Journal of Nutrigenetics and Nutrigenomics最新文献

{"title":"Future directions in nutrition research.","authors":"Jing X Kang","doi":"10.1159/000357910","DOIUrl":"https://doi.org/10.1159/000357910","url":null,"abstract":"Although nutrition is generally regarded as important for human health, it is rarely utilized as a key solution for the chronic diseases that have become a global burden. Is nutrition an ineffective strategy for disease management, or is it that we have yet to demonstrate the practical use of nutrition? To date, the persuasiveness of nutrition research has been hindered by inconsistent findings, contradictory messages, and unproven effectiveness. As a result, nutrition is still not taken quite seriously by the public, and its applications have not been sufficiently implemented in clinical settings. In order to change the mainstream perception of nutrition, we must reconsider our research approach as we move forward in the field. Let us ask ourselves: what can nutrition do for today’s health epidemics? The main challenge of nutrition research lies in its complexity and confounding factors. Unlike pharmaceutical research and drug trials, many factors in our diet and lifestyle can affect the outcomes of nutritional studies, making it difficult to interpret the findings. Large, long-term studies in humans are usually viewed as the gold standard in medical research, and their results often attract media attention and have a greater influence on regulatory policies. However, these types of nutritional studies are especially prone to the confounding factors introduced by the difficulties of long-term compliance and the unavoidable changes in lifestyle over time, such as dietary and behavioral choices. In addition, current nutritional studies inherently suffer from variations in the standards for test materials (e.g., nutritional supplement ingredients), as well as in methodology, reporting, baseline evaluation, and outcome measures. Many studies have also failed to take genetic variation in study subjects into account, even though it is now well-known that this significantly affects individuals’ response to dietary factors. From a translational research standpoint, nutritional findings cannot be readily implemented in clinical settings due to the lack of established biomarkers for evaluating the efficacy of nutritional interventions. In this context, it is essential that we develop new research approaches to demonstrate the potential of nutrition in healthcare. It is my opinion that nutrition research should devote greater effort towards interventional nutrition, in addition to its traditional emphasis on epidemiological and population nutrition. In other words, we should develop nutritional interventions as solutions for the health problems we are facing worldwide. I propose the use of a pathway-based, biomarkerguided, and personalized approach to create integrated metabolic interventions. Published online: January 16, 2014","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 4-5","pages":"I-III"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000357910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32039196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bellagio report on healthy agriculture, healthy nutrition, healthy people.","authors":"Artemis P Simopoulos, Peter G Bourne, Ole Faergeman","doi":"10.1159/000346833","DOIUrl":"https://doi.org/10.1159/000346833","url":null,"abstract":"The Bellagio Report on Healthy Agriculture, Healthy Nutrition, Healthy People is the result of the meeting held at the Rockefeller Foundation Bellagio Center in Lake Como, Italy, 29 October–2 November 2012. The meeting was science-based but policy-oriented. The role and amount of healthy and unhealthy fats, with attention to the relative content of omega-3 and omega-6 fatty acids, sugar, and particularly fructose in foods that may underlie the epidemics of non-communicable diseases (NCD’s) worldwide were extensively discussed. The report concludes that sugar consumption, especially in the form of high energy fructose in soft drinks, poses a major and insidious health threat, especially in children, and most diets, although with regional differences, are deficient in omega-3 fatty acids and too high in omega-6 fatty acids. Gene-nutrient interactions in growth and development and in disease prevention are fundamental to health, therefore regional Centers on Genetics, Nutrition and Fitness for Health should be established worldwide. Heads of state and government must elevate, as a matter of urgency, Nutrition as a national priority, that access to a healthy diet should be considered a human right and that the lead responsibility for Nutrition should be placed in Ministries of Health rather than agriculture so that the health requirements drive agricultural priorities, not vice versa. Nutritional security should be given the same priority as food security.","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 1","pages":"34-42"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000346833","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31378085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging role of MicroRNAs in the regulation of gene expression by nutrients.","authors":"Laura García-Segura,&nbsp;Martha Pérez-Andrade,&nbsp;Juan Miranda-Ríos","doi":"10.1159/000345826","DOIUrl":"https://doi.org/10.1159/000345826","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are a class of evolutionarily conserved, small non-coding RNAs of 19-24 nucleotides in length that regulate gene expression mostly at the posttranscriptional level. They are known to be involved in the control of different processes such as cell cycling, programmed cell death, cell differentiation, tumor development, metastasis, and sensing of nutrient stress. This review summarizes the evidence regarding the changes in miRNA expression that are caused by diets with a deficiency or augmented intake of nutrients such as amino acids, carbohydrates, fatty acids, vitamins, and phytochemicals. As diet is known to influence the expression of miRNAs, miRNA profiling has the potential to be useful in the assessment of nutritional status in dietary intervention studies. Additionally, as it can change miRNA expression, diet may be used as a therapeutic agent to treat many different diseases. Also, we explored here some ideas on therapeutics based on the manipulation of miRNA expression levels for dietary-derived diseases as well as the putative effect of food-derived miRNAs on host gene expression.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 1","pages":"16-31"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000345826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31269019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual saturated and monounsaturated fatty acids trigger distinct transcriptional networks in differentiated 3T3-L1 preadipocytes.","authors":"Brittany Shaw,&nbsp;Samuel Lambert,&nbsp;Monica H T Wong,&nbsp;Jessica C Ralston,&nbsp;Carolina Stryjecki,&nbsp;David M Mutch","doi":"10.1159/000345913","DOIUrl":"https://doi.org/10.1159/000345913","url":null,"abstract":"<p><strong>Background/aims: </strong>Saturated fatty acids (SFA) are widely thought to induce inflammation in adipose tissue (AT), while monounsaturated fatty acids (MUFA) are purported to have the opposite effect; however, it is unclear if individual SFA and MUFA behave similarly. Our goal was to examine adipocyte transcriptional networks regulated by individual SFA (palmitic acid, PA; stearic acid, SA) and MUFA (palmitoleic acid, PMA; oleic acid, OA).</p><p><strong>Methods: </strong>Differentiated preadipocytes were treated with either 250 µM PA, SA, PMA, or OA for 48 h. Gene expression was analyzed using microarrays and real-time RT-PCR. Data were compared with those of a previous study reporting AT gene expression in humans following the consumption of SFA- or MUFA-enriched diets.</p><p><strong>Results: </strong>Individual fatty acid treatments had significant effects on adipocyte gene expression. Functional analyses revealed that PA induced the TLR signalling pathway, while PMA had the opposite effect. SA and OA had similar effects, with increases in key metabolic pathways including mTOR and PPAR signalling and a reduction in TLR signalling. Ccl5 was validated as a candidate gene that may mediate the differential inflammatory effects of SFA and MUFA in AT.</p><p><strong>Conclusions: </strong>Individual SFA and MUFA trigger distinct transcriptional responses in differentiated preadipocytes, with inflammatory and metabolic pathways particularly sensitive to these fatty acids.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000345913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31223666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression profiling in peripheral white blood cells in response to the intake of food with different glycemic index using a DNA microarray.","authors":"Yuka Kawakami,&nbsp;Hisami Yamanaka-Okumura,&nbsp;Masae Sakuma,&nbsp;Yuka Mori,&nbsp;Chisaki Adachi,&nbsp;Yukie Matsumoto,&nbsp;Tadatoshi Sato,&nbsp;Hironori Yamamoto,&nbsp;Yutaka Taketani,&nbsp;Takafumi Katayama,&nbsp;Eiji Takeda","doi":"10.1159/000354247","DOIUrl":"https://doi.org/10.1159/000354247","url":null,"abstract":"<p><strong>Background/aims: </strong>Transcriptomics technology in human nutrition intervention studies would allow for genome-wide screening of the effects of nutrients. We observed the time course of gene expression changes in peripheral white blood cells (WBC) to elucidate the metabolic changes in the postprandial state that are a reflection and a marker of whole body metabolic changes.</p><p><strong>Methods: </strong>In a randomized crossover study, 7 healthy subjects consumed test meals of glucose (GL), white rice (WR) and rolled barley (BAR), each containing 75 g of available carbohydrate, and water (WAT). Blood glucose, insulin and nonesterified fatty acid concentrations, as well as the subjective levels of fullness and hunger were measured. Microarray analysis of the WBC and the real-time PCR were examined during 360 min after the intake of the test meals.</p><p><strong>Results: </strong>The number of genes that changed more than 1.5-fold and the expression patterns in the time course were different between the GL, the WR and the BAR groups. Several genes involved in glycolysis and fatty acid β-oxidation were markedly changed after the intake of the GL, the WR and the BAR; however, these genes did not change at any time point in the WAT.</p><p><strong>Conclusions: </strong>Gene expression profiling in the WBC can reflect food-related metabolic changes, even in the postprandial state.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 3","pages":"154-68"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000354247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31710131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variation in the vitamin D receptor, plasma 25-hydroxyvitamin D, and biomarkers of cardiometabolic disease in Caucasian young adults.","authors":"Bibiana García-Bailo,&nbsp;Joseph Jamnik,&nbsp;Laura A Da Costa,&nbsp;Alaa Badawi,&nbsp;Ahmed El-Sohemy","doi":"10.1159/000354729","DOIUrl":"https://doi.org/10.1159/000354729","url":null,"abstract":"<p><strong>Background/aims: </strong>Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk. However, studies of 25-hydroxyvitamin D [25(OH)D] and cardiometabolic disease are inconsistent. Inconsistencies may result from unaccounted for interactions between VDR genetic variants and 25(OH)D. We examined the effect of 25(OH)D on the association between VDR variants and cardiometabolic disease biomarkers.</p><p><strong>Methods: </strong>The relationship between 25(OH)D, 24 VDR variants, and 10 cardiometabolic biomarkers was examined in 488 Caucasians aged 20-29 years. Covariate-adjusted general linear models were used to examine the interaction effect of 25(OH)D × VDR on each biomarker. When interactions were significant (p < 0.05), relationships were further examined with analysis of covariance, stratified by tertiles of 25(OH)D and adjusted for multiple comparisons.</p><p><strong>Results: </strong>In the lowest tertile of 25(OH)D, major allele homozygotes for rs3819545 had higher insulin and HOMA-IR than minor allele carriers (p ≤ 0.002). Fasting insulin and HOMA-IR were lower in the highest than the lowest tertile of 25(OH)D among major allele homozygotes (p < 0.0001), but minor allele carriers had similar levels regardless of vitamin D status.</p><p><strong>Conclusions: </strong>We identified 25(OH)D-dependent associations between rs3819545 and glycemic dysregulation biomarkers. Major allele homozygotes with low vitamin D status may be at increased risk of insulin resistance.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 4-5","pages":"256-67"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000354729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31770370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Techniques of DNA methylation analysis with nutritional applications.","authors":"Maria L Mansego,&nbsp;Fermín I Milagro,&nbsp;Javier Campión,&nbsp;J Alfredo Martínez","doi":"10.1159/000350749","DOIUrl":"https://doi.org/10.1159/000350749","url":null,"abstract":"<p><p>Epigenetic mechanisms are likely to play an important role in the regulation of metabolism and body weight through gene-nutrient interactions. This review focuses on methods for analyzing one of the most important epigenetic mechanisms, DNA methylation, from single nucleotide to global measurement depending on the study goal and scope. In addition, this study highlights the major principles and methods for DNA methylation analysis with emphasis on nutritional applications. Recent developments concerning epigenetic technologies are showing promising results of DNA methylation levels at a single-base resolution and provide the ability to differentiate between 5-methylcytosine and other nucleotide modifications such as 5-hydroxymethylcytosine. A large number of methods can be used for the analysis of DNA methylation such as pyrosequencing™, primer extension or real-time PCR methods, and genome-wide DNA methylation profile from microarray or sequencing-based methods. Researchers should conduct a preliminary analysis focused on the type of validation and information provided by each technique in order to select the best method fitting for their nutritional research interests. </p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 2","pages":"83-96"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31444202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rs9939609 polymorphism in the FTO gene is associated with fat and fiber intakes in patients with type 2 diabetes.","authors":"Thais Steemburgo,&nbsp;Mirela J Azevedo,&nbsp;Jorge L Gross,&nbsp;Fermin I Milagro,&nbsp;Javier Campión,&nbsp;Jose Alfredo Martínez","doi":"10.1159/000350741","DOIUrl":"https://doi.org/10.1159/000350741","url":null,"abstract":"<p><strong>Background/aims: </strong>The common polymorphism in the FTO gene (rs9939609) has been associated with obesity, type 2 diabetes, and appetite regulation. The aim of this study was to evaluate possible associations of FTO rs9939609 with dietary factors in patients with type 2 diabetes.</p><p><strong>Methods: </strong>This was a cross-sectional study of 236 patients with type 2 diabetes (age 60.0 ± 10.3 years; diabetes duration 12.7 ± 8.2 years; 53.4% females) who were genotyped for FTO rs9939609. Patients underwent clinical and laboratory evaluations and 3-day weighed diet records. Data on dietary intake were categorized as high or low, based on median values.</p><p><strong>Results: </strong>The AA genotype in the FTO gene was positively associated with high fat (>34% energy; OR = 2.17; 95% CI 1.02-4.63) and low fiber intakes (<16 g/day; OR = 2.42; 95% CI 1.05-5.57), adjusted for gender, BMI, total energy intake, systolic blood pressure, and HbA1c. When gender was taken into account, AA females had higher fat (37.4 ± 5.3 vs. 32.6 ± 7.5 and 32.2 ± 6.2% energy; p = 0.005) and lower fiber intakes (12.4 ± 4.4 vs. 15.1 ± 6.3 and 16.7 ± 5.6 g/day; p = 0.023) than patients with TT and AT genotypes. Multiple logistic regression models confirmed female associations for high fat (OR = 9.73; 95% CI 2.12-44.66) and low fiber intakes (OR = 4.28; 95% CI 1.14-16.06; p < 0.05 for all models).</p><p><strong>Conclusions: </strong>Patients with type 2 diabetes, who were carriers of the AA genotype of the FTO rs9939609, had increased fat and decreased fiber consumption, independently of BMI.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"6 2","pages":"97-106"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000350741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31536948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citrus limonin lacks the antichemotherapeutic effect in human models of breast cancer.","authors":"Siva Somasundaram,&nbsp;Janet Price,&nbsp;Karen Pearce,&nbsp;Ryan Shuck,&nbsp;G K Jayaprakasha,&nbsp;Bhimanagouda Patil","doi":"10.1159/000336921","DOIUrl":"https://doi.org/10.1159/000336921","url":null,"abstract":"<p><strong>Background/aims: </strong>Chemicals that interfere with reactive oxygen species metabolism can act as potential candidates for the treatment of cancer. Some of the glucosides of citrus limonin inhibit the endogenously generated reactive oxygen species. The aim is to study the interactions of limonin with chemotherapy.</p><p><strong>Methods: </strong>Breast cancer cell lines MCF-7 (p53 wild type) and MDA-MB-231 (p53 mutant) as well as the nontumorigenic epithelial cell line MCF-10 were used to screen the effect of limonin at 1-, 5- and 10-µM concentrations with camptothecin for apoptosis and NFĸB, p38 and ERK-MAPK signaling kinase assays. The effect of cyclophosphamide and limonin on MDA MB 231 xenografts was also studied.</p><p><strong>Results: </strong>Our results indicate that limonin did not inhibit camptothecin-induced apoptosis in human breast cancer cells in vitro through noninterference of camptothecin-induced phosphorylation of p38 MAPK and ERK-MAPK. Using an in vivo model of human breast cancer, limonin in combination with cyclophosphamide was not found to inhibit the cyclophosphamide-induced tumor regression through a reduced mitotic index of tumor xenograft cells when compared to treatment with cyclophosphamide alone.</p><p><strong>Conclusion: </strong>Both in vitro and in vivo results suggest that limonin could be beneficial for breast cancer patients undergoing chemotherapy.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":" ","pages":"106-14"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000336921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30845966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exonic peroxisome proliferator-activated receptor-γ coactivator-1α variation may mediate the resting energy expenditure through a potential regulatory role on important gene expression in this pathway.","authors":"Khadijeh Mirzaei,&nbsp;Arash Hossein-nezhad,&nbsp;Solaleh Emamgholipour,&nbsp;Hasti Ansar,&nbsp;Mahtab Khosrofar,&nbsp;Ali Tootee,&nbsp;Soudabeh Alatab","doi":"10.1159/000337352","DOIUrl":"https://doi.org/10.1159/000337352","url":null,"abstract":"<p><strong>Background/aims: </strong>We studied peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) gene variations at the 23815227-23815706 positions and examined their possible correlation with obesity-related conditions and resting energy expenditure (REE). We investigated the expression of PPARGC1A, mitogen-activated protein kinase (MAPK) and uncoupling protein 2 (UCP2), which play key roles in cellular energy expenditure, in a cellular model consisting of peripheral blood mononuclear cells, and compared them with various genotypes of the PPARGC1A gene.</p><p><strong>Methods: </strong>In total, 100 normal-weight and 129 obese subjects participated in the current study. All subjects were assessed for REE and body composition. We sequenced the PPARGC1A gene. Real-time PCR was used for determining the PPARGC1A, MAPK, and UCP2 gene expression.</p><p><strong>Results: </strong>There were significant differences in terms of body mass index, fat mass, low-density lipoprotein, insulin levels, REE/kg body weight, and REE/lean body mass among rs17574213 genotypes. There were significant differences in total cholesterol and low-density lipoprotein cholesterol levels among the various genotypes of Gly482Ser (rs8192678) and rs3755863. The relative PPARGC1A, MAPK, and UCP2 gene expressions had similar trends in the two studied SNPs, and the expression level of these genes was lowest in the TT genotype of Gly482Ser and rs3755863 and highest in the CC genotype of Gly482Ser and rs3755863.</p><p><strong>Conclusions: </strong>Our findings suggest that PPARGC1A variations may influence PPARGC1A expression and the coordinating regulators of downstream targets in energy homeostasis. Further study is needed to shed some light on this process.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":" ","pages":"59-71"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000337352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30658527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}