International Medical Journal最新文献

{"title":"CLINICAL AND MORPHOLOGICAL FEATURES OF ADRENAL METASTASES OF RENAL CELL CARCINOMA","authors":"U. Balarabe, D. Shchukin, R. Stetsyshyn","doi":"10.37436/2308-5274-2021-4-9","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-4-9","url":null,"abstract":"The problem of adrenal metastases and the need for ipsilateral adrenalectomy during nephrectomy in the patients with renal cell carcinoma has not yet been resolved. To study the clinical and morphological features of adrenal metastases of renal cell carcinoma and to identify a group of patients with a high probability of their development, pathological findings and case histories of 108 patients who underwent surgery included adrenalectomy or adrenal resection were retrospectively examined. Characteristics of patients and tumors in the groups of adrenal metastases and adrenal bulk formations not being cancer metastases were comparatively analyzed. When analyzing the tumors from the group of benign formations of the ipsilateral adrenal gland, it was found that in most cases they were represented by cortical adrenal adenomas without signs of hormonal activity. The histological structure of benign neoplasms was most often represented by clear cell and mixed−cell adenomas, dark−cell adenoma was observed in one case. The patients of this group complained mostly of common a persistent or intermittent rise of blood pressure. Patients with synchronous adrenal metastases of cancer are characterized by large kidney tumors, signs of local spread. According to the study results, it was concluded that the prognostic value in terms of differential diagnosis of adrenal metastases and adenomas in the patients with renal cell carcinoma there was demonstrated only by macroscopic intravenous cancer. The characteristics of the adrenal glands themselves were not objective prognostic parameters for the differential diagnosis between benign and malignant pathology. Ipsilateral adrenalectomy is indicated in the patients with intravenous renal cell carcinoma.\u0000\u0000Key words: adrenal metastases, renal cell carcinoma, intravenous spread of renal cell carcinoma.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49089471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIOXIDANT PROTECTION OF PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS DEPENDING ON ITS SPREAD DEGREE","authors":"T. L. Viesich, I. Tuchkina, D. Tarawneh","doi":"10.37436/2308-5274-2021-4-6","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-4-6","url":null,"abstract":"External genital endometriosis is one of the most common gynecological proliferative diseases. The disease development is based on molecular and genetic disorders that occur in women and are the result of the cell response to oxidative stress. In endometriosis the polymorphism of genes of detoxification systems, depletion of antioxidant defense mechanisms due to hormonal imbalance and activity of pro−inflammatory processes are called the causes of oxidative stress. Currently, much attention is paid to aspects of the immune system and local peritoneal factors. To develop diagnostic criteria for the stages of external genital endometriosis by determining the activity of enzymes of the antioxidant system and catalase in serum and peritoneal fluid, a study was performed in 86 patients. The research results showed that in external genital endometriosis of stages I−II in the serum of women the catalase activity increased, and that of superoxide dismutase remained at the physiological level. Determination of the studied enzymes in peritoneal fluid indicates that their parameters correspond to the control values in women without endometriosis. Thus, the study showed that the patients experience multidirectional changes in antioxidant system, which are manifested in increased catalase activity at the systemic level at the disease stages I−II and local one at stages III−IV. At the same time, the activity of superoxide dismutases at all stages of the disease in both serum and peritoneal fluid is normal. The state of the antioxidant system is concluded to depend on the peculiarities of micronutrient metabolism. Further study and correction of its possible disorders may positively affect in preventing and treatment of external genital endometriosis in women.\u0000\u0000Key words: external genital endometriosis, antioxidant system, diagnostics.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41716771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF EPILEPTIC MYOCLONIC SEIZURES IN PATIENTS AT DIFFERENT AGE PERIODS","authors":"T. Litovchenko, O. Sukhonosova, A. I. Ekzarkhova, S. Korenev, V. Salnikova, V. B. Olenich","doi":"10.37436/2308-5274-2021-4-11","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-4-11","url":null,"abstract":"The main manifestation of epilepsy is a seizure, the clinical embodiments of which depend on the location of the epileptic focus in brain, the pathways of excitation, brain maturity, and so on. Many neurological diseases, including epilepsy, are myoclonus, i.e. short−term involuntary contractions of single or groups of muscles in the torso and limbs. The prevalence of myoclonus in radically different options for predicting the diseases not only of the nervous system, but also of other organs and systems determines the relevance of this problem. In order to study, analyze and generalize modern approaches to epileptic myoclonus, its diagnosis as well as differential diagnoses, and also treatment at different ages for implementation into practical medicine, 62 children with epilepsy were examined. The results of the study show that myoclonic epileptic seizures are more common in young children. Such conditions were observed in most patients in the structure of idiopathic generalized epilepsy. In children of early age there are very frequent serial attacks which are combined with several other types of attacks: infantile spasms, tonic, clonic, atonic. Most patients had a drug−resistant type of disease. In adolescents the idiopathic forms prevailed. Myoclonic seizures could be combined with other generalized types of seizures. In this study, more than half of the patients had a drug−resistant course due to the encephalitic type of epilepsy. Almost half of the children managed to achieve stable remission for more than a year. Patients received levetiracetam, clonazepam in age doses as mono− and polytherapies. According to the results of the study, it was concluded that the correct diagnosis, timely treatment are the basic principles of management of the patients with myoclonic seizures.\u0000\u0000Key words: epilepsy, children, epileptic myoclonic seizures.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47461112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APPLICATION OF \"L-BIOCOMPLEX\" IN CHRONIC HEART FAILURE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME","authors":"O. Korzh, Y. M. Fylenko","doi":"10.37436/2308-5274-2021-4-2","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-4-2","url":null,"abstract":"The combination of chronic heart failure and metabolic syndrome is a common clinical case. Patients with this pathology belong to the group of a high cardiovascular risk, which is explained by the higher frequency and severity of traditional cardiovascular factors. Of particular interest is the use of \"L−BIOCOMPLEX (liposomal)\" dietary supplement of \"Biolik\" company (Kharkiv, Ukraine), available in liposomal form as a set of L−carnitine + thioctic acid in cardiovascular pathology. To study its effect on treatment efficiency, 40 patients with chronic heart failure in combination with metabolic syndrome were examined. The treatment result for the patients whose complex treatment included \"L−BIOCOMPLEX\" at a dose of 5 ml of L−carnitine and 10 ml of thioctic acid once a day 30 minutes before meals for four weeks, and those receiving only basic therapy. It has been shown that L−BIOCOMPLEX as an additive to standard therapy improves the clinical and functional state of patients: reduces the functional class of chronic heart failure, increases exercise tolerance, enhances diastolic heart function and boosts the left ventricular ejection fraction in the left ventricle. The inclusion of \"L−BIOCOMPLEX\" in the traditional scheme of therapy helped to improve the quality of life of patients. As part of the combination therapy of the patients with chronic heart failure the \"L−BIOCOMPLEX\" positively affects lipid and carbohydrate metabolism, reduces atherogenic lipids, diminishes the severity of insulin resistance. Thus, \"L−BIOCOMPLEX\" has a positive influence on additional risk factors, affecting the cardiovascular prognosis and playing a significant role in the mechanisms of development and progression of heart failure.\u0000\u0000Key words: \"L−BIOCOMPLEX\", L−carnitine, thioctic acid, chronic heart failure, metabolic syndrome.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42676625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF MANIFESTATION AND CLINICAL SIGNS OF DISSOCIATIVE DISORDERS IN COMBATANTS OF THE ARMED FORCES OF UKRAINE PARTICIPATED IN THE ANTI-TERRORIST/JOINT FORCES OPERATION","authors":"N. Danilevska","doi":"10.37436/2308-5274-2021-4-10","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-4-10","url":null,"abstract":"The problem of studying the structure, diagnosis and treatment of mental disorders in Ukrainian servicemen has been acute since the beginning of the Anti−Terrorist Operation in 2014 and later with the change of its format to Operation of Joint Forces with a large number of troops to participate in hostilities. To establish the features of the debut and clinical manifestations of dissociative disorders in servicemen, 34 combatants were examined. Research methods were as follows: anamnestic, psychopathological, psychodiagnostic, statistical. The following dissociative manifestations were noted: motor disorders in the form of tremor of the upper extremities or the whole body, pseudoparesis and pseudoparalysis, motor tics, globus hystericus, seizures in the form of pseudoepileptic seizures, speech disorders, stupor, short−term amnesia, partial vision loss etc. In servicemen, such manifestations were found at symptom and syndrome levels in 55.88 % of cases; those reached the nosological level were observed in 44.12 % and were part of the structure of such disorders as isolated dissociative disorder, maladaptation, post−traumatic stress disorder. The clinical picture and severity of dissociative manifestations depend on the stressor, age and personality traits of the serviceman. Their immediate causes were recognized as: the state of anticipation of an inevitable event, the occurrence of which the patient subconsciously wanted to avoid; the state of being in the middle of a psychologically uncomfortable environment; state of being in a short−term, acute life−threatening situation; condition after the last acute or a number of acute psycho−traumatic situations of a life−threatening nature; in the structure of flashbacks; a condition after or on the background of an acute or chronic psycho−traumatic situation of a life−threatening origin or a state of chronic psycho−emotional and physical fatigue, which was accompanied by sleep deprivation.\u0000\u0000Key words: dissociative disorders, psychopathology, combatants, anti−terrorist/Joint Forces operation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47123670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SONOGRAPHIC MARKERS OF ASSOCIATION OF FOLATE CYCLE POLYMORPHIC GENES AND EPIGENETIC FACTORS","authors":"T. Alieva","doi":"10.37436/2308-5274-2021-1-17","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-17","url":null,"abstract":"Reproductive losses in Ukraine are about twice the European average, but have the same causes: miscarriage, abortion, malformations, parental infertility, death of women of childbearing age and children under six days of age. The study focuses on genetically determined reproductive losses associated with folate cycle polymorphism, some other polymorphisms, and epigenetic factors that increase the risk of adverse pregnancy outcomes. Methods of systematic and demographic analysis studied the indices of medical and statistical observation of the population of the Kharkiv region within the period of 2008−2018 with an emphasis on the results of biochemical, molecular genetic and sonographic examinations of pregnant women. Data on the number of examined pregnant women were analyzed using ultrasonographic and biochemical studies at the level of alpha−fetoprotein, chorionic gonadotropin and free estriol in the framework of selective screening programs for pregnant women. Statistical data on the number of fetuses and newborns who died during the first − sixth day after birth, with a distribution on the basis of full−term have been studied. The data are compared with similar national indices. The directions of reducing the reproductive losses are offered, including complex inspection of pregnant women with use of ultrasonography, biochemical and molecular−genetic methods of diagnostics of genetic diseases and defects of fetus development. Among the epigenetic factors we have identified obesity and old age of pregnant women, among the types of abortions we did medical abortions associated with stillborn pregnancies, as well as miscarriages. The findings of the study can be used to minimize the effects of risk factors for reproductive loss in the activity of general practitioners.\u0000\u0000Key words: polymorphism of folate cycle genes, reproductive losses, miscarriage, congenital malformations of fetus, ultrasonography.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"92-100"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41410562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STAGES OF REHABILITATION OF PATIENTS WITH ACUTE CEREBROVASCULAR ACCIDENT","authors":"I. Kas, I. Petukhova, T. Ustymenko","doi":"10.37436/2308-5274-2021-1-10","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-10","url":null,"abstract":"One of the urgent tasks of modern medicine is organizing the rehabilitation for patients who have suffered a stroke at different stages of rehabilitation. Restoration of impaired functions in such patients occurs in the first 3−5 months from the onset of the disease, that is influenced by a number of factors: duration of the stroke, size of the lesion and pool of lesions, active participation in the process of a patient him−/herself. The main principles of rehabilitation include its early onset in an acute period of stroke; regularity and duration; complexity and multidisciplinarity (formation of multidisciplinary teams); adequacy of rehabilitation measures, i.e. creation of individual programs taking into account the severity of neurological deficit and dysfunction; stages. Different methods of recovery are applied to each patient individually or in combination, or sequentially according to the rehabilitation program, which is based on the analysis of the patient's condition by all members of the multidisciplinary team, taking into account the results of functional testing and objective examination. Medical support, postural correction, kinesitherapy, mechanotherapy (including robotic), field therapy, hardware physiotherapy, massage, acupuncture according to the indications, functional neurotraining and cardiotraining, neuropsychological training are used. The results of research confirm that the integrated use of kinesitherapy, physical factors, balneotherapy, the methods of psychological rehabilitation of patients after stroke provides a faster recovery of neurological deficit, activates non−specific brain systems, restores mental and somatic functions of the body. Therefore, in addition to health, the patient needs to renew his ability to work and social status.\u0000\u0000Key words: acute cerebrovascular accident, medical rehabilitation, stages of rehabilitation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49461838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISTHMOCELE: ETIOLOGY, CLINIC, DIAGNOSIS AND TREATMENT (Literature review)","authors":"L. I. Kandyba, I. M. Sykal, V. Olkhovska, M. Sokół","doi":"10.37436/2308-5274-2021-1-9","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-9","url":null,"abstract":"Modern obstetrics is characterized with a loyal approach to surgical delivery, which has significantly affected the activity of maternity hospitals: the number of complications in childbirth from both the mother and fetus has decreased. The formed scar on the uterus is determined differently when examining the women in the postoperative period. Isthmocele is a hypogenic area in the myometrium within the site of postoperative scar in the form of a \"niche\", diverticulum or sac after cesarean section. It can lead to the development of diseases: abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, bladder dysfunction, as well as be the cause of ectopic pregnancy, uterine rupture, abnormalities in the placenta attachment of. Risk factors for isthmocele include low uterine incisions, a history of cervical removal, cervical dilatation of more than 5 cm, more than five hours of delivery, etc. For the first time the diagnosis of \"isthmocele\" is made at ultrasonic research, more often transvaginal one. The diagnosis is confirmed by hysteroscopy or constructive surgery. An important criterion for ismocele is the degree of deficiency, i.e. the ratio between the the biometry thickness on the scar and adjacent to the scar the myometrium area. Depending on the woman's reproductive plans, conservative or surgical treatment of isthmocele is recommended, using autologous stem cells to regenerate muscle tissue. Conservative treatment involves taking oral contraceptives. Surgical treatment includes the imposition of a two−row single−wing suture. The use of stem cells in the postoperative period allows a rise in the frequency of pregnancies in women with a scar on the uterus in the case of the isthmocele formation.\u0000\u0000Key words: isthmocele, cesarean section, myometrium, autocells.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"52-55"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45568220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF MESENCHYMAL STEM CELLS ON EFFICIENCY OF ANGIOGENESIS, STATE OF VASCULAR TONE, INTENSITY OF LIPID PEROXIDATION AND METABOLIC ACTIVITY OF CARDIOMYOCYTES IN EXPERIMENTAL MYOCARDIAL INFARCTION","authors":"T. Kravchenko, A. Kovalchuk, Ye. S. Akobirov","doi":"10.37436/2308-5274-2021-1-7","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-7","url":null,"abstract":"In contrast to medical and surgical methods of treatment of coronary heart disease and its complications, cellular cardiomyoplasty is aimed at creating new cells and stable lineages of normally functioning heart tissue. Autologous mesenchymal bone marrow stem cells are a promising source for such cardiomyoplasty. To study the effect of stem cell myocardial transplantation on the processes of its post−infarction state, acute myocardial infarction in laboratory rats was experimentally modeled with subsequent transplantation of autologous mesenchymal stem cells of bone marrow and comparative study in blood serum of cardiovyocytes metabolic activity markers, neoangiogenesis, vessel tonus as well as myocardial lipid peroxidation. The cells were intravenously injected into the necrotized myocardium and left ventricle. The study found that regardless of the method of administration, stem cell transplantation contributes to a significant increase in angiogenic factors, i.e. nitrogen oxide and endothelial growth factor, a significant decrease in vasoconstrictor endothelin−1, the level of TBA−active products and haptoglobin, enzyme activity, namely cardiac ischemia markers, increase in ceruloplasmin. All this indicates positive effects: leveling ischemia by improving myocardial perfusion due to compensatory vasodilation, limiting the rate of lipid peroxidation and stimulating antioxidant factors, improving the energy balance of the myocardium by increasing the level of energy substrates and activation of their aerobic pathways. Thus, cellular cardiomyoplasty improves metabolism and prevents the process of post−ischemic myocardial remodeling.\u0000\u0000Key words: cardiomyoplasty, mesenchymal stem cells, myocardial infarction, myocardial metabolism.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41793824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CHARACTERISTICS OF PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES MELLITUS WHO REQUIRE IMPLANTATION OF PERMANENT PACEMAKER","authors":"O. Voronenko, M. Brynza","doi":"10.37436/2308-5274-2021-1-3","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-3","url":null,"abstract":"In recent decades, there has been a rise of chronic heart failure mortality. Among the huge range of modern methods of this pathology treatment, the cardioresynchronizing therapy stands out, it allows the improvement of the patient's heart function, reduces clinical signs of the disease, improves well−being, as well as diminishes morbidity and mortality. The use of this method in the patients with a comorbid pathology, i.e. in those with chronic heart failure and type 2 diabetes, deserves a special attention. In order to determine the clinical characteristics of the patients who required a pacemaker implantation, we examined 203 patients who had reasonable indications for this in accordance with the ACC / ANA and ESC current recommendations. Another important criterion for inclusion into the group of implantation was considered to be the presence of comorbid Diabetes mellitus type 2. The gender and age characteristics of the surveyed population were dominated by elderly male patients. The presence of concomitant cardiovascular pathology depending on the age of patients was analyzed, which showed mostly hypertension of stage 2−3, a constant atrial fibrillation. In structure of comorbid pathology the somatic diseases, including type 2 Diabetes mellitus prevailed. Electrostimulators were implanted into the examined cohort of patients, among which 132 devices worked in DDD mode, 71 of the installed stimulators had the DDDR mode. The research results concluded that the implantation of a pacemaker became a necessary procedure for elderly patients, mostly men, with a high prevalence of cardiovascular (coronary heart disease, hypertension, persistent atrial fibrillation) and somatic pathology in the form of type 2 Diabetes mellitus.\u0000\u0000Key words: chronic heart failure, type 2 diabetes mellitus, pacemaker implantation, clinical features, gender and age characteristics.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43377966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}