Pathologe最新文献_第2页

[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test]. [BRAF V600E突变在转移性结直肠癌中的检测:QuIP轮循试验]。

4区医学

Pathologe Pub Date : 2022-03-01 Epub Date: 2021-11-22 DOI: 10.1007/s00292-021-01022-8

Korinna Jöhrens, Josephine Fischer, Markus Möbs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Laßmann, Martin Werner, Vanessa Borgmann, Hendrik Bläker, Michael Hummel

{"title":"[Detection of BRAF V600E mutation in metastatic colorectal carcinoma : A QuIP round robin test].","authors":"Korinna Jöhrens, Josephine Fischer, Markus Möbs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Laßmann, Martin Werner, Vanessa Borgmann, Hendrik Bläker, Michael Hummel","doi":"10.1007/s00292-021-01022-8","DOIUrl":"https://doi.org/10.1007/s00292-021-01022-8","url":null,"abstract":"<p><p>Round robin testing is an important instrument for quality assurance. Increasingly, this also applies to the results of molecular diagnostics in pathology, which directly influence therapy decisions in precision oncology. In metastatic colorectal carcinoma (mCRC), the focus has been on detecting KRAS and NRAS mutations, whose absence allows therapy with EGFR blocking antibodies. Recently, BRAF has been added as another predictive marker, since mCRC patients with BRAF V600E mutation benefit significantly from treatment with encorafenib (a BRAF inhibitor) in combination with cetuximab (anti-EGFR antibody) after systemic therapy. Due to the approval of this treatment in 2020, it is a pre-requisite that BRAF V600E mutation detection in diagnostic pathologies is reliably performed. Therefore, this round robin test with BRAF V600E testing either by immunohistochemistry or molecular methods was performed. The round robin test results demonstrate that molecular BRAF V600E detection is currently clearly superior to immunohistochemical detection.</p>","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 2","pages":"126-134"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39735327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}