Postepy Dermatologii I Alergologii最新文献

{"title":"Electronic cigarettes in dermatology: a systematic review of the literature.","authors":"Paulina Rutecka, Dawid Wolak, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.144520","DOIUrl":"10.5114/ada.2024.144520","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarettes (e-cigarettes) have been gaining worldwide popularity for several years now, making vaping a major alternative to regular tobacco smoking.</p><p><strong>Aim: </strong>There is still a lack of data on the occurrence of dermatological diseases due to e-cigarettes, so the research was performed.</p><p><strong>Methods: </strong>A systematic review of the literature was performed in Embase and Medline databases. The search included EMTREE and MESH approaches and was conducted according to the PRISMA guidelines.</p><p><strong>Results: </strong>Electronic cigarettes were identified both as an initiating and aggravating factor in several dermatological diseases. Vaping resulted in impaired wound healing and thermal injuries in the healthy skin.</p><p><strong>Conclusions: </strong>Electronic cigarettes have been reported to contribute to the development of various skin diseases and be a source of thermal injury. Lack of data and poor compliance concerning reporting the side effects of vaping make this topic an important issue to monitor.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"446-449"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer.","authors":"Zuzana Prídavková, Lukáš Plank, Peter Žiak, Juraj Halička, Karolína Benca-Kapitánová, Rastislav Vida, Vladimír Bartoš","doi":"10.5114/ada.2024.144402","DOIUrl":"10.5114/ada.2024.144402","url":null,"abstract":"<p><strong>Introduction: </strong>Prognostic biomarkers facilitate the identification of high-risk tumours.</p><p><strong>Aim: </strong>To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.</p><p><strong>Material and methods: </strong>Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.</p><p><strong>Results: </strong>The study cohort included 68 patients with 70 non-melanoma eyelid tumours (<i>n</i> = 70). The basal cell carcinoma was the most frequently present type (97.1%). The median age was 68 years. A tumour size > 5 mm correlates to the aggressive type (<i>p</i> = 0.047). Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (<i>p</i> = 0.076). The average value of Bcl-2 expression in non-aggressive types was 82.65% (<i>p</i> < 0.001). The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (<i>p</i> = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (<i>p</i> = 0.535). No Grade III case was observed in the aggressive types. In 2 cases, the orbital exenteration was carried out (0.03%). In 1 case biological therapy was administered. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 (0.06%) cases.</p><p><strong>Conclusions: </strong>New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"456-462"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of microneedling without and with minoxidil 5% and autologous platelet-rich plasma for androgenetic alopecia in men.","authors":"Szymon Leonik, Michał Smoczok, Beata Bergler-Czop","doi":"10.5114/ada.2024.143496","DOIUrl":"10.5114/ada.2024.143496","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia is the most common form of non-cicatricial hair loss in men. The condition also affects young adults and can cause significant psychological distress. In addition to widely accepted methods, clinicians have at their disposal a number of therapies for which there are no established treatment algorithms.</p><p><strong>Methods: </strong>The study was conducted on a selected group of 92 men aged between 20 and 50 years. The patients were divided into three groups, each with a different therapeutic algorithm: group A - three microneedling treatments 1 month apart, group B - three microneedling treatments 1 month apart and daily topical application of 5% minoxidil, group C - three platelet-rich plasma treatments 1 month apart.</p><p><strong>Results: </strong>Each group showed an increase in mean hair number and density. However, only group C demonstrated a statistically significant increase in hair shaft thickness.</p><p><strong>Conclusions: </strong>Currently, there is no clear consensus in the literature regarding algorithms for microneedling and platelet-rich plasma treatment of the scalp. For the study, we selected a minimum effective algorithm that yielded satisfactory results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"505-514"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis.","authors":"Hao Zhu, Qiang Sun, Hyunsoo Choi, Yang Li, Wei Zhang","doi":"10.5114/ada.2024.143424","DOIUrl":"10.5114/ada.2024.143424","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis (Pso) is an inflammatory autoimmune skin disease. High BMI, and elevated body fat and body weight is associated with risk of Pso development. People with Pso have lower physical activity than people without Pso, so they are at higher risk for comorbidities and underlying disease. Exercise has been shown to improve disease outcomes and inflammation in people with psoriasis.</p><p><strong>Aim: </strong>Meta-analysis study to investigate the physical activity in psoriasis patients.</p><p><strong>Methods: </strong>We designed this study according to the Systematic Reviews and Meta-Analyses (PRISMA) statement. The ISI, Scopus, PubMed, Cochrane Library, and Google Scholar have been used to search articles up to the end of May 2024.</p><p><strong>Results: </strong>A total of 1319 articles were extracted from the databases, and 7 articles were selected for analysis. High-intensity exercise levels were significantly lower in Pso patients than in healthy people (RR = 0.75; 95% CI: 0.60-0.93; <i>p</i> = 0.010). But there was no significant difference between the 2 groups regarding moderate-intensity exercise (RR = 0.80; 95% CI: 0.57-1.12; <i>p</i> = 0.20) and low-intensity exercise (RR = 1.42; 95% CI: 0.36-5.60; <i>p</i> = 0.62). Also, the number of metabolic equivalent task (MET) minutes in the Pso group was significantly lower than in healthy controls (SMD = -0.71; 95% CI: -0.86-0.56; <i>p</i> < 000001). Finally, the post-exercise PASI score decreased significantly in psoriatic patients (SMD = 3.98; 95% CI: 0.48-7.48; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>High-intensity physical activity is significantly lower in Pso patients than in healthy people, MET in the Pso group was significantly lower than in healthy controls, and the post-exercise PASI score decreased significantly in psoriatic patients, which means physical activity intervention can be suggested as a therapeutic method for Pso patients.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"450-455"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset atopic dermatitis induced by vedolizumab: a case series.","authors":"Eleonora Nucera, Sara Urbani, Arianna Aruanno, Franco Scaldaferri, Dario D'Urso, Clara De Simone","doi":"10.5114/ada.2024.144405","DOIUrl":"10.5114/ada.2024.144405","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"542-544"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between Fc epsilon receptor-1α and β (<i>FCER1A</i> and <i>FCER1B</i>) gene polymorphisms in patients with chronic urticaria using omalizumab.","authors":"Hulya Savas, Hatice Uce Ozkol, Gokhan Gorgisen, Halil Özkol, Can Ates, Ahmet Metin, İlknur Yorgun Özdemir","doi":"10.5114/ada.2024.142285","DOIUrl":"https://doi.org/10.5114/ada.2024.142285","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic urticaria requires well-defined treatment strategies in order to achieve a maximum treatment response and maintain the quality of life. Since 2014, omalizumab has been used in chronic urticaria. However, many studies showed that some patients are resistant to omalizumab.</p><p><strong>Aim: </strong>To determine the effects of single nucleotide changes in the <i>FCER1A</i> and <i>FCER1B</i> genes, which are thought to be related to resistance mechanisms, in our population of patients who have not responded to omalizumab treatment.</p><p><strong>Material and methods: </strong>We included 100 patients with chronic urticaria who were treated with omalizumab and 50 healthy individuals. Frequently observed gene polymorphisms, FCER1A (rs2251746) and FCER1B (rs569108), were examined in peripheral blood samples. The regions of rs2251746 and rs569108 gene polymorphisms were amplified using fluorescently labelled probes through real-time polymerase chain reaction (PCR). The analysis was performed bioinformatically via the SNP genotype profiling program.</p><p><strong>Results: </strong>There was no statistically significant relationship between <i>FCER1A</i> (rs2251746) and <i>FCER1B</i> (rs569108) gene polymorphisms in patients and their clinical, demographic characteristics, and the resistance to treatment (<i>p</i> > 0.05). In our study, the mean patient age was found to be higher in the CT group (44.71 ±12.5 years) compared to the TT group (37.34 ±11.5 years) only in the rs2251746 polymorphism (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>In our study, there was no significant relationship between <i>FCER1A</i> and <i>FCER1B</i> gene polymorphisms and resistance to omalizumab therapy. Further, multicentre, large-scale studies are needed to support our results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"357-363"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris.","authors":"Agnieszka Otlewska-Szpotowicz, Wojciech Baran, Zdzisław Woźniak, Jacek Szepietowski, Aleksandra Batycka-Baran","doi":"10.5114/ada.2024.142179","DOIUrl":"https://doi.org/10.5114/ada.2024.142179","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planopilaris (LPP) is an inflammatory, primary scarring alopecia, however its pathogenesis is not completely elucidated. S100A7 is a multifunctional, antimicrobial protein with proinflammatory properties. Interleukin-17 (IL-17) is implicated in the development of various autoimmune skin diseases.</p><p><strong>Aim: </strong>To determine the tissue expression of S100A7, S100A4 and IL-17 in LPP.</p><p><strong>Material and methods: </strong>The immunohistochemical analysis was performed on biopsy specimens obtained from individuals with histologically confirmed lichen planopilaris (<i>n</i> = 23), alopecia areata (AA) (<i>n</i> = 11), and healthy controls (<i>n</i> = 14). The expression was evaluated using Zeiss Axio Imager A2 light microscope.</p><p><strong>Results: </strong>The number of cells showing S100A7 expression was significantly higher in LPP lesional skin compared to AA lesional skin (<i>p</i> = 0.0002) and normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was significantly higher in LPP lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001) and the number of cells showing IL-17 expression was significantly higher in AA lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was not significantly different in LPP lesional skin and in AA lesional skin (<i>p</i> > 0.05). The number of cells showing S100A4 expression was not significantly different in LPP lesional skin, AA lesional skin and in normal skin of healthy controls.</p><p><strong>Conclusions: </strong>The results of our study suggest the possible role of S100A7 and IL-17 in the pathogenesis of LPP.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"364-371"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life in subjects with hidradenitis suppurativa suffering from periodontitis.","authors":"Barbara Paśnik-Chwalik, Beata Jastrząb-Miśkiewicz, Piotr K Krajewski, Łukasz Matusiak, Tomasz Konopka, Jacek C Szepietowski","doi":"10.5114/ada.2024.141614","DOIUrl":"https://doi.org/10.5114/ada.2024.141614","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disorder affecting the pilosebaceous unit in intertriginous body areas, and recent research suggests an association with periodontitis.</p><p><strong>Aim: </strong>To assess oral health-related quality of life (OHRQoL) in patients with HS diagnosed additionally with periodontitis and to compare it to patients with periodontitis alone.</p><p><strong>Material and methods: </strong>The study involved 55 HS patients, with 25 in the HS + P group (both HS and periodontitis) and matched controls in the periodontitis-only group (P group). Outcomes were assessed using the Oral Health Impact Profile (OHIP-14) questionnaire.</p><p><strong>Results: </strong>No significant difference was observed in the mean OHIP-14 total score between the HS + P group and the P group. Patients with HS + P were less likely to undergo the dental evaluation and floss their teeth less frequently compared to the P group.</p><p><strong>Conclusions: </strong>The findings reveal that the coexistence of HS in patients with periodontitis does not significantly influence OHRQoL. Lower dental evaluation frequency and less frequent flossing in HS+P patients suggest reduced attention to oral health practices.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"395-399"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatophagoides pteronyssinus proteins and their role in the diagnostics and management of house dust mite allergy: exploring allergenic components.","authors":"Magdalena Choina, Krzysztof Kowal, Ewa Markut-Miotła, Emilia Majsiak","doi":"10.5114/ada.2024.142390","DOIUrl":"https://doi.org/10.5114/ada.2024.142390","url":null,"abstract":"<p><p>Component-resolved diagnostics enables the detection of allergen-specific immunoglobulins E (asIgE) to house dust mite (HDM) proteins, which may help clinicians to face the difficulties in diagnostics of HDM allergy. Currently, almost 40 proteins of <i>Dermatophagoides</i> species, that are able to bind asIgE, have been identified, and this number will certainly increase. The association between sensitisation to particular molecules and allergy symptoms is extensively studied. This investigation enables us to identify HDM molecules that promote respiratory, skin, or food allergies, and it could help us predict the possible course of allergic diseases. The individual repertoire of asIgE improves our understanding of immunological response, which underlies allergy symptoms, and helps to form individual therapeutic regimens. This review provides clinicians with information on <i>Dermatophagoides pteronyssinus</i> proteins available in commercial arrays, and their role in the diagnostics and management of HDM allergy.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"339-349"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of gut microbiome alterations in plaque psoriasis patients compared to healthy individuals.","authors":"Karina Polak, Tomasz Muszyński, Aleksandra Frątczak, Fanni Meznerics, András Bánvölgyi, Norbert Kiss, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.142394","DOIUrl":"https://doi.org/10.5114/ada.2024.142394","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies have shown significant alterations in the gut microbiome of patients with psoriasis compared to healthy controls.</p><p><strong>Aim: </strong>The primary objective of the current research was to explore the impact of gut microbiome composition on the progression and severity of plaque psoriasis.</p><p><strong>Material and methods: </strong>A total of 20 patients with moderate-to-severe psoriasis and 20 healthy individuals were recruited and provided a stool sample to assess the gut microbiome. After the samples were prepared according to the NGS library preparation workflow, they were sequenced using the Illumina platform and the report was generated that underwent statistical analysis.</p><p><strong>Results: </strong>The microbiome profiles of psoriasis patients exhibited significant differences compared to healthy controls as evidenced by the statistical analysis of various bacterial genera, with the median abundance significantly lower in psoriasis patients compared to healthy controls (<i>p</i> = 0.033). The analysis of the Firmicutes-to-Bacteroidetes ratio, a commonly evaluated marker of dysbiosis, did not reach statistical significance (<i>p</i> = 0.239). However, there was a noticeable trend towards a higher median ratio in psoriasis patients compared to healthy controls. The ratio did not show significant associations with PASI or BSA but trends towards significance with DLQI (<i>B</i> = -12.11, <i>p</i> = 0.095).</p><p><strong>Conclusions: </strong>Overall, the above findings underscore the importance of the gut microbiome in psoriasis and suggest that modulation of specific bacterial genera, especially that with significant differences, could be a potential strategy for therapeutic intervention. Targeting these depleted genera through microbiome-based interventions, such as probiotic supplementation or faecal microbiota transplantation, could potentially help to restore gut homeostasis and alleviate the inflammatory burden in psoriasis.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"378-387"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}