Thamirys Cosmo Grillo Fajardo, Antonio Carlos de Quadros Junior, Clóvis Antonio Lopes Pinto, Geovane Ribeiro Dos Santos, Andrea Cristina Botelho da Silva, Daniel Thome Catalan, Ana Paula Antunes Pascalicchio Bertozzi, Rosa Estela Gazeta, Antonio Fernandes Moron, Saulo Duarte Passos, Alexandra Siqueira Mello, Antoni Soriano-Arandes, Ana Alarcon, Alfredo Garcia-Alix, Alify Bertoldo da Silva, Dora Fix Ventura, Danielle Bruna Leal de Oliveira, Danilla Soares Tambalo, Diego da Silva Lima, Dirce Takako Fujiwara, Edison Luiz Durigon, Eduardo Roberto Bagne, Fernanda Guerra Velasco, Luiz Claudio Portnoi Baran, Fernando Novo Arita, Francisco Del Moral Hernandez, Juliana Paula Gomes de Almeida, Karen Richter Camandulli, Lucas Pires de Castro, Márcia Borges Machado, Mayana Zatz, Maria Manoela Duarte Rodrigues, Maria de Fátima Valente Rizzo, Maria Amélia Farrão, Mirella Nayane Barbosa Leite, Nemésio Florence Filho, Patrícia Carvalho Loiola, Raquel Prestes, Rita de Cássia Aguirre Dezena, Sandra Helena Alves Bonon, Sergio Vranjac, Sérgio Rosemberg, Stephanno Gomes Pereira Sarmento, Steven Sol Witkinchi, Tathiana Ghisi de Souza, Viviane Cristina Martori Pandini, Viviam Paschoarelli Paiva
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引用次数: 0
Abstract
Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.
期刊介绍：
The Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is a journal devoted to research on different aspects of tropical infectious diseases. The journal welcomes original work on all infectious diseases, provided that data and results are directly linked to human health.
The journal publishes, besides original articles, review articles, case reports, brief communications, and letters to the editor. The journal publishes manuscripts only in English.
From 2016 on, the Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is published online only, maintaining the free access.
For more information visit:
- http://www.scielo.br/rimtsp
- http://www.imt.usp.br/revista-imt/
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