Pathologe最新文献_第2页

[S2k guidelines for the diagnosis and treatment of endometriosis-Recommendations for pathology]. [S2k子宫内膜异位症的诊断和治疗指南-病理建议]。

4区医学

Pathologe Pub Date : 2022-03-01 Epub Date: 2021-10-01 DOI: 10.1007/s00292-021-00978-x

Lars-Christian Horn, Anne Kathrin Höhn, Stefanie Burghaus, Sebastian Daniel Schäfer, Uwe Andreas Ulrich, Dietmar Schmidt

{"title":"[S2k guidelines for the diagnosis and treatment of endometriosis-Recommendations for pathology].","authors":"Lars-Christian Horn, Anne Kathrin Höhn, Stefanie Burghaus, Sebastian Daniel Schäfer, Uwe Andreas Ulrich, Dietmar Schmidt","doi":"10.1007/s00292-021-00978-x","DOIUrl":"https://doi.org/10.1007/s00292-021-00978-x","url":null,"abstract":"The present article summarises the recommendations for the handling, histopathological workup, diagnostics and reporting in surgical pathology of biopsies and resection specimens in patients with the clinical diagnosis of endometriosis. In addition to practical aspects of pathology, the guidelines also take into account the clinical requirements for histopathology for the optimal diagnosis and therapy of the patients.Based on the definition of endometriosis of the corpus uteri (adenomyosis uteri) most commonly used in the pathological literature, this was defined in the guidelines as the detection of the endometriosis focus in the myometrium at a distance from the endomyometrial border of a medium-sized visual field (100× magnification), which in metric units corresponds to around 2.5 mm. In bowel resection specimens, the status of the resection margins had to be documented within the histopathological report.Also mentioned are the requirements for the reporting of carcinomas associated with endometriosis, including the immunohistochemical evaluation of steroid hormone receptors and mismatch repair proteins.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39500765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[New aspects in fine needle biopsies of the lymph nodes]. [淋巴结细针活检新进展]。

4区医学

Pathologe Pub Date : 2022-03-01 Epub Date: 2022-01-06 DOI: 10.1007/s00292-021-01044-2

Beata Bode-Lesniewska

{"title":"[New aspects in fine needle biopsies of the lymph nodes].","authors":"Beata Bode-Lesniewska","doi":"10.1007/s00292-021-01044-2","DOIUrl":"https://doi.org/10.1007/s00292-021-01044-2","url":null,"abstract":"Background: The cytology of lymph nodes is a cost-effective method with a short turnaround time and low risk to patients that delivers valuable information on the cause of the lymphadenopathies.Objectives: To discuss the value of lymph node cytology in the diagnosis of lymph node swellings.Methods: Analysis of the causes of the controversially discussed aspects of lymph node cytology. Presentation of the diagnostic groups of lymph node cytology according to the Sydney system.Results: The technical aspects of lymph node sampling during fine needle biopsy, as well as the subsequent preparation of the correctly fixed direct smears and the triage of the sample for the auxiliary studies, may pose a significant challenge for some puncturers. The whole spectrum of modern pathologic auxiliary studies can be applied to correctly triaged cytologic samples. The diagnoses of fine needle biopsies of the lymph nodes can be divided into five groups according to the recently proposed Sydney reporting system: insufficient/non-diagnostic, benign, atypical, suspicious, and malignant. Further details concerning the diagnosis as well as recommendations on how to proceed are additionally included in cytologic reports.Conclusions: The improvement of lymph node sampling as well as the technical aspects of the sample handling, including the application of auxiliary studies, considerably increase the diagnostic value of fine needle biopsy of the lymph nodes. Wide implementation of the usage of the diagnostic groups for reporting fine needle biopsies of the lymph nodes can standardize reporting and improve communication with other clinical specialists.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"109-116"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test]. [BRAF V600E突变在转移性结直肠癌中的检测:QuIP轮循试验]。

4区医学

Pathologe Pub Date : 2022-03-01 Epub Date: 2021-11-22 DOI: 10.1007/s00292-021-01022-8

Korinna Jöhrens, Josephine Fischer, Markus Möbs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Laßmann, Martin Werner, Vanessa Borgmann, Hendrik Bläker, Michael Hummel

{"title":"[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test].","authors":"Korinna Jöhrens, Josephine Fischer, Markus Möbs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Laßmann, Martin Werner, Vanessa Borgmann, Hendrik Bläker, Michael Hummel","doi":"10.1007/s00292-021-01022-8","DOIUrl":"https://doi.org/10.1007/s00292-021-01022-8","url":null,"abstract":"Round robin testing is an important instrument for quality assurance. Increasingly, this also applies to the results of molecular diagnostics in pathology, which directly influence therapy decisions in precision oncology. In metastatic colorectal carcinoma (mCRC), the focus has been on detecting KRAS and NRAS mutations, whose absence allows therapy with EGFR blocking antibodies. Recently, BRAF has been added as another predictive marker, since mCRC patients with BRAF V600E mutation benefit significantly from treatment with encorafenib (a BRAF inhibitor) in combination with cetuximab (anti-EGFR antibody) after systemic therapy. Due to the approval of this treatment in 2020, it is a pre-requisite that BRAF V600E mutation detection in diagnostic pathologies is reliably performed. Therefore, this round robin test with BRAF V600E testing either by immunohistochemistry or molecular methods was performed. The round robin test results demonstrate that molecular BRAF V600E detection is currently clearly superior to immunohistochemical detection.","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"126-134"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39735327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitteilungen der Österreichischen Gesellschaft für Klinische Pathologie und Molekularpathologie 奥地利临床病理学和分子病理学学会出版物

4区医学

Pathologe Pub Date : 2022-03-01 DOI: 10.1007/s00292-022-01055-7

引用次数: 0

[The molecular pathological breviary: allele frequencies in NGS analysis]. 【分子病理简章:NGS分析中的等位基因频率】。

4区医学

Pathologe Pub Date : 2022-03-01 Epub Date: 2021-10-13 DOI: 10.1007/s00292-021-01003-x

Ulrich Lehmann, Albrecht Stenzinger

引用次数: 0

Mitteilungen der Deutschen Gesellschaft für Pathologie 德国病理学会新闻

4区医学