HereditasPub Date : 2016-04-26DOI: 10.1186/s41065-016-0009-x
P. Tanhuanpää, M. Erkkilä, R. Kalendar, A. Schulman, O. Manninen
{"title":"Assessment of genetic diversity in Nordic timothy (Phleum pratense L.)","authors":"P. Tanhuanpää, M. Erkkilä, R. Kalendar, A. Schulman, O. Manninen","doi":"10.1186/s41065-016-0009-x","DOIUrl":"https://doi.org/10.1186/s41065-016-0009-x","url":null,"abstract":"","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2016-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41065-016-0009-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65774143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2016-02-22DOI: 10.1186/s41065-016-0006-0
M. Rojano-Rodríguez, J. Beristain-Hernández, Beatríz Zavaleta-Villa, P. Maravilla, M. Romero-Valdovinos, A. Olivo-Díaz
{"title":"Leptin receptor gene polymorphisms and morbid obesity in Mexican patients","authors":"M. Rojano-Rodríguez, J. Beristain-Hernández, Beatríz Zavaleta-Villa, P. Maravilla, M. Romero-Valdovinos, A. Olivo-Díaz","doi":"10.1186/s41065-016-0006-0","DOIUrl":"https://doi.org/10.1186/s41065-016-0006-0","url":null,"abstract":"","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s41065-016-0006-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65773957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2016-02-01DOI: 10.16288/J.YCZZ.15-194
Z. Yiran, Z. Meiling, Z. Zhichao, Z. Yunjiao, Ma Xin
{"title":"Epigenetic regulation of genomic imprinting in germline cells and preimplantation embryos","authors":"Z. Yiran, Z. Meiling, Z. Zhichao, Z. Yunjiao, Ma Xin","doi":"10.16288/J.YCZZ.15-194","DOIUrl":"https://doi.org/10.16288/J.YCZZ.15-194","url":null,"abstract":"Genomic imprinting is an epigenetic process that distinguishes parental alleles and results in specific expression of paternal and maternal genes. Imprints are acquired in the process of gametogenesis when genome-wide epigenetic reprogramming occurs and are maintained during early embryonic development. Therefore, the recognition and maintenance of imprints are very important in genome-wide reprogramming. In this review, we summarize the progresses of imprints removal in primordial germ cells (PGCs), imprints acquisition in parental PGCs, and imprints maintenance during early embryonic development. We also discuss the functional mechanisms of epigenetic factors which protect imprinted genes from whole genome DNA methylation.","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.16288/J.YCZZ.15-194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67512524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2016-02-01DOI: 10.16288/j.yczz.15-417
Fan-guo Chen, Qing-qing Li
{"title":"[Research progress in lampbrush chromosomes and some suggestions for their use in genetics teaching].","authors":"Fan-guo Chen, Qing-qing Li","doi":"10.16288/j.yczz.15-417","DOIUrl":"https://doi.org/10.16288/j.yczz.15-417","url":null,"abstract":"Lampbrush chromosomes (LBCs) are transient giant transcripts that exist at the diplotene stage of the first meiotic division in female gametocytes of almost all animals except mammals. LBCs are named for their lampbrush-like structure, however, they received the lowest research attention in studies of three classical cytogenetic chromosomes. They have been excellent models for studying the structure, organization, transcription, and transcriptional processing of chromosomes during meiosis. Here we briefly summarized these studies and LBCs forming mechanism and also discussed their possible functions, such as providing enough transcriptional products for embryonic development by oocytes LBCs or polyploidy demonstrated by previous reports. Finally, we discussed the possibility of introducing this typical case into our genetics teaching to inspire students' interest in genetics.","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.16288/j.yczz.15-417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67512633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2016-01-15eCollection Date: 2016-01-01DOI: 10.1186/s41065-015-0005-6
Daniela Matenaar, Linda Bröder, Axel Hochkirch
{"title":"A preliminary phylogeny of the South African Lentulidae.","authors":"Daniela Matenaar, Linda Bröder, Axel Hochkirch","doi":"10.1186/s41065-015-0005-6","DOIUrl":"10.1186/s41065-015-0005-6","url":null,"abstract":"<p><strong>Background: </strong>The grasshopper family Lentulidae is endemic to eastern and southern Africa, with its center of diversity situated in South Africa, the highest diversity being found in the Cape Floristic Region, which is one of the global biodiversity hotspots. The family consists of 35 genera sorted in two subfamilies. This study provides first insights into the phylogeny of Lentulidae. Two mitochondrial genes (12S and NDS) were sequenced and the phylogeny was inferred through Maximum Likelihood and Bayesian Inference.</p><p><strong>Results: </strong>Our results indicate that the current classification into the subfamilies Lentulinae and Shelforditinae may be incorrect as <i>Uvarovidium, Leatettix</i> (Shelforditinae) and <i>Devylderia</i> (Lentulinae) clustered together in one main clade, while <i>Betiscoides, Basutacris</i> and <i>Gymnidium</i> (all Lentulinae) formed the second main clade. The genera <i>Uvarovidium</i> and <i>Leatettix</i>, which had been assigned to the Acrididae (subfamily Hemiacridinae) in the past, grouped within the Lentulidae, confirming their current assignment to this family. The East African <i>Usambilla</i> group is likely to represent a sister clade to the south African <i>Lentula</i> and <i>Eremidium</i>. Diversification patterns in the genus <i>Devylderia</i> and <i>Betiscoides</i> suggest a higher number of species than currently known.</p><p><strong>Conclusions: </strong>Our phylogeny is not in line with the current systematics of Lentulidae, suggesting that a broader sampling and a study of the genitalia would be useful to clarify the taxonomy. Furthermore, some genera (particularly <i>Betiscoides</i> and <i>Devylderia</i>) are in need of taxonomic revision, as the number of species within these genera is likely to be higher than the current taxonomy suggests.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2016-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65773934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2015-12-01DOI: 10.16288/J.YCZZ.15-192
L. Guilin, N. Lili, L. Haifeng, G. Jia-zhong
{"title":"[Structure and function of insulin-like growth factor acid-labile subunits in mammalian homologues].","authors":"L. Guilin, N. Lili, L. Haifeng, G. Jia-zhong","doi":"10.16288/J.YCZZ.15-192","DOIUrl":"https://doi.org/10.16288/J.YCZZ.15-192","url":null,"abstract":"Insulin-like growth factors (IGFs) act as a critical signaling pathway in animals and play significant roles in body growth, development, and occurrence and progression of animal diseases. In the past, structural and functional studies of ligands, receptors and even specific binding proteins in the IGFs system have been extensively investigated. However, the functional study of insulin-like growth factor acid-labile subunit (IGFALS) mainly focused on the prolonging half-life of IGFs. Increasing number of studies indicated that mutations in the IGFALS DNA sequence and low expression level of IGFALS proteins can lead to growth and development retardation in animals. In this review, we summarize recent structural and functional studies of IGFALS in mammals, aiming to further identify detailed genetic mechanism of IGFALS.","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67512515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2015-12-01DOI: 10.16288/J.YCZZ.15-233
Z. Jinwei, Luo Yi, W. Yuhao, H. Liujun, L. Mingzhou, Wang Xun
{"title":"MicroRNA regulates animal adipocyte differentiation","authors":"Z. Jinwei, Luo Yi, W. Yuhao, H. Liujun, L. Mingzhou, Wang Xun","doi":"10.16288/J.YCZZ.15-233","DOIUrl":"https://doi.org/10.16288/J.YCZZ.15-233","url":null,"abstract":"Adipose tissues play a critical role in the regulation of energy metabolism and homeostasis, and is also an important endocrine organ. Adipocyte differentiation is a complicated physiological process during which mesenchymal stem cells differentiate into adipocytes. This process is synergistically regulated by a large number of transcription factors, hormones and signaling pathway molecules. As a class of endogenous non-coding RNA (ncRNA), microRNAs (miRNAs) regulate gene expression mainly through post-transcriptional translational repression. In recent years, numerous studies have demonstrated that miRNA could have an impact on adipocyte differentiation and adipogenesis by modulating the expression levels of several adipogenic transcription factors and key signaling molecules. In this review, we summarize the mechanism of miRNA in regulating the differentiation of white/brown/beige adipocytes and the relevant signaling pathways and key factors, in the hope of providing theoretical guidance and new thoughts for treating obesity and other metabolic diseases.","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67512568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
HereditasPub Date : 2015-11-01DOI: 10.16288/j.yczz.15-093
Sheng-song Xie, Yi Zhang, Li-sheng Zhang, Guang-lei Li, Chang-zhi Zhao, Pan Ni, Shu-hong Zhao
{"title":"[sgRNA design for the CRISPR/Cas9 system and evaluation of its off-target effects].","authors":"Sheng-song Xie, Yi Zhang, Li-sheng Zhang, Guang-lei Li, Chang-zhi Zhao, Pan Ni, Shu-hong Zhao","doi":"10.16288/j.yczz.15-093","DOIUrl":"10.16288/j.yczz.15-093","url":null,"abstract":"<p><p>The third generation of CRISPR/Cas9-mediated genome editing technology has been successfully applied to genome modification of various species including animals, plants and microorganisms. How to improve the efficiency of CRISPR/Cas9 genome editing and reduce its off-target effects has been extensively explored in this field. Using sgRNA (Small guide RNA) with high efficiency and specificity is one of the critical factors for successful genome editing. Several software have been developed for sgRNA design and/or off-target evaluation, which have advantages and disadvantages respectively. In this review, we summarize characters of 16 kinds online and standalone software for sgRNA design and/or off-target evaluation and conduct a comparative analysis of these different kinds of software through developing 38 evaluation indexes. We also summarize 11 experimental approaches for testing genome editing efficiency and off-target effects as well as how to screen highly efficient and specific sgRNA.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.16288/j.yczz.15-093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67512954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}