Pathologe最新文献_第5页

[Meeting report of the Cytopathology Working Group of the German Society for Pathology 2021]. [2021年德国病理学会细胞病理学工作组会议报告]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-10-05 DOI: 10.1007/s00292-021-00993-y

Dietmar Schmidt

引用次数: 0

[Genetic evolution of in situ follicular neoplasia to t(14;18)-positive aggressive B-cell lymphoma]. [原位滤泡性肿瘤到t(14;18)阳性侵袭性b细胞淋巴瘤的遗传进化]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-10-20 DOI: 10.1007/s00292-021-01011-x

A Vogelsberg, J Steinhilber, B Mankel, B Federmann, J Schmidt, I A Montes-Mojarro, K Hüttl, M Rodriguez-Pinilla, P Baskaran, S Nahnsen, M A Piris, G Ott, L Quintanilla-Martinez, I Bonzheim, F Fend

{"title":"[Genetic evolution of in situ follicular neoplasia to t(14;18)-positive aggressive B-cell lymphoma].","authors":"A Vogelsberg, J Steinhilber, B Mankel, B Federmann, J Schmidt, I A Montes-Mojarro, K Hüttl, M Rodriguez-Pinilla, P Baskaran, S Nahnsen, M A Piris, G Ott, L Quintanilla-Martinez, I Bonzheim, F Fend","doi":"10.1007/s00292-021-01011-x","DOIUrl":"https://doi.org/10.1007/s00292-021-01011-x","url":null,"abstract":"Background: In situ follicular neoplasia (ISFN) is a t(14;18)(q32;q21)+ precursor lesion of follicular lymphoma (FL), which in turn can transform into diffuse large B‑cell lymphoma (DLBCL). For DLBCL that arise de novo, no precursor lesion is known. Given the high frequency of the t(14;18) translocation in de novo DLBCL as well, we investigated whether they can also arise from ISFN without FL as an intermediate step.Objectives: To investigate the clonal evolution of ISFN to DLBCL - transformed from FL and de novo.Materials and methods: Identification of ISFN lesions in patients with DLBCL was performed by BCL2 staining of reactive lymphoid tissues. ISFN and DLBCL were subsequently analyzed by fluorescence in situ hybridization, clonality analyses, sequencing of the t(14;18) breakpoint, and targeted next-generation sequencing.Results: 10 cases with paired ISFN and DLBCL samples were identified, 6 of which were de novo DLBCL and 4 transformed from FL. 3 DLBCL carried MYC-rearrangements in addition to the t(14;18) and were classified as high-grade B‑cell lymphoma (HGBL). The clonal relationship of ISFN and DLBCL/HGBL was confirmed for all cases. CREBBP, KMT2D, EZH2, TNFRSF14, and BCL2 were the genes most frequently mutated, with the distribution of private and shared mutations pointing to 2 different scenarios of clonal evolution. In most cases, DLBCL/HGBL, ISFN, and, if also present, FL had evolved divergently from a common progenitor, whereas linear evolution was less frequent.Conclusion: We show for the first time that t(14;18)+ DLBCL/HGBL can arise directly from ISFN without FL as an intermediate step and that during this progression, divergent evolution is common.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":" ","pages":"122-128"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39535976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Satzung der Rudolf-Virchow-Stiftung für Pathologie. 病理学基金会章程。

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Pathologe Pub Date : 2021-12-01 DOI: 10.1007/s00292-021-01034-4

引用次数: 0

[Clinical, radiological, and histopathological features of pulmonary post-COVID syndrome : A form of autoimmune-mediated interstitial lung disease?] 肺炎后综合征的临床、影像学和组织病理学特征:一种自身免疫介导的间质性肺病?］

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Pathologe Pub Date : 2021-12-01 DOI: 10.1007/s00292-021-01024-6

K Steinestel, A Czech, C Hackenbroch, W Bloch, D Gagiannis

{"title":"[Clinical, radiological, and histopathological features of pulmonary post-COVID syndrome : A form of autoimmune-mediated interstitial lung disease?]","authors":"K Steinestel, A Czech, C Hackenbroch, W Bloch, D Gagiannis","doi":"10.1007/s00292-021-01024-6","DOIUrl":"https://doi.org/10.1007/s00292-021-01024-6","url":null,"abstract":"Background: About 10% of patients develop persistent symptoms after mild/moderate COVID-19. We have previously reported detection of antinuclear autoantibodies/extractable nuclear antigens (ANA/ENA) in patients with severe COVID-19.Objectives: The aim of this small pilot study was to characterize long-/post-COVID and to evaluate possible similarities between lung involvement in long-/post-COVID and connective tissue disease (CTD).Methods: We prospectively enrolled 33 previously healthy patients with persistent pulmonal symptoms after mild/moderate COVID-19 without hospitalization (median age, 39 years). We performed clinical evaluation including pulmonary function tests, computed tomography (CT), and serology for ANA/ENA. In 29 of 33 patients, transbronchial biopsies (TBBs) were taken for histopathological assessment.Results: Most patients presented with disturbed oxygen pulse in spiroergometry and slight lymphocytosis in bronchoalveolar lavage (BAL) fluid. The CT pattern showed bronchial wall thickening and increased low-attenuation volume. Autoantibodies were detected in 13 of 33 patients (39.4%). Histopathological assessment showed interstitial lymphocytosis with alveolar fibrin and organizing pneumonia. Ultrastructural analyses revealed interstitial collagen deposition.Conclusion: While histopathology of pulmonary long-/post-COVID alone is unspecific, the combination with clinical and radiological features together with detection of autoantibodies would allow for a diagnosis of interstitial pneumonia with autoimmune features (IPAF). Since we observe interstitial collagen deposition and since IPAF/CTD-ILD might progress to fibrosis, the persistence of autoantibodies and possible fibrotic change should be closely monitored in autoantibody-positive long-/post-COVID patients.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"42 Suppl 2","pages":"160-164"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9463977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[Meeting of the Working Group Hematopathology of the German Society of Pathology (DGP) : DGP congress on 9 June 2021]. [德国病理学会(DGP)血液病理学工作组会议:2021年6月9日DGP大会]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-10-20 DOI: 10.1007/s00292-021-01018-4

German Ott

引用次数: 0

[Meeting report of the Uropathology Working Group of the German Society of Pathology 2021]. [德国病理学会泌尿病理学工作组会议报告2021]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-08-18 DOI: 10.1007/s00292-021-00976-z

Henning Reis, Nadine T Gaisa

引用次数: 0

[Digital teaching in pathology: experiences from Mainz]. 病理学数字化教学:美因茨的经验

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-11-23 DOI: 10.1007/s00292-021-01028-2

Beate K Straub, Tiemo S Gerber, Holger Buggenhagen, Bettina Jäger, Clemens Sommer, Wilfried Roth

{"title":"[Digital teaching in pathology: experiences from Mainz].","authors":"Beate K Straub, Tiemo S Gerber, Holger Buggenhagen, Bettina Jäger, Clemens Sommer, Wilfried Roth","doi":"10.1007/s00292-021-01028-2","DOIUrl":"https://doi.org/10.1007/s00292-021-01028-2","url":null,"abstract":"Background: Due to the corona pandemic, digital teaching has become especially important in education and has led to a restructuring of teaching, not only in the subject of surgical pathology.Objectives: In this article, different forms of e‑learning are presented and illustrated using the example of teaching surgical pathology and neuropathology at the University Medical Center Mainz.Results: Before the onset of the corona pandemic in spring 2020, digitization had already assumed great importance for teaching in the technology- and method-oriented subject of surgical pathology. In particular, the possibility of virtual microscopy via scanned slides with a digital slide server has been used in many pathology institutes. Virtual microscopy often partially or completely replaced conventional microscopy of histologic slide collections. Complementary virtual learning offers are becoming more and more important. These include asynchronously provided lectures or macroscopy videos, video conferences, scripts and communication via learning platforms. In addition, electronic exams have become an indispensable part of teaching. Nevertheless, the corona pandemic revealed how important personal contact with students is to achieve optimal learning success; learning forms with a combination of face-to-face teaching and e‑learning in the sense of blended learning are of particular importance.Conclusions: As part of blended learning, digital teaching is an ideal complement to face-to-face teaching and is changing teaching in the longer term, not only in the field of surgical pathology. Digital learning formats will remain in the future and will at least partially replace classroom formats such as lectures.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":" ","pages":"142-148"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Meeting report of the Bone, Joint and Soft Tissue Pathology Working Group : DGP conference on 10 June 2021]. [骨、关节和软组织病理工作组会议报告:2021年6月10日DGP会议]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-10-05 DOI: 10.1007/s00292-021-00995-w

S Scheil-Bertram, E Wardelmann

引用次数: 0

[Report of the Molecular Pathology Working Group: Virtual Pathology Days of the DGP]. [分子病理工作组报告:DGP的虚拟病理日]。

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Pathologe Pub Date : 2021-12-01 Epub Date: 2021-10-20 DOI: 10.1007/s00292-021-01010-y

Silke Laßmann, Florian Haller, Udo Siebolts

引用次数: 0

[Report on the meeting of the Head and Neck Pathology Working Group : 2021 Virtual Pathology Conference of the German Society for Pathology]. [头颈病理工作组会议报告:德国病理学会2021虚拟病理会议]。