Hereditas最新文献

{"title":"Quantitative trait loci mapping of metal concentrations in leaves of the maize IBM population","authors":"Zvonimir Zdunić,&nbsp;Sonja Grljušić,&nbsp;Tatjana Ledenčan,&nbsp;Tomislav Duvnjak,&nbsp;Domagoj Šimić","doi":"10.1111/hrd2.00048","DOIUrl":"10.1111/hrd2.00048","url":null,"abstract":"<p>Characterizing concentrations of several beneficiary and toxic metals in maize leaves is of importance for ionomic studies and for silage production. The intermated B73 × Mo17 maize population (IBM) was evaluated for concentrations of eight metals (cadmium – Cd, copper – Cu, iron – Fe, potassium – K, magnesium – Mg, manganese – Mn, strontium – Sr and zinc – Zn) in ear-leaf to map quantitative trait loci (QTL) with 2161 molecular markers across the genome. QTL analysis revealed nine significant QTLs for concentrations of Cd, Cu, Fe, K, Mg and Sr combined over two environments. Median resolution for the QTL interval was less than 1 cM on a regular F₂ map, which is a big improvement compared with the prior mapping (8 cM). The highest LOD scores of 15.52 and 15.31 were detected for K and Cd concentrations, respectively, explaining more than 20 percent of the phenotypic variance. No QTLs were found to be colocalized. QTL mapping in the IBM population did not confirm our earlier QTL results demonstrating considerable QTL ×genetic background interaction. The only exception is confirmation of the major QTL for Cd accumulation on chromosome 2. Our results could facilitate further genetic and physical mapping of genes for metal accumulation in maize.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/hrd2.00048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32517735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of novel mutations in BRCA1 in Iranian families with breast cancer","authors":"Ariane Sadr-Nabavi,&nbsp;Mahtab Dastpak,&nbsp;Fatemeh Homaei-Shandiz,&nbsp;Ahmad Reza Bahrami,&nbsp;Hamid-Reza Bidkhori,&nbsp;Mahmood Raeesolmohaddeseen","doi":"10.1111/hrd2.00040","DOIUrl":"10.1111/hrd2.00040","url":null,"abstract":"<p>In Iran and the rest of the world, breast cancer (BC) is the most common malignancy in women. Familial history and age are significant risk factors for the development of this disease in Iran. Most hereditary BCs are associated with inherited mutations in the <i>BRCA1</i> and <i>BRCA2 genes</i>. Some recent studies demonstrated that <i>BRCA1</i> mutations are seen in high-risk women with family histories of BC. In this report we investigated all <i>BRCA1</i> exons from 40 female patients with family histories of BC and one BC twin, and report a novel mutation in this gene in one patient. As controls, <i>BRCA1</i> exons from 100 normal women and the BC-free twin of the BC twin were also examined for this mutation. None of the women in the normal group harbored the mutation. Whether this variation is specific for the Iranian population or for special subgroups remains to be determined.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/hrd2.00040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32518129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsatellite-based genetic diversity among accessions of maize landraces from Sinaloa in México","authors":"Karen V. Pineda-Hidalgo,&nbsp;Karla P. Méndez-Marroquín,&nbsp;Elthon Vega Alvarez,&nbsp;Jeanett Chávez-Ontiveros,&nbsp;Pedro Sánchez-Peña,&nbsp;Jose A. Garzón-Tiznado,&nbsp;Misael O. Vega-García,&nbsp;Jose A. López-Valenzuela","doi":"10.1111/j.1601-5223.2013.00019.x","DOIUrl":"10.1111/j.1601-5223.2013.00019.x","url":null,"abstract":"<p>In the state of Sinaloa México, traditional farmers still cultivate maize accessions with a wide diversity of morphological characteristics, but the gene reservoir maintained in these populations has been poorly studied and it is being lost due to changes in land use and the adoption of hybrid commercial varieties. The aim of this study was to evaluate the genetic diversity of some of these maize populations to contribute to their preservation. Twenty eight accessions were used for the analysis. DNA was extracted from 396 individuals and probed with 20 microsatellites distributed across the maize genome. A total of 121 alleles were obtained (average of 6.1 alleles per locus) and a total genetic diversity of 0.72. The UPGMA-cluster analysis, model-based population structure and principal component analysis revealed three major groups, one formed mainly by accessions of races typical of the Northwestern lowlands (Chapalote, Dulcillo del Noroeste, Tabloncillo Perla, Blando de Sonora and Elotero de Sinaloa) and the other two with accessions mainly from Tabloncillo and Tuxpeño. The high number of alleles per locus and total genetic diversity found in this study demonstrate a broad genetic basis of the accessions of maize landraces from Sinaloa, representing a gene reservoir useful in breeding programs.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00019.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollen-mediated gene flow from a commercial potato cultivar to the wild relative S. chacoense Bitter under experimental field conditions in Argentina","authors":"Mauricio A. Capurro,&nbsp;Elsa L. Camadro,&nbsp;Ricardo W. Masuelli","doi":"10.1111/j.1601-5223.2013.00018.x","DOIUrl":"10.1111/j.1601-5223.2013.00018.x","url":null,"abstract":"<p>The common potato, <i>Solanum tuberosum</i> ssp. <i>tuberosum</i> (tbr, 2n = 4x = 48; 4EBN), has many closely related wild tuber-bearing species. Around 28 to 35 of them spontaneously grow in Argentina overlapping, in some areas, with the crop and/or experimental transgenic potatoes. Although it is well proven that hybridization barriers in potatoes can be incomplete, information on gene flow between cultivated and wild germplasm is scarce. Thus, a gene flow field experiment with a circular array was set up in Balcarce, Argentina, in 2009, and evaluated over two seasons. The tetraploid tbr cultivar Huinkul MAG and one compatible cloned genotype of the related wild potato <i>S. chacoense</i> Bitter (chc, 2n = 2x = 24; 2EBN), which produced 2n eggs, were used, respectively, as pollen donor and receptor. Berries with hybrid seeds – as revealed by ploidy and RAPD profiles – were obtained in one season, at 30 m from the pollen donor. These results reinforce others previously obtained with the same pollen donor and a male sterile tbr cultivar in a similar array, pointing out to the need of increasing isolation distances in areas of overlap between cultivated and wild potato germplasm to prevent or minimize undesirable pollen-mediated gene flow.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00018.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31945175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed breeding system in the hermaphroditic land slug Arion intermedius (Stylommatophora, Arionidae)","authors":"Kurt Jordaens,&nbsp;Natalie Van Houtte,&nbsp;Philippe Helsen,&nbsp;Karin Breugelmans,&nbsp;Peter Jaksons,&nbsp;Thierry Backeljau","doi":"10.1111/j.1601-5223.2013.02272.x","DOIUrl":"10.1111/j.1601-5223.2013.02272.x","url":null,"abstract":"<p>Theory suggests that hermaphroditic plants and animals should be either entirely outcrossing or entirely selfing. As such, very few hermaphroditic plants and basommatophoran snails have a mixed breeding system. However, reliable estimates of selfing rates are lacking for most hermaphroditic animals. This partly prevents to delineate the relative contributions of the selective factors that determine selfing and outcrossing rates in hermaphroditic animal taxa. Here, we studied the population genetic structure of, and breeding system in, 11 populations of the hermaphroditic land slug <i>Arion intermedius</i> using five polymorphic microsatellite loci. Moreover, genotype frequencies deviated significantly from Hardy–Weinberg equilibrium expectations for most of the loci in all populations suggesting some level of selfing. Estimates of the selfing level <i>s</i>, suggest moderate levels of outcrossing (mean <i>s</i> based on <i>F</i>_IS= 0.84; mean <i>s</i> based on the two-locus heterozygosity disequilibrium = 0.20, or with a ML approach = 0.22). Our study therefore suggests that <i>A. intermedius</i> has a mixed breeding system. A re-analysis of allozyme data from another arionid slug ( subgenus <i>Carinarion</i>) indicates that mixed breeding may be more common in arionid slugs than hitherto was assumed. These results seem therefore at variance with current theoretical and empirical predictions and opens perspectives for the study on the evolutionary factors driving mixed breeding systems in animals.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.02272.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40267957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GH gene polymorphisms and expression associated with egg laying in muscovy ducks (Cairina moschata)","authors":"X. Wu,&nbsp;M. J. Yan,&nbsp;S. Y. Lian,&nbsp;X. T. Liu,&nbsp;A. Li","doi":"10.1111/j.1601-5223.2013.00016.x","DOIUrl":"10.1111/j.1601-5223.2013.00016.x","url":null,"abstract":"<p>Accumulated evidence suggests that the growth hormone (<i>GH</i>) gene plays a physiological role in the control of reproductive function. Here, we examined the correlation between egg-laying traits and <i>GH</i> gene polymorphisms and expression patterns in the muscovy duck (<i>Cairina moschata</i>). PCR single-strand conformation polymorphism was used to identify polymorphisms in intron 3 of <i>GH</i>. One single nucleotide polymorphism (g.3270 A &gt; G) was detected by sequencing, and the frequencies of the A and G alleles in the population were 0.65 and 0.35, respectively. A comparison test showed that the AA genotype group had more consecutive laying days and more eggs at 300 days than the GG genotype group (P &lt; 0.05); however, there was no significant difference for the age at first laying (P &gt; 0.05). Such a significant correlation between <i>GH</i> polymorphisms and egg-laying performance suggested that <i>GH</i> could be a candidate locus affecting the laying trait in muscovy duck. Furthermore, real-time fluorescent quantitative PCR demonstrated that <i>GH</i> is expressed in all selected tissues, but is highly expressed in the hypothalamic–pituitary–gonadal axis and heart. This unique expression pattern suggested that <i>GH</i> may exert its local physiological function through the autocrine or paracrine pathway during gonad development and growth in the muscovy duck. The data presented in this paper revealed <i>GH</i> polymorphisms and expression patterns in the muscovy duck and indicated a potential regulatory effect of GH on reproduction.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00016.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marker assisted selection of low phytic acid trait in maize (Zea mays L.)","authors":"S. Sureshkumar,&nbsp;P. Tamilkumar,&nbsp;N. Senthil,&nbsp;P. Nagarajan,&nbsp;A. U. Thangavelu,&nbsp;M. Raveendran,&nbsp;S. Vellaikumar,&nbsp;K. N. Ganesan,&nbsp;R. Balagopal,&nbsp;G. Vijayalakshmi,&nbsp;V. Shobana","doi":"10.1111/j.1601-5223.2013.00030.x","DOIUrl":"10.1111/j.1601-5223.2013.00030.x","url":null,"abstract":"<p>Maize is the third important major food crop. Breeding for low phytate maize genotypes is an effective strategy for decreasing the content of kernel phytic acid (a chelator of cations such as Ca²⁺ and Fe³⁺) and thereby increasing the bioavailability of nutritive minerals in human diet and animal feed. Previous studies have established that a mutant plant with a <i>lpa2-2</i> allele accumulates less phytic acid in seeds. Therefore, the marker assisted backcross breeding (MABB), which involves introgression of <i>lpa2-2</i> recessive allele (which confer low phytate trait) from a <i>lpa2-2</i> mutant line into a well-adapted line using backcrosses and selection of lines possessing <i>lpa2-2</i> allele in each backcross population using molecular markers, is an effective strategy for developing low phytate maize. So far, no studies have developed any <i>lpa2-2</i> allele specific molecular markers for this purpose. Here, using backcross and selfed progenies, obtained by crossing low phytate mutant line ‘EC 659418’ (i.e. donor of <i>lpa2-2</i> allele) into agronomically superior line ‘UMI395’, we have validated that a SSR marker ‘umc2230’, located 0.4 cM downstream of <i>lpa2-2</i>, cosegregate, in a Mendelian fashion, with low phytic acid trait. Therefore umc2230 can be dependably used in MABB for the development of low phytate maize.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00030.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Range-wide genetic structure of maritime pine predates the last glacial maximum: evidence from nuclear DNA","authors":"Krassimir D. Naydenov,&nbsp;Alexander Alexandrov,&nbsp;Vlado Matevski,&nbsp;Kole Vasilevski,&nbsp;Michel K. Naydenov,&nbsp;Veselka Gyuleva,&nbsp;Christopher Carcaillet,&nbsp;Nadya Wahid,&nbsp;Salim Kamary","doi":"10.1111/j.1601-5223.2013.00027.x","DOIUrl":"10.1111/j.1601-5223.2013.00027.x","url":null,"abstract":"<p>Using nuclear simple sequence repeats (nuSSRs), we determined the genetic variability in the natural distribution range of maritime pine (<i>Pinus pinaster</i>) in the western Mediterranean region. We analysed the role of global and significant climatic fluctuations in driving the evolutionary diversification of this species. We attempted to determine the impact of the last glacial maximum (LGM) and human activity on genetic variation and to identify the effect of bottlenecks, admixing, migration, time to the most recent common ancestor (TMRCA), and recent splits. A total of 972 individuals were analysed. The sample represented 27 natural populations from the western Mediterranean region, which encompasses most of the natural range of <i>P. pinaster</i>. Using eight nuSSRs, we analysed genetic diversity indices for each population and group of populations. We also examined the interpopulation structure by the frequency and distance method and investigated genetic barriers, signals of historical demographic fluctuations, phylogeographic structure, admixing, rate of mutation, migration, as well as testing the hypothesis of isolation by distance (IBD). Both cluster analyses showed similar population genetic structure with three genetic barriers that divided the samples into four large groups. Intensive migration was only detected during the period of the last glacial maximum (LGM), which permitted the mutation rate of the markers used to be calculated. The majority of the population was found to exhibit signs of a recent bottleneck and its timing showed a clear northeast–southwest geographic distribution. A clearly defined phylogeographic structure (<i>N</i>_st &gt; <i>G</i>_st and <i>R</i>_st &gt; <i>G</i>_st) under IBD was established, and showed the highest divergence between groups of populations separated by physical barriers, such as the Strait of Gibraltar, the Mediterranean Sea and the Pyrenees. The high level of intergroup genetic differentiation (Φ_IS= 20.26) was attributed to a long historical isolation (which occurred before the last 18 000 years) between the principal maritime pine population groups that occurred due to physical barriers that limited pollen and seed transfer, combined with a minimal effective radius of distribution. The low level of genetic diversity among the populations was combined with genetic drift and a recent bottleneck during the period of human activity. Significant migration across barriers was due to spontaneous phenomena during the LGM, which had no significant impact on the genetic structure owing to its relatively short duration and the fragmented species. The phylogeographic structure under the assumption of IBD was well established for <i>P. pinaster</i> in each of the principal population groups.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2014-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00027.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32175482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromosome evolution in Neotropical butterflies","authors":"Anssi Saura,&nbsp;Barbara Von Schoultz,&nbsp;Anja O. Saura,&nbsp;Keith S. Brown Jr.","doi":"10.1111/j.1601-5223.2013.00008.x","DOIUrl":"10.1111/j.1601-5223.2013.00008.x","url":null,"abstract":"<p>We list the chromosome numbers for 65 species of Neotropical Hesperiidae and 104 species or subspecies of Pieridae. In Hesperiidae the tribe Pyrrhopygini have a modal n = 28, Eudaminae and Pyrgini a modal n = 31, while Hesperiinae have n = around 29. Among Pieridae, Coliadinae have a strong modal n = 31 and among Pierinae Anthocharidini are almost fixed for n = 15 while Pierini vary with n = 26 as the most common chromosome number. Dismorphiinae show wide variation. We discuss these results in the context of chromosome numbers of over 1400 Neotropical butterfly species and subspecies derived from about 3000 populations published here and in earlier papers of a series. The overall results show that many Neotropical groups are characterized by karyotype instability with several derived modal numbers or none at all, while almost all taxa of Lepidoptera studied from the other parts of the world have one of n = 29–31 as modal numbers. Possibly chromosome number changes become fixed in the course of speciation driven by biotic interactions. Population subdivision and structuring facilitate karyotype change. Factors that stabilize chromosome numbers include hybridization among species sharing the same number, migration, sexual selection and possibly the distribution of chromosomes within the nucleus.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2013-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.00008.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31589741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IHH gene polymorphism among three horse breeds and its application for association test in horses with osteochondrosis","authors":"T. Zabek,&nbsp;P. Golonka,&nbsp;A. Fornal,&nbsp;E. Semik","doi":"10.1111/j.1601-5223.2013.02282.x","DOIUrl":"10.1111/j.1601-5223.2013.02282.x","url":null,"abstract":"<p>Genetic polymorphism of <i>IHH</i> gene were investigated in Angloarabian, Polish Coldblood and Polish Halfbred horses with the inclusion of a group of Polish Halfbreds affected by osteochondrosis. <i>IHH</i> is a good candidate gene for association study of developmental disorders mainly affecting skeleton development. DNA sequence spanning <i>IHH</i> gene annotated in the horse genome and its putative promoter were investigated using SANGER sequencing. Analysis of genetic variability at polymorphic sites in the <i>IHH</i> gene body and the promoter region confirmed genetic differences between warmblood and coldblood horse breeds. A test for allelic and genotypic association at particular SNP sites revealed no association with osteochondrosis in investigated group of Polish Halfbreds. It was concluded that participation of different warmblood breeds in pedigrees of Polish Halfbreds make it difficult to search for genetic variants being associated with this complex disorder in this breed. <i>IHH</i> gene polymorphism investigated among three different horse populations would be valuable for further studies on equine bone developmental disorders.</p>","PeriodicalId":55057,"journal":{"name":"Hereditas","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2013-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1601-5223.2013.02282.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31589742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}