Ocular Surface最新文献

{"title":"Systems biology of dry eye: Unraveling molecular mechanisms through multi-omics integration","authors":"Zhirui Zhang ,&nbsp;Changxing Liu ,&nbsp;Lingying Zhao ,&nbsp;Jing Yao","doi":"10.1016/j.jtos.2024.12.010","DOIUrl":"10.1016/j.jtos.2024.12.010","url":null,"abstract":"<div><div>Dry eye disease (DED) is a multifactorial condition with complex and incompletely understood molecular mechanisms. Advances in multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and microbiomics, have provided new insights into the pathophysiology of DED. Genomic analyses have identified key genetic variants linked to immune regulation and lacrimal gland function. Transcriptomic studies reveal upregulated inflammatory pathways in ocular surface tissues, implicating these as core drivers of chronic inflammation. Proteomic research highlights significant alterations in tear protein composition, especially proteins involved in inflammation and tissue repair. Metabolomics studies focus on disrupted lipid metabolism and oxidative stress, which are crucial in maintaining tear film stability. Furthermore, microbiome research has demonstrated reduced microbial diversity and increased pathogenic bacteria, exacerbating inflammatory responses. The integration of multi-omics data allows for the identification of novel biomarkers and therapeutic targets, enabling precision diagnostics and personalized treatments. Therefore, this review highlights the critical importance of multi-omics approaches in deepening our understanding of DED's complex molecular mechanisms and their potential to transform clinical management and therapeutic innovations in this challenging field.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 25-40"},"PeriodicalIF":5.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice patterns in the management of dry eye disease: A TFOS international survey 2023-24","authors":"James S. Wolffsohn ,&nbsp;David A. Semp ,&nbsp;Debarun Dutta ,&nbsp;Lyndon Jones ,&nbsp;Jennifer P. Craig ,&nbsp;the TFOS ambassadors","doi":"10.1016/j.jtos.2024.12.008","DOIUrl":"10.1016/j.jtos.2024.12.008","url":null,"abstract":"<div><h3>Aims</h3><div>To understand current clinical management of dry eye disease (DED), based on its perceived severity and subtype, by practitioners across the world.</div></div><div><h3>Methods</h3><div>The content of the anonymous survey was chosen to reflect the DED management strategies reported by the Tear Film and Ocular Surface Society (TFOS) second Dry Eye Workshop (DEWS II). Questions were designed to ascertain practitioner treatment choice, depending on the subtype and severity of DED. It was first created in English and then translated/back-translated into 14 languages for online completion.</div></div><div><h3>Results</h3><div>Completed surveys were received from 905 eye care practitioners (52 % optometrists and 42 % ophthalmologists) from across the globe. Many treatment strategies for DED were observed to be utilised by respondents, independent of severity and subtype, the most common being advice (82 %), low (82 %) and high (81 %) viscosity unpreserved lubricants and lid wipes/scrubs (79 %). Several treatments were prescribed across all severity levels (scaled from 1 mild to 10 severe), such as advice (median 4.5, range 4.8), artificial tears (median 5.1, range 4.6) and nutritional supplements (median 5.3, range 4.2). Others were prescribed more frequently with increasing disease severity, for instance, biologics (median 8.2, range 2.8) and surgical approaches (median 8.1, range 2.2). While a similar number of practitioners reported prescribing advice, artificial tears and anti-inflammatories regardless of DED subtype, the commonly reported approaches for aqueous deficient DED were punctal occlusion, therapeutic contact lenses and secretagogues, while the use of oral essential fatty acids, topical lipid-containing products, lid hygiene and lid warming were the preferred management choices for evaporative DED.</div></div><div><h3>Conclusions</h3><div>There remains great variability in clinical approaches to DED management and until research-evidence definitively informs improved guidance, data from this survey may be useful for clinicians to benchmark their practice.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 164-172"},"PeriodicalIF":5.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological insights into Childhood vernal keratoconjunctivitis in India: Unravelling clinical presentation and environmental influences – The EPIC VKC study – Fourth report of the ICMR EYE SEE study group","authors":"Yogita Gupta ,&nbsp;Radhika Tandon ,&nbsp;Praveen Vashisht ,&nbsp;Vivek Gupta ,&nbsp;Jyoti Bhuyan ,&nbsp;Sachchidanand Singh ,&nbsp;G.V.S. Murthy","doi":"10.1016/j.jtos.2024.12.007","DOIUrl":"10.1016/j.jtos.2024.12.007","url":null,"abstract":"<div><h3>Purpose</h3><div>To study the epidemiology and clinical presentation of allergic eye diseases (AEDs) and Vernal Keratoconjunctivitis (VKC).</div></div><div><h3>Methods</h3><div>A cross-sectional- cum-cohort study was conducted in rural and urban areas in different geographical locations (plains, hilly, high-altitude and coastal) in India. Children (5–15 years) were included, information on exposure to environmental factors gathered, participants screened for AED and VKC on torch light, followed by a comprehensive eye examination. Cases were compared with controls. Physical environmental parameters (ultraviolet A/UVA flux) were also measured.</div></div><div><h3>Results</h3><div>In all, 8231 participants were screened, 410 had AED (56 % males, mean age 13.7 ± 4.5 years) and 92 had VKC (66.3 % males, mean age 14.5 ± 4.4 years). The likelihood of AED was higher for ages 11–16 years (OR 1.51, <em>p</em> &lt; 0.03, urban areas (OR 1.44, p = 0.049), poor socioeconomic status (OR 1.5, <em>p</em> = 0.007), exposure to smoke of incense sticks (OR 1.88, <em>p</em> = 0.001), bright sunlight (OR 3.56, <em>p</em> &lt; 0.0001), dust/pollution exposure (OR 2.49, p = 0.001) and winter season (OR 2.73, <em>p</em> = 0.003). AEDs were less likely in coastal areas (OR 0.14, <em>p</em> &lt; 0.001). Exacerbating influences for VKC were windy weather (OR 4.35, <em>p</em> = 0.01) and spring season (OR 13.45, <em>p</em> = 0.001). VKC prevalence was higher in rural (69.6 %) than urban areas (30.4 %) (<em>p</em> = 0.03); with 11.9 % visual impairment. Palpebral VKC was the commonest type (82.6 %). Maximum UVA mean flux was noted in plains.</div></div><div><h3>Conclusion</h3><div>The prevalence of AEDs and VKC in the community is 4.98 (95%CI: 4.51–5.45)% and 1.11 (95%CI: 0.89–1.34)%, respectively. AEDs have association with pollution or dust exposure and winter season. Palpebral VKC is the commonest clinical form of VKC.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 41-55"},"PeriodicalIF":5.9,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe corneal manifestations of graft-versus-host disease: Experience of a tertiary referral center","authors":"A. Bourdin ,&nbsp;V. Gournay ,&nbsp;S. Doan ,&nbsp;P.H. Prata ,&nbsp;E. Kaphan ,&nbsp;D. Michonneau ,&nbsp;G. Socié ,&nbsp;R. Peffault de Latour ,&nbsp;E.E. Gabison","doi":"10.1016/j.jtos.2024.12.005","DOIUrl":"10.1016/j.jtos.2024.12.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). GVHD may affect several organs, including ocular manifestations, ranging from dry eye syndrome to sight-threatening corneal ulceration or perforation. Limited information is available about characteristics and treatments of ocular GVHD and its relation to general prognosis.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from 140 patients from a tertiary ophthalmological center and confronted it with systemic data from a national bone marrow transplantation database.</div></div><div><h3>Results</h3><div>Most patients were treated with artificial tears, vitamin A ointment, topical anti-inflammatory agents (mostly cyclosporin and steroid drops), autologous serum eye drops, scleral lenses and punctal silicone plugs. We identified a high proportion of severe ocular manifestations, such as corneal ulceration or perforation (33 patients, 23.6 %), occurring with a median of 39 months (interquartile range (IQR): 16–96) after transplantation. Overall survival did not differ in patients with severe to non-severe ocular GVHD (5-year mortality of 8 % without and 13 % with severe ocular involvement, p = 0.53 for survival curves comparisons). Multivariate analysis revealed that male patients and HLA mismatch allo-HSCT were independently associated with an increased risk of severe ocular manifestations. Moreover, a high proportion of complications occurred after non-steroidal anti-inflammatory drug (NSAID) treatments.</div></div><div><h3>Conclusions</h3><div>Patients with GVHD should therefore undergo close ophthalmological monitoring and they should not, in any case, be treated with local ocular NSAIDs, due to the severity of potential complications.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 19-24"},"PeriodicalIF":5.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of lysophosphatidic acid and its receptors in corneal nerve regeneration","authors":"Maryam Kheyrollah ,&nbsp;Nicola Brandt ,&nbsp;Anja U. Bräuer ,&nbsp;Stefan Schrader ,&nbsp;Sonja Mertsch","doi":"10.1016/j.jtos.2024.12.006","DOIUrl":"10.1016/j.jtos.2024.12.006","url":null,"abstract":"<div><div>The integrity of corneal nerves is critical for ocular surface health, and damages can lead to Neurotrophic Keratopathy (NK). Despite the regenerative abilities of the peripheral nerve system (PNS), corneal nerve regeneration is often incomplete, and the underlying mechanisms are poorly understood. This study aims to identify potential factors that can enhance corneal nerve regeneration for NK treatment, with a focus on Lysophosphatidic acid (LPA).</div><div>Thus, the effect of LPA and its underlying pathways in nerve regeneration is investigated in detail using <em>in vitro</em> mouse sensory neurons. To elucidate the impact of LPA as well as to reveal the responsible receptor, several functional assays as well as siRNA-based knock-down experiments were conducted. Additionally, possible changes in underlying pathways were investigated on mRNA levels.</div><div>LPA-treated neurons significantly reduced fiber growth. However, LPAR2 knockdown neurons (<em>Lpar2</em>-KD) following LPA treatment showed a significant increase in fiber length. Additionally, LPA-treated neurons demonstrated enhanced levels of <em>Lpar2</em> mRNA. On the other hand, nerve regeneration indicators such as <em>Ngf</em>, <em>Gap-43</em>, and <em>Cdc42</em>, along with LPA downstream signaling components like <em>Pi3k</em> and <em>Ras</em>, were elevated in <em>Lpar2</em>-KD neurons.</div><div>In conclusion, this study elucidates the inhibitory effects of LPA on fiber outgrowth of sensory neurons. Furthermore, LPAR2 was identified as the responsible receptor for the LPA effect. Thus, <em>Lpar2</em> knockdown might be a promising therapeutic approach to enhance neuronal regeneration in patients with NK.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 10-18"},"PeriodicalIF":5.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells","authors":"Luka Lapajne ,&nbsp;Monika Lakk ,&nbsp;Christopher N. Rudzitis ,&nbsp;Shruti Vemaraju ,&nbsp;Richard A. Lang ,&nbsp;Marko Hawlina ,&nbsp;David Križaj","doi":"10.1016/j.jtos.2024.12.002","DOIUrl":"10.1016/j.jtos.2024.12.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate intrinsic phototransduction in the corneal epithelium and its role in intracellular and inflammatory signaling.</div></div><div><h3>Methods</h3><div>Optical imaging in isolated corneal epithelial cells (CECs) and debrided epithelia was combined with molecular, biochemical, pharmacological assays and gene deletion studies to track UVB-induced calcium signaling and release of cytokines, chemokines and matrix remodeling enzymes. Results from wild type mouse CECs were compared to data obtained from <em>Opn5</em>^{<em>−/−</em>} and <em>Trpv4</em>^{<em>−/−</em>} cells.</div></div><div><h3>Results</h3><div>UVB stimuli and TRPV4 activity induced epithelial release of IL-1β, IL-17, matrix metalloproteinases MMP-3/MMP-9, and thymic stromal lymphopoietin (TSLP). UVB stimuli evoked [Ca²⁺]_i elevations in dissociated mouse CECs that were partially reduced by inhibition of TRPV4 channels, <em>Trpv4</em> knockdown and replacement of control saline with Ca²⁺-free saline. UVB-induced Ca²⁺ responses were significantly suppressed by OPN5 deletion and by inhibition of phospholipase C signaling, and responses were abrogated in cells with depleted intracellular Ca²⁺ stores.</div></div><div><h3>Conclusions</h3><div>Mammalian CECs are intrinsically and constitutively photosensitive. UVB photons are transduced by neuropsin, phospholipase C and CICR signaling, with mouse but not human CE transduction exhibiting a UVB-sensitive TRPV4 component. TRPV4 activity and UVB transduction are linked to cell-autonomous release of proinflammatory, matrix remodeling and nociceptive interleukins and MMPS. TRPV4-induced cytokine release may contribute to the pain induced by mechanical injury of the cornea and CEC photosensing may alert and protect the visual system from ultraviolet B (UVB) radiation -induced snow blindness, injury, vision loss and cancer.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"36 ","pages":"Pages 1-9"},"PeriodicalIF":5.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial","authors":"Laura E. Downie ,&nbsp;Jennifer P. Craig ,&nbsp;Fiona Stapleton ,&nbsp;Jacqueline Tan ,&nbsp;Lyndon W. Jones ,&nbsp;Alison Ng ,&nbsp;Mark Hinds ,&nbsp;Charles Bosworth ,&nbsp;Yair Alster","doi":"10.1016/j.jtos.2024.11.008","DOIUrl":"10.1016/j.jtos.2024.11.008","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the efficacy and safety of AZR-MD-001 (0.5 % and 1.0 %) ophthalmic ointment, relative to vehicle, over 3–6 months of treatment, in participants with meibomian gland dysfunction (MGD).</div></div><div><h3>Methods</h3><div>This was a Phase 2, randomized, vehicle-controlled, multicenter extension clinical trial. Eligible participants were adults with MGD (meibomian gland secretion score (MGS) ≤12 out of 15 glands) who discontinued all other dry eye or MGD treatments. Participants were randomized 1:1:1 to apply AZR-MD-001 1.0 %, 0.5 %, or vehicle to the lower eyelids, twice weekly. Key exploratory endpoints included the least-squared mean difference between groups in the change from baseline in clinical signs (meibomian gland yielding score; MGYLS) and symptoms (Ocular Surface Disease Index; OSDI), at clinic visits at Month 4.5 and 6, and safety measures from 36 months.</div></div><div><h3>Results</h3><div>Participants (66.5 % female) were randomized, at baseline, to AZR-MD-001 0.5 % (n = 82), 1.0 % (n = 83), or vehicle (n = 80). Statistically significant improvements, compared to vehicle, were observed at Month 6 in MGYLS for both AZR-MD-001 groups (0.5 % group: 1.9, 95 % CI 0.9 to 2.8, <em>P</em> = 0.002; 1.0 % group: 1.1, 95 % CI 0.2 to 2.1, <em>P</em> = 0.026), and in OSDI score for the 0.5 % group (−4.5, 95 % CI -8.0 to −0.9, <em>P</em> = 0.0135). The most common adverse events for AZR-MD-001 were application site pain, superficial punctate keratitis and eye pain; most were mild to moderate in severity, and decreased in incidence over time.</div></div><div><h3>Conclusions</h3><div>AZR-MD-001 (0.5 %) was efficacious in treating signs and symptoms of MGD over six months, with a lower observed incidence of new adverse events over time.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"35 ","pages":"Pages 15-24"},"PeriodicalIF":5.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy","authors":"Nefeli Eleni Kounatidou ,&nbsp;Evangelos Vitkos ,&nbsp;Sotiria Palioura","doi":"10.1016/j.jtos.2024.11.006","DOIUrl":"10.1016/j.jtos.2024.11.006","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this review is to explore the molecular foundations of ocular surface squamous neoplasia (OSSN), focusing on the genetic and epigenetic aspects. While current management strategies include surgical excision and medical therapies, the understanding of OSSN's molecular basis remains limited, hindering the development of targeted treatments.</div></div><div><h3>Methods</h3><div>A comprehensive MEDLINE search was conducted for literature published between January 1993 and October 2023. Only studies with original data on molecular, genetic, or epigenetic mechanisms, such as mutations, gene expression, and genetic predispositions were included. Articles were excluded if they focused solely on clinical management without addressing these factors, or if they were reviews, editorials, or opinion pieces.</div></div><div><h3>Results</h3><div>The search yielded a total of 108 articles, out of which 39 articles met the criteria for further analysis. Investigations into OSSN have identified key DNA mutations in the TP53, HGF, EGFR, TERT, and CDKN2A genes, indicating common oncogenic pathways shared with other squamous cell carcinomas (SCCs). Significant epigenetic changes were identified, including DNA methylation, histone modifications, and altered miRNA expression patterns. Epigenetic dysregulation of critical tumor suppressors and oncoproteins, further highlight the complex genetic landscape of OSSN.</div></div><div><h3>Conclusion</h3><div>The molecular alterations identified in OSSN not only enhance our understanding of its biology but also have potential as novel biomarkers for early detection, prognostic evaluation, and as therapeutic targets. The identification of genetic and epigenetic markers in OSSN signifies progress towards personalized medicine approaches. Further studies and collaborative efforts are essential to validate these molecular markers and translate them into clinical practice, potentially revolutionizing OSSN management and improving patient outcomes.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"35 ","pages":"Pages 1-14"},"PeriodicalIF":5.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study","authors":"Michael T.M. Wang,&nbsp;Barry Power,&nbsp;Ally L. Xue,&nbsp;Jennifer P. Craig","doi":"10.1016/j.jtos.2024.09.004","DOIUrl":"10.1016/j.jtos.2024.09.004","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"34 ","pages":"Pages 415-417"},"PeriodicalIF":5.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell death pathways in dry eye disease: Insights into ocular surface inflammation","authors":"Jiani Li ,&nbsp;Xiaorui Bao ,&nbsp;Shujia Guo ,&nbsp;Yuhan Huang ,&nbsp;Caihong Huang ,&nbsp;Jiaoyue Hu ,&nbsp;Zuguo Liu","doi":"10.1016/j.jtos.2024.11.004","DOIUrl":"10.1016/j.jtos.2024.11.004","url":null,"abstract":"<div><div>Dry eye disease (DED) is increasingly prevalent, with inflammation playing a crucial role in its pathogenesis. Severe cases of DED result in significant ocular discomfort and visual impairment due to damage and loss of ocular surface epithelial cells. The precise mechanisms underlying the loss of these epithelial cells remain a subject of ongoing research and debate. Programmed cell death (PCD) mechanisms, including pyroptosis, apoptosis, and necroptosis, are known to be critical in maintaining ocular surface homeostasis and responding to stressors in DED. The concept of PANoptosis, which integrates elements of various PCD pathways, has been implicated in the development of numerous systemic diseases, including infections, cancer, neurodegenerative, and inflammatory conditions. It also provides novel insights into the inflammatory processes underlying DED. This review highlights the crosstalk of PCD pathways in DED, particularly the significance of PANoptosis in ocular inflammation and its potential as a therapeutic target for more effective interventions.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"34 ","pages":"Pages 535-544"},"PeriodicalIF":5.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}