[Pathology of hepatocellular carcinoma].

4区医学 Q3 Medicine

Pathologe Pub Date : 2022-02-01 Epub Date: 2022-01-04 DOI:10.1007/s00292-021-01038-0

Thomas Longerich, Peter Schirmacher

引用次数: 1

Abstract

Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide and has a well-defined etiology. It develops in a stepwise process with morphologically defined precursor lesions. Typing of highly differentiated hepatocellular tumors is supported by immunohistological marker panel and the so-called matrix diagnosis. The recent World Health Organization (WHO) classification defined morpho-molecular HCC subtypes showing typical clinical and prognostic characteristics. If HCC subtyping is considered in future clinical studies of advanced HCC, this could help to introduce personalized HCC therapy. Currently, precision oncology is not available for HCC.

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[肝细胞癌病理]。

肝细胞癌(HCC)是全球癌症相关死亡的第三大原因，其病因明确。它的发展是一个循序渐进的过程，具有形态学上明确的前驱病变。高分化肝细胞肿瘤的分型是由免疫组织学标记板和所谓的基质诊断支持的。最近世界卫生组织(WHO)的分类定义了HCC的形态分子亚型，显示了典型的临床和预后特征。如果在未来晚期HCC的临床研究中考虑HCC亚型，这将有助于引入个性化的HCC治疗。目前，精确肿瘤学还不能用于HCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathologe 医学-病理学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Der Pathologe is an internationally recognized journal and combines practical relevance with scientific competence. The journal informs all pathologists working on departments and institutes as well as morphologically interested scientists about developments in the field of pathology. The journal serves both the scientific exchange and the continuing education of pathologists. Comprehensive reviews on a specific topical issue focus on providing evidenced based information under consideration of practical experience. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange.