International Medical Journal最新文献

{"title":"STATE OF SYSTEMIC HEMODYNAMICS FOR CHILDREN WITH CONGENITAL SURGICAL PATHOLOGY IN DIFFERENT COMBINED ANESTHESIA TYPES","authors":"O. Vlasov","doi":"10.37436/2308-5274-2021-1-5","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-5","url":null,"abstract":"General anesthesia for a surgical correction of congenital malformations in children is accompanied, in particular, by the disorders of systemic hemodynamics. In order to assess the impact of different types of combined anesthesia on the state of systemic hemodynamics in surgical correction of congenital malformations, a retrospective study of the treatment of 150 newborns and infants was conducted. These were children with various congenital malformations, but the most common were intestinal obstruction and abdominal tumors. Three groups of patients were formed depending on the type of combined anesthesia during surgical correction of abnormalities: I − inhalation (sevorane) + regional anesthesia; II − inhalation (sevorane) + intravenous anesthesia (fentanyl); III − total intravenous anesthesia with two drugs: analgesic (fentanyl) and drug sleep on the background of intravenous injection of hypnotics (20 % sodium oxybutyrate). There were preformed the surgeries: thoracic, urological, abdominal. The study was retrospectively evaluated in five stages. The analysis of systemic hemodynamics showed a tendency to reduce diastolic blood pressure in children treated with anesthesia with two intravenous drugs (hypnotic and fentanyl), during all observation stages and a significant decrease in this index at the most painful and traumatic period. At the time of induction of anesthesia in children there was a decrease in heart rate. According to the research results, it is concluded that when using the pre−hypnotics as part of combined anesthesia in children with congenital malformations during surgery there is a risk of complications from central hemodynamics in the form of vasodilation, which leads to a drop in blood pressure and increases compensatively the heart contractions.\u0000\u0000Key words: infants, congenital malformations, anesthesia, hemodynamics.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47144399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF NEUROPHYSIOLOGICAL FEATURES IN YOUNG WOMEN AND MEN SUFFERING FROM EPILEPSY","authors":"A. Voitiuk, T. Litovchenko","doi":"10.37436/2308-5274-2021-1-11","DOIUrl":"https://doi.org/10.37436/2308-5274-2021-1-11","url":null,"abstract":"The definition of epilepsy via the concept of neuronal discharge indicates the crucial importance of electroencephalography (EEG) in epileptology. This pathology is a certain problem for each sex, that requires gender−specific approaches when managing and treating such patients. To investigate them, 30 men and 30 women aged 18−44 years with a reliable diagnosis of epilepsy were examined. A comprehensive clinical, neurological and neurophysiological study of patients was performed, taking into account the data of clinical case and life history. Each patient was assessed for neurological status according to traditional methods, electrophysiological method of examination (routine EEG) was used. On the results of electroencephalography in individuals of both sexes with epilepsy, there was a decrease in the amplitude of the α−rhythm, but a significant slowdown in this rhythm was not detected. Most patients had high−amplitude (> 20 μV) and low−frequency β1−rhythm. Low−frequency high−amplitude slow−wave activity was regarded as an EEG reflection of degenerative−dystrophic processes in brain. Photostimulation caused paroxysms of bilaterally synchronous sharp and slow waves, complexes of \"acute−slow\" wave. Hyperventilation led to an increase in the θ−rhythm amplitude, appearance of δ−waves, higher expression of true epileptiform phenomena: adhesions, \"acute wave−slow wave\" complexes, \"spike−slow wave\" complexes. A comparative analysis of the obtained results allowed to conclude that the changes in bioelectrical activity in epilepsy occur according to the general mechanisms of epileptogenesis, regardless of gender.\u0000\u0000Key words: epilepsy, electroencephalogram, comparative analysis, young men and women.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43404045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATHOGENETIC ROLE OF MYOCARDIAL FIBROSIS: FOCUS ON EXTRACELLULAR MATRIX","authors":"T. Ambrosova, T. Ashcheulova","doi":"10.37436/2308-5274-2020-4-3","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-3","url":null,"abstract":"The main cardiovascular diseases affect the processes of myocardial remodeling, which further contributes to the formation of systolic or diastolic heart dysfunction. The formation of myocardial dysfunction is primarily associated with left ventricular hypertrophy when under hemodynamic loading, firstly, wall rigidity increases, secondly, myocardial fibrosis is formed. The latter is one of the key factors of the hypertrophic process caused by the accumulation of collagen, which leads to a aggravation of the left ventricle relaxation processes. Cardiac remodeling is defined as a group of molecular, cellular, and interstitial changes that are clinically manifested by alterations in the size, shape, and function of heart as a result of the heart muscle injury. It has been determined that fibrosis is an early morphological sign of injury in patients with left ventricular overload, as well as a factor in the development of diastolic and systolic dysfunctions. Compensatory left ventricular hypertrophy transforms into heart failure due to the fibrosis development. In hypertrophy the content of elastic collagen type III decreases and rigid collagen type I increases. The essential role of the extracellular matrix in myocardial fibrosis formation is emphasized. Cardiac fibrosis is a process of pathological remodeling of the extracellular matrix, which leads to abnormalities in its composition and dysfunction of the heart muscle. The extracellular matrix plays a key role in organogenesis and post−traumatic healing in tissue injuries. The study of intercellular interactions of the extracellular matrix will provide a better understanding of the mechanisms of changes in geometry and function of the heart, and investigation of the activity of matrix components will open new opportunities for targeted therapeutic effects on molecular mechanisms of cardiac remodeling.\u0000\u0000Key words: diastolic dysfunction, extracellular matrix, myocardial fibrosis, cardiomyocytes, fibroblasts.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"21-24"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42034639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAIN PREDICTORS OF CORONAVIRUS DISEASE SEVERITY PROGNOSIS","authors":"O. Bobrova, N. G. Mikhanovska, K. Kryvonos, S. Vorobyov","doi":"10.37436/2308-5274-2020-4-14","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-14","url":null,"abstract":"Coronavirus disease can have a variety of clinical symptoms, ranged from asymptomatic to severe and even critical ones. To date, an information on the epidemiology, clinical features, prevention and treatment of this disease is insufficient, which requires a further study of the problem. To personalize the treatment, it is important to determine the leading clinical and laboratory predictors to forecast the severity of COVID−19. The algorithm of examination of a patient includes the assessment of all complaints, data of the anamnesis of the disease, epidemiological anamnesis. The combination of clinical examination to determine the severity of the patient's condition includes physical examination, the one of diagnostic material using methods of nucleic acid amplification and / or enzyme−linked immunosorbent assay, pulse oximetry. Laboratory, etiological diagnostics, tests and antibodies play an important role. In case of hospitalization of the patients with moderate, severe and extremely severe infection, clinical studies are required such as: general (clinical) and biochemical blood test, coagulogram, diagnosis of disseminated intravascular coagulation syndrome, as well as identification of risk factors. Instrumental and radiological diagnostics include: pulse oximetry with measurement of SpO2 level, computed tomography and ultrasound examination of lungs and pleural cavities, electrocardiography. Comprehensive evaluation of clinical and laboratory data of patients allows to determine a clinically confirmed COVID−19, to route the patient and to start complex therapy in time. A promising direction is the introduction of the method of quantitative diagnostics by polymerase chain reaction on SARS−CoV−2 RNA in the activity of laboratories of Ukraine, which will help to individualize the degree of viral load in patients, improve treatment control.\u0000\u0000Key words: COVID−19, predictors of course severity, methods of laboratory diagnostics, quantitative polymerase chain reaction.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47141075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SHORT-TERM RESULTS IN PATIENTS WITH REFRACTORY ANGINA TREATMENT USING STEM CELLS","authors":"S. Estrin, T. Kravchenko, A. Kovalchuk","doi":"10.37436/2308-5274-2020-4-6","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-6","url":null,"abstract":"Despite the large range of drugs and surgical interventions, there is currently a significant number of patients with angina, in whom the surgery is impossible for various reasons, and drug therapy is not effective enough. In contrast to these methods of treating coronary heart disease and its complications, cell cardiomyoplasty is aimed at creating new cells and stable lineages of normally functioning heart tissue. Autologous bone marrow mesenchymal stem cells are the promising source for such a cardiomyoplasty. To improve the treatment results in the patients suffered from coronary heart disease with refractory angina and heart failure, there was comparatively studied the effect of intravenous administration of autologous mesenchymal bone marrow stem cells on the effectiveness of myocardial remodeling at months 3 and 6, that was assessed by stenocardiography and echocardiography insufficiency, indices of quality of life and tolerance to physical activity. As a result, it was reliably established that the patients receiving autologous cell therapy in combination with traditional methods had a reduced incidence of anginal attacks, decreased functional class of heart failure and angina, improved left ventricular contractile function, improved exercise tolerance and quality of life. Thus, intravenous administration of autologous bone marrow mesenchymal stem cells to patients with chronic ischemic disease, which is manifested in refractory angina and complicated by heart failure is a safe alternative to other treatments and has its advantages. There has been an improvement in the heart pumping function and the life quality of patients.\u0000\u0000Key words: cardiomyoplasty, stem cells, heart failure, refractory angina.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45665359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION OF INTRAOPERATIVE COMPLICATIONS IN PATIENTS WITH ACUTE AORTIC SYNDROME","authors":"O. V. Buchnieva, Y. Pisklova","doi":"10.37436/2308-5274-2020-4-5","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-5","url":null,"abstract":"Among the methods of treatment of acute aortic pathology in many cases, the surgery remains the method of choice. In order to improve the results of treatment for the patients with acute aortic syndrome by reducing the number of acute intraoperative lesions of organs and systems, a study was conducted, wherein there were analyzed the results of surgical treatment of 166 patients with thoracic and / or abdominal aortic lesions. The advantages of the developed and implemented in practice diagnostic and treatment algorithm for such patients in the pre−, intra− and postoperative periods have been considered. Upon admission to clinic, the main tasks were the maximum elucidation of the diagnosis and rapid structuring of surgery, which were started as soon as possible, primarily to control the blood loss. Hardware reinfusion of all blood lost from aortic rupture was mandatory. The most significant systemic complications were determined by cardiac, renal, respiratory and neurological ones. The proposed diagnostic and treatment algorithm has been concluded to be able of reducing the time and increase of the care efficiency for this category of patients. Programmed and systematic prevention of the most common and most dangerous intraoperative complications of acute aortic syndrome prevents their occurrence, reduces severity, improves the treatment outcomes. Intraoperative autohemotransfusion can reduce the total volume of blood loss, volume of infusion of donor drugs, and, consequently, frequency of acute kidney and lung injury in the intra− and early postoperative periods. The overall results of treatment for the patients with acute aortic syndrome largely depend on the experience of medical staff and equipment of a specialized hospital.\u0000\u0000Key words: aorta, acute aortic syndrome, aortic aneurysm, aortic dissection, surgical treatment, autohemotransfusion.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45209548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN ASPECTS OF REPRODUCTIVE FUNCTION RECOVERY IN PATIENTS UNDERWENT SURGERY FOR TUBAL PREGNANCY","authors":"M. Kozub","doi":"10.37436/2308-5274-2020-4-8","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-8","url":null,"abstract":"Among the causes of tubal pregnancy are the main inflammatory diseases of female genital organs, presence of adhesions in the pelvis, which developed as a result of previous laparotomy. The purpose of experimental and clinical studies was to increase the effectiveness of reproductive health in women with advanced tubal pregnancy and to develop new approaches to improve its techniques using endoscopy, anti−adhesion drugs, placental cryoextract, physiotherapy and assisted reproductive technologies. To justify the use of these methods, an experiment was performed in 196 adult female Wistar rats and 90 female BALB / C mice. There were analyzed the data of clinical observations of 518 women for whom different methods of treatment and rehabilitation of reproductive function were used. It was proven that the use of streptodornase with streptokinase in the patients helped to reduce the incidence of adhesions by 1.6 times; polyethylene oxide with carboxymethyl cellulose, streptodornase with streptokinase and cryoextract of the placenta did in 2.2 times; sodium hyaluronate, streptodornase with streptokinase and cryoextract of the placenta increased it in 2.6 times compared with the intraoperatively detected degree of adhesion. To optimize the method of recovering reproductive function in the patients with tubal pregnancy, the use of laparoscopic organ−preserving treatment with intraoperative administration of anti−adhesive drugs as well as a combined physiotherapeutic treatment was advisable. The inclusion of assisted reproductive technologies in the above two−stage treatment of the patients who did not become pregnant naturally contributed to the onset of uterine pregnancy in 64.9−75.7 % of cases, which did not differ significantly from this index in the control group.\u0000\u0000Key words: tubal pregnancy, reproductive function, laparoscopy, tubotomy, radio wave energy, adhesion process, anti−adhesion barrier, physiotherapeutic treatment, model of premature ovarian failure, placental cryoextract.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48219169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE CHARACTERISTICS OF INFLUENCE OF RISK FACTORS ON SUBJECTIVE ASSESSMENT OF SCHOOLCHILDREN'S HEALTH","authors":"Zhanna Sotnikova-Meleshkina","doi":"10.37436/2308-5274-2020-4-16","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-16","url":null,"abstract":"In modern medicine, self−assessment of health is a reliable, affordable, objective tool for a large−scale clinical and hygienic research, the WHO recommends it as one of the main indices for monitoring the health and quality of life. By means of a screening survey, it is possible to determine not only the medical and social characteristics of an individual and a team, but also to establish the degree of prevalence of threatening symptoms at the pre−nosological level in different age and gender groups. To assess the level of influence of the daily routine elements as risk factors on the subjective assessment of health by middle schoolers using the diagnostic method titled as \"Screening of the survey on schoolchildren health\" a study among 200 students aged 12−14 in secondary education institutions was conducted. According to the results of self−assessment of their own health, the most common signs were asthenia ones especially among girls. A significant number of students did not follow the recommended duration of night sleep and walks in fresh air, the mode of visual load and physical activity. One−factor analysis of variance revealed the level of influence on the formation of pathological conditions (cardiorheumatological, endocrine, ophthalmic, hematological, dental and otolaryngological pathology, signs of asthenia and hypovitaminosis) failure to comply with basic elements of the daily routine. The most important for the general level of health problems are the time of homework, watching TV time, computer games or using other gadgets, diet, these are the ones that are considered to be controlled factors in the development of childhood pathology. Signs of cardiorheumatological and hematological diseases, asthenia and mental disorders were the most sensitive to daily disorders.\u0000\u0000Key words: schoolchildren, subjective assessment of health status, screening, risk factors, daily routine.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41853291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHARMACOLOGICAL TREATMENT OF AUTISM SPECTRUM DISORDERS: DIRECTIONS AND PROSPECTS","authors":"L. A. Bodnar","doi":"10.37436/2308-5274-2020-4-9","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-9","url":null,"abstract":"Autism spectrum disorders are developmental disabilities that occur in early childhood and are characterized with a persistent deficit of social interaction. Treatment of this disease is often multimodal and may include early intensive behavioral therapy (applied behavioral analysis), speech therapy, occupational and physiotherapy, social skills training, special education and training. Modern options for drug treatment of the autism spectrum remain limited. There is no evidence that any of the known drugs have a significant effect on social exclusion, which is one of the characteristic symptoms of this disorder. However, there are potential effects on its other disorders; in particular, risperidone and aripiprazole have the highest level of evidence for the irritability treatment. Memantine, riluzole, amantadine, and buspirone reduced irritability in children with autism spectrum disorders when administered in combination with risperidone. One of the common manifestations of the autism spectrum in children is a symptom of attention deficit / hyperactivity disorder. Methylphenidate has been reported to be effective in treating hyperactivity, but its efficacy in children with autism spectrum disorders is usually lower than in those developing physiologically. The efficacy of prolonged−release guanfacine and clonidine has been demonstrated. Stereotyped and repetitive behaviors in autism spectrum disorders are difficult to treat. Antidepressants have been shown to be ineffective in children with these disorders. Moreover, children with autism spectrum disorders develop more severe side effects when taking these drugs. Cannabidiol is likely to be a promising substance for the treatment of autism spectrum disorders, but there are still insufficient convincing clinical data on the efficacy and safety of cannabinoid therapy.\u0000\u0000Key words: autism spectrum disorders, comorbid conditions, treatment.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47469054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERNATIONAL SEVERE WARNING REQUIREMENTS AND SMART DECISIONS IN CHOICE TACTICS FOR FLUOROQUINOLONES","authors":"O. Yakovleva, O. Hoina-Kardasevich","doi":"10.37436/2308-5274-2020-4-13","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-13","url":null,"abstract":"The paper is devoted to the review of the reports on current ideas about adverse reactions of using the fluoroquinolones. As a group of antibiotics with a wide range of effects on microbial pathogens, they have recently found a sufficient use in infectious diseases in clinical practice. However, the spread of indications is accompanied by the accumulation of information about the growth of adverse reactions. Among the first mentioned ones there were reactions in gastrointestinal tract, allergic reactions, photosensitization, prolongation of the QT interval, deterioration of joint and tendon function, lesions of the nervous system. Some toxic reactions contributed to the banning of certain drugs: temafloxacin, grepafloxacin, trovafloxacin. Further observations were made on the development of hypoglycemic reactions, eosinophilia, liver damage. Among the mechanisms of toxicity the free radical reactions, structural modifications of the antibiotic molecule are considered. Therefore, both the United States (FDA) and European experts are paying close attention to serious warnings to limit the indications for these drugs. Some studies have shown an increase in the frequency of tendon rupture, as well as the risk of aortic aneurysm and its rupture, due to the mechanisms of effects on collagen metabolism, widely present in the tissues of the joints and surrounding tissues and in the aorta. The reports demonstrate the frequency of lesions to joints, muscles, nervous system and separately formulated complications in the mental sphere of patients. The accumulation of information on the injury of the nervous system and mental disorders resulted in the proposal to limit the indications for the easy course of infections, with their recurrence in urinary tract infections, diarrhea prevention. Restrictions also include as follows: old age of patients, previous anamnestic reactions to these drugs, diseases of the joints and kidneys, interaction with glucocorticoids.\u0000\u0000Key words: fluoroquinolones, adverse reactions, restrictions on indications, international recommendations.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48134043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}