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[New aspects in fine needle biopsies of the lymph nodes]. [淋巴结细针活检新进展]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2022-01-06 DOI: 10.1007/s00292-021-01044-2
Beata Bode-Lesniewska
{"title":"[New aspects in fine needle biopsies of the lymph nodes].","authors":"Beata Bode-Lesniewska","doi":"10.1007/s00292-021-01044-2","DOIUrl":"https://doi.org/10.1007/s00292-021-01044-2","url":null,"abstract":"<p><strong>Background: </strong>The cytology of lymph nodes is a cost-effective method with a short turnaround time and low risk to patients that delivers valuable information on the cause of the lymphadenopathies.</p><p><strong>Objectives: </strong>To discuss the value of lymph node cytology in the diagnosis of lymph node swellings.</p><p><strong>Methods: </strong>Analysis of the causes of the controversially discussed aspects of lymph node cytology. Presentation of the diagnostic groups of lymph node cytology according to the Sydney system.</p><p><strong>Results: </strong>The technical aspects of lymph node sampling during fine needle biopsy, as well as the subsequent preparation of the correctly fixed direct smears and the triage of the sample for the auxiliary studies, may pose a significant challenge for some puncturers. The whole spectrum of modern pathologic auxiliary studies can be applied to correctly triaged cytologic samples. The diagnoses of fine needle biopsies of the lymph nodes can be divided into five groups according to the recently proposed Sydney reporting system: insufficient/non-diagnostic, benign, atypical, suspicious, and malignant. Further details concerning the diagnosis as well as recommendations on how to proceed are additionally included in cytologic reports.</p><p><strong>Conclusions: </strong>The improvement of lymph node sampling as well as the technical aspects of the sample handling, including the application of auxiliary studies, considerably increase the diagnostic value of fine needle biopsy of the lymph nodes. Wide implementation of the usage of the diagnostic groups for reporting fine needle biopsies of the lymph nodes can standardize reporting and improve communication with other clinical specialists.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"109-116"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test]. [BRAF V600E突变在转移性结直肠癌中的检测:QuIP轮循试验]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2021-11-22 DOI: 10.1007/s00292-021-01022-8
Korinna Jöhrens, Josephine Fischer, Markus Möbs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Laßmann, Martin Werner, Vanessa Borgmann, Hendrik Bläker, Michael Hummel
{"title":"[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test].","authors":"Korinna Jöhrens,&nbsp;Josephine Fischer,&nbsp;Markus Möbs,&nbsp;Klaus Junker,&nbsp;Jutta Kirfel,&nbsp;Sven Perner,&nbsp;Silke Laßmann,&nbsp;Martin Werner,&nbsp;Vanessa Borgmann,&nbsp;Hendrik Bläker,&nbsp;Michael Hummel","doi":"10.1007/s00292-021-01022-8","DOIUrl":"https://doi.org/10.1007/s00292-021-01022-8","url":null,"abstract":"<p><p>Round robin testing is an important instrument for quality assurance. Increasingly, this also applies to the results of molecular diagnostics in pathology, which directly influence therapy decisions in precision oncology. In metastatic colorectal carcinoma (mCRC), the focus has been on detecting KRAS and NRAS mutations, whose absence allows therapy with EGFR blocking antibodies. Recently, BRAF has been added as another predictive marker, since mCRC patients with BRAF V600E mutation benefit significantly from treatment with encorafenib (a BRAF inhibitor) in combination with cetuximab (anti-EGFR antibody) after systemic therapy. Due to the approval of this treatment in 2020, it is a pre-requisite that BRAF V600E mutation detection in diagnostic pathologies is reliably performed. Therefore, this round robin test with BRAF V600E testing either by immunohistochemistry or molecular methods was performed. The round robin test results demonstrate that molecular BRAF V600E detection is currently clearly superior to immunohistochemical detection.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"126-134"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39735327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The molecular pathological breviary: allele frequencies in NGS analysis]. 【分子病理简章:NGS分析中的等位基因频率】。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2021-10-13 DOI: 10.1007/s00292-021-01003-x
Ulrich Lehmann, Albrecht Stenzinger
{"title":"[The molecular pathological breviary: allele frequencies in NGS analysis].","authors":"Ulrich Lehmann,&nbsp;Albrecht Stenzinger","doi":"10.1007/s00292-021-01003-x","DOIUrl":"https://doi.org/10.1007/s00292-021-01003-x","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"154-156"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39513642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen der Deutschen Gesellschaft für Pathologie 德国病理学会新闻
4区 医学
Pathologe Pub Date : 2022-03-01 DOI: 10.1007/s00292-022-01056-6
{"title":"Mitteilungen der Deutschen Gesellschaft für Pathologie","authors":"","doi":"10.1007/s00292-022-01056-6","DOIUrl":"https://doi.org/10.1007/s00292-022-01056-6","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 1","pages":"167"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49450584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The value of molecular testing of thyroid aspirates]. [甲状腺抽吸物分子检测的价值]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2022-01-10 DOI: 10.1007/s00292-021-01049-x
O Chijioke
{"title":"[The value of molecular testing of thyroid aspirates].","authors":"O Chijioke","doi":"10.1007/s00292-021-01049-x","DOIUrl":"https://doi.org/10.1007/s00292-021-01049-x","url":null,"abstract":"<p><p>In the evaluation of thyroid nodules, cytopathology of thyroid fine-needle aspiration specimens plays a central role. Established classification schemes should be used. In the case of indeterminate cytology, additional molecular tests may be used. However, the stratification of indeterminate thyroid nodules into malignant and benign lesions based on molecular tests alone, apart from costly commercial assays from US vendors, has so far been clearly limited. Molecular testing of single genetic alterations that can confirm malignancy in papillary, poorly differentiated, and anaplastic thyroid carcinomas is helpful and relatively easy to perform. However, negative test results by no means exclude malignant neoplasia. Predictive markers for single entities (BRAF V600E, RET mutations and RET fusions) should be tested in all advanced thyroid carcinomas.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"105-108"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39685658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Intrauterine fetal demise in extensive SARS-CoV-2-associated placental maternal vascular malperfusion in the setting of SARS-CoV-2 placentitis (severe acute respiratory syndrome coronavirus 2)]. [在SARS-CoV-2胎盘炎(严重急性呼吸综合征冠状病毒2)的背景下，广泛的SARS-CoV-2相关的母体胎盘血管灌注不良导致宫内胎儿死亡]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2021-12-15 DOI: 10.1007/s00292-021-01035-3
Marie-Lisa Eich, Thomas Menter, Nils Fabian Mokwa, Berthold Grüttner, Annette M Müller
{"title":"[Intrauterine fetal demise in extensive SARS-CoV-2-associated placental maternal vascular malperfusion in the setting of SARS-CoV-2 placentitis (severe acute respiratory syndrome coronavirus 2)].","authors":"Marie-Lisa Eich,&nbsp;Thomas Menter,&nbsp;Nils Fabian Mokwa,&nbsp;Berthold Grüttner,&nbsp;Annette M Müller","doi":"10.1007/s00292-021-01035-3","DOIUrl":"https://doi.org/10.1007/s00292-021-01035-3","url":null,"abstract":"<p><p>We report a case of a placenta with extensive maternal vascular malperfusion and chronic histiocytic intervillositis corresponding to SARS-CoV‑2 placentitis in the context of fetal demise at 31 weeks of gestation. Placental swamp and PCR of the placental parenchyma, umbilical cord and amnion-chorion membrane showed SARS-CoV-2- and B‑betacoronavirus-specific RNA. Maternal vascular malperfusion has been described in cases of SARS-CoV‑2 infection; however, the manifested severity of this case in the setting of a severe SARS-CoV‑2 placentitis is rare. It emphasizes the need of a maternal prophylactic anticoagulation.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"135-139"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Histopathological evaluation of nonalcoholic fatty liver disease : Automated evaluation of liver biopsies]. [非酒精性脂肪肝的组织病理学评估:肝活检的自动评估]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2022-02-16 DOI: 10.1007/s00292-022-01052-w
Nada Abedin, Andrea Tannapfel, Peter J Wild, Iris Tischoff
{"title":"[Histopathological evaluation of nonalcoholic fatty liver disease : Automated evaluation of liver biopsies].","authors":"Nada Abedin,&nbsp;Andrea Tannapfel,&nbsp;Peter J Wild,&nbsp;Iris Tischoff","doi":"10.1007/s00292-022-01052-w","DOIUrl":"https://doi.org/10.1007/s00292-022-01052-w","url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent chronic liver diseases with a rising incidence in industrial countries. This is accompanied by an increased prevalence for NAFLD-associated liver cirrhosis and an increased risk for developing hepatocellular carcinoma. The current gold standard in the diagnostics is a liver biopsy. The histopathological evaluation is performed through semiquantitative scoring. To optimize the standardization and quantification of the existing scoring systems, in the coming years procedures with artificial intelligence, such as deep learning models could be used. Fields of application could be the supplementation of conventional histopathological diagnostics, the identification of new predictive parameters for estimating the prognosis and the prediction of a possible response to treatment.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"157-166"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39928748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benign Müllerian-type epithelial inclusions in a lymph node of a patient with prostatic adenocarcinoma : Avoiding overdiagnosis of metastases]. [前列腺腺癌患者淋巴结良性<s:1>勒氏型上皮包涵体:避免过度诊断转移]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2021-12-17 DOI: 10.1007/s00292-021-01039-z
Piero Caneve, Christoph Fraune
{"title":"[Benign Müllerian-type epithelial inclusions in a lymph node of a patient with prostatic adenocarcinoma : Avoiding overdiagnosis of metastases].","authors":"Piero Caneve,&nbsp;Christoph Fraune","doi":"10.1007/s00292-021-01039-z","DOIUrl":"https://doi.org/10.1007/s00292-021-01039-z","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"140-142"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39823156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The pathologist Hans Klein (1912-1984) : Autopsy of his role in the "Third Reich"]. [病理学家汉斯·克莱因(1912-1984):解剖他在“第三帝国”中的角色]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2021-06-22 DOI: 10.1007/s00292-021-00954-5
Saskia Wilhelmy, Dominik Groß, Mathias Schmidt
{"title":"[The pathologist Hans Klein (1912-1984) : Autopsy of his role in the \"Third Reich\"].","authors":"Saskia Wilhelmy,&nbsp;Dominik Groß,&nbsp;Mathias Schmidt","doi":"10.1007/s00292-021-00954-5","DOIUrl":"https://doi.org/10.1007/s00292-021-00954-5","url":null,"abstract":"<p><p>The role of pathologist Hans Klein during the National Socialist era and his career in post-war Germany have hardly received systematic attention. During World War II, Hans Klein worked in two medical institutions, where he collaborated with individuals who were significantly involved in Nazi crimes. Klein's participation initially extended mainly to his work as an employed pathologist at the Rudolf Virchow Hospital in Berlin. There he was introduced to autopsy practices in the context of the children's euthanasia programme and autopsies of victims of medical experiments. Later, a shift in his activities is noticeable at the Hohenlychen Sanatorium. Klein's activities there increasingly involved independent research or voluntary collaboration in the projects of other scientists that were closely connected to the SS and experiments on human beings in concentration camps. He never had to face justice. His role was not further investigated by the Allies - probably due to his non-existent Nazi party and SS membership.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"143-153"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00292-021-00954-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39098478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic and predictive markers in urinary tract cytology]. [尿路细胞学的诊断和预测标志物]。
4区 医学
Pathologe Pub Date : 2022-03-01 Epub Date: 2022-02-08 DOI: 10.1007/s00292-022-01053-9
Tatjana Vlajnic, Lukas Bubendorf
{"title":"[Diagnostic and predictive markers in urinary tract cytology].","authors":"Tatjana Vlajnic, Lukas Bubendorf","doi":"10.1007/s00292-022-01053-9","DOIUrl":"10.1007/s00292-022-01053-9","url":null,"abstract":"<p><p>Multiprobe fluorescence in situ hybridization (FISH) still remains the gold standard for clarifying inconclusive atypia in urinary cytology in daily routine practice. The Paris Classification System (The Paris System, TPS) provides an important basis for the specific indication of FISH and emphasizes the importance of morphological correlation for an integrative approach to diagnosis. Next-generation sequencing technology in urinary specimens, which is highly sensitive for simultaneous detection of multiple genetic alterations, is also likely to play a diagnostic role in the near future.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39899092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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