Injury-International Journal of the Care of the Injured最新文献

{"title":"New developments in locking plate osteosynthesis – A narrative review","authors":"Benedikt J. Braun,&nbsp;Steffen Roßlenbroich,&nbsp;Maximilian M. Menger,&nbsp;Tina Histing","doi":"10.1016/j.injury.2026.113443","DOIUrl":"10.1016/j.injury.2026.113443","url":null,"abstract":"<div><div>Plate osteosynthesis has evolved significantly, progressing from the first plates with externally protruding screws to anatomically precontoured systems designed for minimally invasive application. In this narrative review, we provide a brief recap of the history of locked plating and highlight the most relevant developments of the last two decades. These include anatomical innovations and mechanobiologically optimized plates, as well as emerging systems capable of monitoring the fracture healing progress.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 ","pages":"Article 113443"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149257845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface topography and nanostructural modifications for the prevention of bacterial infections","authors":"Gabriela Graziani,&nbsp;Daniele Ghezzi","doi":"10.1016/j.injury.2026.113727","DOIUrl":"10.1016/j.injury.2026.113727","url":null,"abstract":"<div><div>Implant-associated infections represent severe complications in orthopaedics and trauma surgery, largely driven by early bacterial adhesion and subsequent biofilm formation on device surfaces. The increasing incidence of multidrug-resistant pathogens further complicates management and underscores the urgent need for preventive, antibiotic-free strategies. Surface functionalization of implantable metals has emerged as a key approach to inhibit bacterial colonization at the implant–tissue interface while minimizing systemic toxicity and selective pressure for resistance. This review provides a comprehensive and clinically oriented overview of two major surface-based strategies: micro/nano-scale surface patterning (non-releasing approaches) and nanostructured antibacterial metallic coatings (releasing or contact-killing systems). Surface patterning modifies topography, wettability, and surface charge to reduce bacterial adhesion or induce mechanical disruption of bacterial membranes. Although highly promising in vitro and not reliant on the release of antimicrobial agents, hence not inserting compounds with potential toxicity, current evidence indicates that patterned surfaces alone often provide limited and transient protection in vivo, where protein adsorption and complex microbial communities may mask topographical effects. In contrast, nanostructured antibacterial metallic coatings offer broad-spectrum antibacterial and antibiofilm activity through ion release and/or contact-mediated mechanisms. Advances in plasma-assisted deposition technologies, including magnetron sputtering, pulsed laser deposition, and ionized jet deposition, enable precise control over coating thickness, morphology, and ion-release kinetics, thereby enhancing antibacterial efficacy while preserving biocompatibility and osteogenic potential. Recent in vivo data support the durability and safety of thin nanostructured coatings, highlighting their translational potential. Although not-yet clinically available, due to challenges in clinical translation of biomedical devices, these strategies can build a new generation of antibacterial device, with efficacy targeted to the microbial community and to tackling biofilm. Comparative observations suggest that while surface patterning represents a valuable complementary strategy, nanostructured metallic thin films currently provide more robust and clinically relevant antimicrobial performance. Future research should prioritize standardized antibiofilm testing models, validation in complex in vivo settings, combination strategies integrating patterning and coatings, and the rational tuning of multi-metal systems to address heterogeneous microbial communities.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 ","pages":"Article 113727"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149279041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgeon-performed iliac fascia catheter versus epidural analgesia versus no regional analgesia after anterior acetabular fracture surgery: A retrospective comparative study of 85 patients","authors":"Victor Bouffier,&nbsp;Jules Grèze,&nbsp;Clément Villaret,&nbsp;Mélanie Veloso,&nbsp;Caroline Sanchez,&nbsp;Mehdi Boudissa,&nbsp;Pierre Bouzat","doi":"10.1016/j.injury.2026.113708","DOIUrl":"10.1016/j.injury.2026.113708","url":null,"abstract":"<div><h3>Purpose</h3><div>Perioperative analgesia after acetabular fracture surgery remains difficult. During anterior approaches, the surgeon can place a catheter against the femoral nerve through the ilioinguinal approach, or beneath the psoas muscle during the modified Stoppa approach, without any additional procedure. This technique has never been described. We evaluated the analgesic efficacy of this surgical iliac fascia block in acetabular fracture surgery (SIFBAF) after isolated anterior acetabular fracture surgery.</div></div><div><h3>Methods</h3><div>We retrospectively included all adults who underwent isolated anterior acetabular fracture repair through an ilioinguinal, pararectus or modified Stoppa approach at a single centre between June 2022 and April 2025. Cumulative morphine consumption over the first three postoperative days was compared between three groups: SIFBAF, epidural analgesia, and no regional analgesia. Daily morphine consumption and visual analogue scale (VAS) scores were analysed with mixed models. Adjusted and sensitivity analyses were also performed.</div></div><div><h3>Results</h3><div>Eighty-five of 121 eligible patients were analysed (SIFBAF, n = 31; epidural, n = 30; no regional analgesia, n = 24). Median cumulative morphine consumption was 5.0 mg [0.42–10.5], 6.0 mg [1.67–12.2] and 12.7 mg [3.75–30.2] respectively (p = 0.123). In a mixed negative binomial model, daily consumption was lower with SIFBAF (IRR 0.49, 95% CI 0.19–1.25) and with epidural analgesia (IRR 0.49, 95% CI 0.19–1.26) than without regional analgesia, but the effect of group was not significant (p = 0.237). Consumption fell steeply over time in all groups (p &lt; 0.001). Adjustment and three sensitivity analyses left these results unchanged. VAS scores stayed below 3 out of 10 and did not differ between groups. Catheters were still in place at day 3 in 64.5% of the SIFBAF group and 43.3% of the epidural group (p = 0.126).</div></div><div><h3>Conclusion</h3><div>SIFBAF did not significantly reduce opioid consumption. It is nevertheless simple to place, fits into the anterior acetabular approach, and gave opioid consumption and pain scores that did not differ significantly from those obtained with epidural analgesia. These findings are hypothesis-generating and support a future randomised trial.</div></div><div><h3>Level of evidence</h3><div>Level III, retrospective comparative therapeutic study.</div></div><div><h3>Reporting guideline</h3><div>the study is reported according to the STROBE statement. The completed checklist is submitted as a separate file.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 10","pages":"Article 113708"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of complex humeral shaft fractures (AO/OTA 12-C): A multicenter comparison of open plating, MIPO, and intramedullary nailing","authors":"Yong-Cheol Yoon,&nbsp;Hyung Keun Song,&nbsp;Hyoung-Keun Oh,&nbsp;Won-Seok Cho,&nbsp;Joon-Woo Kim","doi":"10.1016/j.injury.2026.113685","DOIUrl":"10.1016/j.injury.2026.113685","url":null,"abstract":"<div><h3>Background</h3><div>The optimal fixation strategy for complex humeral shaft fractures, especially those with severe comminution, remains controversial. This study compared clinical and radiological outcomes after open reduction and internal fixation (ORIF), minimally invasive plate osteosynthesis (MIPO), or intramedullary (IM) nailing for AO/OTA type 12-C humeral shaft fractures.</div></div><div><h3>Patients and methods</h3><div>This multicenter retrospective comparative study included 75 adults with AO/OTA type 12-C humeral shaft fractures treated surgically between 2015 and 2023. Patients were grouped by the fixation method, as follows: ORIF (n = 26), MIPO (n = 30), and IM nailing (n = 19). Radiological outcomes and complications were recorded. Functional outcomes were assessed using the Disabilities of the Arm, Shoulder, and Hand (DASH) score, Mayo Elbow Performance Score (MEPS), and joint range of motion (ROM).</div></div><div><h3>Results</h3><div>Baseline demographics and fracture characteristics did not differ significantly among the groups; however, IM nailing had numerically higher polytrauma rates and median Injury Severity Score. The operative time was significantly longer with ORIF (143.0 vs. 102.1 vs. 95.5 min; P &lt; 0.001), and the intraoperative blood loss was greater with ORIF than with MIPO or IM nailing (292.0 vs. 196.2 vs. 182.3 mL; P &lt; 0.001). Radiographic union occurred in 92.3%, 93.3%, and 84.2% of the patients after ORIF, MIPO, and IM nailing, respectively (P = 0.53). Postoperative radial nerve palsy occurred in five patients (ORIF, 3; MIPO, 1; IM nailing, 1); all but one resolved within 6 months. Nonunion, malunion, and reoperation rates differed only numerically. Functional outcomes, including DASH score (P = 0.11), MEPS (P = 0.18), elbow ROM (P = 0.09), shoulder forward flexion (P = 0.264), and shoulder abduction (P = 0.228), did not differ significantly across the fixation methods.</div></div><div><h3>Conclusion</h3><div>All three techniques achieved acceptable union and functional outcomes in AO/OTA type 12-C humeral shaft fractures. MIPO showed a numerically favorable trend toward fewer complications and less surgical invasiveness than ORIF. IM nailing showed numerical trends toward higher nonunion and malunion rates and slightly lower shoulder mobility, whereas ORIF required longer operative times and demonstrated greater intraoperative blood loss. Considering the retrospective design, surgeon-selected allocation, and limited statistical power, these findings warrant caution. The fixation strategy should be tailored to the fracture morphology, soft-tissue condition, patient factors, and surgeon experience.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 10","pages":"Article 113685"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148946419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of PMMA bone cement in trauma surgery: A narrative review","authors":"Micha Holla,&nbsp;Harith Migdad,&nbsp;Taco Blokhuis","doi":"10.1016/j.injury.2026.113728","DOIUrl":"10.1016/j.injury.2026.113728","url":null,"abstract":"<div><h3>Background</h3><div>Polymethylmethacrylate (PMMA) bone cement has been used for decades in orthopaedic surgery, primarily for fixation of endoprostheses. In trauma surgery, its role is more heterogeneous and often underappreciated.</div></div><div><h3>Methods</h3><div>This narrative review summarizes the material properties, biological behavior, and clinical applications of PMMA in trauma surgery, including prosthesis fixation, screw augmentation, and its use as a temporary spacer. Finally, the use of PMMA used as a permanent spacer, including technical tips is described.</div></div><div><h3>Results</h3><div>PMMA provides high compressive strength, minimal shrinkage, and reliable handling characteristics. Cement augmentation improves implant anchorage in osteoporotic bone. As a spacer, PMMA plays a key role in staged reconstruction. Finally, in selected patients and as a salvage procedure, PMMA may function as a permanent load-sharing implant when combined with stable internal fixation.</div></div><div><h3>Conclusion</h3><div>PMMA remains a versatile, inexpensive, and widely available tool in trauma surgery beyond its classical role in arthroplasty.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 ","pages":"Article 113728"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149257842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Past, present and future of distal radius corrective osteotomy: From 2D based reconstruction to 3D data-driven, patient specific care","authors":"Tom G.J. Loonen,&nbsp;Thomas J.J. Maal,&nbsp;Michael J.R. Edwards,&nbsp;Vincent M.A. Stirler","doi":"10.1016/j.injury.2026.113447","DOIUrl":"10.1016/j.injury.2026.113447","url":null,"abstract":"<div><div>Corrective osteotomy for distal radius malunion has evolved from two-dimensional (2D) radiograph based planning and surgeon performed geometric analysis to advanced three-dimensional (3D) virtual surgical planning (VSP). Historically guided by predefined radiographic parameters, contemporary practice increasingly emphasizes symptom severity and patient-specific functional goals. CT-based 3D models, contralateral surface matching, and patient-specific guides and implants have improved the accuracy of deformity correction. However, greater anatomical precision does not automatically translate into superior functional outcomes. Future progress depends on standardized evaluation frameworks, multicenter data collection, and predictive models to determine the clinical value of virtual surgical planning (VSP) and patient-specific implants (PSI) in delivering individualized, cost-effective and function-oriented care across the entire treatment pathway.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 ","pages":"Article 113447"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149257999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational injuries among orthopaedic surgeons in Greece: A cross-sectional study","authors":"Konstantinos Zampetakis,&nbsp;Rozalia Dimitriou,&nbsp;Kalliopi Alpantaki,&nbsp;Constantinos Chaniotakis,&nbsp;Alexandros Tsioupros,&nbsp;Nikolaos Ritzakis,&nbsp;Ioannis Ktistakis,&nbsp;Ioannis M. Stavrakakis","doi":"10.1016/j.injury.2026.113688","DOIUrl":"10.1016/j.injury.2026.113688","url":null,"abstract":"<div><h3>Introduction</h3><div>Orthopaedic surgery is a high-risk specialty for occupational injuries, both physical and psychological, while European data remain limited. This study assessed the prevalence, spectrum, risk factors, and impact of occupational injuries among orthopaedic surgeons in Greece.</div></div><div><h3>Methods</h3><div>A de novo web-based questionnaire was distributed to 1118 members of the Hellenic Association of Orthopaedic Surgery and Traumatology (HAOST). Survey items included demographics, professional characteristics, workload, injury history and type, affected anatomical regions, injury impact, reporting behavior, and prior ergonomic training. Descriptive analysis and appropriate logistic regression and chi-square tests were performed.</div></div><div><h3>Results</h3><div>A total of 137 surgeons completed the survey (response rate 12.2%). The mean age was 43.4 years, and most participants were male (82.6%). Overall, 103 surgeons (75.2%) reported at least one occupational injury. Among injured participants, acute and sharp object injuries (97.1%), psychological or emotional strain (89.3%), and musculoskeletal disorders (79.6%) predominated. Hands and wrists were most commonly affected (72.8%). Medication was required in 38 cases (37.9%) and work absence in 13 (12.6%). Only 31 incidents (30.1%) were formally reported, and 12 surgeons (11.7%) had received previous training. Female gender was protective factor (p = 0.042). Sports medicine was associated with lower injury risk (p = 0.021), while traumatology showed higher odds of injury (OR 3.75, p = 0.114). No associations were observed for age, experience, workplace, or prior training.</div></div><div><h3>Conclusion</h3><div>This study provides the first national data on occupational injuries among Greek orthopaedic surgeons. The high prevalence observed underscores the need for structured preventive strategies focused on ergonomics and occupational health education.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 10","pages":"Article 113688"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the best pin care for external fixation pins?","authors":"Cole Elaschuk,&nbsp;Aran Nikpay,&nbsp;Richard Buckley","doi":"10.1016/j.injury.2026.113716","DOIUrl":"10.1016/j.injury.2026.113716","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 10","pages":"Article 113716"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific instrument with 3D printing technology in orthopaedic trauma: A narrative review","authors":"Pui Yan Wong,&nbsp;Chaoran Liu,&nbsp;Huang Tao,&nbsp;Baoqi Li,&nbsp;Minghui Yang,&nbsp;Chunpeng Zhao,&nbsp;Ting Li,&nbsp;Yu Wang,&nbsp;Hangyu Gu,&nbsp;Ning Zhang,&nbsp;Wing Hoi Cheung,&nbsp;Chun Sing Chui,&nbsp;Sheung Wai Law,&nbsp;Xinbao Wu,&nbsp;Ronald Man Yeung Wong","doi":"10.1016/j.injury.2026.113543","DOIUrl":"10.1016/j.injury.2026.113543","url":null,"abstract":"<div><div>3D printing technology has been increasingly used in orthopaedic surgery. Current literature has demonstrated the benefits of applying 3D printing in orthopaedic trauma with the use of patient-specific instruments (PSI) including surgical guides and implants on selected bone fracture regions. This narrative review outlines the development of PSI including the navigation templates and implants using 3D printing technology. A comprehensive summary was presented for the application and effectiveness of PSI for fracture treatment in the upper extremities, pelvic region and lower extremities surgeries, particularly in regards to operative time, surgical accuracy and functional outcomes. 3D-printed patient-specific navigation guide had been used in reduction and fixation surgeries such as for navigating Kirschner wires (K-wire) insertion and screw placement in different bone fracture regions. PSI significantly increased surgical accuracy of K-wire insertion and screw placements, with significant reduction in operative time. For functional outcomes, 3D-printed navigation guide was comparable to conventional surgery. There are increasing studies exploring the clinical feasibility of patient-specific metal implant using 3D printing technology with advantage of high accuracy in fracture surgeries. Future studies to investigate the clinical efficacy of the patient-specific metal implants are warranted.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 ","pages":"Article 113543"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149257997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric digit replantation: A mixed methods outcomes study","authors":"Karim Saoud,&nbsp;Jordan G. Bruce,&nbsp;Carrie Bettlach,&nbsp;Thomas H. Tung,&nbsp;Ida K. Fox","doi":"10.1016/j.injury.2026.113641","DOIUrl":"10.1016/j.injury.2026.113641","url":null,"abstract":"<div><h3>Background</h3><div>Indications for pediatric digital replantation/revascularization (replant/revasc) are broader than those for adults. Pediatric patients suffer many of the same challenges seen in adult replant/revasc patients with similar rates of digit salvage. The purpose of this study was to review the incidence of and long-term outcomes after pediatric replant/revasc.</div></div><div><h3>Methods</h3><div>Data was collected from medical records of patients presenting to our Level 1 Trauma Pediatric Hospital Emergency Room between January 2011 and March 2017. All charts with ICD-9 codes for upper extremity trauma were queried and reviewed. Additional data was collected on patients undergoing digit replant/revasc or revision amputation. Patients whose replant/revasc digits survived to the first post-operative visit underwent further outcomes assessment.</div></div><div><h3>Results</h3><div>Of the 1364 patients who presented with upper extremity trauma over the study period, 19 underwent replant/revasc and 12 digits survived to the first post-operative visit. 10 of the patients and their families participated in interviews (mean follow up 89 months (range 74–119) post-procedure). Children and parents had different perspectives on their treatment experience. Six patients reported excellent function with no limitations in schoolwork or sports. Nine patients and seven parents stated they would choose to undergo replant/revasc surgery again.</div></div><div><h3>Conclusions</h3><div>Replant/revasc was often technically successful, albeit with difficult short and long-term courses. The majority of patients reported excellent function and return to normal activities; however, many reported ongoing negative physical and psychological outcomes. Future larger scale and comparative studies would improve our understanding of indications for and long-term sequelae of pediatric digit replant/revasc.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 10","pages":"Article 113641"},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}