Study of gut microbiome alterations in plaque psoriasis patients compared to healthy individuals.

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2024-08-01 Epub Date: 2024-08-21 DOI:10.5114/ada.2024.142394
Karina Polak, Tomasz Muszyński, Aleksandra Frątczak, Fanni Meznerics, András Bánvölgyi, Norbert Kiss, Bartosz Miziołek, Beata Bergler-Czop
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Abstract

Introduction: Many studies have shown significant alterations in the gut microbiome of patients with psoriasis compared to healthy controls.

Aim: The primary objective of the current research was to explore the impact of gut microbiome composition on the progression and severity of plaque psoriasis.

Material and methods: A total of 20 patients with moderate-to-severe psoriasis and 20 healthy individuals were recruited and provided a stool sample to assess the gut microbiome. After the samples were prepared according to the NGS library preparation workflow, they were sequenced using the Illumina platform and the report was generated that underwent statistical analysis.

Results: The microbiome profiles of psoriasis patients exhibited significant differences compared to healthy controls as evidenced by the statistical analysis of various bacterial genera, with the median abundance significantly lower in psoriasis patients compared to healthy controls (p = 0.033). The analysis of the Firmicutes-to-Bacteroidetes ratio, a commonly evaluated marker of dysbiosis, did not reach statistical significance (p = 0.239). However, there was a noticeable trend towards a higher median ratio in psoriasis patients compared to healthy controls. The ratio did not show significant associations with PASI or BSA but trends towards significance with DLQI (B = -12.11, p = 0.095).

Conclusions: Overall, the above findings underscore the importance of the gut microbiome in psoriasis and suggest that modulation of specific bacterial genera, especially that with significant differences, could be a potential strategy for therapeutic intervention. Targeting these depleted genera through microbiome-based interventions, such as probiotic supplementation or faecal microbiota transplantation, could potentially help to restore gut homeostasis and alleviate the inflammatory burden in psoriasis.

研究斑块型银屑病患者与健康人相比肠道微生物组的变化。
导言:许多研究表明,与健康对照组相比,银屑病患者的肠道微生物组发生了明显变化。目的:本研究的主要目的是探讨肠道微生物组的组成对斑块状银屑病的进展和严重程度的影响:共招募了20名中重度银屑病患者和20名健康人,并提供粪便样本以评估肠道微生物组。按照 NGS 文库制备工作流程制备样本后,使用 Illumina 平台进行测序,并生成报告进行统计分析:结果:与健康对照组相比,银屑病患者的微生物组特征表现出显著差异,这体现在对各种细菌属的统计分析上,银屑病患者的中位丰度明显低于健康对照组(p = 0.033)。对菌群失调的常用评估指标--固着菌与类杆菌之比进行的分析未达到统计学意义(p = 0.239)。不过,与健康对照组相比,银屑病患者的中位比值有明显升高的趋势。该比率与 PASI 或 BSA 没有明显关联,但与 DLQI 有显著关联趋势(B = -12.11,p = 0.095):总之,上述发现强调了肠道微生物组在银屑病中的重要性,并表明调节特定细菌属,尤其是差异显著的细菌属,可能是一种潜在的治疗干预策略。通过基于微生物组的干预措施(如补充益生菌或粪便微生物群移植)来针对这些耗竭的菌属,可能有助于恢复肠道平衡并减轻银屑病的炎症负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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