Regional Anesthesia and Pain Medicine最新文献_第4页

Investigation of lumbar spine movement during unilateral lower extremity flexion. 单侧下肢屈曲时腰椎运动的研究。

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2023-104505

Masashi Fujii, Tsutomu Shirakawa, Yasuyo Kawabata

引用次数: 0

In reply: Epidural analgesia after surgery - time to review the gold standard? 回复术后硬膜外镇痛--是时候重新审视黄金标准了？

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2024-105504

Anuj B Patel, Gerard J Kerins, Brian D Sites, Chloe Nadine M Duprat, Matthew Davis

引用次数: 0

Iliopsoas plane block does not improve pain after primary total hip arthroplasty in the presence of multimodal analgesia: a single institution randomized controlled trial. 髂腰肌平面阻滞不能改善初级全髋关节置换术后多模式镇痛的疼痛：一项单机构随机对照试验。

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2023-105092

Ji Yeong Kim, Jong Seok Lee, Ji Young Kim, Eun Jang Yoon, Wootaek Lee, Seungyeon Lee, Do-Hyeong Kim

{"title":"Iliopsoas plane block does not improve pain after primary total hip arthroplasty in the presence of multimodal analgesia: a single institution randomized controlled trial.","authors":"Ji Yeong Kim, Jong Seok Lee, Ji Young Kim, Eun Jang Yoon, Wootaek Lee, Seungyeon Lee, Do-Hyeong Kim","doi":"10.1136/rapm-2023-105092","DOIUrl":"10.1136/rapm-2023-105092","url":null,"abstract":"Background: The clinical analgesic efficacy of iliopsoas plane block remains a subject of discussion. This study aimed to assess the analgesic efficacy of iliopsoas plane block under general anesthesia using multimodal analgesia.Methods: Fifty-six adult patients who underwent elective primary hip arthroplasty were enrolled. Patients were randomized to receive either a single-shot iliopsoas plane block (10 mL 0.75% ropivacaine with 1:200 000 epinephrine) or a sham block (10 mL normal saline). All patients received general anesthesia, multimodal analgesia (preoperative buprenorphine patch, 5 µg/h), intraoperative intravenous dexamethasone (8 mg) and nefopam (20 mg), and round-the-clock acetaminophen and celecoxib. The primary outcome was the numeric rating scale pain score at rest 6 hour after surgery.Results: Iliopsoas plane block did not have a notable advantage over the sham block in terms of pain relief at rest, as assessed by the numeric rating scale score, 6 hour after total hip arthroplasty (iliopsoas plane block: median, 4.0; IQR, 2.0-5.8; sham: median, 5.5; IQR, 2.3-6.8; median difference, -1.0; 95% CI -2.0 to 0.0; p≥0.999). Linear mixed model analysis showed no differences in pain scores, opioid consumption, quadriceps strength, or quality of recovery between the groups.Conclusions: Iliopsoas plane block did not improve postoperative analgesia following total hip arthroplasty under general anesthesia with a multimodal analgesic regimen. The blockade of sensory femoral branches supplying the anterior hip capsule using iliopsoas plane block may not yield additional benefits concerning patient outcomes in the aforementioned clinical context.Trial registration number: NCT05212038, https://clinicaltrials.gov/ct2/show/NCT05212038.","PeriodicalId":54503,"journal":{"name":"Regional Anesthesia and Pain Medicine","volume":" ","pages":"257-263"},"PeriodicalIF":5.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in the association between epidural analgesia and length of stay by surgery type: an observational study. 不同手术类型硬膜外镇痛与住院时间之间的差异：一项观察性研究。

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2023-105194

Anuj B Patel, Gerard J Kerins, Brian D Sites, Chloe Nadine M Duprat, Matthew Davis

{"title":"Differences in the association between epidural analgesia and length of stay by surgery type: an observational study.","authors":"Anuj B Patel, Gerard J Kerins, Brian D Sites, Chloe Nadine M Duprat, Matthew Davis","doi":"10.1136/rapm-2023-105194","DOIUrl":"10.1136/rapm-2023-105194","url":null,"abstract":"Introduction: Despite a decline in the use of thoracic epidural analgesia related in part to concerns for delayed discharge, it is unknown whether changes in length of stay (LOS) associated with epidural analgesia vary by surgery type. Therefore, we determined the degree to which the association between epidural analgesia (vs no epidural) and LOS differed by surgery type.Methods: We conducted an observational study using data from 1747 patients who had either non-emergent open abdominal, thoracic, or vascular surgery at a single tertiary academic hospital. The primary outcome was hospital LOS and the incidence of a prolonged hospital LOS defined as 21 days or longer. Secondary endpoints included escalation of care, 30-day all-cause readmission, and reason for epidural not being placed. The association between epidural status and dichotomous endpoints was examined using logistic regression.Results: Among the 1747 patients, 85.7% (1499) received epidural analgesia. 78% (1364) underwent abdominal, 11.5% (200) thoracic, and 10.5% (183) vascular surgeries. After adjustment for differences, receiving epidural analgesia (vs no epidural) was associated with a 45% reduction in the likelihood of a prolonged LOS (p<0.05). This relationship varied by surgery type: abdominal (OR 0.42, 95% CI 0.23 to 0.79, p<0.001), vascular (OR 1.66, 95% CI 0.17 to 16.1, p=0.14), and thoracic (OR 1.07, 95% CI 0.20 to 5.70, p=0.93). Among abdominal surgical patients, epidural analgesia was associated with a median decrease in LOS by 1.4 days and a 37% reduction in the likelihood of 30-day readmission (adjusted OR 0.63, 0.41 to 0.97, p<0.05). Among thoracic surgical patients, epidural analgesia was associated with a median increase in LOS by 3.2 days.Conclusions: The relationship between epidural analgesia and LOS appears to be different among different surgical populations.","PeriodicalId":54503,"journal":{"name":"Regional Anesthesia and Pain Medicine","volume":" ","pages":"252-256"},"PeriodicalIF":5.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidural analgesia after surgery: time to review the gold standard? 术后硬膜外镇痛：是时候重新审视黄金标准了？

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2024-105439

Karli M Spann, Amir L Butt, Danielle R Zabala, Aimee Pak

引用次数: 0

Peripheral nerve block and the antimicrobial proprieties of local anesthetics. 周围神经阻滞和局部麻醉剂的抗菌特性。

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2024-105461

Andreas Clipet-Jensen, Hans Fjeldsøe-Nielsen, Birgitte Berthelsen

引用次数: 0

Reply: 'Danger, Danger, Gaston Labat! Does zero-shot artificial intelligence correlate with anticoagulation guideline recommendations for neuraxial anesthesia?' 回复：危险，危险，加斯东-拉巴特！零注射人工智能与神经麻醉抗凝指南建议相关吗？

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-03-05 DOI: 10.1136/rapm-2024-105441

Nathan C Hurley, Rajnish K Gupta, Kristopher M Schroeder, Aaron S Hess

引用次数: 0

Response to letter to the editor: Hidden influence? Unmasking conflicts of interest from randomized clinical trials on spinal cord stimulation for chronic pain.

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-02-27 DOI: 10.1136/rapm-2024-106329

Ryan S D'Souza, Johana Klasova, Nasir Hussain

引用次数: 0

Elevated 18:1 lysophosphatidylcholine contributes to neuropathic pain in peripheral nerve injury.

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-02-27 DOI: 10.1136/rapm-2024-106195

Jinxuan Ren, Lina Yu, Jiaqi Lin, Ying Liu, Longfei Ma, Yangyuxin Huang, Na Sun, Yutao Deng, Da Zhong, Binglin Zhou, Baochun Jiang, Min Yan

{"title":"Elevated 18:1 lysophosphatidylcholine contributes to neuropathic pain in peripheral nerve injury.","authors":"Jinxuan Ren, Lina Yu, Jiaqi Lin, Ying Liu, Longfei Ma, Yangyuxin Huang, Na Sun, Yutao Deng, Da Zhong, Binglin Zhou, Baochun Jiang, Min Yan","doi":"10.1136/rapm-2024-106195","DOIUrl":"https://doi.org/10.1136/rapm-2024-106195","url":null,"abstract":"Background: Neuropathic pain is a maladaptive and chronic condition with limited effective treatments. Although recent studies have suggested that certain lipid metabolites, like lysophosphatidylcholine (LPC), may contribute to chronic pain, their specific roles and mechanisms remain unclear.Objective: This study investigated the role and mechanism of LPC(18:1), a lipid subtype, in neuropathic pain caused by nerve injury.Methods: Using a mouse model of spinal nerve ligation, LPC(18:1) levels were measured in serum, dorsal root ganglion (DRG), spinal cord (SC) and cerebrospinal fluid (CSF). Nociception was assessed using von Frey and Hargreaves' methods, while molecular analyses explored inflammatory pathways and oxidative stress.Results: LPC(18:1) levels significantly increased in the serum, DRG and CSF after nerve injury. Administration of LPC(18:1) induced heightened pain responses and activated inflammatory pathways, including protein kinase C (PKC) and extracellular regulated protein kinase (ERK) in the DRG, as well as glial cells in the SC. The findings suggested that oxidative stress played a role in LPC(18:1) production, and its effects were mediated by G protein-coupled receptor 132 (GPR132).Conclusion: LPC(18:1) may serve as a potential biomarker and therapeutic target for managing neuropathic pain.","PeriodicalId":54503,"journal":{"name":"Regional Anesthesia and Pain Medicine","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: Hidden influence? Unmasking conflicts of interest from randomized clinical trials on spinal cord stimulation for chronic pain.

IF 5.1 2区医学

Regional Anesthesia and Pain Medicine Pub Date : 2025-02-27 DOI: 10.1136/rapm-2024-106181

Guy Henri Hans, Lisa Bernaerts, Ella Roelant, Maarten Moens

引用次数: 0