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ROLE OF ADIPOSE TISSUE AND ADIPOKINES IN CHRONIC INFLAMMATION DEVELOPMENT ON METABOLIC SYNDROME BACKGROUND 脂肪组织和脂肪因子在代谢综合征慢性炎症发展中的作用
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-15
N. A. Shutova, I. Kuzmina
{"title":"ROLE OF ADIPOSE TISSUE AND ADIPOKINES IN CHRONIC INFLAMMATION DEVELOPMENT ON METABOLIC SYNDROME BACKGROUND","authors":"N. A. Shutova, I. Kuzmina","doi":"10.37436/2308-5274-2021-1-15","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-15","url":null,"abstract":"The most pressing issue that combines obesity and insulin resistance is chronic subclinical inflammation, which affects the metabolic and secretory functions of adipose tissue, and is important for the development of pathological processes. The morphological basis of inflammation is the infiltration of adipose tissue by immune competent cells. Biologically active substances specific for adipose tissue are considered to be the collagen−like protein adiponectin and the protein hormone leptin, which are secreted in adipocytes. Leptin stimulates the cellular immune response and increases the production of pro−inflammatory cytokines, and adiponectin is thought to have anti−inflammatory properties. With the development of metabolic syndrome, the concentration of adiponectin in blood decreases, and that of leptin increases. To establish the relationship between serum leptin levels with markers of systemic inflammation and spontaneous production of proinflammatory cytokines as well as mononuclear blood leukocytes, an experimental study was conducted, i.e. modeling the metabolic syndrome in white female rats WAG / GSto aged 5−6 months. The predominance of proinflammatory cytokines: interleukins − 1β, −6, −8, −10, TNF−α in supernatants of mononuclear leukocytes with increasing leptin concentration, which is consistent with the view of its ability to stimulate cell immunity and affect the production of proinflammatory cytokines. It is proven that an increase in leptin levels in metabolic syndrome is not only a symptom that characterizes the functional state of adipose tissue, but also causes spontaneous production of proinflammatory cytokines and mononuclear leukocytes in blood, that is pathogenetically interrelated with the systemic inflammatory response. It is established that the change in the cytokine profile in the serum becomes a forecast of the formation and effectiveness of treatment of metabolic syndrome on the background of obesity.\u0000\u0000Key words: obesity, metabolic syndrome, undifferentiated chronic inflammation, cytokines.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41948675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
EVALUATION OF MICROBIOCENOSIS OF LARGE INTESTINE AND INTESTINAL PERMEABILITY IN OBESE ADOLESCENTS 肥胖青少年大肠微生物病与肠通透性的评价
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-4
M. Khomenko, T. Osolodchenko
{"title":"EVALUATION OF MICROBIOCENOSIS OF LARGE INTESTINE AND INTESTINAL PERMEABILITY IN OBESE ADOLESCENTS","authors":"M. Khomenko, T. Osolodchenko","doi":"10.37436/2308-5274-2021-1-4","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-4","url":null,"abstract":"Obesity is one of the most common non−infectious diseases worldwide among both adults and children. It is associated with the development of diseases such as metabolic syndrome, type 2 diabetes, non−alcoholic fatty liver disease, cardiovascular disease etc. The mechanisms proposed to explain the development and progression of obesity include chronic low−intensity inflammation, bacterial translocation, and endotoxemia, which may resulted from dysbiosis and increased intestinal permeability. To study anthropometric parameters, levels of zonulin, lipopolysaccharide, interleukin−6 and interleukin−10, indices of the colon microbiota, 74 adolescents with obesity aged 12−17 years were examined. The correlation analysis of anthropometric and laboratory indices, between anthropometric ones and those of microflora of a large intestine depending on sex was performed. It is noted that obesity is accompanied by the formation of intestinal dysbiosis in 78.2 % of patients with a decrease in the obligate microflora and an increase in the conditionally pathogenic microflora. In adolescent patients, a significant rise in interleukin−6 levels and a tendency to increase interleukin−10 levels compared with adolescents with normal weight, which is a sign of low−intensity inflammation. There was a significant increase in zonulin levels in obese adolescents compared with those in the control group, that may be an evidence of increased intestinal permeability. Positive correlations have been reported between the body weight, abdominal fat distribution, and increased intestinal permeability as well as activation of low−intensity inflammation. In obese adolescents, in the presence of dysbiotic disorders, it is advisable to harmonize the diet and style and correct intestinal dysbiosis with the intestinal barrier restoration of.\u0000\u0000Key words: zonulin, lipopolysaccharide, interleukins, microbiota, adolescents, obesity.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42534932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CEREBROVASCULAR DISORDERS IN PATIENTS WITH COVID-19 COVID-19患者的脑血管疾病
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-12
Yu. V. Shmatko, O. Bondar
{"title":"CEREBROVASCULAR DISORDERS IN PATIENTS WITH COVID-19","authors":"Yu. V. Shmatko, O. Bondar","doi":"10.37436/2308-5274-2021-1-12","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-12","url":null,"abstract":"COVID−19 is an acute respiratory viral disease caused by the RNA virus of the SARS−CoV−2 (2019 nCoV) coronavirus family and can have both mild course in the form of acute respiratory viral infection and severe one with frequent complications such as pneumonia, thrombosis, cerebrovascular disorders and high mortality. Hypoxia of the brain and spinal cord is associated with impaired gas exchange in the pulmonary alveoli, progressive respiratory failure with subsequent decompensation of function and structural damage to all organs and systems. Neurological disorders in COVID−19, observed in almost a half of patients, can be divided into three groups: manifestations of the central nervous system, lesions of the peripheral nervous system, myopathy. In order to study the lesion of the nervous system in patients with COVID−19, a history of acute cerebrovascular disorders and clinical picture of stroke without the emergence of new foci in neuroimaging, three clinical cases were analyzed. All patients complained of speech impairment, disorientation in time and space, numbness and weakness in the extremities on the background of acute cerebrovascular accident in the anamnesis, accompanied by general weakness and fever to subfebrile figures. COVID−19 pneumonia was observed during computed tomography of the lungs. However, during neuroimaging new foci of infarction were not identified. Thus, given the lack of new foci of infarction during neuroimaging, lack of hypercoagulation and cardiac causes, it can be concluded that focal symptoms in patients with COVID−19 with a history of stroke cause hypoxia of brain cells in the area around the necrotic foci resulted from previous heart attacks.\u0000\u0000Key words: nervous system, lesions, COVID−19, coronaviruses, encephalopathy, hypoxia.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41499285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
WAYS TO IMPROVE DIAGNOSIS OF PATIENTS WITH POSTCHOLECYSTECTOMY SYNDROME 提高胆囊切除术后综合征诊断水平的方法
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-6
O. V. Gorbulitch, S. Yefimenko, S. A. Pavlychenko, O. Lazutkina, K. Aleksanian
{"title":"WAYS TO IMPROVE DIAGNOSIS OF PATIENTS WITH POSTCHOLECYSTECTOMY SYNDROME","authors":"O. V. Gorbulitch, S. Yefimenko, S. A. Pavlychenko, O. Lazutkina, K. Aleksanian","doi":"10.37436/2308-5274-2021-1-6","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-6","url":null,"abstract":"Postcholecystectomy syndrome is a symptom complex that occurs or worsens after cholecystectomy and is a functional and / or organic disorder. It often complicates the post−surgery course of gallstone disease. The presence of symptoms of the disease indicates a deterioration in the quality of life of patients, but the diagnostic examination is not always possible to detect morphological or functional changes. Thus, at present the syndrome is an urgent problem of gastroenterology and biliary surgery. Diagnostic issues with a differentiated approach to the functional or organic nature of postcholecystectomy syndrome are important for the choice of further treatment tactics. In order to improve the diagnostic algorithm taking into account the changes in the area of the major duodenal papilla, a study was conducted in 137 patients. To determine the functional disorders of the sphincter of Oddi there was used the method of ultrasound investigation of hepatobiliary area and Vater's papilla with choleretic loading on Boyden as well as the Grigoriev's methods in the absence of organic obstruction of the terminal choledochus at previous stages of examination. Morphological changes in the major duodenal papilla area were evaluated using the technique of parietal ph−impedancemetry, which was performed on the background of benign mechanical jaundice in the patients after cholecystectomy during endoscopic retrograde cholangiopancreatography prior to endoscopic papillosphincterotomy. The obtained results help to perform a differentiated approach to the patients who underwent cholecystectomy, taking into account morphofunctional changes in the area of the major duodenal papilla and allow the implementation of the selected methods to the research algorithm of patients with postcholecystectomy syndrome.\u0000\u0000Key words: postcholecystectomy syndrome, functional and organic changes of major duodenal papilla, patency of the terminal choledochus, treatment tactics.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44667107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PREMATURE AGING INDICES IN PATIENTS WITH MODERATE CARDIOVASCULAR RISK 中度心血管风险患者的早衰指数
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-1
A. Radchenko, T. Bondar, A. Potapenko
{"title":"PREMATURE AGING INDICES IN PATIENTS WITH MODERATE CARDIOVASCULAR RISK","authors":"A. Radchenko, T. Bondar, A. Potapenko","doi":"10.37436/2308-5274-2021-1-1","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-1","url":null,"abstract":"Aging is characterized with a gradual aggravation of organ function throughout life and can occur both physiologically and prematurely. With premature aging there is an early decrease in the adaptive mechanisms of all physiological systems of the body, there is a significant reduction in physical and mental activities, that contributes to the early development of age−related pathology. Genetic and epigenetic factors, as well as environmental ones can be the causes of different rates of aging. It is not possible to accurately determine the onset of old age by biological characteristics, because people with the same calendar age are not always the same as for biological one. To establish the association of age−related disease factors with the markers of premature aging and biological age in the patients of various age groups, a study was performed in the patients aged 25−44 and 45−59 years with moderate cardiovascular risk in accordance with the SCORE scale. The primary task for predicting and preventing the age−associated diseases is to identify genetic, molecular and cellular factors that determine the rate of aging and increase the risk of age−associated diseases. The role of cardiovascular risk factors in premature aging has been determined. It is established that the most important factors that lead to an increase in biological age and formation of age−associated diseases are the disorders of lipid and carbohydrate metabolism and level of oxidative stress, importance of which progresses with age. The relationship between cardiovascular risk factors and biological age, estimated with different methods, their influence on telomere length, that allows the designing of an algorithm to determine the markers of premature aging in different age groups for early and effective prevention of metabolic−associated diseases, has been established.\u0000\u0000Key words: biological age, cardiovascular risk, premature aging, telomere length.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44811317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
MAIN ISSUES OF CHILDREN'S INCIDENCE OF ACUTE OTITIS MEDIA AND PROSPECTS TO SOLVE THEM 儿童急性中耳炎发病的主要问题及解决前景
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-13
O. Kulikova, Y. V. Lozova
{"title":"MAIN ISSUES OF CHILDREN'S INCIDENCE OF ACUTE OTITIS MEDIA AND PROSPECTS TO SOLVE THEM","authors":"O. Kulikova, Y. V. Lozova","doi":"10.37436/2308-5274-2021-1-13","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-13","url":null,"abstract":"The problem of acute otitis media in children is relevant because of the prevalence, social significance, possibility of rapid development of both life−threatening intracranial and intralabyrinthine, mastoid complications, as well as acute or prolonged dysfunction of adjacent cranial nerves, especially auditory, vestibular ones. In order to determine the frequency of various forms of acute otitis media, the nature and extent of its complications in children of different ages there was conducted a retrospective analysis of medical histories of patients treated at the City Clinical Hospital № 30 Kharkiv within 2015−2019. There was stated that the biggest group was composed by the patients with a purulent form of the disease, a slightly smaller number of patients had secretory and viral processes. But when analyzing the data over the years, of interest is the fact that during the period when the number of purulent forms decreased, the number of viral ones increased. Complications include mastoiditis, acute sensorineural hearing loss, cerebrospinal fluid and hypertension and intoxication syndromes. It is important that in acute purulent and viral otitis there is an intoxication syndrome along with the manifestations of acute sensorineural hearing loss. Signs of vestibular dysfunction in children can be disguised as symptoms of intoxication, they are much more difficult to detect. Considering the fact that the snail and the labyrinth are washed by the same liquid, it is logical to assume that in this situation the vestibular analyzer suffers together with the auditory one. Therefore, along with otoneurological research it is necessary to apply instrumental methods for establishment of latent disturbances of function of the vestibular analyzer. According to the research results it was concluded that a more detailed study of vestibular analyzer dysfunction in children with acute otitis media, as they are disguised as symptoms of intoxication.\u0000\u0000Key words: acute otitis media, frequency, complications, vestibular disorders, children.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44616694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
FORMATION, ASSESSMENT AND CORRECTION OF COGNITIVE DISORDERS IN PATIENTS WITH COMORBID CHRONIC OBSTRUCTIVE PULMONARY AND CORONARY HEART DISEASES 慢性阻塞性肺和冠心病合并症患者认知障碍的形成、评估和纠正
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-2
A. Tokarieva
{"title":"FORMATION, ASSESSMENT AND CORRECTION OF COGNITIVE DISORDERS IN PATIENTS WITH COMORBID CHRONIC OBSTRUCTIVE PULMONARY AND CORONARY HEART DISEASES","authors":"A. Tokarieva","doi":"10.37436/2308-5274-2021-1-2","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-2","url":null,"abstract":"Chronic obstructive pulmonary disease is an important health, social and economic issue. It is one of the leading morbidity and mortality causes worldwide. Comorbid pathology of chronic obstructive pulmonary and coronary heart diseases occurs quite often. For the patients over 60 years, the frequency of their combination directly depends on age due to common pathogenetic mechanisms (oxidative stress, endothelial dysfunction, systemic inflammation, etc.). Often these diseases are accompanied with cognitive disorders. Impaired memory and other cognitive functions significantly reduce the quality of life of the patients, negatively affect professional activities, reduce the ability to learn, reduce compliance with therapy, complicate psychological contact with the physician, and worsen the lives of relatives. But there is still no common clear understanding of many aspects of the development of cognitive disorders, their mechanisms in chronic obstructive pulmonary disease in combination with coronary heart disease. Therefore, there is no single standard method to treat such patients. In addition to medications (vasoactive and neurotropic drugs), alternative methods are used to treat cognitive disorders, namely these are special exercises to train memory and attention (cognitive training). Methods aimed at increasing the patient's motivation, learning effective memorization strategies, training the ability to maintain a long−term concentration, active involvement of emotional support and imagination are relevant. The use of available non−drug methods, dosed exercise and proper nutrition can reduce the severity of cognitive disorders and thereby improve the quality of life of the patients and their immediate environment.\u0000\u0000Key words: chronic obstructive pulmonary disease, coronary heart disease, comorbidity, cognitive disorders","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"10-18"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42942190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DACRYOCYSTITIS AS AN OTOLARYNGOLOGICAL PROBLEM: OWN TREATMENT EXPERIENCE 泪囊炎作为耳鼻喉科疾病的治疗体会
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-14
S. Samusenko, I. Filatova
{"title":"DACRYOCYSTITIS AS AN OTOLARYNGOLOGICAL PROBLEM: OWN TREATMENT EXPERIENCE","authors":"S. Samusenko, I. Filatova","doi":"10.37436/2308-5274-2021-1-14","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-14","url":null,"abstract":"The urgency of improving the effectiveness of dacryocystitis treatment is determined by: their stable proportion among eye diseases, a high percentage of post−traumatic, iatrogenic and chronic forms, ability to be a source of dangerous complications and social significance. Existing anatomical and physiological relations and values of rhinogenic factors determine the involvement of otolaryngologists in dacryocystitis treatment. In order to determine the characteristics of the contingent of patients with dacryocystitis, structure of rhinogenic factors, methods of examination, surgical treatment and principles of postoperative management of patients, a study was conducted with 107 patients with chronic disease. The clinical effectiveness in diagnosis and planning of surgical intervention of the combination of endonasal optical rhinoscopy, probing and contrast of the nasolacrimal pathway with triombrast with subsequent radiological and (or) CT examination was determined. It is shown that the correction of endonasal structures should be performed simultaneously with dacryocystorhinostomy. The efficiency of the classical West−Bokstein surgery has been determined, the necessity of an individual approach to its planning has been shown. The main tasks of each stage of the surgery, which significantly affect its outcome, are established. When performed correctly, the effectiveness of \"plastic\" and \"simple\" rhinostomy, management of patients with and without stenting is almost the same. It has been proven that the use of radio wave and shaver techniques can greatly simplify the stages of the surgery and improve healing. Based on the obtained results, a conclusion was made about the expediency of involving an otolaryngologist in the consultation of patients with chronic dacryocystitis in each case. The criterion for choosing treatment tactics in favor of endonasal endoscopic dacryocystorhinostomy is the presence of rhinogenic factors of dacryocystitis.\u0000\u0000Key words: dacryocystitis, endonasal endoscopic dacryocystorhinostomy, rhinogenic factors, stenting, surgical treatment, epiphora, lacrimation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47472371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FACTORS OF PERIOPERATIVE MORTALITY IN PATIENTS WITH GROWING RENAL CELL CARCINOMA IN INFERIOR VENA CAVA LUMEN 下腔静脉内生长的肾细胞癌围手术期死亡因素分析
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-8
O. Makovozov, I. Antonian, G. Khareba, R. Stetsyshyn, A. Maltsev, P. Mozzhakov
{"title":"FACTORS OF PERIOPERATIVE MORTALITY IN PATIENTS WITH GROWING RENAL CELL CARCINOMA IN INFERIOR VENA CAVA LUMEN","authors":"O. Makovozov, I. Antonian, G. Khareba, R. Stetsyshyn, A. Maltsev, P. Mozzhakov","doi":"10.37436/2308-5274-2021-1-8","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-8","url":null,"abstract":"Difficult surgical cases of tumors of the inferior vena cava occur very often, because this intervention is characterized with technical difficulties and severe intraoperative complications. The most dangerous of these include massive bleeding, acute heart failure, and pulmonary embolism by tumor masses, which are the most common causes of perioperative mortality. Vena cava trombectomy is a special operation that can be accompanied by heavy bleeding at virtually any stage. The causes and frequency of mortality in 108 patients operated for renal cell carcinoma with growing to the inferior vena cava were retrospectively analyzed. Reliable factors for the prognosis of perioperative mortality in this pathology have been identified. Factors that characterize the tumor thrombus features, as well as parameters related to general condition of a patient, have been found to be of the greatest importance. The results of the study showed that the level of perioperative mortality in caval tumor thrombi is 8.3 % when using surgical methods without artificial circulation. The presented patient population contained a significant proportion of so−called \"high\" thrombi of III−IV levels, thrombi invading the wall of the inferior vena cava, as well as retrograde spread of intraluminal tumor. The main causes of death were acute heart failure, intraoperative bleeding, pulmonary embolism with tumor masses and acute renal failure. The prognostic value of perioperative mortality was demonstrated by the following thrombus factors: its \"high\" level, invasion of intraluminal tumor into the caval wall, signs of complete obstruction of caval blood flow. The mortality rate was objectively affected by severe heart failure, signs of pulmonary embolism before surgery.\u0000\u0000Key words: inferior vena cava, tumor thrombus, renal cell carcinoma, vena cava trombectomy, lethality.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42662332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MODERN ULTRASONOGRAPHY TECHNIQUES FOR MASSIVE INJURIES OF SHOULDER JOINT ROTATOR CUFF TENDONS 肩关节肩袖肌腱大面积损伤的现代超声技术
International Medical Journal Pub Date : 2021-02-18 DOI: 10.37436/2308-5274-2021-1-16
T. Dudnyk
{"title":"MODERN ULTRASONOGRAPHY TECHNIQUES FOR MASSIVE INJURIES OF SHOULDER JOINT ROTATOR CUFF TENDONS","authors":"T. Dudnyk","doi":"10.37436/2308-5274-2021-1-16","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-16","url":null,"abstract":"Recently the development of medical technologies has led to a significant progress in diagnosis of the shoulder joint diseases. The leading role in this was played by an improvement of such imaging methods as magnetic resonance imaging, high−resolution ultrasound scanning, having an advantage over traditional radiography, as they allow the diagnosis the pathology not only of bone structures but also of soft tissues. Magnetic resonance imaging has become the main method of visualizing the soft tissue structures of musculoskeletal system, but the high cost of the study, lack of clear and distinct indications for it reduce the number of patients. Ultrasound has proven to be one of the main methods of objective diagnosis in patients with musculoskeletal pathology, and high−frequency sensors can visualize articular cartilage and its structure, tendons of the shoulder rotator cuff and tendons of the long head of the biceps. In order to determine the most significant differential diagnostic criteria for massive rupture of the shoulder rotational cuff with the help of two−dimensional mode, color and energy Doppler mapping and functional ultrasonography, 32 patients operated on this subject were examined. The following ultrasound data were evaluated: homogeneity, echogenicity, integrity of tendon contours, presence of effusion in bursae and tendon sheaths, number of vascular signals in the affected area during color and energy Doppler mapping, if needed − the results of functional tests. Thus, modern ultrasound capabilities allow its use both for primary diagnosis and for monitoring the treatment process, which, in turn, directly affects the choice of treatment.\u0000\u0000Key words: shoulder joint, rotator cuff, ultrasound, diagnostics.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"88-91"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45861467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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