Revista Do Instituto De Medicina Tropical De Sao Paulo最新文献

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Clinical characteristics of coronavirus disease 2019 patients with hepatitis B virus super-infection.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466074
Shan Yu, Cunzheng Song
{"title":"Clinical characteristics of coronavirus disease 2019 patients with hepatitis B virus super-infection.","authors":"Shan Yu, Cunzheng Song","doi":"10.1590/S1678-9946202466074","DOIUrl":"10.1590/S1678-9946202466074","url":null,"abstract":"<p><p>COVID-19 and hepatitis B disease are significant global pandemics, both of which can lead to liver damage. This study aims to report the clinical course of liver function and disease prognosis of COVID-19 patients with hepatitis B virus (HBV) super-infections. A total of 249 outpatients with COVID-19 were enrolled in this study from December 1, 2023 to February 28, 2024. Clinical characteristics, laboratory data, chest CT findings, and patients' treatment and outcomes were collected and analyzed retrospectively. Of the 249 outpatients, 37 (14.9%) were super-infected with HBV, whereas 212 (85.1%) showed no such outcome. This study found no significant differences between the two groups regarding age, gender, symptoms, complications, or chest CT findings. However, COVID-19 patients super-infected with HBV showed lower white blood cell, neutrophil, and platelet counts (p < 0.05). Additionally, total bilirubin levels were significantly higher in the SARS-CoV-2/HBV super-infected group compared to the COVID-19-only group (p = 0.022). After the first week of similar treatment, both groups showed almost identical outcomes, including hospitalization, severity, and mortality rates. Thus, SARS-CoV-2/HBV super-infection slightly affected liver function but did not worsen COVID-19 outcomes. Routine HBV monitoring and liver function tests are recommended to manage COVID-19 patients with HBV super-infections. This study found no clear indications of the need to change the therapeutic prescription for COVID-19 in cases of HBV super-infections.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e74"},"PeriodicalIF":1.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence of Strongyloides stercoralis, human T-lymphotropic virus, and Chagas disease in the Peruvian Amazon: a cross-sectional study.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466073
Martin Casapía-Morales, Wilma-Selva Casanova-Rojas, Jhosephi Vázquez-Ascate, Cristiam-Armando Carey-Angeles, Carlos Alvarez-Antonio, Freddy-Franco Alava-Arévalo, Silvia Otero-Rodríguez, José-Manuel Ramos-Rincón
{"title":"Seroprevalence of Strongyloides stercoralis, human T-lymphotropic virus, and Chagas disease in the Peruvian Amazon: a cross-sectional study.","authors":"Martin Casapía-Morales, Wilma-Selva Casanova-Rojas, Jhosephi Vázquez-Ascate, Cristiam-Armando Carey-Angeles, Carlos Alvarez-Antonio, Freddy-Franco Alava-Arévalo, Silvia Otero-Rodríguez, José-Manuel Ramos-Rincón","doi":"10.1590/S1678-9946202466073","DOIUrl":"10.1590/S1678-9946202466073","url":null,"abstract":"<p><p>Strongyloides stercoralis infections, human T-lymphotropic virus (HTLV) infections, and Chagas diseases occur throughout many regions of Central and South America, including Peru. This study aimed to evaluate the seroprevalence of S. stercoralis, HTLV, and Chagas disease in Iquitos (Peruvian Amazon) and the associated epidemiological conditions for S. stercoralis seroprevalence in Iquitos. A population-based cross-sectional study was conducted from May 1 to June 15, 2020, to assess the seroprevalence of S. stercoralis [lysate antigen ELISA (enzyme linked immunosorbent assay)], HTLV (recombinant antigen ELISA), and Chagas disease (crude and recombinant antigen ELISAs). Of the 396 included individuals, 257 were seropositive for S. stercoralis (a 64.9% prevalence, 95% confidence interval [CI] 60.0% to 69.4%). In the multivariable analysis, seropositivity for S. stercoralis was higher in women (odds ratio [OR] 1.60, 95% CI 1.03 to 2.66) and residents of Punchana (OR 3.47, 95% CI 1.51 to 7.93), whereas residence in Iquitos was associated with lower positivity (OR 0.52, 95% CI 0.32 to 0.85). In total, four individuals were positive for HTLV (1.0% seroprevalence, 95% CI 0.3% to 2.7%), and none were positive for Chagas disease (0.0% seroprevalence, 95% CI 0.0% to 1.2%). The seroprevalence of S. stercoralis in Iquitos is high, particularly among women and residents of Punchana. The presence of HTLV infection indicates that the virus is circulating in Iquitos. This study found no cases of Chagas disease.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e73"},"PeriodicalIF":1.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate-immune cell distribution in pediatric HIV patients and uninfected controls.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466075
Cynthia Oliveira Aquino, Fernanda Mariz Pereira, Ana Cristina Cisne Frota, Cristina Barroso Hofer, Lucimar Gonçalves Milagres, Wânia Ferraz Pereira Manfro
{"title":"Innate-immune cell distribution in pediatric HIV patients and uninfected controls.","authors":"Cynthia Oliveira Aquino, Fernanda Mariz Pereira, Ana Cristina Cisne Frota, Cristina Barroso Hofer, Lucimar Gonçalves Milagres, Wânia Ferraz Pereira Manfro","doi":"10.1590/S1678-9946202466075","DOIUrl":"10.1590/S1678-9946202466075","url":null,"abstract":"<p><p>Innate immune cells are important players during an infection. The frequency of monocytes, myeloid-derived suppressor cells (MDSCs), natural killer (NK), and NKT cells were assessed in blood samples of children and adolescents living with HIV (CALHIV) and HIV-uninfected (HU) children. Blood samples from 10 CALHIV (treated or not) and six HU individuals were collected for approximately one year. Flow cytometry was employed to phenotypically characterize cell populations. We found a lower frequency of classical monocytes in CALHIV patients compared to the HU group (35.75% vs. 62.60%, respectively) but a higher frequency of CD56-CD16+ NK cells in CALHIV patients compared to the HU group (1.45% vs. 0.44%, respectively). At baseline, the frequency of monocytic-MDSCs inversely correlated with CD56dimCD16+ NK cells (r= -0.73, p=0.020), CD56-CD16+ NK cells (r= -0.78, p=0.010), and with intermediate monocytes (r= -0.71, p=0.027) in the CALHIV group. We also found a negative correlation between CD56++CD16+- and CD56dimCD16+ NK cells with CD4 T cells frequency at baseline. The results suggest an alteration in the innate compartment of the CALHIV cohort, which may contribute to their susceptibility to infections.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e75"},"PeriodicalIF":1.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zika virus infection and acute transverse myelitis: a comprehensive systematic review.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466066
Bianca Aparecida Colognese, Nayara Argollo
{"title":"Zika virus infection and acute transverse myelitis: a comprehensive systematic review.","authors":"Bianca Aparecida Colognese, Nayara Argollo","doi":"10.1590/S1678-9946202466066","DOIUrl":"10.1590/S1678-9946202466066","url":null,"abstract":"<p><p>The Zika virus (ZIKV) has been associated with several complications, including acute transverse myelitis (ATM), an acute inflammation of the spinal cord, with rapid development of motor, sensory and dysautonomic symptoms. It is a rare disease, and its clinical features, as well as differences in relation to idiopathic ATMs, are still not completely known. The objective of this paper is to review the literature in search of clinical features and complementary exams of ATM post-ZIKV infection, alone or in association with other neurological conditions (mixed diseases), as well as its treatments and prognoses. The search was made on 5 databases, using the PRISMA methodology (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Nine articles were selected (total of 20 subjects), which were divided between isolated ATM and mixed neurological syndromes with ATM. The study found a predominance of individuals aged 20 to 30. Among the six subjects in the mixed group, three were over 50 years old. The median prodromal period was 2 days for the mixed diseases group and 7 days for the isolated ATM group. Some individuals in the isolated ATM group exhibited signs of dysautonomia, such as syncope, postural lability, and arrhythmia. The mixed group had a higher incidence of coinfections, with 4 cases compared to 1 case in the isolated ATM group. Over 50% of the individuals had moderate to moderately severe disability. These findings suggest that severe conditions may progress to significant sequelae, highlighting the need for prompt diagnosis and treatment, particularly during endemic periods.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e66"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of communication on measles vaccination on digital platforms in the Brazilian context: challenges and perspectives.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466068
Maria da Penha Soares Silva, Vera Lúcia Gattás, Expedito José de Albuquerque Luna
{"title":"Dynamics of communication on measles vaccination on digital platforms in the Brazilian context: challenges and perspectives.","authors":"Maria da Penha Soares Silva, Vera Lúcia Gattás, Expedito José de Albuquerque Luna","doi":"10.1590/S1678-9946202466068","DOIUrl":"10.1590/S1678-9946202466068","url":null,"abstract":"<p><p>The infodemic and the spread of disinformation have fostered mistrust in vaccines, health institutions, and governments, contributing to a global decline in vaccination coverage and the resurgence of vaccine-preventable diseases like measles. In recent years, the use of digital platforms to access health information, including vaccines, has increased significantly. However, the rapid dissemination of disinformation on these under-regulated platforms can greatly influence vaccination behavior. This study aimed to identify and analyze the main arguments used on Facebook® regarding measles vaccination. Posts and comments in Brazilian Portuguese were extracted using keywords such as \"Measles Vaccines,\" \"Triple Viral,\" and \"Tetra Viral\" from general and anti-vaccine pages from January 2017 to December 31, 2020. A sample from both datasets was selected and analyzed using deductive content analysis. Of the posts, 213 (84.5%) were classified as pro-vaccine, primarily promoting vaccination campaigns, with limited discussions on vaccine risk-benefit and collective responsibility. Notably, anti-vaccine pages, though fewer in number and followers, were more active in posting than pro-vaccine pages. Of the anti-vaccine posts, 118 (59.3%) focused on undermining vaccine safety and efficacy, spreading disinformation to downplay disease risks. Although pro-vaccine messages showed the highest engagement on the platform, more effective communication strategies are needed to complement traditional health systems, as anti-vaccine posts appear to influence vaccination behavior, particularly among hesitant communities.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e68"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the public health laboratory network for tegumentary leishmaniasis in an endemic area of Brazil.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466070
Fernanda Alvarenga Cardoso Medeiros, Job Alves Souza Filho, Maria Inês Fernandes Pimentel, Ilka Afonso Reis, Daniel Menezes-Souza, Aline Fagundes da Silva, Andreza Pain Marcelino
{"title":"Evaluation of the public health laboratory network for tegumentary leishmaniasis in an endemic area of Brazil.","authors":"Fernanda Alvarenga Cardoso Medeiros, Job Alves Souza Filho, Maria Inês Fernandes Pimentel, Ilka Afonso Reis, Daniel Menezes-Souza, Aline Fagundes da Silva, Andreza Pain Marcelino","doi":"10.1590/S1678-9946202466070","DOIUrl":"10.1590/S1678-9946202466070","url":null,"abstract":"<p><p>Diagnostic networks ensure efficiency in disease diagnosis. A descriptive study evaluated the network of public health laboratories (NPHL) in Minas Gerais State, Brazil, using diagnostic results for tegumentary leishmaniasis (TL) from the laboratory management system in 2017-2020. Out of 1,369 individuals analyzed, 704 (51.4%) cases of TL were confirmed, with 610 (86.7%) by direct parasitological examination (DPE) and 94 (13.4%) by polymerase chain reaction (PCR). Notably, 25.3% of cases with DPE-negative results were PCR-positive. Consecutive diagnostic tests enhanced diagnosis of TL. NPHL-MG is a promising model for expanding similar networks and improving disease control.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e70"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466069
Camila Malta Romano, Vitor Gabriel Lopes da Silva, Luciane Sussuchi da Silva, Carolina Sanchez Aranda, Cristina Mendes de Oliveira, Marilda Mendonça Teixeira Siqueira, Elisa Cavalcante Pereira, Paola Cristina Resende, Nancy Cristina Junqueira Bellei, José Eduardo Levi, Maria Isabel de Moraes-Pinto
{"title":"Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI.","authors":"Camila Malta Romano, Vitor Gabriel Lopes da Silva, Luciane Sussuchi da Silva, Carolina Sanchez Aranda, Cristina Mendes de Oliveira, Marilda Mendonça Teixeira Siqueira, Elisa Cavalcante Pereira, Paola Cristina Resende, Nancy Cristina Junqueira Bellei, José Eduardo Levi, Maria Isabel de Moraes-Pinto","doi":"10.1590/S1678-9946202466069","DOIUrl":"10.1590/S1678-9946202466069","url":null,"abstract":"<p><p>An immunocompromised patient was infected by the SARS-CoV-2 variant of interest named Zeta (P.2) in February 2021. More than one year later, he suffered from symptomatic COVID-19 and sequencing revealed the same variant, which accumulated 23 substitutions. This case illustrates intra-host evolution of a particular SARS-CoV-2 variant, highlighting the importance of genomic surveillance of immunocompromised patients.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e69"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrotal abscess caused by Candida glabrata in a patient with uncontrolled diabetes mellitus and chronic renal failure.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466071
Mehmet Ali Tüz, Derya Tuna Ecer, Tuğba Kula Atik, Oktay Yapıcı
{"title":"Scrotal abscess caused by Candida glabrata in a patient with uncontrolled diabetes mellitus and chronic renal failure.","authors":"Mehmet Ali Tüz, Derya Tuna Ecer, Tuğba Kula Atik, Oktay Yapıcı","doi":"10.1590/S1678-9946202466071","DOIUrl":"10.1590/S1678-9946202466071","url":null,"abstract":"<p><p>Candida glabrata is a yeast which incidence has increased in recent years and usually causes urogenital and bloodstream infections. Its resistance to fluconazole hinders C. glabrata infections treatment. This case report presents a case of candidemia and scrotal abscess caused by C. glabrata, which was successfully treated with liposomal amphotericin B. The primary treatment options for C. glabrata candidemia are echinocandins and amphotericin B formulations. However, echinocandins and lipid-based amphotericin B formulations do not properly pass through the urinary system. Amphotericin B deoxycholate has a high risk of side effects and is difficult to obtain. The treatment option for candidemia caused by fluconazole-resistant C. glabrata secondary to urinary tract infection is unclear and there are no sufficient studies. For treatment, liposomal amphotericin B may be considered, especially for scrotal and prostatic fluconazole-resistant fungal abscesses. More studies comparing the penetration of antifungals into scrotal and prostatic tissue and the success of antifungal treatment in these tissue infections are needed.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e71"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon: a population-based panel study.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466072
Fabiana Martins de Paula, Bruna Barroso Gomes, Dirce Mary Correia Lima Meisel, William Henry Roldan, Mônica da Silva Nunes, Marcelo Urbano Ferreira, Ronaldo Cesar Borges Gryschek
{"title":"Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon: a population-based panel study.","authors":"Fabiana Martins de Paula, Bruna Barroso Gomes, Dirce Mary Correia Lima Meisel, William Henry Roldan, Mônica da Silva Nunes, Marcelo Urbano Ferreira, Ronaldo Cesar Borges Gryschek","doi":"10.1590/S1678-9946202466072","DOIUrl":"10.1590/S1678-9946202466072","url":null,"abstract":"<p><p>Using a panel study design, we aimed to estimate the seroconversion and seroreversion rates of anti-Strongyloides IgG antibodies from surveys carried out 11 months apart in a rural community in the Amazon Basin in Brazil. We used enzyme immunoassays to measure anti-Strongyloides IgG antibodies in 325 baseline plasma samples and 224 others that were collected 11 months later from residents in the agricultural settlement of Granada, Acre State. We observed anti-Strongyloides IgG antibodies in 21.8% of the baseline samples (which showed that 3.4% of participants had larvae in their stool) and in 23.7% of the follow-up samples. The seroconversion rate estimated at 9.7 episodes/100 person-years at risk agrees with ongoing transmission. Specific antibodies were relatively short-lived and nine (25.0%) of 36 seropositive participants at baseline were seronegative when retested 11 months later. Fecal surveys can severely underestimate the prevalence of S. stercoralis infection in rural Amazonians. Serology provides a field-deployable diagnostic tool to find high-prevalence populations, identify associated risk factors, and monitor intervention programs.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e72"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil/lymphocyte and platelet/lymphocyte ratio in seropositive women for human immunodeficiency virus (HIV) and human papillomavirus (HPV) coinfection.
IF 1.5 4区 医学
Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1590/S1678-9946202466067
Karina Donato Fook, Maria José Abigail Mendes Araújo, Alessandra Costa de Sales Muniz, Mônika Machado de Carvalho, Ana Cléa Cutrim Diniz de Morais, Deborah Rocha de Araújo, Sulayne Janayna Araújo Guimarães, Camila Penha Abreu Souza, Carla Déa Trindade Barbosa, Maria Fernanda Lima Bertolaccini, Ilka Kassandra Pereira Belfort, Fernanda Ferreira Lopes, Sally Cristina Moutinho Monteiro
{"title":"Neutrophil/lymphocyte and platelet/lymphocyte ratio in seropositive women for human immunodeficiency virus (HIV) and human papillomavirus (HPV) coinfection.","authors":"Karina Donato Fook, Maria José Abigail Mendes Araújo, Alessandra Costa de Sales Muniz, Mônika Machado de Carvalho, Ana Cléa Cutrim Diniz de Morais, Deborah Rocha de Araújo, Sulayne Janayna Araújo Guimarães, Camila Penha Abreu Souza, Carla Déa Trindade Barbosa, Maria Fernanda Lima Bertolaccini, Ilka Kassandra Pereira Belfort, Fernanda Ferreira Lopes, Sally Cristina Moutinho Monteiro","doi":"10.1590/S1678-9946202466067","DOIUrl":"10.1590/S1678-9946202466067","url":null,"abstract":"<p><p>This study aims to investigate the possible association between neutrophil/lymphocyte and platelet/lymphocyte ratio in women with HIV, undergoing antiretroviral treatment, with HPV coinfection. This is a cross-sectional study with HIV positive women; their biological samples were collected for laboratory tests (complete blood count) and oncotic cytology for detection of HPV DNA, by PCR-Nested (PGMY and GP primers). Viral load and CD4 and CD8 T-cells counts were obtained from medical records. The data were analyzed, comparing the two groups: those with coinfection and those without it. From 82 HIV seropositive women, 50% exhibited HPV coinfection and 12.2% of coinfected patients had cervical cell alterations. Quantification of viral load, CD4 and CD8 T-cells count, CD4 / CD8 ratio and neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratio presented significant differences between groups (p<0.05). The predicting power of NLR and PLR in differentiating HIV/HPV coinfection which demonstrated differences between groups (AUC of 0.882 and 0.776 for NLR and PLR, respectively). There is a relation between the neutrophil/lymphocyte and platelet/lymphocyte ratio with HIV/HPV coinfection in women undergoing antiretroviral treatment, suggesting a state of greater and persistent systemic inflammation, reflecting as a biomarker for screening and monitoring these patients.</p>","PeriodicalId":54466,"journal":{"name":"Revista Do Instituto De Medicina Tropical De Sao Paulo","volume":"66 ","pages":"e67"},"PeriodicalIF":1.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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