目前对瘢痕疙瘩形成的遗传原因的认识

Q2 Medicine

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 DOI:10.1016/j.jisp.2016.10.024

Donald A. Glass II

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引用次数: 79

摘要

瘢痕疙瘩是皮肤伤口愈合的旺盛反应。几条线索的证据表明，瘢痕疙瘩是由遗传因素的影响。本文将通过家族遗传模式讨论我们目前对瘢痕形成的遗传影响的理解;流行率的种族差异;有瘢痕疙瘩的综合征;连锁分析、全基因组关联研究和混合图谱研究;转化生长因子β和p53变异研究;以及人类白细胞抗原多态性。

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Current Understanding of the Genetic Causes of Keloid Formation

Keloids are an exuberant response to cutaneous wound healing. Several lines of evidence suggest that keloid scarring is influenced by genetic factors. This review will discuss our current understanding of genetic influences on keloidal scarring via familial inheritance patterns; ethnic differences in prevalence; syndromes with keloid occurrence; linkage analysis, genome-wide association studies, and admixture mapping studies; transforming growth factor beta and p53 variant studies; and human leukocyte antigen polymorphisms.

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来源期刊

Journal of Investigative Dermatology Symposium Proceedings 医学-皮肤病学

自引率

0.00%

发文量

期刊介绍： Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.