Journal of Investigative Dermatology Symposium Proceedings最新文献_第9页

002 The NEW HAvUN Score: Risk-Stratification for Cellulitis from Non-cellulitic Conditions of the Lower Extremity 002新的HAvUN评分：下肢非蜂窝组织炎的风险分层

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.004

Ezaldein Harib ∗, Waldman Abigail, Grunseich Karl, Jubanyik Karen

引用次数: 0

018 IMPACT OF COSMETIC PRODUCTS WITH HYDROQUINONE ON THE MEASURE OF CAPILLARY BLOOD SUGAR IN DIABETIC SENEGALESE WOMEN: CASE CONTROL STUDY 018含对苯二酚的化妆品对塞内加尔糖尿病妇女毛细血管血糖测定的影响：病例对照研究

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.020

F. Ly , C.C. Ebelle , K. Sylla , A. Sarr , A. Diop , M.T. Ndiaye Diop , N. Sall Diop , A. Diouf , H. Hakim , E.A. Sy , A. Kane

引用次数: 0

Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus 阿奎宁抑制皮肌炎和红斑狼疮中肿瘤坏死因子-α和IFN-α的作用

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.11.001

Paul Alves , Muhammad M. Bashir , Maria Wysocka , Majid Zeidi , Rui Feng , Victoria P. Werth

{"title":"Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus","authors":"Paul Alves , Muhammad M. Bashir , Maria Wysocka , Majid Zeidi , Rui Feng , Victoria P. Werth","doi":"10.1016/j.jisp.2016.11.001","DOIUrl":"10.1016/j.jisp.2016.11.001","url":null,"abstract":"<div><p>Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To quantify the effects of HCQ versus QC in suppressing secretion of tumor necrosis factor-α (TNF-α) and IFN-α from the peripheral blood mononuclear cells of DM and CLE patients, lipopolysaccharide-stimulated and control peripheral blood mononuclear cells from DM and CLE patients and control subjects were analyzed for the effect of HCQ and QC on TNF-α and IFN-α production using ELISA testing. Flow cytometry showed the effects of these therapies on intracellular TNF-α in myeloid dendritic cells and monocytes of DM patients and control subjects. QC significantly suppressed TNF-α relative to HCQ from unstimulated and lipopolysaccharide-stimulated peripheral blood mononuclear cells of DM and CLE patients (<em>P</em> < 0.0001). It suppressed IFN-α as significantly as HCQ from cytosine phosphodiester guanine–stimulated peripheral blood mononuclear cells of DM and CLE patients (<em>P</em> < 0.0001). Flow cytometry showed that QC significantly suppressed intracellular expression of TNF-α from the lipopolysaccharide-stimulated myeloid dendritic cells and monocytes of DM patients (<em>P</em>-values ≤ 0.0008). In conclusion, QC likely has a different mechanism of action than HCQ, given the broader inhibition of proinflammatory cytokines, including both TNF-α and IFN-α.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S57-S63"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

003 Ultraviolet Radiation-Induced Risk of Cutaneous Melanoma in Hispanics 003紫外线辐射诱发西班牙裔皮肤黑色素瘤的风险

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.005

Amrita Dasgupta , Meena Katdare ∗

引用次数: 0

Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes 前列腺素D2利用ROS信号成分促进角化细胞中睾酮的产生

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2017.01.003

Alon Mantel , J. Tyson McDonald , Kennedy Goldsborough , Valerie M. Harvey , Joanne Chan

{"title":"Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes","authors":"Alon Mantel , J. Tyson McDonald , Kennedy Goldsborough , Valerie M. Harvey , Joanne Chan","doi":"10.1016/j.jisp.2017.01.003","DOIUrl":"10.1016/j.jisp.2017.01.003","url":null,"abstract":"<div><p>Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"18 2","pages":"Pages S81-S84"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2017.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35380891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

017 Lichen Planus Colocalized with Vitiligo: Coincidence? 017扁平苔藓与白癜风合并：巧合？

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.019

Kristyn Beck, Lauren Barnes, Valerie Harvey

引用次数: 0

019 Tinea versicolor on black skin: clinical aspects about 103 patients in Dakar Senegal 019黑色皮肤上的花斑癣：塞内加尔达喀尔103名患者的临床情况

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.021

F. Ly , S. Mjahed , P. Diousse , K. Diongue , A. Diop , M.T. Ndiaye Diop , A. Diouf Kebe , H. Hakim , F. Fall , T. Dieng , A. Kane

引用次数: 1

Title Page/Disclaimer Statement 标题页/免责声明

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/S1087-0024(17)30022-9

引用次数: 0

008 Vitamin D status in phototype VI Senegalese patients with systemic lupus erythematosus (SLE): A case control study 008系统性红斑狼疮（SLE）光照VI型塞内加尔患者的维生素D状况：一项病例对照研究

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.010

F. Ly , H. Mansouri , S. Ndongo , H. Hakim , M.T. Diop Ndiaye , A. Diop , A. Diouf , F. Fall , N. Sall Diop

引用次数: 0

013 Prostaglandin D2 enhances testosterone metabolism by ROS-mediated altered redox potential in keratinocytes 013前列腺素D2通过ROS介导的角质形成细胞氧化还原电位的改变增强睾酮代谢

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2017-10-01 Epub Date: 2017-09-20 DOI: 10.1016/j.jisp.2016.10.015

Alon Mantel , John McDonald , Alice Pentland , Meena Katdare , Joanne Chan

引用次数: 0