The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome

IF 5.9 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface Pub Date : 2024-08-14 DOI:10.1016/j.jtos.2024.08.010

Namrata Sharma, Vishal Kumar, Aafreen Bari, Renu Venugopal, Shivam Sharma, Tushar Agarwal, Tanuj Dada, Neelam Pushker

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引用次数: 0

Abstract

Purpose

To study the outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Steven Johnson Syndrome.

Methods

It was an ambispective, interventional case series conducted at Rajendra Prasad Centre for Ophthalmic Sciences, Delhi, India from 2022 to 2023 evaluating the outcomes of minor salivary gland transplantation with anchorage of the minor salivary glands to superior rectus muscle in twenty cases of severe dry eye disease secondary to chronic Steven-Johnson Syndrome. The pre-operative clinical parameters were compared to those at post-operative 1 year follow-up.

Results

At 1 year follow-up, there was an improvement in mean Schirmer-1 value (p = 0.0004), hyperemia score (p = 0.0004), keratinization score (p = 0.04), corneal epithelial defect score (p = 0.0004), corneal opacification score (p = 0.001), corneal neovascularization score (p = 0.001), palisades of Vogt score (p = 0.007), corneal keratinization score (p = 0.04) and corneal conjunctivalization score (p = 0.08).

Conclusion

The minor salivary gland transplantation is a viable management option for cases with severe dry eye disease secondary to chronic Steven Johnson Syndrome with clinical improvement in corneal and conjunctival parameters of the ocular surface.

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小唾液腺移植治疗慢性史蒂文斯-约翰逊综合征继发性严重干眼症的临床疗效。

目的：研究小唾液腺移植治疗继发于慢性史蒂文-约翰逊综合征的严重干眼症的效果：这是 2022 年至 2023 年期间在印度德里 Rajendra Prasad 眼科科学中心进行的一项前瞻性、介入性病例系列研究，评估了小唾液腺移植手术的效果，并将小唾液腺固定在上直肌上，用于治疗 20 例继发于慢性史蒂芬-约翰逊综合征的严重干眼症。将术前的临床参数与术后 1 年随访时的临床参数进行了比较：随访 1 年时，Schirmer-1 平均值（p=0.0004）、充血评分（p=0.0004）、角质化评分（p=0.04）、角膜上皮缺损评分（p=0.0004）、角膜不透明评分（p=0.001）、角膜新生血管评分（p=0.001）、Vogt 宫评分（p=0.007）、角膜角质化评分（p=0.04）和角膜结膜化评分（p=0.08）：小唾液腺移植对于继发于慢性史蒂文-约翰逊综合征的严重干眼症病例是一种可行的治疗方案，可改善眼表角膜和结膜的临床参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Surface 医学-眼科学

CiteScore

11.60

自引率

14.10%

发文量

审稿时长

39 days

期刊介绍： The Ocular Surface, a quarterly, a peer-reviewed journal, is an authoritative resource that integrates and interprets major findings in diverse fields related to the ocular surface, including ophthalmology, optometry, genetics, molecular biology, pharmacology, immunology, infectious disease, and epidemiology. Its critical review articles cover the most current knowledge on medical and surgical management of ocular surface pathology, new understandings of ocular surface physiology, the meaning of recent discoveries on how the ocular surface responds to injury and disease, and updates on drug and device development. The journal also publishes select original research reports and articles describing cutting-edge techniques and technology in the field. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center