International Medical Journal最新文献

{"title":"FEATURES OF MYOFASCIAL PAIN SYNDROME OF CERVICAL LOCALIZATION IN YOUNG PATIENTS WITH FORWARD HEAD POSTURE","authors":"G. V. Logvinenko, M. I. Voloshyna","doi":"10.37436/2308-5274-2020-4-11","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-11","url":null,"abstract":"One of the most common variants of non−specific muscle pain is myofascial one. To establish the features of myofascial pain syndrome of cervical localization and its impact on daily life in young patients withforward head posture, 37 patients were examined. There were performed clinical−neurological, vertebro−neurological examination (visual diagnosis of static disorders, manual diagnosis, kinesthetic examination of muscles), photogrammetric measurement of craniovertebral angle, assessment of neck pain on a visual analog scale and its impact on patients. In all patients a visual diagnosis revealed a shift of regional center of gravity at the cervical level forward with the formation of the head forward posrture, which was confirmed by measuring the value of the craniovertebral angle − 48.3±1.56 °. There was a negative correlation between the value of craniovertebral angle and assessment of pain on a scale (r = −0.91, p < 0.05), as well as between the value of craniovertebral angle and index of vital disorders in neck pain (r = −0.93, p < 0.05), which indicates the effect of forward shifting the regional center of gravity on the severity of cervicalgia and the degree of its impact on the daily lives of young patients. Based on the results of the study, conclusions were drawn. Myofascial cervical pain syndrome in young patients with head forward posture is characterized with a bigger number of muscle groups involved into the pathological process with shortening of the head and neck extensor muscles as well as the formation of active trigger points, greater severity of neck pain and the negative impact of cervicalgia on daily life compared to the patients with a neutral head posture.\u0000\u0000Key words: forward head posture, myofascial pain syndrome, trigger point, cervicalgia.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44896335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND PATHOGENETIC FEATURES OF MILD TRAUMATIC BRAIN INJURY DISTANT PERIOD","authors":"I. A. Hryhorova, O. O. Teslenko, L. V. Tykhonova","doi":"10.37436/2308-5274-2020-4-10","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-10","url":null,"abstract":"Plastic and energetic reorganization of brain after its traumatic injury lasts for many years, and impaired adaptive neuroplasticity can lead to progressive development. In the long term, even with a minor injury, the organic neurological symptoms are mitigated and autonomic and psychopathological disorders come to the fore, which are the main cause of social and occupational maladaptation of patients. To identify and analyze the clinical and pathogenetic features of the long−term period of mild traumatic brain injury, 100 patients aged 20−60 years who underwent it 1−5 years ago were examined. Patients underwent clinical−neurological, neuropsychological and biochemical studies. The reparative capacity of brain was assessed by determining the content of neurotrophic factors in the serum: brain−derived neurotrophic factor (BDNF), nerve growth factor (beta−NGF) and protein−promoter of apoptosis Bcl−2 by enzyme−linked immunosorbent assay. The results of the study confirm the idea that mild traumatic brain injury most often affects the mid−stem structures of the brain, which play a leading role in ensuring the human body adaptation. Clinically, this was manifested by asthenic, autonomic and neurocognitive disorders, which is a reflection of persistent neuronal dysfunction. Decreased BDNF expression and increased beta−NGF in the long term may be a marker of neuronal dysfunction, a persistent disorder of adaptive neuroplasticity that is closely associated with emotional and neurocognitive disorders. The level of Bcl−2 remains consistently high, significantly higher than control values, even with prolonging duration of the post−traumatic period. This feature is likely to be of regulatory character as an apoptosis inhibitor.\u0000\u0000Key words: mild traumatic brain injury, pathogenesis, clinic, diagnosis, neuroplasticity.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47676504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BLOOD PRESSURE, HYPOCHONDRIA AND DEPRESSION: MATHEMATICAL MODELS OF RELATIONSHIP","authors":"M. Pavlovska","doi":"10.37436/2308-5274-2020-4-2","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-2","url":null,"abstract":"Modern clinical diagnostics has standards and medical systems for the diagnosis of hypertension, advanced information technology. Mathematical models of the relationship between systolic blood pressure and psychological indices of hypochondria and depression have been described. Methods of mathematical statistics were applied as follows: factor, cluster, discriminant, regression analyzes, Markov chains, polynomial splines and neural networks, they were implemented in software products, such as NeuroModelDBPM, \"Monitoring\", VerMed. The presented model of interaction of systolic arterial pressure, Hs−hypochondria, D−depression confirms an importance of these states at an initial stage of arterial hypertension and allows the allocation of four options of psychosomatic relations in patients: organ and system somatic defeats of psychosomatic character, somaticized psychiatric reactions, reactions of exogenous type. It has been shown that disharmonious personality traits, risk factors, disorder of chronobiological structure of blood pressure, left ventricular hypertrophy and its diastolic dysfunction contribute to the formation of nosogeny in hypertension. Their development is hindered by harmonious personality traits, keeping a healthy lifestyle, minimal changes in the chronobiological structure of blood pressure, a slight degree of left ventricular hypertrophy and its diastolic dysfunction. The leading cardiovascular risk factors in patients with hypertension are stress, burdened heredity, low physical activity, carbohydrate abuse, higher education and high socioeconomic status. Nosogeny in hypertension should also be considered as a risk factor, as well as should be taken into account in the stratification of the overall cardiovascular risk and accomplishing a proper adjustments.\u0000\u0000Key words: arterial hypertension, mathematical statistics, arterial pressure, hypochondria, depression, information technology.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44149007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMBINED TREATMENT OF PATIENTS WITH ENDOMETRIAL CANCER I-II (Т1-2N0M0) TAKING INTO ACCOUNT THE LEVEL OF EXPRESSION OF MOLECULAR BIOLOGICAL TUMOR MARKERS","authors":"A. A. Mikhanovskii, O. Sukhina, N. Artamonova, Yuliia Vladimirovna Kharchenko","doi":"10.37436/2308-5274-2020-4-7","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-7","url":null,"abstract":"One of the most relevant and promising areas in the world of oncogynecology, enabling deeper understanding of the etiology and pathogenesis of malignant growth, to study the processes occurring in women, is the study of molecular biological markers, characterizing apoptosis, cell proliferation and angiogenesis. To increase the effectiveness of combined treatment of the patients with endometrial cancer I−II (Т1−2N0M0) stages and prevent the occurrence of local recurrences as well as distant metastases on the basis of investigating the molecular biological features of tumor and their prognostic value, a study based on clinical observations of 125 women was performed. Their treatment included surgery and a postoperative course of remote radiation therapy. The strategy of adjuvant therapy was designed according to the definition of the group of increased risk of cancer recurrence in the patients with negative receptor status (ER, PR) based on the degree of differentiation of endometrial adenocarcinoma (G), depth of tumor invasion into the myometrium and its location in the cavity as well as the level of expression of molecular biological markers (VEGF, Bcl−2, Ki−67). To select the tactics of further treatment, each of the indices was evaluated in points on a scale. Next, the intervals of the total value of S points were set, depending on which the program of combined adjuvant therapy was chosen: up to 6 points the contact radiation therapy was performed, 7−12 points − there was applied a remote in the postoperative period; 13 points − after remote and contact radiation, six more cycles of chemotherapy were added. Analysis of the research results showed that the developed method of combined treatment of patients with endometrial cancer I−II (Т1−2N0M0) stages allows the personalization of the protocol of adjuvant therapy and recurrence prevention.\u0000\u0000Key words: endometrial cancer, molecular biological markers, treatment results, adjuvant therapy.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70056667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF ULTRASONOGRAPHY IN DIAGNOSIS OF SPINAL STENOSIS WITH LUMBAR OSTEOCHONDROSIS","authors":"R. Abdullaiev","doi":"10.37436/2308-5274-2020-4-15","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-15","url":null,"abstract":"Diagnostic visual examinations for patients with any type of spinal stenosis include either magnetic resonance imaging or computed tomography with myelogram, sometimes both tests are prescribed to patients. Ultrasound is usually most effective for tissues with a high content of collagen, i.e. tendons, ligaments, joint capsules and fascia. In osteochondrosis, spinal ultrasonography is used to determine whether a back pain is the result of cracks or a herniated disc. To evaluate the possibilities of ultrasound in diagnosis of lumbar spine stenosis, an analysis of its results in 48 patients aged 41−57 years. Forty five of them were diagnosed with intervertebral disc herniation, 3 with protrusion of various localization and hypertrophy of the yellow ligament. All the patients underwent radiography, magnetic resonance or computed tomography, as well as ultrasound. In 24 patients the laminectomy was performed in 31 discs. In 21 cases, the hernia was paramedian, in 17 it was − median and in 14 this was circular. Laminectomies were performed much more frequently due to median and circular hernias. The slightest deformation of spinal canal is observed in the posterolateral localization of hernia or protrusion. In thin individuals, ultrasound images of the spinal canal elements were excellent, in those with moderate weight they were slightly inferior to magnetic resonance imaging. In three cases of spinal canal stenosis in obese patients who underwent laminectomy, the results of ultrasonography were unsatisfactory and the decision for surgery was made only on the basis of magnetic resonance imaging. It is concluded that ultrasound is a very informative way of assessing the degree of lumbar spine stenosis resulted from degenerative changes in intervertebral discs.\u0000\u0000Key words: ultrasonography, spinal canal stenosis, lumbar osteochondrosis, lumbar intervertebral discs.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48437285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OSTEOMYELITIS OF STERNUM: DIAGNOSIS AND SURGICAL TREATMENT","authors":"Valerii Volodymyrovych Boiko, V. N. Lykhman, D. Myroshnychenko, Ya. V. Shafer, S. V. Tkach, Andrei Alekseevich Merkulov, Ye. O. Bilodid, O. V. Nedilko","doi":"10.37436/2308-5274-2020-4-4","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-4","url":null,"abstract":"Postoperative sternomediastinal infections significantly affect morbidity and mortality, as well as the hospitalization duration and treatment cost for cardiac surgery patients. The use of median sternotomy has a number of complications, primarily infectious, which can occur with the formation of superficial or deep wound infection, diastase and fragmentation of the sternum, and sometimes with destabilization of the chest bony skeleton. The development of sternal osteomyelitis is associated with a significant reduction in long−term survival. The results of treatment for the patients with the sternum osteomyelitis after sternotomies, being at the State Institution \"V. T. Zaitsev Institute of General and Emergency Surgery of the NAMS of Ukraine\" in Kharkiv within the period of 2014−2020, have been analyzed. Diagnosis of patients with osteomyelitis of the sternum comprised fistulography, multispiral computed tomography, ultrasound. The material for the bacterial study was the discharges of a sternal wound. Antibiotic susceptibility of isolated bacterial cultures was studied by disco−diffusion and in agar. There were 32 strains of microorganisms, representatives of different taxa. S. aureus was dominant and accounted for 23.81 % of the total number of isolates of this genus. Among antibiotics, the most effective in vitro were lincomycin and especially carbapenems (imipenem). When treating the patients with sternal osteomyelitis, VAC therapy was used, as well as open wound management by dressings depending on the wound process stage. The results of the study suggest that multi−slice computed tomography should be preferred in the diagnosis of osteomyelitis of sternum, which allows the diagnosis verification in 98 % of cases, and the use of ultrasonography is important to monitor the clearance and healing of sternotomy wounds. The use of VAC therapy has helped to reduce the length of hospital stay of patients.\u0000\u0000Key words: sternum osteomyelitis, VAC therapy, multispiral computed tomography, bacterial culture.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF EFFECTIVENESS OF SPECIALIZED OTOLARYNGOLOGICAL CARE TO CHILDREN OF METROPOLIS AS EXEMPLIFIED BY THE CITY OF KHARKIV","authors":"O. I. Serdjuk, S. Samusenko, I. Filatova","doi":"10.37436/2308-5274-2020-4-12","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-4-12","url":null,"abstract":"The availability of medical resources to provide an otolaryngological care to children in the metropolis as exemplified by the city of Kharkiv was comparatively analyzed. The indices of medical service density as well as the available otolaryngological beds of the city residents have been established to be stable and on the background of reducing their number in Ukraine by the end of 2017 exceed the latter except reducing thechildren's otolaryngological beds by 19.4 %. The revealed excess in an average number of bed occupancy, its turnover and reduction of the duration of inpatient treatment indicates an active use of the hospital bed capacity. It has been statistically proven that on the background of sufficient medical resources there are decreased as follows: the number of patients' visits to otolaryngologists in polyclinics of the Ministry of Health of Ukraine; relative index of the number of children who left the hospital due to diseases of the ear and mastoid process, coverage of the Kharkiv children aged 0−14 years with reduced hearing acuity with preventive examinations. The Kharkiv region is shown to occupy the first ranking place among the regions of Ukraine in terms of the disability level due to diseases of the ear and mastoid process. It was found that in the structure of primary disability the children aged 3 to 6 years and those with deafness were mainly determined. The described dynamics of indices has been more clearly traced since 2014. The above data indicate the existing shortcomings when treating the upper respiratory tract, ear and mastoid process diseases, mainly due to imperfect interaction of otolaryngological care service elements for children, inefficiency of typical medical routes. All this determines the relevance of developing an effective functional model of specialized otolaryngological care for children in the metropolis based on determining and monitoring of indices of simulated pathology quality treatment, training of doctors at all levels of care providing.\u0000\u0000Key words: efficiency of specialized otolaryngological care, children of the metropolis, analysis of medical resources, disability.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48883168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN OXYGENATION IN CHILDREN WITH RESPIRATORY FAILURE","authors":"O. Filyk","doi":"10.37436/2308-5274-2020-3-2","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-2","url":null,"abstract":"Acute respiratory failure is a component of the multiorgan dysfunction syndrome and a common cause of death among the children treated in intensive care units. Readiness to wean a patient from a mechanical ventilation is determined by a set of indices, including the data on the level of hypoxemia and its ability to regress under the influence of oxygen therapy. The indices such as the paO2/FiO2 and SpO2/FiO2 ratios are valid for determining the severity of hypoxemia. In order to study the dynamics of changes in SpO2/FiO2, paO2/FiO2, oxygenation index and the one of frequent shallow breathing in the children with acute respiratory failure as well as to substantiate the criteria for their readiness to wean from pulmonary ventilation, a prospective, observational cohort investigation in patients aged from 1 month to 18 years was performed. The patients of group I received pulmonary−protective strategy of mechanical lung ventilation, II − in addition to it received the diaphragm−protective strategy. The ratios of SpO2/FiO2 and paO2/FiO2, oxygenation index and frequent shallow respiration index were calculated. Weaning was considered successful if the patient did not require a respiratory therapy after extubation for the next 48 hours. The primary endpoint of the assessment was the duration of weaning from mechanical ventilation, the secondary ones were the SpO2 / FiO2, paO2 / FiO2, oxygenation index, the one of frequent shallow breathing. Significant differences in SpO2 / FiO2 and paO2 / FiO2 indices were found on days 5 and 9 of the study. It was found that at paO2 / FiO2 values less than 200 and SpO2 / FiO2 less than 265 the prognosis of weaning is unfavorable.\u0000\u0000Key words: children, oxygenation, mechanical ventilation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"10-13"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45377238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAUSES OF ADVERSE SURGERY EFFECTS IN TREATMENT OF PATIENTS WITH ESOPHAGUS STENOTIC DISEASES","authors":"A. Korolevska, S. Y. Bityak, V. V. Zhidetskyi, A. B. Starikova, Y. Novikov","doi":"10.37436/2308-5274-2020-3-5","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-5","url":null,"abstract":"Esophageal stenosis requires a responsible approach to the choice of rational treatment tactics. Intraoperatively, bleeding, interponate necrosis, complications associated with the wrong choice of the path of the interponate imposition to the neck, damage to the nutrient vessel (the arcade rupture), pleural leaves during the formation of the thoracic tunnel, n. vagus and its branches, pneumothorax, hemothorax, uncontrolled mediastinal bleeding, the need for drainage of the pleural cavity due to injury to the latter, iatrogenic splenectomy, membranous tracheal tear. Post−surgery complications are developed at different times after esophagoplasty. Most often, early postoperative complications occur because of the wound: bleeding and failure of the sutures of the anastomosis line. Complications resulted from the respiratory system are as follows: tracheobronchitis, pleurisy, \"congestive\", nosocomial pneumonia and atelectasis, pleural empyema. In the remote post−surgery period, the patients may experience: stenosis of the esophageal (or pharyngeal) anastomosis, adhesions, fistulas, reflux, peptic ulcers of the esophagus, pain, inflections and excess loops, complications associated with mechanical trauma of implant, scar−altered cancer esophagus, polyposis of the colon, various disorders associated with primary trauma, nonspecific complications. Damage to the recurrent nerve in patients causes constant hoarseness and difficult swallowing. Occasionally there are cardiac arrhythmias in the form of atrial fibrillation, \"sympathetic\" pleurisy, reflux, post−vagotomy symptom and dumping syndrome, delayed gastric emptying due to insufficient dilated pyloromyotomy in the patients with a combination of stenosis of the esophageal lumen and esophageal lumen hernia.\u0000\u0000Key words: esophageal stenosis, esophageal anastomosis, postoperative complications.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44637740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL SIGNIFICANCE OF EXPRESSION RATE OF MIRNA-29A IN PATIENTS WITH CHRONIC VIRAL HEPATITIS","authors":"O. Shevchenko-Makarenko","doi":"10.37436/2308-5274-2020-3-16","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-16","url":null,"abstract":"Chronic viral hepatitis C is an urgent problem of hepatology. During the rapid development of epigenetics, small molecules, namely microRNA and microRNA−29a are actively studied in liver pathology. For this purpose, the level of miRNA−29a expression was studied in 74 patients having chronic viral hepatitis C with the first HCV genotype. Aberrant hyperexpression of miRNA−29a in the patients, the ability to differentiate the patients with chronic viral hepatitis C with sensitivity and specificity of the model of ROC analysis Se = 67.57 % and Sp = 90.91 %, DE = 79.24 % compared with healthy individuals. The expression of miRNA−29a was studied in the patients with chronic viral hepatitis C, who had a poor experience with antiviral therapy with interferon−containing protocols. The expression level of miRNA−29a was determined according to the manufacturer's protocol using the TaqMan® microRNA reverse transcription kit (Applied Biosystems, USA).The mean level of miRNA−29a expression in the patients with chronic viral hepatitis C (Me) and in groups of patients was assessed depending on previous experience of antiviral therapy. Aberrant hyperexpression of miRNA−29a was detected in the patients with chronic viral hepatitis C. In naive patients the level of miRNA−29a expression was 1.65 (1.27; 2.28) conventional units and in the patients with failed antiviral therapy according to regimens containing interferon was 1.64 (0.79; 2.20) conventional units compared with the control group (p = 0.002, H), which may reflect the potential mechanism of persistence of HCV infection. Thus, the expression level of miRNA−29a can be an additional biomarker in the pathogenesis of chronic viral hepatitis C, which can be used in the monitoring and treatment of patients, become the basis for prescribing the patients more effective protocols of targeted antiviral drugs and allow personification of treatment tactics.\u0000\u0000Key words: chronic viral hepatitis C, previous experience of antiviral therapy, miRNA−29a, aberrant hyperexpression.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"09 1","pages":"83-86"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70056574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}