Eurointervention最新文献

{"title":"Hybrid quantification of absolute perfusion requires accurate measurement of myocardial mass.","authors":"Nils P Johnson, K Lance Gould","doi":"10.4244/EIJ-E-24-00051","DOIUrl":"https://doi.org/10.4244/EIJ-E-24-00051","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 19","pages":"e1196-e1198"},"PeriodicalIF":7.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of fractional flow reserve using intravascular ultrasound.","authors":"Munenori Okubo, Masanori Kawasaki, Hiroyuki Yagami, Toru Tanigaki, Yoshiaki Kawase, Hitoshi Matsuo, Takahiko Suzuki","doi":"10.4244/EIJ-D-24-00010","DOIUrl":"https://doi.org/10.4244/EIJ-D-24-00010","url":null,"abstract":"<p><strong>Background: </strong>In order to identify coronary lesions that cause myocardial ischaemia and require revascularisation, fractional flow reserve (FFR) is widely recommended. Recently, a method of estimating the FFR using morphological features measured by an imaging device was developed. However, all the previously developed methods are conducted offline, and such analysis takes approximately 10 minutes.</p><p><strong>Aims: </strong>The aim of this present study was to develop an online measurement of the FFR using an intravascular ultrasound (IVUS) quantitative method (IQ-FFR).</p><p><strong>Methods: </strong>This prospective, single-centre study included coronary lesions that met the following criteria: (1) presence of at least one stenosis (25-99%); (2) both IVUS and FFR measurement performed just before and after stent implantation, with the wire-derived FFR measured with a standard method; and (3) acquisition of clear images throughout the entire coronary branch.</p><p><strong>Results: </strong>We developed an IVUS analysis system that automatically measures the cross-sectional area every 0.5 mm, and we calculated the IQ-FFR. In the prediction study, we calculated the IQ-FFR on the assumption that one stent of arbitrary length and diameter was implanted. After stent implantation, the wire-derived FFR was measured and compared with the calculated IQ-FFR. We compared 270 coronary lesions with stenosis rates of 32-99%. IQ-FFR measurements were strongly correlated with the wire-derived FFR (r=0.896). In the prediction study, the clinical accuracy of predicting whether the FFR would be greater or less than 0.80 after stent implantation was 87.5%.</p><p><strong>Conclusions: </strong>The IQ-FFR is a promising method to identify coronary lesions requiring revascularisation and to predict the FFR after stent implantation.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 19","pages":"e1237-e1247"},"PeriodicalIF":7.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplification of continuous intracoronary thermodilution.","authors":"Thabo Mahendiran, Samer Fawaz, Michele Viscusi, Danielle Keulards, Caïa Crooijmans, Tijn P J Jansen, Henk Everaars, Emanuele Gallinoro, Alessandro Candreva, Frederic Bouisset, Takuya Mizukami, Dario Bertolone, Marta Belmonte, Ruiko Seki, Johan Svanerud, Jeroen Sonck, Adriaan Wilgenhof, Thomas R Keeble, Peter Damman, Paul Knaapen, Carlos Collet, Nico H J Pijls, Bernard De Bruyne","doi":"10.4244/EIJ-D-24-00215","DOIUrl":"https://doi.org/10.4244/EIJ-D-24-00215","url":null,"abstract":"<p><strong>Background: </strong>Continuous intracoronary thermodilution with saline allows for the accurate measurement of volumetric blood flow (Q) and absolute microvascular resistance (R_μ). However, this requires repositioning of the temperature sensor by the operator to measure the entry temperature of the saline infusate, denoted as T_i.</p><p><strong>Aims: </strong>We evaluated whether Ti could be predicted based on known parameters without compromising the accuracy of calculated Q. This would significantly simplify the technique and render it completely operator independent.</p><p><strong>Methods: </strong>In a derivation cohort of 371 patients with Q measured both at rest and during hyperaemia, multivariate linear regression was used to derive an equation for the prediction of T_i. Agreement between standard Q (calculated with measured T_i) and simplified Q (calculated with predicted T_i) was assessed in a validation cohort of 120 patients that underwent repeat Q measurements. The accuracy of simplified Q was assessed in a second validation cohort of 23 patients with [¹⁵O]H₂O positron emission tomography (PET)-derived Q measurements.</p><p><strong>Results: </strong>Simplified Q exhibited strong agreement with standard Q (r=0.94, confidence interval [CI]: 0.93-0.95; intraclass correlation coefficient [ICC] 0.94, CI: 0.92-0.95; both p<0.001). Simplified Q exhibited excellent agreement with PET-derived Q (r=0.86, CI: 0.75-0.92; ICC=0.84, CI: 0.72-0.91; both p<0.001). Compared with standard Q, there were no statistically significant differences between correlation coefficients (p=0.29) or standard deviations of absolute differences with PET-derived Q (p=0.85).</p><p><strong>Conclusions: </strong>Predicting T_i resulted in an excellent agreement with measured T_i for the assessment of coronary blood flow. It significantly simplifies continuous intracoronary thermodilution and renders absolute coronary flow measurements completely operator independent.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 19","pages":"e1217-e1226"},"PeriodicalIF":7.6,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IVUS has more robust data than OCT for PCI guidance: PROS and CONS.","authors":"Akiko Maehara, Jorge Sanz-Sánchez, Hector M Garcia-Garcia","doi":"10.4244/EIJ-E-24-00028","DOIUrl":"https://doi.org/10.4244/EIJ-E-24-00028","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 18","pages":"e1132-e1135"},"PeriodicalIF":7.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular response following implantation of the third-generation drug-eluting resorbable coronary magnesium scaffold: an intravascular imaging analysis of the BIOMAG-I first-in-human study.","authors":"Masaru Seguchi, Alp Aytekin, Erion Xhepa, Michael Haude, Adrian Wlodarczak, René J van der Schaaf, Jan Torzewski, Bert Ferdinande, Javier Escaned, Juan F Iglesias, Johan Bennett, Gabor G Toth, Ralph Toelg, Marcus Wiemer, Göran Olivecrona, Paul Vermeersch, Ron Waksman, Hector M Garcia-Garcia, Michael Joner","doi":"10.4244/EIJ-D-24-00055","DOIUrl":"https://doi.org/10.4244/EIJ-D-24-00055","url":null,"abstract":"<p><strong>Background: </strong>The 12-month outcomes of BIOMAG-I - the first-in-human study investigating the third-generation drug-eluting resorbable magnesium scaffold (DREAMS 3G) - showed promising results regarding clinical outcomes and late lumen loss.</p><p><strong>Aims: </strong>The current study aimed to investigate vascular healing parameters assessed by optical coherence tomography (OCT) and intravascular ultrasound (IVUS), focusing on strut visibility, vessel and scaffold areas, and neointimal growth patterns.</p><p><strong>Methods: </strong>This is a BIOMAG-I substudy including patients with available serial OCT and IVUS data. We conducted a frame-based analysis of OCT findings in conjunction with IVUS-derived vessel and scaffold areas, evaluating the qualitative and quantitative aspects of vascular healing.</p><p><strong>Results: </strong>Among the 116 patients enrolled in this trial, 56 patients treated with DREAMS 3G were included in the analysis. At 12 months, OCT imaging revealed that 99.0% of the struts were invisible, and no malapposed struts were depicted. While the vessel area showed no significant difference between the timepoints, the minimum lumen area significantly decreased from post-percutaneous coronary intervention to 6 months (6.88 mm² to 4.75 mm²; p<0.0001), but no significant changes were observed between 6 and 12 months. Protruding neointimal tissue (PNT) - a unique neointimal presentation observed following resorbable magnesium scaffold implantation - was observed in 89.3% of the study patients at 12 months, and its area exhibited a 47.4% decrease from 6 to 12 months.</p><p><strong>Conclusions: </strong>This imaging substudy revealed that, at 12-month follow-up, virtually all struts of the DREAMS 3G scaffold became invisible, without evident malapposition. The vascular healing response to DREAMS 3G implantation also appeared favourable up to 12 months, which is indicated by advanced strut degradation and spontaneous regressing PNT between 6 and 12 months.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 18","pages":"e1173-e1183"},"PeriodicalIF":7.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of lesion morphology on stent elongation during bifurcation PCI: an in vivo OCT study.","authors":"Michael McGarvey,Lap-Tin Lam,Muhamad Abd Razak,Jennifer Barraclough,Kevin O'Gallagher,Ian Webb,Narbeh Melikian,Sundeep Kalra,Philip MacCarthy,Ajay M Shah,Jonathan M Hill,Thomas W Johnson,Jonathan Byrne,Rafal Dworakowski,Nilesh Pareek","doi":"10.4244/eij-d-23-00663","DOIUrl":"https://doi.org/10.4244/eij-d-23-00663","url":null,"abstract":"BACKGROUNDRecent observations in silico and in vivo reported that, during proximal optimisation technique, drug-eluting stents (DES) elongate, challenging conventional wisdom. The interaction between plaque morphology and radial expansion is well established, but little is known about the impact of plaque morphology on elongation.AIMSWe aimed to assess the longitudinal mechanical behaviour of contemporary DES in vivo and evaluate the relationship between post-percutaneous coronary intervention (PCI) stent elongation and lesion morphology, as assessed with optical coherence tomography (OCT).METHODSPatients treated with OCT-guided PCI to left main or left anterior descending artery bifurcations, between July 2017 and March 2022, from the King's Optical coherence Database Analysis Compendium were included. Patients were excluded if there were overlapping stents, if they had undergone prior PCI, or if there was inadequate image quality. Lesions were characterised as fibrocalcific, fibrous or lipid-rich by pre-PCI OCT. Following stent post-dilatation, stent expansion and final stent length were assessed. The primary outcome was the percentage change in stent length from baseline.RESULTSOf 501 eligible consecutive patients from this period, 116 were included. The median age was 66 years (interquartile range [IQR] 57-76), 31% were female, and 53.4% were treated for an acute coronary syndrome. A total of 50.0% of lesions were classified as fibrocalcific, 6.9% were fibrous, and 43.1% were lipid-rich. The change in relative stent length was 4.4% (IQR 1.0-8.9), with an increase of 3.1% (IQR 0.5-6.3) in fibrocalcific lesions, 3.3% (IQR 0.5-5.9) in fibrous lesions, and 6.4% (IQR 3.1-11.1) in lipid-rich plaque (p=0.006). In multivariate regression modelling, lipid-rich plaque was an independent predictor of stent elongation (odds ratio 3.689, 95% confidence interval: 1.604-8.484).CONCLUSIONSContemporary DES elongate following implantation and post-dilatation, and this is significantly mediated by plaque morphology. This is an important consideration when planning a strategy for DES implantation.","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 1","pages":"e1184-e1194"},"PeriodicalIF":6.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial intracoronary imaging to predict efficacy and safety of magnesium-based resorbable scaffolds.","authors":"Lorenz Räber, Ryota Kakizaki","doi":"10.4244/EIJ-E-24-00044","DOIUrl":"https://doi.org/10.4244/EIJ-E-24-00044","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 18","pages":"e1124-e1126"},"PeriodicalIF":7.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment extent of femoropopliteal disease and clinical outcomes following endovascular therapy.","authors":"Yong-Hoon Yoon, Jae-Hwan Lee, Won-Mook Hwang, Hyun-Woong Park, Jae-Hyung Roh, Seung-Jun Lee, Young-Guk Ko, Chul-Min Ahn, Cheol Woong Yu, Seung-Whan Lee, Young Jin Youn, Jong Kwan Park, Chang-Hwan Yoon, Seung-Woon Rha, Pil-Ki Min, Seung-Hyuk Choi, In-Ho Chae, Donghoon Choi, Of The K-Vis Investigators On Behalf","doi":"10.4244/EIJ-D-24-00037","DOIUrl":"https://doi.org/10.4244/EIJ-D-24-00037","url":null,"abstract":"<p><strong>Background: </strong>Endovascular therapy (EVT) has become the preferred treatment modality for femoropopliteal disease. However, there is limited evidence regarding its procedural and clinical outcomes according to the affected area.</p><p><strong>Aims: </strong>The aim of this study is to investigate clinical outcomes and device effectiveness according to treatment extent in the superficial femoral artery (SFA), popliteal artery (PA), or both.</p><p><strong>Methods: </strong>In this study, we analysed EVT for SFA (2,404 limbs), PA (155 limbs), SFA/PA (383 limbs) using the population in the K-VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases) registry. The primary endpoint was target lesion revascularisation (TLR) at 2 years.</p><p><strong>Results: </strong>The SFA/PA group exhibited a higher prevalence of anatomical complexity, characterised by long lesions, moderate to severe calcification, and total occlusion. The procedures were successful in 97.2% of SFA, 92.9% of PA, and 95.6% of SFA/PA EVTs. The 2-year TLR rates were 21.1%, 18.6%, and 32.7% in the SFA, PA, and SFA/PA groups, respectively. SFA/PA EVT was associated with a significantly increased risk for TLR compared to the SFA group (adjusted hazard ratio [HR] 1.48 [1.09-2.00]; p=0.008) and a trend towards an increased risk compared to the PA group (adjusted HR 1.80 [1.00-3.27]; p=0.052). After overlap weighting, the use of a drug-coated balloon (DCB) was shown to be beneficial, with the lowest TLR rate after SFA and SFA/PA EVT.</p><p><strong>Conclusions: </strong>In this large real-world registry, SFA/PA EVT was associated with an increased risk for TLR at 2 years compared to the SFA or PA EVT groups, with favourable outcomes when using a DCB or drug-eluting stent in the SFA/PA EVT group.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 18","pages":"e1154-e1162"},"PeriodicalIF":7.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of acute limb ischaemia caused by femoropopliteal stent thrombosis.","authors":"Sho Nakao, Osamu Iida, Mitsuyoshi Takahara, Nobuhiro Suematsu, Terutoshi Yamaoka, Daisuke Matsuda, Tatsuya Nakama, Masahiko Fujihara, Kazuki Tobita, Eiji Koyama, Takuya Haraguchi, Kenji Ogata, Toshiaki Mano","doi":"10.4244/EIJ-D-24-00016","DOIUrl":"10.4244/EIJ-D-24-00016","url":null,"abstract":"<p><strong>Background: </strong>Although femoropopliteal-specific stents have durable patency, stent thrombosis (ST) may occur, which can lead to acute limb ischaemia (ALI).</p><p><strong>Aims: </strong>We aimed to investigate the clinical features and outcomes of ALI caused by femoropopliteal ST in patients with lower extremity artery disease.</p><p><strong>Methods: </strong>This multicentre retrospective study included 499 patients with ALI - of whom 108 patients had ALI caused by femoropopliteal ST (ST-ALI) and 391 patients had ALI caused by other aetiologies (de novo ALI) - who underwent treatment between September 2011 and March 2023. Clinical features and outcomes were compared between the two groups. The primary outcome measure was 12-month amputation-free survival; factors associated with amputation or death were investigated using multivariate Cox proportional hazards regression analysis.</p><p><strong>Results: </strong>Patients with ST-ALI were significantly more likely to exhibit conventional atherosclerotic risk factors, including diabetes mellitus (63% vs 26%) and haemodialysis (51% vs 10%) compared to patients with de novo ALI, whereas patients with de novo ALI were older (80 years vs 74 years) and more likely to have atrial fibrillation (49% vs 18%) than patients with ST-ALI. The 12-month amputation-free survival rate was significantly lower in the ST-ALI group than that in the de novo ALI group (51% vs 76%; p<0.001). Multivariate analysis revealed that ST-ALI, older age, haemodialysis, atrial fibrillation, the presence of a wound, peak C-reactive protein level, and non-ambulatory status all have an independent, positive association with death or major amputation.</p><p><strong>Conclusions: </strong>The current study revealed that patients with ST-ALI had worse clinical outcomes than those with de novo ALI, highlighting the need to maximise ST prevention.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"20 18","pages":"e1163-e1172"},"PeriodicalIF":7.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute limb ischaemia from stent thrombosis: bad luck or bad protoplasm?","authors":"Sahil A Parikh,Robert S Zilinyi","doi":"10.4244/eij-e-24-00050","DOIUrl":"https://doi.org/10.4244/eij-e-24-00050","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"208 1","pages":"e1122-e1123"},"PeriodicalIF":6.2,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142262044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}