Michal Orczykowski, Marcin Kowalski, Maciej Bak, Anna Jargielo, Filip Machaj, Michal Swierczewski, Krystyna Guzek, Magdalena Topczewska, Piotr Urbanek, Bodalski Robert, Andrzej Glowniak, Pawel Derejko, Maciej Sterlinski, Maria Bilinska, Lukasz Szumowski
{"title":"Radiofrequency Versus Cryoballoon 180-Day Mortality Risk After Atrial Fibrillation Ablation: An 8-Year Analysis.","authors":"Michal Orczykowski, Marcin Kowalski, Maciej Bak, Anna Jargielo, Filip Machaj, Michal Swierczewski, Krystyna Guzek, Magdalena Topczewska, Piotr Urbanek, Bodalski Robert, Andrzej Glowniak, Pawel Derejko, Maciej Sterlinski, Maria Bilinska, Lukasz Szumowski","doi":"10.1111/pace.15164","DOIUrl":"10.1111/pace.15164","url":null,"abstract":"<p><strong>Introduction: </strong>Catheter ablation (CA) is a preferred treatment for atrial fibrillation (AF), often outperforming antiarrhythmic medications in maintaining sinus rhythm and managing symptoms. One of the most important features of any treatment method, alongside its effectiveness, is its safety.</p><p><strong>Methods: </strong>This study evaluates 180-day all-cause mortality rates post-ablation using data from the National Health Fund in Poland (NHF-P), encompassing over 99% of AF CAs and 100% of deaths in Poland from 2012 to 2019.</p><p><strong>Results: </strong>Our analysis, which included 31,214 ablations on 26,767 patients (34.8% female), compared cryoballoon and radiofrequency (RF) ablation techniques and assessed mortality rates and risk factors. The study revealed a 180-day mortality rate of 0.56%, with the highest rate observed in patients over 80 years old (2.67%) and the lowest in those aged 18-34 years (0.29%). Mortality did not significantly differ between cryoballoon (0.48%) and RF ablation (0.65%; p = 0.072). The risk of mortality did not differ between patients undergoing a first-time ablation and those having subsequent procedures (p = 0.90, OR 0.92). Significant risk factors for increased mortality included male sex, kidney disease, heart failure, diabetes, prior myocardial infarction, and a history of malignancy.</p><p><strong>Conclusion: </strong>The 180-day mortality rate after AF ablation procedure reached 0.56%, with no significant difference between cryoballoon and RF ablation. Further research, including matched control groups and extended follow-up periods, is essential to better understand the benefits and risks of CA for AF, particularly in the oldest patient groups.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"363-366"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Segreti, Marco Torre, Matteo Parollo, Lorenzo Pistelli, Andrea Di Cori, Giulio Zucchelli
{"title":"Leadless Pacemaker Implantation Following Lead Extraction in a Patient With Recent Percutaneous Tricuspid Valve Repair.","authors":"Luca Segreti, Marco Torre, Matteo Parollo, Lorenzo Pistelli, Andrea Di Cori, Giulio Zucchelli","doi":"10.1111/pace.15150","DOIUrl":"10.1111/pace.15150","url":null,"abstract":"<p><p>This case details the successful implantation of a leadless pacemaker following the extraction of transvenous leads in a 72-year-old female patient with a complex cardiovascular history. The patient had undergone a series of cardiac interventions, including a recent percutaneous tricuspid valve repair with a metal clip implant due to severe regurgitation. After presenting with an infection at the pacemaker site, methicillin-resistant Staphylococcus hominis was identified, necessitating the removal of the entire pacing system. A leadless pacemaker was subsequently implanted without complications, despite the recent tricuspid valve repair. This case highlights the efficacy and safety of leadless pacemakers in complex clinical scenarios, especially when traditional transvenous systems are no longer viable due to infections or other complications. The report underscores the importance of personalized management strategies for cardiac device infections, illustrating that leadless pacemakers offer a feasible and safe alternative even in patients with previous valvular interventions.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"320-324"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mattia Liccardo, Ersilia Cipolletta, Emma Arezzi, Monica Sicuranza, Maria Rea, Pietro Ricciardi, Giovanni Napolitano
{"title":"External DC Shocks of Symptomatic Supraventricular Tachycardia During Screw-In Leadless Pacemaker Implant: A Case Report.","authors":"Mattia Liccardo, Ersilia Cipolletta, Emma Arezzi, Monica Sicuranza, Maria Rea, Pietro Ricciardi, Giovanni Napolitano","doi":"10.1111/pace.15134","DOIUrl":"10.1111/pace.15134","url":null,"abstract":"<p><p>We present the case of a 64-year-old man who, during the implantation of an active-fixation leadless pacemaker (LP, Aveir VR, Abbott, USA), underwent several external defibrillation shocks up to 240 Joules, due to symptomatic sustained supraventricular tachycardia at 160 bpm. The shocks, delivered both before and after the screwing of the device in the low interventricular septum, did not cause any technical damage to the device, and no complications were observed. The device was then deployed successfully. To our knowledge, this is the first documented case of external cardioversion (ECV) in a patient with an active-fixation LP. The results suggest that ECV in these patients appears to be safe and feasible.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"315-319"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guo Fuding, Zhao Xiaohua, Yang Sen, He Chende, Lu Mei, Yang Jing, Li Dongyan, Liao Qiwei, Li Shaolong
{"title":"Enhanced Procedural Efficacy in Typical Atrial Flutter Ablation With a Visualizable Steerable Sheath.","authors":"Guo Fuding, Zhao Xiaohua, Yang Sen, He Chende, Lu Mei, Yang Jing, Li Dongyan, Liao Qiwei, Li Shaolong","doi":"10.1111/pace.15143","DOIUrl":"10.1111/pace.15143","url":null,"abstract":"<p><strong>Objective: </strong>The Vizigo sheath, a novel visualizable steerable sheath, has been utilized effectively in the clinical management of atrial fibrillation. However, its application in the ablation of typical atrial flutter (AFL) remains unexplored. This study aims to evaluate and compare the efficacy and safety of the Vizigo sheath against a conventional fixed sheath during catheter ablation for typical AFL.</p><p><strong>Methods: </strong>This single-center cohort study involved 60 patients undergoing their first AFL ablation procedure. Patients were divided into two groups: the Vizigo sheath group and the fixed sheath group. The primary endpoints included procedural efficiency, lesion quality, and recurrence rates.</p><p><strong>Results: </strong>The Vizigo sheath demonstrated significant advantages over the fixed sheath, including a shorter procedure time (59.8 ± 13.8 vs. 71.5 ± 11.8 min; p = 0.0008) and reduced fluoroscopy duration (0.96 ± 0.32 vs. 1.31 ± 0.24 min; p < 0.0001). The initial bidirectional block rate was also higher in the Vizigo sheath group (84% vs. 68%). A detailed analysis of the cavotricuspid isthmus (CTI) revealed significant differences in the anterior 2/3 of the CTI, where the Vizigo sheath demonstrated greater catheter contact force, higher ablation index, increased force-time integral, and larger impedance drops (all p < 0.05). In contrast, no significant differences were observed between groups in the posterior 1/3 of the CTI. Both groups achieved a 100% acute procedural success rate, with no major complications reported. During a mean follow-up period of 18.68 months, the AFL recurrence rates were comparable between the two groups (p = 0.75).</p><p><strong>Conclusions: </strong>The Vizigo sheath enhances procedural efficiency and lesion quality during AFL ablation, particularly in challenging anatomical regions, and offers notable advantages over traditional fixed sheaths. Further studies are needed to assess its long-term clinical benefits.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"294-301"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodrigo Rufino Pereira Silva, Carolina Jerônimo Magalhães, Caio Correia da Silva, José Nunes de Alencar Neto
{"title":"Painful Left Bundle Branch Block Syndrome: A Systematic Review of Treatment Strategies in Case Reports.","authors":"Rodrigo Rufino Pereira Silva, Carolina Jerônimo Magalhães, Caio Correia da Silva, José Nunes de Alencar Neto","doi":"10.1111/pace.15156","DOIUrl":"10.1111/pace.15156","url":null,"abstract":"<p><strong>Background: </strong>Painful left bundle branch block (PLBBB) syndrome remains a poorly understood cardiac anomaly. This systematic review consolidates case report evidence to elucidate effective management strategies and patient outcomes.</p><p><strong>Methods: </strong>Databases including PubMed, Scopus, Web of Science, and Scielo were searched without restrictions on language or publication date. Following PRISMA guidelines, 128 articles were identified, with 31 meeting inclusion criteria. Data were extracted on patient demographics, clinical presentation, treatment regimens, and outcomes using Microsoft Excel and assessed for bias with the Joanna Briggs Institute's tool.</p><p><strong>Results: </strong>The analysis included 45 patients with a mean age of 55.46 ± 12.23. Predominantly, LBBB episodes occurred during exercise (73.3%). Initial treatments comprised beta-blockers/calcium channel blockers (55.56%), pacemaker implantation (13.3%), antianginal medications (13.3%), and other modalities (17.7%). Refractoriness to initial treatment was observed in 66.7% of patients, with subsequent pacemaker implantation resolving symptoms in most cases. An overall satisfactory response was seen in 73.3% of patients post-treatment adjustments.</p><p><strong>Conclusions: </strong>The diverse approaches in treatment highlight the necessity for tailored therapeutic strategies. While pacemakers have demonstrated efficacy in controlling symptoms in several reported cases, it is essential to recognize the complex nature of this intervention. Pacemaker implantation, being a surgical procedure, carries long-lasting implications for patients. Hence, the continuation of pharmacological treatments might still be preferable until more definitive research is available. This review emphasizes the urgent need for further research to establish evidence-based guidelines, particularly concerning the selection of first line of treatment, to optimize outcomes for PLBBB syndrome.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"343-350"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danial Saleem, Jacob P Elrod, Vibhu Parcha, Harish Doppalapudi
{"title":"Pacing Below the Programmed Rate.","authors":"Danial Saleem, Jacob P Elrod, Vibhu Parcha, Harish Doppalapudi","doi":"10.1111/pace.15163","DOIUrl":"10.1111/pace.15163","url":null,"abstract":"","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"311-314"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization of Myocardial Recovery in Patients With Tachycardiomyopathy.","authors":"Neeta Bachani, Harshad Shah, Raghav Bansal, Vijay Soorampally, Gopi Krishna Panicker, Yash Lokhandwala","doi":"10.1111/pace.15116","DOIUrl":"10.1111/pace.15116","url":null,"abstract":"<p><strong>Background: </strong>The degree and time course of improvement in left ventricular (LV) function with treatment in patients with tachycardiomyopathy (TCMP) is highly variable. This study aims to clinically characterize the recovery of TCMP based on the extent and course of improvement in LV function and identify predictors of complete myocardial recovery.</p><p><strong>Methods: </strong>In this prospective, single-center, observational study, patients with suspected TCMP who underwent successful tachyarrhythmia termination/control were included. Clinical and echocardiographic assessment of LV function was done at baseline, within 1 h after tachyarrhythmia termination, 24 h later, and at 12 weeks follow-up.</p><p><strong>Results: </strong>Ninety-nine patients were enrolled in the study. Six patients had immediate normalization of LV ejection fraction (LVEF) with reversion to sinus rhythm and were labeled as \"pseudo-TCMP\"; the remaining 93 patients were included in the analysis. Based on complete versus partial normalization of LVEF at 12-week follow-up, 50 patients (53.8%) were labeled as completely recovered TCMP and 43 (46.2%) as partially recovered TCMP respectively. Causative arrhythmias included atrial fibrillation (38%), focal atrial tachycardia (28%), atrial flutter (22%), ventricular arrhythmias (11%), and orthodromic re-entrant tachycardia (2%). The LVEF at presentation was 0.25 ± 0.05 which improved to 0.36 ± 0.11 within 1 h after tachycardia termination (p < 0.0001), 0.41 ± 0.14 24 h later (p = 0.009) and to 0.52 ± 0.12 at 12 weeks follow-up (p < 0.0001). Male gender was the only differentiating statistically significant variable between completely recovered and partially recovered TCMP, 24 (48%) versus 30 (69.7%) respectively (p = 0.0339).</p><p><strong>Conclusion: </strong>Nearly half of the TCMP patients have complete recovery of LV function at 12 weeks follow-up, while the other half have a partial recovery only. There was no robust predictor of complete myocardial recovery.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"329-333"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongyu Liu, Zhenhong Jiang, Yang Shen, Ying Shao, Yuhao Su, Daowu Wang, Ramon Brugada, Kui Hong
{"title":"Topological Distribution of KCNH2 Variants and Genotype-Phenotype Relationship in Patients With Long QT Syndrome.","authors":"Hongyu Liu, Zhenhong Jiang, Yang Shen, Ying Shao, Yuhao Su, Daowu Wang, Ramon Brugada, Kui Hong","doi":"10.1111/pace.15145","DOIUrl":"10.1111/pace.15145","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to investigate the topological distribution of single nucleotide variants (SNVs) in the KCNH2 gene from patients with type 2 long QT syndrome (LQT2) and to explore the genotype-phenotype relationships.</p><p><strong>Methods: </strong>Information on KCNH2 variants in LQT2 patients was retrospectively obtained from the HGMD, ClinVar, and PubMed databases through October 2022. Pathogenicity of SNV was classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines. Unpaired t-tests and Fisher's exacts were used to analyze the SNV distributions across structural and functional domains, and their correlation with clinical phenotypes.</p><p><strong>Results: </strong>A total of 2826 variants were obtained; 2152 were SNVs, 1328 of which were nonsynonymous SNVs (nsSNVs) associated with LQT2. Enrichment analysis revealed that 602 pathogenic (P) and likely pathogenic (LP) nsSNVs were significantly enriched at S5, H5, S6, Extra3, and Extra4. In addition, 759 nsSNVs and 289 P/LP nsSNVs within function domain were enriched at the per-arnt-sim (PAS) and selectivity filter (SF) functional domain. Clinical data revealed that patients with nsSNVs enriched at the N-terminal, S5-H5-S6 region and PAS domain were associated with an increased risk of syncope. Moreover, nsSNVs located at the N-terminal, S5-H5-S6 region, and PAS, SF domains were associated with an increased risk of life-threatening cardiac events, including Torsade de Pointes (TdP) and sudden cardiac death (SCD), and were predominantly female.</p><p><strong>Conclusion: </strong>KCNH2 nsSNVs located at the N-terminal, S5-H5-S6 region, and the PAS and SF functional domains are associated with an increased risk of life-threatening cardiac events in LQT2 patients.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"351-362"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Wetherbee Nelson, Lynn Erickson, Jodi L Zilinski, Yanzhu Zhao, Anna Karos, Teresa Whitman, Imran K Niazi
{"title":"Concurrent Micra Leadless Pacemaker Implantation and AVN Ablation: Computer Modeling of Novel Risk Mitigation Strategy.","authors":"Daniel Wetherbee Nelson, Lynn Erickson, Jodi L Zilinski, Yanzhu Zhao, Anna Karos, Teresa Whitman, Imran K Niazi","doi":"10.1111/pace.15149","DOIUrl":"10.1111/pace.15149","url":null,"abstract":"<p><strong>Background: </strong>Concurrent Micra leadless pacemaker (Medtronic, Minneapolis, Minnesota) implantation and atrioventricular node (AVN) ablation has been shown to be feasible and safe in patients with symptomatic, drug-refractory atrial fibrillation (AF). However, major complications within the 30 days after concurrent Micra implantation and AVN ablation have been reported. We evaluated the efficacy and safety of the concurrent procedure at our institution.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective case series of patients who underwent concurrent Micra implantation and radiofrequency (RF) AVN ablation from January 2019 to May 2023. A simulated computer model was created to characterize the interaction between the dissipated power at the Micra cathodal electrode as a function of the distance between the RF ablation catheter and the location of the return electrode.</p><p><strong>Results: </strong>Fifteen patients were included. Most were elderly, White, female, and had persistent AF. One had transient, acute loss of ventricular capture that resulted in asystole and required emergent pacing from the ablation catheter. A proposed strategy of moving the RF return electrode to a cranial position from a caudal position was shown by computer modeling to direct more RF current away from the Micra and lower the dissipated power at the Micra cathodal electrode.</p><p><strong>Conclusion: </strong>Concurrent Micra implantation and AVN ablation is feasible and safe and has high procedural success. An acute rise in pacing threshold can occur from RF energy, resulting in asystole. Computer modeling showed that placing the RF return electrode in the cranial position resulted in lower dissipated power at the Micra cathodal electrode.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":"287-293"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Hassan Waseem, Zain Ul Abideen, Ayesha Ahmed, Barka Sajid, Ameer Haider Cheema, Noor Ul Huda Ramzan, Amina Tahir, Sania Aimen
{"title":"Pulsed Field Versus High-Power Short-Duration Radiofrequency Ablation in Atrial Fibrillation: A Meta-Analysis.","authors":"Muhammad Hassan Waseem, Zain Ul Abideen, Ayesha Ahmed, Barka Sajid, Ameer Haider Cheema, Noor Ul Huda Ramzan, Amina Tahir, Sania Aimen","doi":"10.1111/pace.15166","DOIUrl":"https://doi.org/10.1111/pace.15166","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation, which has increased in prevalence by 33% over the past two decades, affects 59 million people worldwide. It is treated using thermal and nonthermal techniques like radiofrequency, cryoballoon, laser, and pulsed-field ablation (PFA). This meta-analysis is the first to compare PFA with high-power short-duration radiofrequency ablation (HPSD-RFA).</p><p><strong>Methods: </strong>We comprehensively searched PubMed, Cochrane Central, and ScienceDirect from inception to August 2024. In Review Manager 5.4.1, we pooled risk ratios (RRs) and weighted mean difference (WMD) along with 95% confidence intervals for dichotomous and continuous outcomes, respectively, and employed a random effects model. Study quality was assessed via the Newcastle-Ottawa Scale, and funnel plots were used to evaluate the risk of publication bias.</p><p><strong>Results: </strong>Seven studies with a total of 1538 patients were analyzed in this meta-analysis. PFA was associated with a shorter total procedural time (MD = -36.39 min; 95% CI: [-46.23, -26.55]; p < 0.00001; I<sup>2</sup> = 90%), left atrial dwell time (MD = -33.22 min; 95% CI: [-53.21, -13.23]; p = 0.001; I<sup>2</sup> = 93%), and a longer fluoroscopy time compared to the HPSD-RFA (MD = 9.06 min; 95% CI: [6.13, 11.99]; p < 0.00001; I<sup>2</sup> = 96%). Other outcomes were comparable between the two arms.</p><p><strong>Conclusion: </strong>PFA outperforms HPSD ablation in terms of procedural efficiency outcomes except for the total fluoroscopy time. Still, both techniques are comparable regarding safety and arrhythmia control outcomes.</p>","PeriodicalId":54653,"journal":{"name":"Pace-Pacing and Clinical Electrophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}