [95 % CI: 1.17–1.92], <em>p</em> = 0.02), longer time between admission and the first onset of symptoms (1.02 [0.99–1.05], <em>p</em> = 0.049), concomitant atrial fibrillation/flutter (2.84 [1.37–5.70], <em>p</em> = 0.004), nicotinism (2.49 [1.37–4.49], <em>p</em> = 0.002), and eGFR&lt;60 ml/min/1.73m² (2.44 [1.08–5.59], <em>p</em> = 0.033). Factors independently increasing the odds of myocardial infarction and/or stroke were dementia (4.55 [0.97–19.3], <em>p</em> = 0.044), hemiplegia (12.67 [3.12–46.1], <em>p</em> &lt; 0.001), nicotinism (3.36 [1.30–10.4], <em>p</em> = 0.013) and higher C-reactive protein concentration (1.01 [1.00–1.01], <em>p</em> = 0.040). Factors independently increasing the odds of thromboembolic events were longer hospitalization (1.08 [1.05–1.10], <em>p</em> &lt; 0.001) and higher d-dimers (1.04 [1.02–1.05], &lt;0.001).</p></div><div><h3>Conclusions</h3><p>The risk of cardiovascular complications was especially pronounced in patients with older age, pre-existing cardiovascular disease and more sever pneumonia at presentation to care. This underlines the importance of close and careful clinical follow-up in the course of COVID-19 for specific patients’ populations, including a pro-active approach in diagnosis.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324001171/pdfft?md5=4e8f234ff8ab86049b7b594b4da96895&pid=1-s2.0-S0147956324001171-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Board of Directors","authors":"","doi":"10.1016/S0147-9563(24)00106-7","DOIUrl":"https://doi.org/10.1016/S0147-9563(24)00106-7","url":null,"abstract":"","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324001067/pdfft?md5=bcdf087f282a0751c8668e4778b5460d&pid=1-s2.0-S0147956324001067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oxidative balance score and heart failure in the older adults: Results from the NHANES 2005–2018","authors":"Jian Jia ,&nbsp;Zhonghua Sun ,&nbsp;Xinyu Tao ,&nbsp;Yanli Tong ,&nbsp;Han Feng ,&nbsp;Jiahui Yang ,&nbsp;Xiang Lu ,&nbsp;Chen Qu ,&nbsp;Zhengxia Liu ,&nbsp;Jun Wu","doi":"10.1016/j.hrtlng.2024.06.006","DOIUrl":"10.1016/j.hrtlng.2024.06.006","url":null,"abstract":"<div><h3>Background</h3><p>Heart failure (HF) imposes a substantial burden on older adults, and healthy diets and lifestyles may bring with benefits. However, quantifiable studies on the dietary and lifestyle risk factors for HF are scant. The Oxidative Balance Score (OBS) reflects the oxidative stress status of dietary components and lifestyle factors, but its relationship with HF risk is unclear.</p></div><div><h3>Objective</h3><p>We aims to explore the association between OBS and the prevalence of HF.</p></div><div><h3>Methods</h3><p>Using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2018, the association between OBS and the HF prevalence was analyzed by weighted logistic regression and restricted cubic splines (RCS). Subgroup and sensitivity analyses assessed the stability of the results.</p></div><div><h3>Results</h3><p>The prevalence of HF in the cohort of 6238 older adults was 5.55 %. Compared to the lowest quintile, the adjusted ORs for HF in the highest quintile of OBS and lifestyle OBS were 0.57 (95 % CI: 0.33,0.97) and 0.21 (95 %CI: 0.09,0.50), respectively. The association between OBS and HF prevalence remained stable across different models and subgroups. RCS revealed a potential inflection point. Sensitivity analysis validated the negative association between OBS and HF prevalence, and the correlation analysis between OBS and serum γ-glutamyltransferase (γ-GGT) confirmed the reliability of the study design.</p></div><div><h3>Conclusion</h3><p>The OBS is negatively associated with HF prevalence in older adults, and may help prevent HF in this population.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324001134/pdfft?md5=a9708328ee67270b370c4c4e6fb14f02&pid=1-s2.0-S0147956324001134-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of forced awakening on morning blood pressure surge","authors":"Yeonsu Kim PhD, BSN, RN ,&nbsp;Jill Howie Esquivel PhD, RN, NP ,&nbsp;Meghan Kathleen Mattos PhD, RN, CNL ,&nbsp;Eric M. Davis MD ,&nbsp;Jeongok Logan PhD, MSN, RN","doi":"10.1016/j.hrtlng.2024.06.011","DOIUrl":"10.1016/j.hrtlng.2024.06.011","url":null,"abstract":"<div><h3>Background</h3><p>Poor sleep quality can cause an increase in morning blood pressure surge (MBPS), an independent risk factor of cardiovascular disease (CVD) events. Awakening induced by external factors such as alarm clocks, may also contribute to increased MBPS.</p></div><div><h3>Objectives</h3><p>To (1) compare the MBPS and sleep quality parameters between natural and forced awakenings and (2) examine the potential impact of forced awakening on MBPS, independent of sleep quality.</p></div><div><h3>Methods</h3><p>Thirty-two healthy adults participated in this pilot study, which included one night of natural awakening and one night of forced awakening (i.e., sleep was interrupted by an alarm after five hours). Objective and self-reported sleep quality parameters were measured using a multisensory wristband and sleep diaries, respectively, and beat-to-beat blood pressure variability was assessed using a continuous blood pressure monitor. Analyses included a paired <em>t</em>-test (objective 1) and linear mixed models (objective 2).</p></div><div><h3>Results</h3><p>Participants predominantly consisted of young, healthy, and highly educated Asian adults. During the night of sleep with forced awakening, significantly higher MBPS, lower objective wakefulness after sleep onset, and lower self-reported sleep latency were observed, compared to the night with natural awakening. Forced awakening was significantly associated with increased MBPS after controlling for age, sex, mean arterial pressure, and sleep quality.</p></div><div><h3>Conclusions</h3><p>Forced awakening may significantly increase MBPS, consequently heightening the risk of CVD events. Study findings should be validated in a larger sample. Further research is also warranted to examine the impact of forced awakening on MBPS in individuals with CVD.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of COVID-19 associated bradycardia using heart rate variability analysis in a case-control study of ARDS patients","authors":"Hugo Dumargne ,&nbsp;Hugues Patural ,&nbsp;François Charbonnieras ,&nbsp;David Charier ,&nbsp;Charlotte Biscarrat ,&nbsp;Matthieu Chivot ,&nbsp;Laurent Argaud ,&nbsp;Martin Cour ,&nbsp;Auguste Dargent","doi":"10.1016/j.hrtlng.2024.06.014","DOIUrl":"10.1016/j.hrtlng.2024.06.014","url":null,"abstract":"<div><h3>Background</h3><p>Bradycardia and dysautonomia observed during SARS-Cov2 infection suggests involvement of the autonomic nervous system (ANS). Limited data exists on ANS dysregulation and its association with outcomes in patients with acute respiratory distress syndrome (ARDS) related to COVID-19 (C-ARDS) or other etiologies (NC-ARDS).</p></div><div><h3>Objectives</h3><p>We aimed to explore sympathovagal balance, assessed by heart rate variability (HRV), and its clinical prognostic value in C-ARDS compared with NC-ARDS.</p></div><div><h3>Methods</h3><p>A single-center, prospective case-control study was conducted. Consecutive patients meeting ARDS criteria between 2020 and 2022 were included. HRV was assessed using 1-hour electrographic tracing during a stable, daytime period.</p></div><div><h3>Results</h3><p>Twenty-four patients with C-ARDS and 19 with NC-ARDS were included. Age, sex and ARDS severity were similar between groups. The median heart rate was markedly lower in the C-ARDS group than in the NC-ARDS group (60 [53–72] versus 101 [91–112] bpm, <em>p</em>&lt;.001). Most of HRV parameters were significantly increased in patients with C-ARDS. HRV correlated with heart rate only in patients with C-ARDS. A positive correlation was found between the low-to high-frequency ratio (LF/HF) and length of intensive care unit stay (<em>r</em> = 0.576, <em>p</em>&lt;.001).</p></div><div><h3>Conclusion</h3><p>This study confirmed that C-ARDS was associated with marked bradycardia and severe ANS impairment, suggesting a sympathovagal imbalance with vagal overtone. Poor outcomes appeared to be more related to sympathetic rather than parasympathetic hyperactivation.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147956324001225/pdfft?md5=ae5c163824fc14678624c7d435ceab17&pid=1-s2.0-S0147956324001225-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory, cardiovascular and musculoskeletal mechanisms involved in the pathophysiology of pulmonary hypertension: An updated systematic review of preclinical and clinical studies","authors":"Thaís C Freire ,&nbsp;Marília S Ferreira ,&nbsp;Kátia De Angelis ,&nbsp;Marcelle Paula-Ribeiro","doi":"10.1016/j.hrtlng.2024.06.001","DOIUrl":"10.1016/j.hrtlng.2024.06.001","url":null,"abstract":"<div><p>Background: Progressive exercise intolerance is a hallmark of pulmonary hypertension (pH), severely impacting patients' independence and quality of life (QoL). Accumulating evidence over the last decade shows that combined abnormalities in peripheral reflexes and target organs contribute to disease progression and exercise intolerance. Objective: The aim of this study was to review the literature of the last decade on the contribution of the cardiovascular, respiratory, and musculoskeletal systems to pathophysiology and exercise intolerance in pH. Methods: A systematic literature search was conducted using specific terms in PubMed, SciELO, and the Cochrane Library databases for original pre-clinical or clinical studies published between 2013 and 2023. Studies followed randomized controlled/non-randomized controlled and pre-post designs. Results: The systematic review identified 25 articles reporting functional or structural changes in the respiratory, cardiovascular, and musculoskeletal systems in pH. Moreover, altered biomarkers in these systems, lower cardiac baroreflex, and heightened peripheral chemoreflex activity seemed to contribute to functional changes associated with poor prognosis and exercise intolerance in pH. Potential therapeutic strategies acutely explored involved manipulating the baroreflex and peripheral chemoreflex, improving cardiovascular autonomic control via cardiac vagal control, and targeting specific pathways such as GPER1, GDF-15, miR-126, and the JMJD1C gene. Conclusion: Information published in the last 10 years advances the notion that pH pathophysiology involves functional and structural changes in the respiratory, cardiovascular, and musculoskeletal systems and their integration with peripheral reflexes. These findings suggest potential therapeutic targets, yet unexplored in clinical trials, that could assist in improving exercise tolerance and QoL in patients with pH.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of single-limb exercises on functional exercise capacity, pulmonary function and dyspnea in patients with COPD","authors":"Alper Kemal Gürbüz ,&nbsp;Aynur Demirel","doi":"10.1016/j.hrtlng.2024.06.004","DOIUrl":"10.1016/j.hrtlng.2024.06.004","url":null,"abstract":"<div><h3>Background</h3><p>Aeorobic exercise is an essential component of the pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). Single-limb exercises are a type of aeorobic exercise that aims to increase patient tolerance by reducing the workload of the respiratory system.</p></div><div><h3>Objektives</h3><p>The aim of our systematic review was to determine the effects of single-limb exercises on pulmonary function, dyspnea, fatigue, and muscle dysfunction in patients with COPD.</p></div><div><h3>Methods</h3><p>Searches were performed using PubMed, Pedro, Google Scholar, MEDLINE, EMBASE, Scopus, Cochrane Library, Web of Science databases. Publications from the beginning to 2023 searched. Studies were selected by two authors by scanning the title, Mesh terms abstract in Rayyan QCRI software. Selected studies were subjected to full-text screening by applying selection criteria. Randomized controlled, case-control, cohort studies were included.</p></div><div><h3>Results</h3><p>In the first screening according to mesh terms, 1011 articles were identified. After the screening criteria and duplicate articles were evaluated, 10 articles were included. This systematic review includes seven case-control, one randomized control trial (RCT), one cross-sectional, and one non-randomized study. A total of 157 patients with COPD received treatment in these studies. According to the Bakker scale, single-limb exercises have been shown to improve pulmonary function with strong evidence. There is strong evidence that single-limb exercises have no effect on dyspnea and fatigue in COPD patients. There is limited evidence that single-limb exercises have an effect on functional exercise capacity.</p></div><div><h3>Conclusion</h3><p>Single-limb exercise can advised in terms of improving pulmonary function in patients with COPD. Current systematic review has found single limb exercise has no effect on dyspnea and fatigue perception. No side effects were reported in the studies and these exercises can be considered safe.</p></div>","PeriodicalId":55064,"journal":{"name":"Heart & Lung","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}