International Medical Journal最新文献

{"title":"USE OF ENTEROSORPTION TO PREVENT ENDOTOXEMIA IN ACUTE INTESTINAL OBSTRUCTION","authors":"A. N. Shevchenko, Andrei Alekseevich Merkulov, S. V. Tkach, D. Myroshnychenko, I. Volchenko, Ye. O. Bilodid, K. M. Yatsko, P. O. Gordienko","doi":"10.37436/2308-5274-2020-3-3","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-3","url":null,"abstract":"The relevance of studying the measures to prevent the development of endotoxemia in acute intestinal obstruction is stipulated with an increasing incidence of multiple organ failure in debilitated patients and infectious−toxic shock. The development of endotoxemia is often accompanied with a secondary infection. Toxic effects of bacteria in small intestine, the trigger of which is their translocation and transformation of the small intestine into a focus of microbial invasion, prolongs the postoperative period, which increases the length of stay in the surgical hospital. Much attention is paid to the pathogenesis of the development of small bowel contamination syndrome, which results in changes in intestinal biocenosis and increased intoxication of the body, which worsens the patient general condition. To examine the results of entersorption as a method of detoxification and control of infectious and toxic complications in the patients with an acute intestinal obstruction before surgery to optimize surgical tactics and prevent post−surgery complications, a study was conducted in 36 patients with different stages of the disease. The effectiveness of detoxification in the combined treatment of an acute intestinal obstruction has been confirmed, which is indicated by the reduced pain, regression of radiological signs of obstruction in the patients and early normalization of their main clinical, laboratory and instrumental parameters. The use of the method of enterosorption as part of a comprehensive approach in the period after surgery contributed to the early restoration of intestinal motility, reducing the number of complications, improving the general condition of patients. Thus, the method of enterosorption is one of the most effective of modern detoxification methods, which determines its relevance and further prospects to study this problem.\u0000\u0000Key words: acute intestinal obstruction, endotoxemia, enterosorption.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"14-17"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47878697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN PRINCIPLES OF MANAGEMENT OF WOMEN WITH ABNORMAL UTERINE BLEEDING, TAKING INTO ACCOUNT THE BLOOD COAGULATION SYSTEM STATE","authors":"O. Kuzmina","doi":"10.37436/2308-5274-2020-3-7","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-7","url":null,"abstract":"Abnormal uterine bleeding in women of childbearing potential requires effective emergency care. To determine the features of disorders in the hemostasis system, 120 women were directly examined at the time of bleeding on admission to the hospital, during treatment on days 5−7 of the menstrual cycle, as well as after 6−12 months from the end of treatment. Determination of congenital and acquired defects of the hemostasis system became the main criterion for the selection of combined and isolated forms of abnormal uterine bleeding. Treatment measures for patients were etiopathogenetically selected and individually the intensity of bleeding, the degree of anemia, coagulation parameters were taken into account. The staged treatment involved stopping the bleeding, regulating the menstrual cycle and further preventing the bleeding. It has been found that uterine bleeding in reproductive age in the absence of etiopathogenetic treatment leads to the development of posthemorrhagic anemia. The severity and nature of bleeding is determined by the presence of defects in the platelet system of the hemostasis system with impaired platelet aggregation function. The study of total coagulation potential, primary hemostasis and the state of intravascular hemocoagulation in the patients using the methods for estimating the amount of platelet aggregation allows to detect and differentiate disorders in the hemostasis system. According to the results of the study, it can be concluded that the use of fibrinolysis inhibitors in the patients with abnormal uterine bleeding helps to increase the activity of the blood coagulation system and complete cessation of bleeding on the 2nd−5th day. Prophylactic administration of antifibrinolytic drugs from the first day of the menstrual cycle reduces blood loss, stabilizes menstrual function and significantly improves the psycho−emotional state of patients.\u0000\u0000Key words: abnormal uterine bleeding, blood clotting, fibrinolysis inhibitors.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41544987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MORBIDITY IN UKRAINIAN CHILDREN WITH DISEASES OF UPPER AIRWAYS, EAR AND PAPILLARY PROCESS: MODERN ASPECTS","authors":"S. Samusenko, I. Filatova","doi":"10.37436/2308-5274-2020-3-12","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-12","url":null,"abstract":"To determine the main trends in an incidence of childhood diseases of the upper airways, ear and papillary process, the data of the official state statistical information of the Ministry of Health of Ukraine were studied. The dynamics of prevalence and morbidity of children with these diseases in 2009−2017 were analyzed. An increase in the prevalence and incidence of respiratory diseases among the citizens and residents of rural areas by 26.8 % and 30.3 %, respectively, and a decrease in the above indices in urban children by 4.1 % and 3 % respectively were recorded. The incidence and prevalence of ear and papillary process diseases among the urban population increased by 31.8 % and 23.5 % in 2017 compared to 2009, in contrast to the incidence in rural residents for the same diseases (6.2 % and 1.7 %). The tendency of increase in the incidence and prevalence of diseases of the ear and papillary process in children aged 0−14 years by 12.5 % and 10.3 %, and in adolescents these were by 5 % and 11.1 %, respectively. The prevalence of acute pharyngitis and tonsillitis increased by 35 %, laryngitis and tracheitis it did by 20 %, for allergic rhinitis this was by 21.4 % with a decrease in the prevalence of chronic diseases of the tonsils and adenoids by 19.4 % among children aged 0−17 and 16.4 % respectively. The inexpediency of allocating such nosologies as chronic rhinitis and chronic laryngitis for statistical accounting of the state of upper airways morbidity has been determined. It is established that the lack of significant dynamics of morbidity for certain diseases of the ear and papillary process was due to clinically incorrect formation of groups of nosologies for statistical accounting. Prospects for further research to address shortcomings and improve the quality of specialized care have been outlined.\u0000\u0000Key words: morbidity and prevalence of diseases of the upper airways, ear and papillary process, statistical accounting, children of Ukraine.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44106909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF CAPILLARY BLOOD FLOW IN PATIENTS WITH PATHOLOGY OF INTRANASAL STRUCTURES AND NASAL BREATHING DISORDERS","authors":"N. Shushliapina, O. Y. Cherniakova","doi":"10.37436/2308-5274-2020-3-11","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-11","url":null,"abstract":"The investigation of the vascular microcirculation system is important for diagnosis, assessment of the severity and nature of pathological processes in human body, monitoring the effectiveness of treatment. Monitoring the state of microcirculation in impaired respiratory function of the nose helps to study the subtle mechanisms of regulation of vascular−tissue relations. To do this, there were used the biomicroscopic methods to study capillary blood flow, one of the most relevant and promising is optical capillaroscopy of the nail bed. This method makes it possible to identify at the evidence level the peculiarities of the functioning of the peripheral circulatory system by the state of the capillary system and to evaluate the effectiveness of treatment by the rheological properties of blood in hematological practice. There were examined 145 patients by means of computer capillaroscopy to study the rate of capillary circulation in the patients with pathology of intranasal structures and nasal breathing disorders. All patients underwent a complete clinical examination, routine instrumental examinations, and computer capillaroscopy using a video capillaroscope with a visual magnification of up to 550 times. The obtained images were stored and processed according to a special software. During the characterization of the capillaroscopic picture there were evaluated: pathological tortuosity, change in the caliber of arterioles and venules, disorganization of the capillary network, the number of functioning capillaries. Changes in the speed and nature of capillary blood flow (accelerated, slow, stasis) were observed. The optical capillaroscopy method allows not only to visually assess the condition of microvessels, but also to determine such an important parameter as blood circulation, actually, it can replace the study of laser Doppler. Such data will be important in the diagnosis of respiratory and olfactory disorders and the formation of adequate tactics for their treatment.\u0000\u0000Key words: microcirculation, microcirculatory tract, capillary circulation, nasal obstruction, nasal breathing disorders, pathology of intranasal structures, computer capillaroscopy.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44969182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINIC AND COMPLICATIONS OF COVID-19 CORONAVIRUS DISEASE WITH PATHOGENESIS ELEMENTS","authors":"I. V. Аndrusovich","doi":"10.37436/2308-5274-2020-3-14","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-14","url":null,"abstract":"The longer the COVID−19 coronavirus pandemic lasts, the more information about its clinical manifestations is accumulated. The incubation period of COVID−19 ranges from 2 to 14 days, rarely up to 3 weeks, but in a significant number of cases an infection is not accompanied with the appearance of clinical symptoms. Currently, the following variants of the clinical course of COVID−19 can be identified as follows: viral load; subclinical; slight; uncomplicated with damage to only the upper respiratory tract; mild pneumonia, severe pneumonia, acute respiratory distress syndrome, etc. The clinical course of COVID−19 depends on the severity, the criteria of which are the intoxication manifestation, the degree of fever and the dominant syndrome. Mild / moderate forms are manifested by frequent increase in body temperature up to 38 ° C, respiratory symptoms, headache, myalgias, palpitations and general malaise. Patients stop distinguishing smells and feel the taste of food. Approximately from the 7th to the 9th days of the disease there are problems with breathing, which indicates the impairment of the lower respiratory tract and the beginning of the second phase of the disease, and its course is regarded as severe. Severe forms of the disease can also be manifested by impaired coordination of movements, slurred speech. In 1 to 4 % of patients there is developed the psychosis in the form of hallucinations. In the elderly, COVID−19 may be accompanied by delirium, lowering blood pressure. The risks of adverse disease are associated with somatic diseases: cardiovascular and nervous systems, respiratory tract, hormonal disorders, etc. Otitis, sinusitis, sepsis, bronchopulmonary infection, thrombosis, myocarditis etc. can be the complications of COVID−19. Computer tomography is an instrumental test that demonstrates the damage of lungs with coronavirus and allows to assess its severity.\u0000\u0000Key words: coronavirus infection, COVID−19, clinical variants, severity, pneumonia, acute respiratory distress syndrome.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"72-79"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43908396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ASSESSMENT OF β-DEFENSIN LEVELS IN PATIENTS WITH CHRONIC ECZEMA OF VARYING SEVERITY","authors":"K. I. Lysenko","doi":"10.37436/2308-5274-2020-3-13","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-13","url":null,"abstract":"The infectious nature of the process in microbial eczema or complications of bacterial infection of true eczema indicates an impairment in the immune system, especially innate immunity. Primary pathogen receptors, the complement system, phagocytosis, interferons, and endogenous antibiotic peptides play a crucial role in the body's innate defense. The first line of defense is provided by antimicrobial peptides, which are non−specific factors of humoral immunity, and have endotoxin−neutralizing and immune modulatory activity, as well as act against a wide range of microorganisms. One of them is defensins, which are cationic amphipathic peptides with a length of 30 to 42 amino acids with a three−stranded β−plate structure containing three disulfide bonds. The main producers of human β−defensins (Human Beta Defensin) are various epithelial cells, including keratinocytes. Defensins have antibacterial, antiviral, antifungal and antiparasitic effects. β−defensins are active against gram−positive and gram−negative bacteria, in addition, they exhibit anti−yeast activity. In patients, the severity of dermatosis was determined based on the calculation of EASI (Eczema Area Severity Index), the content of Human Beta Defensin was done with enzyme−linked immunosorbent assay, in the serum of patients with chronic eczema, it was increased 15.9 times compared to the control group. Quantitative levels of Human Beta Defensin 2 have been shown to be closely related to the disease severity. The content of Human Beta Defensin 2 in the serum of patients with chronic eczema may be a marker of the dermatosis severity.\u0000\u0000Key words: chronic eczema, true and microbial eczema, pathogenesis, β−defensin, severity.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48809846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF CLINICAL MANIFESTATIONS OF POST-TRAUMATIC NEUROPATHIES AND PLEXOPATHIES RESULTED FROM GUNSHOT AND NON-GUNSHOT INJURIES OF EXTREMITIES","authors":"O. Borodai, Yu.V. Kas","doi":"10.37436/2308-5274-2020-3-9","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-9","url":null,"abstract":"The number of traumatic injuries to nerve stems and plexuses is steadily increasing in peacetime during armed conflicts and terrorist acts. In wartime, peripheral nerve injuries are much more common, and a great deal of the knowledge about peripheral nerve damage and repair is based on combat experience. The study of the clinical course of post−traumatic neuropathies and plexopathies contributes to the development of clinical and neurological criteria and compensatory−restorative responses in traumatic lesions of the peripheral nervous system, helps to assess the functional significance of various parts of the nervous system when compensating a damaged functional unit. To study the features of clinical manifestations of post−traumatic gunshot and non−gunshot neuropathies and plexopathies, 63 patients underwent clinical and neurological examination with topical and clinical diagnoses, collection of detailed anamnesis and complaints, electroneuromyography and ultrasound examination. Movement disorders, characterized by peripheral paresis or plegia of the corresponding muscle group and accompanied with a reduced or lost tendon and periosteal reflexes, were common. Sensitivity disorders were a combination of prolapse (anesthesia, hypoesthesia) and irritation (paresthesia, hyperpathy, hyperesthesia). Autonomic disorders (vascular, secretory and trophic) in traumatic neuropathies differ depending on the clinical individuality of peripheral nerves. Vascular disorders were more often detected with partial damage to nerve structures and were accompanied by local edema. Of the secretory disorders, the most constant sign of impaired nerve conduction was sweating disorder. In the clinical picture of the pain syndrome, i.e. causalgia, the pain sensations by type of burning dominated. The intensity of the pain syndrome in severe cases was very high, in some cases the pain was exacerbated by irritation of the senses. The clinical picture of causalgia is characterized by an increased pain when warming the injured limb and it reduced when cooled, that is a \"symptom of a wet rag.\" Knowledge of clinical features allows the detection of the peripheral nervous system lesions at the early stages of pathology, performance of dynamic clinical and neurological observation and treatment, timely use of modern additional research methods to address further treatment tactics that restore limb function, improve quality of life.\u0000\u0000Key words: post−traumatic neuropathy and plexopathy, peripheral nervous system, gunshot wounds of nerves and plexuses.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49333270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETIOPATHOGENETIC ASPECTS, CLINICAL AND DIAGNOSTIC CRITERIA AS WELL AS COMPREHENSIVE APPROACH TO TREATMENT OF METABOLIC SYNDROME IN WOMEN OF REPRODUCTIVE AGE","authors":"O. Dolenko","doi":"10.37436/2308-5274-2020-3-8","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-8","url":null,"abstract":"The development of metabolic syndrome in women of reproductive age is one of the most common causes of anovulatory infertility, miscarriage in early pregnancy. In this pathology treatment in women there is used a comprehensive approach, which aims to restore specific functions, i.e. menstrual, secretory and reproductive ones. Important points are the detection of metabolic disorders in the patients before the formation of polycystic ovaries, normalization of body weight. In order to study the clinical effectiveness of the herbal drug \"Glucemedin\" in the combined treatment of metabolic syndrome in 40 women of reproductive age, a clinical and laboratory investigation was performed, also transvaginal ultrasound and body mass index were determined. In the first group of patients as the main treatment the metformin was prescribed hydrochloride as monotherapy in a dosage of 500 mg 2 times a day, in the second there was added phytodrug \"Glucemedin\" in a dosage of 1 capsule 3 times a day. The combined treatment showed a more pronounced dynamics of reduction of total and free cholesterol, low−density lipoprotein, triglycerides, atherogenic factor, decreased body mass index compared with the patients receiving metformin monotherapy. Based on analysis of the results of clinical and laboratory studies a high clinical efficiency of the herbal phytodrug \"Glucemedin\", which is stipulated with the pronounced effect on lipid spectrum of blood. The presence of natural components being a part of the phytodrug \"Glucemedin\", their high bioavailability, safety of the drug, no side effects and contraindications indicate its pronounced clinical effectiveness and feasibility of inclusion into the treatment of metabolic syndrome in women of childbearing age.\u0000\u0000Key words: metabolic syndrome, lipid profile, body mass index, transvaginal ultrasound, Glucemedin, clinical efficiency, combined treatment, women of reproductive age.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"40-44"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42920217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGE FEATURES OF SOME FORMS OF HERPESVIRUS INFECTION","authors":"M. Popov, D. Dorosh, S. G. Malanchuk, O. Gololobova, Yu. O. Grechishkina, A. Sorokina","doi":"10.37436/2308-5274-2020-3-15","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-15","url":null,"abstract":"Epstein−Barr virus occupies an important place in the structure of infectious lesions of herpesvirus etiology. In order to study the age−related course of chronic infection caused by Epstein−Barr virus, a study was conducted with involvement of 141 patients. According to the results of our study, we found that a chronic infection caused by Epstein−Barr virus is characterized with polymorphism of clinical symptoms, there are certain features of its manifestations depending on the age of patients. Among the clinical manifestations of the infection, chronic tonsillitis, chronic fatigue syndrome and peripheral lymphadenopathy were most often found. Peripheral lymphadenopathy, hepatolienal syndrome and chronic tonsillitis were most common in the patients aged 18−25 years, prolonged subfebrility was noted in the age group of 26−35 years, and chronic fatigue syndrome, arthralgia and myalgia among were observed in the patients aged 36−45 years. A study of the recurrence rate in patients with chronic infection caused by Epstein−Barr virus of different age groups revealed that patients aged 18−25 and 26−35 years had 1−2 recurrences during the year, and those aged 36−45 years had 4 ones and more. Analysis of the results of laboratory studies showed that the patients with chronic infection caused by Epstein−Barr virus, compared with the control group showed a significant increase in erythrocyte sedimentation rate, relative lymphocytes and monocytes, as well as a decrease in absolute and relative neutrophil content, indicating leukocyte blood formula, characteristic of the viral etiology of the disease associated with Epstein−Barr virus. There was no correlation between the clinical analysis of blood with age of the patients with chronic infection caused by Epstein−Barr virus.\u0000\u0000Key words: herpesvirus infection, chronic Epstein − Barr virus infection, disease course, clinical and laboratory parameters, immune system.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45718406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND THERAPEUTIC VALUE OF ADIPOKINES IN PATIENTS WITH CHRONIC KIDNEY DISEASE","authors":"Y. M. Fylenko","doi":"10.37436/2308-5274-2020-3-1","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-3-1","url":null,"abstract":"This review is devoted to the analysis of the role of adipokines in formation of pathological changes in renal function and structure. The patients with chronic kidney disease have a high risk of cardiovascular disease. Currently, the role of systemic hormonal and metabolic factors in the pathogenesis of the kidneys is growing. A promising area of pathogenetic prevention and treatment of kidney disease is an interdisciplinary approach, whereat the adipokine imbalance is of particular interest. Adipose tissue and its messengers, adipokines, are known to be highly associated with kidney disease. Adipocytes are metabolically active cells, producing the signaling lipids, metabolites and protein factors, i.e. adipokines. The interaction of adipose tissue with the kidney is called the adipose kidney axis, being important for the normal functioning of the body, as well as its response to an injury. It has a strong therapeutic potential in respect of the growing rates of chronic kidney disease. Adipocyte hypertrophy is often accompanied by the development of tissue fibrosis, hypoxia, and secretion of pro−inflammatory cytokines (such as tumor necrosis factor or interleukin, which triggers the cell inflammation). Dysfunction of adipose tissue contributes to the development of cardiovascular disease at the local and systemic levels. Thus, for the early diagnosis of chronic kidney disease into the diagnostic program, in addition to the generally accepted indices, the determination of adipokines: for example, serum leptin, adiponectin, omentin, visfatin, microalbuminuria, blood lipid spectrum, intrarenal and functional status of the kidneys with the assessment of functional renal reserve is recommended to be included. Early detection of the disease, new approaches to its diagnosis and treatment can help in reducing the risk of a high incidence and mortality from renal disease.\u0000\u0000Key words: chronic kidney disease, nephropathy, adipokines, leptin, resistin, adiponectin, visfatin, omentin.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2020-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}