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[Erratum to: Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC)]. [勘误：嗜酸性、实性和囊性肾细胞癌（ESC-RCC）]。
4区 医学
Pathologe Pub Date : 2025-11-01 DOI: 10.1007/s00292-021-01014-8
Arndt Hartmann, Abbas Agaimy
{"title":"[Erratum to: Eosinophilic, solid, and cystic renal cell carcinoma (ESC-RCC)].","authors":"Arndt Hartmann, Abbas Agaimy","doi":"10.1007/s00292-021-01014-8","DOIUrl":"10.1007/s00292-021-01014-8","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":" ","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39556594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy. 扫源光学相干断层血管造影在糖尿病视网膜病变诊断和治疗中的应用进展。
4区 医学
Pathologe Pub Date : 2023-02-06 eCollection Date: 2023-01-01 DOI: 10.3389/fopht.2023.1116391
Jinyan Zhang, Qianqian Huo, Deyu Xia, Mingfang Wang, Xiuyun Li
{"title":"Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy.","authors":"Jinyan Zhang, Qianqian Huo, Deyu Xia, Mingfang Wang, Xiuyun Li","doi":"10.3389/fopht.2023.1116391","DOIUrl":"10.3389/fopht.2023.1116391","url":null,"abstract":"<p><p>Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the leading causes of global blinding. More attention should be paid to the diagnosis, treatment and prognosis of DR. Swept-source optical coherence tomography angiography (SS-OCTA) is a novel imaging technique presented in recent years. It can accurately present the various levels of the retina, choriocapillaris, macula, and the optic papillary microcirculation, which is new to the diagnosis and prognosis of DR. However, SS-OCTA is limited by poor fixation or severe media clouding and is susceptible to motion artefacts and segmentation errors. Future limitations need to be addressed and large prospective trials conducted to refine the relevance of SS-OCTA to DR. The present study reviews the advances in clinical application of SS-OCTA in diagnosis, treatment and prognosis of DR.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"22 1","pages":"1116391"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74089301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experiences with telepathology in northern Afghanistan : A 10-year success story]. [阿富汗北部心灵病理学的经验：一个10年的成功故事]。
4区 医学
Pathologe Pub Date : 2022-07-01 Epub Date: 2022-03-03 DOI: 10.1007/s00292-022-01060-w
Gerhard Stauch, Rokai Raoufi, Atiq Sediqi, Peter Dalquen, Peter Fritz, Christian Aichmüller, Manasi Aichmüller-Ratnaparkhe, Monika Hubler
{"title":"[Experiences with telepathology in northern Afghanistan : A 10-year success story].","authors":"Gerhard Stauch, Rokai Raoufi, Atiq Sediqi, Peter Dalquen, Peter Fritz, Christian Aichmüller, Manasi Aichmüller-Ratnaparkhe, Monika Hubler","doi":"10.1007/s00292-022-01060-w","DOIUrl":"10.1007/s00292-022-01060-w","url":null,"abstract":"<p><p>Afghanistan is in a military conflict lasting more than 20 years and according to recent political development, in a downhill spiral towards a failed society. This scenario faces the question of the usefulness of international medical aid, especially morphological diagnostics in crisis situations. On the basis of ten years of experience from a telemedicine project, need, feasibility and results in Afghanistan will be discussed. General and country-specific problems and the sustainability of an international partnership are discussed. In summary our experience is: (1) Telemedicine is possible and necessary even in countries with high conflict potential. It is integrated into routine care by local medical care taker, (2) Accompanying video conferences are a significant improvement in telemedical diagnostics, (3) \"High level\" consultations can bridge the gap between sophisticated western diagnostics and medicine in the partner country in selected cases and (4) Scientific work is possible on the basis of the medical data collected on site and the image material generated.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 1","pages":"303-310"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52483329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification]. [2020年WHO分类背景下子宫平滑肌肉瘤的实用诊断方面]。
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-04-12 DOI: 10.1007/s00292-022-01064-6
Lars-Christian Horn, Grit Gesine Ruth Hiller, Doris Mayr, Elisa Schmoeckel, Anne Kathrin Höhn
{"title":"[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification].","authors":"Lars-Christian Horn, Grit Gesine Ruth Hiller, Doris Mayr, Elisa Schmoeckel, Anne Kathrin Höhn","doi":"10.1007/s00292-022-01064-6","DOIUrl":"10.1007/s00292-022-01064-6","url":null,"abstract":"<p><p>The 2020 WHO Classification defines the spindle cell, epithelioid, and myxoid variants as subtypes of uterine leiomyosarcomas (LMS). Presence of cellular atypia (size variation of polymorphic nuclei > 2-3:1), tumor cell necroses, and mitotic count (usually ≥ 10 MF/10 HPF) are still the key features for diagnostic separation from uterine leiomyomas. Preanalytic variables, staining quality, as well as intralesional geographic distribution may affect the mitotic count. Smooth muscle tumors of uncertain malignant potential (STUMP) still exist as a not yet well-characterized diagnostic entity. Immunohistochemical stains against p16, p53, Ki-67, and WT‑1 may aid differential diagnosis in selected cases. Diagnostic molecular pathology is not yet relevant for diagnosis.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"196-201"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The molecular pathology breviary: what do hybrid capture, anchored multiplex PCR and amplicon-based mean?] 分子病理学简章:杂交捕获、锚定多重PCR和基于扩增子的PCR是什么意思?]
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-01-04 DOI: 10.1007/s00292-021-01036-2
Ulrich Lehmann, Albrecht Stenzinger
{"title":"[The molecular pathology breviary: what do hybrid capture, anchored multiplex PCR and amplicon-based mean?]","authors":"Ulrich Lehmann, Albrecht Stenzinger","doi":"10.1007/s00292-021-01036-2","DOIUrl":"10.1007/s00292-021-01036-2","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"229-230"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39872998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Epithelial childhood liver tumors : An overview of the new WHO classification for pediatric tumors]. [儿童上皮性肝肿瘤：世卫组织小儿肿瘤新分类综述]。
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-04-06 DOI: 10.1007/s00292-022-01067-3
J F Lau, C Vokuhl
{"title":"[Epithelial childhood liver tumors : An overview of the new WHO classification for pediatric tumors].","authors":"J F Lau, C Vokuhl","doi":"10.1007/s00292-022-01067-3","DOIUrl":"https://doi.org/10.1007/s00292-022-01067-3","url":null,"abstract":"<p><p>Pediatric liver tumors are very rare tumors and account for less than 1% of all childhood malignancies. By far the most common tumors are hepatoblastomas. This review discusses epithelial malignant childhood liver tumors, with particular attention to the morphology of the different hepatoblastoma subtypes. In addition, other malignant liver tumors such as the so-called hepatocellular tumor NOS and the second-most common childhood liver tumor, the hepatocellular carcinoma, are discussed. In addition to the typical morphological characteristics, the immunohistochemical and molecular aspects are also be presented, which can help to distinguish these entities with often overlapping morphology.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"202-209"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Automation and application of robotics in the pathology laboratory]. 【机器人技术在病理实验室的自动化与应用】。
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-04-24 DOI: 10.1007/s00292-022-01073-5
Hermann Herbst, Thomas Rüdiger, Constantin Hofmann
{"title":"[Automation and application of robotics in the pathology laboratory].","authors":"Hermann Herbst, Thomas Rüdiger, Constantin Hofmann","doi":"10.1007/s00292-022-01073-5","DOIUrl":"https://doi.org/10.1007/s00292-022-01073-5","url":null,"abstract":"<p><p>Over the last 20 years, numerous technical innovations have been introduced to the histopathology laboratory, providing tools for improved standardization and occupational safety. Digital tracking serves as a backbone accompanying the workflow from labeling cassettes and slides to the final steps of preparation of whole slide images and archiving blocks and sections. Multifunctional devices eliminated time consuming manual work prone to mistakes and loss of materials. At present, collaborative robots take over manual work that was considered to be exclusive to humans. The advent of these new technologies is expected to ameliorate the increasing staffing shortage in the laboratory and on the side of histopathologists as well.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"210-217"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Endometrial and other rare uterine sarcomas : Diagnostic aspects in the context of the 2020 WHO classification]. [子宫内膜和其他罕见子宫肉瘤：在2020年WHO分类背景下的诊断方面]。
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-04-01 DOI: 10.1007/s00292-022-01072-6
Doris Mayr, Lars-Christian Horn, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Elisa Schmoeckel
{"title":"[Endometrial and other rare uterine sarcomas : Diagnostic aspects in the context of the 2020 WHO classification].","authors":"Doris Mayr, Lars-Christian Horn, Grit Gesine Ruth Hiller, Anne Kathrin Höhn, Elisa Schmoeckel","doi":"10.1007/s00292-022-01072-6","DOIUrl":"https://doi.org/10.1007/s00292-022-01072-6","url":null,"abstract":"<p><p>Uterine sarcomas are a heterogeneous group of rare malignancies. Mostly (40-50%), they are leiomyosarcomas, followed by endometrial stromal sarcomas (ESS), low-grade (LG) and high-grade (HG), as well as undifferentiated sarcoma of the uterus (UUS) and adenosarcomas (AS). Other, non-organ-specific tumours such as NTRK-rearranged spindle cell neoplasia, perivascular epithelioid cell tumour (PEComa) and inflammatory myofibroblastic tumour (IMT) are extremely difficult to differentiate.In the most recent WHO classification, endometrial stromal tumours are subdivided as follows: benign, expansively growing endometrial stromal nodule (ESN) with sharp demarcation, the histologically similar-looking LG-ESS with infiltrative growth, the highly malignant HG-ESS and, as a diagnosis of exclusion, the highly aggressive UUS lacking specific lines of differentiation. LG-ESS can be differentiated from HG-ESS in most cases histomorphologically and immunohistochemically, but molecular investigations are necessary in individual cases. HG-ESS can be divided into 4 subtypes (YWHAE/NUTM2 fusion low-grade component, YWHAE/NUTM2 fusion high-grade component, ZC3H7B-BCOR fusion or BCOR-ITD) on the basis of molecular findings. Prognostically unfavourable factors in AS are severe sarcomatous overgrowth, deep myometrial invasion, high-grade histology and lymphatic vessel invasion. Tumours with NTRK fusion are immunohistochemically positive for S100 and TRK. PEComas express cathepsin K and HMB45, as well as TFE3 when translocation is present. Almost every IMT shows an alteration in the ALK gene In the case of overlapping morphology and simultaneous therapeutic and prognostic relevance, it is becoming increasingly important to verify or confirm the suspected histomorphological diagnosis by immunohistochemical and possibly molecular investigations.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"183-195"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence: a solution for the lack of pathologists?] 【人工智能：病理学家匮乏的解决方案？】]
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-04-11 DOI: 10.1007/s00292-022-01071-7
Philipp Jurmeister, Klaus-Robert Müller, Frederick Klauschen
{"title":"[Artificial intelligence: a solution for the lack of pathologists?]","authors":"Philipp Jurmeister, Klaus-Robert Müller, Frederick Klauschen","doi":"10.1007/s00292-022-01071-7","DOIUrl":"https://doi.org/10.1007/s00292-022-01071-7","url":null,"abstract":"<p><p>Given the rapid developments, there is no doubt that artificial intelligence (AI) will substantially impact pathological diagnostics. However, it remains an open question if AI will primarily be another diagnostic tool, such as immunohistochemistry, or if AI will also be able to replace human expertise. Most current studies on AI in histopathology deal with relatively simple diagnostic problems and are not yet capable of coping with the complexity of routine diagnostics. While some methods in molecular pathology would already be unthinkable without AI, it remains to be shown how AI will also be able to help with difficult histomorphological differential diagnoses in the future.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"218-221"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Basic nephropathology for pathologists-part 1 : Kidney biopsy-inflammation and immune complexes]. 病理学家的基本肾脏病理学-第1部分：肾活检-炎症和免疫复合物。
4区 医学
Pathologe Pub Date : 2022-05-01 Epub Date: 2022-03-28 DOI: 10.1007/s00292-022-01061-9
Maike Büttner-Herold, Ariana Gaspert, Kerstin Amann
{"title":"[Basic nephropathology for pathologists-part 1 : Kidney biopsy-inflammation and immune complexes].","authors":"Maike Büttner-Herold, Ariana Gaspert, Kerstin Amann","doi":"10.1007/s00292-022-01061-9","DOIUrl":"https://doi.org/10.1007/s00292-022-01061-9","url":null,"abstract":"<p><p>The assessment of kidney biopsies is mainly confined to specialized centres. However, sometimes a kidney biopsy is submitted to a general pathologist, and in addition peritumorous renal parenchyma in tumour nephrectomies can have concomitant non-neoplastic renal disease. Here we present a survey of inflammatory and immunologic changes in all renal compartments, which may in part indicate the need of prompt therapeutic intervention such as in vasculitis, glomerulonephritis and interstitial nephritis. It is important to take into account that renal involvement of vasculitis is mainly centred in glomeruli and only to a much lesser extent in arteries, and that the frequently observed interstitial inflammation very often is an epiphenomenon of another primary kidney disease and not an independent disease process. Typical renal patterns of injury are emphasised.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 3","pages":"231-246"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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