Journal of Investigative Dermatology Symposium Proceedings最新文献_第8页

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/S1087-0024(17)30021-7

引用次数: 0

From Bench to Bedside: The Hampton University Skin of Color Research Institute 2015 Skin of Color Symposium 从长凳到床边:汉普顿大学肤色研究所2015年肤色研讨会

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.001

Clinton W. Enos , Valerie M. Harvey

{"title":"From Bench to Bedside: The Hampton University Skin of Color Research Institute 2015 Skin of Color Symposium","authors":"Clinton W. Enos , Valerie M. Harvey","doi":"10.1016/j.jisp.2016.10.001","DOIUrl":"10.1016/j.jisp.2016.10.001","url":null,"abstract":"<div><p>The Hampton University Skin of Color Research Institute <em>Skin of Color Symposium 2015: From Bench to Bedside</em> was held in Williamsburg, Virginia at the Williamsburg Lodge, November 13–15, 2015. The conference was designed to promote, develop, and advance the education, knowledge, and research of cutaneous disorders disproportionately affecting people of racial and ethnic minority groups. Centered on the theme of “From Bench to Bedside”, the symposium provided a program featuring a diverse panel of nationally recognized physician-scientists, basic scientists, and clinicians who updated attendees on the latest research advances across multiple relevant disciplines, including public health, basic science, and the clinical diagnosis and management of select complex and rare dermatologic conditions. Featured sessions included recent advances in vitiligo, disorders of hyperpigmentation, keloids, central centripetal cicatricial alopecia, and cutaneous lupus.</p><p>We expect that the scientific sessions and interactive panel discussions, combined with the synergistic environment that has characterized this conference, will spur the formation of new collaborations and scientific discovery and, ultimately, will culminate in novel treatments for dermatologic disorders disproportionately affecting individuals with skin of color.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S29-S30"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35381937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

009 Treatment of Melasma with Oral Tranexamic Acid 009口服氨甲环酸治疗黄褐斑

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.011

Cynthia O. Anyanwu, Eunice Del Rosario, Amit G. Pandya

引用次数: 1

007 Impotence: a rare methotrexate side effect 007阳痿：罕见的甲氨蝶呤副作用

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.009

Lauren Barnes, Lauren Hartman, Tara Buehler-Bota, Karina Parr

引用次数: 0

Genomic Investigation of Lupus in the Skin 皮肤红斑狼疮的基因组研究

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.09.002

Animesh A. Sinha , Rama Dey-Rao

{"title":"Genomic Investigation of Lupus in the Skin","authors":"Animesh A. Sinha , Rama Dey-Rao","doi":"10.1016/j.jisp.2016.09.002","DOIUrl":"10.1016/j.jisp.2016.09.002","url":null,"abstract":"<div><p>Lupus erythematosus is a chronic autoimmune disorder with a protean clinical manifestation affecting virtually every organ including skin, with tremendous variation between patients. This makes it vital to stratify patients on a molecular basis. We used gene microarray technology for large-scale screening combined with bioinformatics to investigate global patterns of gene expression in cutaneous lupus erythematosus to allow further insights into disease heterogeneity. Unbiased clustering exposed a clear separation between cutaneous lupus erythematosus skin and blood samples. Pathway-based analyses of the differentially expressed genes from sample groups within skin and blood showed prominent apoptosis and interferon response signals. Given their well-known role in systemic lupus, the two processes are potentially critical to cutaneous lupus erythematosus as well. We found both coincident and distinct features between systemic lupus and cutaneous lupus erythematosus, as well as several pathways and processes that are specific to the cutaneous disease that offer potential therapeutic choices in the future. Finally, we identified shared cutaneous lupus erythematosus-skin and -blood transcriptional “hot spots” located on the genome that include several differentially expressed genes previously associated with the systemic disease. The differentially expressed genes included in the hot spots with no systemic lupus associations can potentially be targeted in future studies aimed at identifying risk genes related to cutaneous disease.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S75-S80"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo 补充调节性T细胞以阻止白癜风中的色素脱失

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.023

I. Caroline Le Poole , Shikhar Mehrotra

{"title":"Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo","authors":"I. Caroline Le Poole , Shikhar Mehrotra","doi":"10.1016/j.jisp.2016.10.023","DOIUrl":"10.1016/j.jisp.2016.10.023","url":null,"abstract":"<div><p>Vitiligo is a cutaneous autoimmune disease, especially devastating to patients with darker skin tones because of the contrast between unaffected and lesional skin. We studied immune cells infiltrating vitiligo skin and found very few regulatory T cells (Tregs). Vitiligo was not associated with a reduced frequency or function of circulating Tregs. To manipulate Treg function, we used mouse models expressing melanocyte-reactive TCRs, following changes in pelage color. We also isolated splenocytes to measure Treg function and evaluated cutaneous Treg abundance. Even small numbers of Tregs transferred into depigmenting mice could effectively interfere with depigmentation. The same holds true for treatment with rapamycin, readily translatable for use in human patients; such treatment may be well tolerated. Because vitiligo skin is relatively devoid of cells that produce the chemokine CCL22, whereas circulating Tregs express normal levels of its receptor CCR4, we overexpressed Ccl22 in the skin of vitiligo-prone mice to assess the resulting levels of depigmentation. Markedly reduced depigmentation was accompanied by Treg infiltration to the skin. With several options available to support a healthy balance between Tregs and effector T cells, the next challenge will be to render such treatment antigen specific and avoid general immunosuppression.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S38-S45"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.10.023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35381940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

011 Central Centrifugal Cicatricial Alopecia (CCCA) Under the Scope: Histological Similarities between CCCA and Lichen Planopilaris 011范围内的中央离心性瘢痕性脱发（CCCA）：CCCA与扁平苔藓的组织学相似性

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.013

Ariana Eginli, Erin Landis, Amy McMichael

引用次数: 0

Current Understanding of the Genetic Causes of Keloid Formation 目前对瘢痕疙瘩形成的遗传原因的认识

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.10.024

Donald A. Glass II

引用次数: 79

Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action 中央离心式瘢痕性脱发:新的见解和行动呼吁

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2017.01.004

Ncoza C. Dlova , Kimberly S. Salkey , Valerie D. Callender , Amy J. McMichael

引用次数: 34

Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus 阿奎宁抑制皮肌炎和红斑狼疮中肿瘤坏死因子-α和IFN-α的作用

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI: 10.1016/j.jisp.2016.11.001

Paul Alves , Muhammad M. Bashir , Maria Wysocka , Majid Zeidi , Rui Feng , Victoria P. Werth

{"title":"Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus","authors":"Paul Alves , Muhammad M. Bashir , Maria Wysocka , Majid Zeidi , Rui Feng , Victoria P. Werth","doi":"10.1016/j.jisp.2016.11.001","DOIUrl":"10.1016/j.jisp.2016.11.001","url":null,"abstract":"<div><p>Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To quantify the effects of HCQ versus QC in suppressing secretion of tumor necrosis factor-α (TNF-α) and IFN-α from the peripheral blood mononuclear cells of DM and CLE patients, lipopolysaccharide-stimulated and control peripheral blood mononuclear cells from DM and CLE patients and control subjects were analyzed for the effect of HCQ and QC on TNF-α and IFN-α production using ELISA testing. Flow cytometry showed the effects of these therapies on intracellular TNF-α in myeloid dendritic cells and monocytes of DM patients and control subjects. QC significantly suppressed TNF-α relative to HCQ from unstimulated and lipopolysaccharide-stimulated peripheral blood mononuclear cells of DM and CLE patients (<em>P</em> < 0.0001). It suppressed IFN-α as significantly as HCQ from cytosine phosphodiester guanine–stimulated peripheral blood mononuclear cells of DM and CLE patients (<em>P</em> < 0.0001). Flow cytometry showed that QC significantly suppressed intracellular expression of TNF-α from the lipopolysaccharide-stimulated myeloid dendritic cells and monocytes of DM patients (<em>P</em>-values ≤ 0.0008). In conclusion, QC likely has a different mechanism of action than HCQ, given the broader inhibition of proinflammatory cytokines, including both TNF-α and IFN-α.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S57-S63"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26