将泪液神经肽 Y 作为 1 型糖尿病患者外周微血管并发症的非侵入性标记物。

IF 5.9 1区 医学 Q1 OPHTHALMOLOGY
Alexis Ceecee Britten-Jones , Mengliang Wu , Leslie J. Roberts , Richard J. MacIsaac , Haihan Jiao , Jennifer P. Craig , Holly R. Chinnery , Laura E. Downie
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引用次数: 0

摘要

目的:研究 1 型糖尿病患者的泪液神经肽 Y (NPY) 和 P 物质浓度,并对同时患有和未患有糖尿病视网膜病变 (DR) 和周围神经病变的患者进行比较:这项横断面研究涉及 41 名患有 1 型糖尿病且无中度 DR 的患者和 22 名健康对照者。评估内容包括临床眼表参数、角膜神经属性量化(基于体内共聚焦显微镜成像)、DR 分级以及小纤维和大纤维神经病变评估。采用酶联免疫吸附法测定了泪液样本中 NPY 和 P 物质的浓度:结果:1 型糖尿病和长度依赖性小纤维神经病变(SFN)患者的泪液 NPY 浓度平均值(± 标准偏差)低于对照组(10.84±4.10 ng/mL vs 14.72±3.12 ng/mL;p=0.004),但与无 SFN 的 1 型糖尿病患者(13.39±4.66 ng/mL;p=0.11)无显著差异。与无/轻度DR(13.79±4.76 ng/mL;p=0.0005)和对照组相比,1型糖尿病和轻度/中度非增生性DR患者的泪液NPY水平较低(10.44±3.46 ng/mL)。在单独的线性回归模型中,在对参与者的年龄、性别和干眼症进行调整后,SFN(β=-0.75,p=0.02)和轻度/中度 DR(β=-0.84,p=0.009)的存在与对照组的泪液 NPY 水平显著相关。泪液物质P浓度没有组间差异:结论:泪液NPY可作为与1型糖尿病相关的外周微血管并发症的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tear neuropeptide Y as a non-invasive marker of peripheral microvascular complications in type 1 diabetes

Aims

To investigate tear neuropeptide Y (NPY) and substance P concentrations in individuals with type 1 diabetes, comparing those with and without both diabetic retinopathy (DR) and peripheral neuropathy.

Methods

This cross-sectional study involved 41 participants with type 1 diabetes and none to moderate DR, and 22 healthy controls. Assessments included clinical ocular surface parameters, quantification of corneal nerve attributes (based on in vivo confocal microscopy imaging), DR grading, and evaluation for small and large fibre neuropathy. Concentrations of NPY and substance P in tear samples were measured using enzyme-linked immunosorbent assay.

Results

Mean (± standard deviation) tear NPY concentrations in participants with type 1 diabetes and length-dependent small fibre neuropathy (SFN) was lower than in controls (10.84 ± 4.10 ng/mL vs 14.72 ± 3.12 ng/mL; p=0.004), but not significantly different from type 1 diabetes participants without SFN (13.39 ± 4.66 ng/mL; p=0.11). Tear NPY levels were lower in individuals with type 1 diabetes and mild/moderate non-proliferative DR (10.44 ± 3.46 ng/mL) compared to none/minimal DR (13.79 ± 4.76 ng/mL; p=0.0005) and controls. In separate linear regression models, both the presence of SFN (β = −0.75, p=0.02) and the presence of mild/moderate DR (β = −0.84, p=0.009) were significantly associated with tear NPY levels relative to controls, after adjusting for participant age, sex, and dry eye disease. There were no inter-group differences for tear substance P concentrations.

Conclusions

Tear NPY has potential utility as an indicator of peripheral microvascular complications associated with type 1 diabetes.

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来源期刊
Ocular Surface
Ocular Surface 医学-眼科学
CiteScore
11.60
自引率
14.10%
发文量
97
审稿时长
39 days
期刊介绍: The Ocular Surface, a quarterly, a peer-reviewed journal, is an authoritative resource that integrates and interprets major findings in diverse fields related to the ocular surface, including ophthalmology, optometry, genetics, molecular biology, pharmacology, immunology, infectious disease, and epidemiology. Its critical review articles cover the most current knowledge on medical and surgical management of ocular surface pathology, new understandings of ocular surface physiology, the meaning of recent discoveries on how the ocular surface responds to injury and disease, and updates on drug and device development. The journal also publishes select original research reports and articles describing cutting-edge techniques and technology in the field. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
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