Dialogues in Clinical Neuroscience最新文献_第6页

The endocannabinoid system in modulating fear, anxiety, and stress . 调节恐惧、焦虑和压力的内源性大麻素系统 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-09-01 DOI: 10.31887/DCNS.2020.22.3/rmaldonado

Rafael Maldonado, David Cabañero, Elena Martín-García

引用次数: 26

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders . 内源性大麻素作为神经精神疾病中非愉悦性植物大麻素作用和肠道微生物组功能障碍的底物 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-09-01 DOI: 10.31887/DCNS.2020.22.3/vdimarzo

Vincenzo Di Marzo

{"title":"The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders\u2029.","authors":"Vincenzo Di Marzo","doi":"10.31887/DCNS.2020.22.3/vdimarzo","DOIUrl":"10.31887/DCNS.2020.22.3/vdimarzo","url":null,"abstract":"The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB1 and CB2 receptors. Its expansion to include several eCB-like lipid mediators, their metabolic enzymes, and their molecular targets, forms the endocannabinoidome (eCBome). This complex signaling system is deeply involved in the onset, progress, and symptoms of major neuropsychiatric disorders and provides a substrate for future therapeutic drugs against these diseases. Such drugs may include not only THC, the major psychotropic component of cannabis, but also other, noneuphoric plant cannabinoids. These compounds, unlike THC, possess a wide therapeutic window, possibly due to their capability of hitting several eCBome and non-eCBome receptors. This is particularly true for cannabidiol, which is one of the most studied cannabinoids and shows promise for the treatment of a wide range of mental and mood disorders. The eCBome plays a role also in the microbiota-gut-brain axis, which is emerging as an important actor in the control of affective and cognitive functions and in their pathological alterations.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 3","pages":"259-269"},"PeriodicalIF":8.3,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/a0/DialoguesClinNeurosci-22-259.PMC7605024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38683367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

First case report of tDCS efficacy in severe chemsex addiction . tDCS治疗重度化学性成瘾首例报道 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-09-01 DOI: 10.31887/DCNS.2020.22.3/lmalandain

Léo Malandain, Jean-Victor Blanc, Florian Ferreri, Timothée Giorgiadis, Sophie Mosser, Stéphane Mouchabac, Florence Thibaut

引用次数: 7

Adolescent development and growing divides in the digital age . 青少年发展和数字时代日益扩大的鸿沟 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/codgers

Candice L Odgers, Michaeline R Jensen

引用次数: 15

Adolescent brain and the natural allure of digital media . 青少年大脑与数字媒体的天然诱惑 .

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/jgiedd

Jay N Giedd

引用次数: 0

The impact of the digital revolution  on human brain and behavior: where  do we stand? . 数字革命 对人类大脑和行为的影响: 我们站在哪里? 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/mkorte

Martin Korte

引用次数: 26

Going digital: how technology use may influence human brains and behavior . 走向数字化:技术使用如何影响人类大脑和行为 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/mhoehe

Margret R Hoehe, Florence Thibaut

{"title":"Going digital: how technology use may influence human brains and behavior\u2029.","authors":"Margret R Hoehe, Florence Thibaut","doi":"10.31887/DCNS.2020.22.2/mhoehe","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.2/mhoehe","url":null,"abstract":"The digital revolution has changed, and continues to change, our world and our lives. Currently, major aspects of our lives have moved online due to the coronavirus pandemic, and social distancing has necessitated virtual togetherness. In a synopsis of 10 articles we present ample evidence that the use of digital technology may influence human brains and behavior in both negative and positive ways. For instance, brain imaging techniques show concrete morphological alterations in early childhood and during adolescence that are associated with intensive digital media use. Technology use apparently affects brain functions, for example visual perception, language, and cognition. Extensive studies could not confirm common concerns that excessive screen time is linked to mental health problems, or the deterioration of well-being. Nevertheless, it is important to use digital technology consciously, creatively, and sensibly to improve personal and professional relationships. Digital technology has great potential for mental health assessment and treatment, and the improvement of personal mental performance.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 2","pages":"93-97"},"PeriodicalIF":8.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/f9/DialoguesClinNeurosci-22-93.PMC7366947.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38190212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Virtual reality as a clinical tool in mental health research and practice . 虚拟现实作为心理健康研究和实践的临床工具 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/lvalmaggia

Imogen H Bell, Jennifer Nicholas, Mario Alvarez-Jimenez, Andrew Thompson, Lucia Valmaggia

{"title":"Virtual reality as a clinical tool in mental health research and practice\u2029.","authors":"Imogen H Bell, Jennifer Nicholas, Mario Alvarez-Jimenez, Andrew Thompson, Lucia Valmaggia","doi":"10.31887/DCNS.2020.22.2/lvalmaggia","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.2/lvalmaggia","url":null,"abstract":"Virtual reality (VR) is a potentially powerful technology for enhancing assessment in mental health. At any time or place, individuals can be transported into immersive and interactive virtual worlds that are fully controlled by the researcher or clinician. This capability is central to recent interest in how VR might be harnessed in both treatment and assessment of mental health conditions. The current review provides a summary of the advantages of using VR for assessment in mental health, focusing on increasing ecological validity of highly controlled environments, enhancing personalization and engagement, and capturing real-time, automated data in real-world contexts. Considerations for the implementation of VR in research and clinical settings are discussed, including current issues with cost and access, developing evidence base, technical challenges, and ethical implications. The opportunities and challenges of VR are important to understand as researchers and clinicians look to harness this technology to improve mental health outcomes.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 2","pages":"169-177"},"PeriodicalIF":8.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/70/DialoguesClinNeurosci-22-169.PMC7366939.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38184374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 68

Neurobiological mechanisms underlying internet gaming disorder . 网络游戏障碍的神经生物学机制 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/aweinstein

Aviv Weinstein, Michel Lejoyeux

{"title":"Neurobiological mechanisms underlying internet gaming disorder\u2029.","authors":"Aviv Weinstein, Michel Lejoyeux","doi":"10.31887/DCNS.2020.22.2/aweinstein","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.2/aweinstein","url":null,"abstract":"This review summarizes studies on the neurobiological correlates of internet gaming disorder (IGD), presently the most direct approach to analyzing the impact of digital technology and the internet on brain mechanisms. Brain imaging studies have shown that IGD shares, to a large extent, neurobiological alterations that are typical for other addictions, such as: (i) activation in brain regions associated with reward, as evident from cue exposure and craving studies and neurotransmitter systems studies that indicate an involvement of dopamine-mediated reward mechanisms; (ii) reduced activity in impulse control areas and impaired decision making; and (iii) reduced functional connectivity in brain networks that are involved in cognitive control, executive function, motivation, and reward. Moreover, there are structural changes, mainly reduction in gray-matter volume and white-matter density. Comorbidity studies indicate that executive control networks in attention deficit-hyperactivity disorder (ADHD) may increase the susceptibility to develop IGD. Most importantly, this review also outlines findings that show the effects of excessive use of screens, here referring to the playing of computer games, which activate many brain regions associated with cognitive, motor, and sensory function and not directly involved in other forms of addiction. This review describes and summarizes comprehensively the neurobiological correlates of addictive internet use in adolescents and young adults.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 2","pages":"113-126"},"PeriodicalIF":8.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/fd/DialoguesClinNeurosci-22-113.PMC7366941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38190214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Brain health consequences of digital technology use . 使用数字技术对大脑健康的影响 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-06-01 DOI: 10.31887/DCNS.2020.22.2/gsmall

Gary W Small, Jooyeon Lee, Aaron Kaufman, Jason Jalil, Prabha Siddarth, Himaja Gaddipati, Teena D Moody, Susan Y Bookheimer

{"title":"Brain health consequences of digital technology use\u2029.","authors":"Gary W Small, Jooyeon Lee, Aaron Kaufman, Jason Jalil, Prabha Siddarth, Himaja Gaddipati, Teena D Moody, Susan Y Bookheimer","doi":"10.31887/DCNS.2020.22.2/gsmall","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.2/gsmall","url":null,"abstract":"Emerging scientific evidence indicates that frequent digital technology use has a significant impact-both negative and positive-on brain function and behavior. Potential harmful effects of extensive screen time and technology use include heightened attention-deficit symptoms, impaired emotional and social intelligence, technology addiction, social isolation, impaired brain development, and disrupted sleep. However, various apps, videogames, and other online tools may benefit brain health. Functional imaging scans show that internet-naive older adults who learn to search online show significant increases in brain neural activity during simulated internet searches. Certain computer programs and videogames may improve memory, multitasking skills, fluid intelligence, and other cognitive abilities. Some apps and digital tools offer mental health interventions providing self-management, monitoring, skills training, and other interventions that may improve mood and behavior. Additional research on the positive and negative brain health effects of technology is needed to elucidate mechanisms and underlying causal relationships.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 2","pages":"179-187"},"PeriodicalIF":8.3,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/75/DialoguesClinNeurosci-22-179.PMC7366948.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38184375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 80