吸烟和家养动物暴露与中国东南部成年人肺功能下降的相互作用

IF 2.6 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2025-05-21 DOI:10.1016/j.hrtlng.2025.05.007

Le-Yun Tan , Li Yang , Ming-Tao Yu , Mei-Ling Jin , Xiao-Ping Lin , Yu-Hui Chen , Li Dong , Hui Cai , Xiao-Yang Chen , Shuai Huang , Cheng-Shui Chen , Fan Zhang , Qing-Ying Zhang

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引用次数: 0

摘要

吸烟与家畜的接触经常同时发生。然而，关于吸烟和家畜暴露对成人肺功能的独立或联合影响的流行病学证据有限。目的探讨吸烟与家畜暴露对成人肺功能的相互作用。方法本研究共从中国东南部招募6277名成年人。肺功能测量包括1 s内用力呼气量（FEV1）；强制肺活量;FEV1 / FVC的比率;呼气峰流量；用力呼气流量（FEF） 25%、fef50%、fef75%。通过在线性回归中加入产品项来评估吸烟与家畜暴露之间的相互作用，并使用产品项系数（β相互作用）作为相互作用的度量。对吸烟行为和动物类型进行分层分析。结果在吸烟者中，暴露于家养动物的肺功能下降比未暴露于家养动物的肺功能下降更严重：FVC、FEV1、FEV1/FVC比值和PEF的β相互作用分别为-0.13 （95% CI: -0.23, -0.03）、-0.15（-0.23,-0.08）、-1.78（-3.29,-0.27）和-0.43 (-0.67,-0.20)，β相互作用随吸烟行为而变化，FEV1/FVC比值最大。此外，我们发现只有家禽暴露与吸烟表现出相互作用，FVC的β相互作用；残;FEV1 / FVC的比率;脉动电场;fef25%、fef50%分别为-0.22(-0.35、-0.08)；-0.24 (-0.34, -0.15)；-2.93 (-4.86, -1.00)；-0.64 (-0.94, -0.35)；-0.51(-0.86, -0.15),和-0.32(-0.53,-0.11),分别。结论接触家禽加重了吸烟对成人肺功能的不良影响。本研究提示从事家禽相关行业的个体应戒烟，以减少肺功能下降。

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Interaction of smoking and domestic animal exposure associated with decreased lung function in adults of Southeastern China

Background

Exposure to smoking and domestic animals often occur simultaneously. However, epidemiological evidence on the independent and combined effects of smoking and domestic animal exposure on adult lung function is limited.

Objectives

The purpose of this study was to explore the interaction of smoking and domestic animal exposure on adult lung function.

Methods

A total of 6,277 adults were recruited from Southeastern China in this study. Lung function measurements included forced expiratory volume in 1 s (FEV1); forced vital capacity (FVC); FEV1/FVC ratio; peak expiratory flow (PEF); and forced expiratory flow (FEF)25 %, FEF50 %, and FEF75 %. The interaction between smoking and domestic animal exposure was assessed by including a product term in the linear regressions, with the coefficient of the product term (β_interaction) used as a measure of interaction. Stratified analysis was conducted for smoking behavior and animal types.

Results

Among smokers, lung function declined more in those with domestic animal exposure than in those without: the β_interactions for FVC, FEV1, FEV1/FVC ratio, and PEF were -0.13 (95 % CI: -0.23, -0.03), -0.15 (-0.23, -0.08), -1.78 (-3.29, -0.27), and -0.43 (-0.67, -0.20), respectively, with them varied with smoking behavior and was greatest on FEV1/FVC ratio. Moreover, we found that only poultry exposure exhibited an interaction with smoking, the β_interactions for FVC; FEV1; FEV1/FVC ratio; PEF; FEF25 %, and FEF50 % were -0.22 (-0.35, -0.08); -0.24 (-0.34, -0.15); -2.93 (-4.86, -1.00); -0.64 (-0.94, -0.35); -0.51 (-0.86, -0.15), and -0.32 (-0.53, -0.11), respectively.

Conclusions

Poultry exposure exacerbated the adverse effects of smoking on lung function in adults. This study suggests that individuals engaged in poultry-related industries should quit smoking to reduce lung function decline.

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来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.