Archives of Endocrinology Metabolism最新文献_第9页

Differentiated thyroid carcinoma: what the nonspecialists needs to know. 分化型甲状腺癌：非专业人士须知。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-29 DOI: 10.20945/2359-4292-2023-0375

Ana O Hoff, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Helton Estrela Ramos, Gustavo Cancela Penna, Lucas Vieira Dos Santos, Ana Luiza Maia, Daniel Oliveira Brito, Franco Pelissari Vizzotto

{"title":"Differentiated thyroid carcinoma: what the nonspecialists needs to know.","authors":"Ana O Hoff, Aline Lauda Freitas Chaves, Thiago Bueno de Oliveira, Helton Estrela Ramos, Gustavo Cancela Penna, Lucas Vieira Dos Santos, Ana Luiza Maia, Daniel Oliveira Brito, Franco Pelissari Vizzotto","doi":"10.20945/2359-4292-2023-0375","DOIUrl":"10.20945/2359-4292-2023-0375","url":null,"abstract":"Differentiated thyroid carcinoma (DTC) accounts for most cases of thyroid cancer, and the heterogeneity of DTC requires that management decisions be taken by a multidisciplinary team involving endocrinologists, head and neck surgeons, nuclear medicine physicians, pathologists, radiologists, radiation oncologists, and medical oncologists. It is important for nonspecialists to recognize and refer patients with DTC who will benefit from a specialized approach. Recent advances in knowledge and changes in management of DTC call for the need to raise awareness on the part of these nonspecialist physicians, including general endocrinologists and medical oncologists at large. We provide an overview of diagnostic and therapeutic principles in DTC, especially those that bear direct implication on day-to-day management of these patients by generalists. Patients with DTC may be broadly categorized as having localized, locally persistent/recurrent, or metastatic disease. Current recommendations for DTC include a three-tiered system that classifies patients with localized disease into low, intermediate, or high risk of persistent or recurrent disease. Risk stratification should be performed at baseline and repeated on an ongoing basis, depending on clinical evolution. One of the overarching goals in the management of DTC is the need to personalize treatment by tailoring its modality and intensity according to ongoing prognostic stratification, evolving knowledge about the disease, and patient characteristics and preference. In metastatic disease that is refractory to radioactive iodine, thyroid tumors are being reclassified into molecular subtypes that better reflect their biological properties and for which molecular alterations can be targeted with specific agents.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e230375"},"PeriodicalIF":1.7,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple basal infusion rates in open-loop insulin delivery systems: is there a metabolic benefit? 开环胰岛素输送系统中的多种基础输注率：是否有代谢益处？

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-23 DOI: 10.20945/2359-4292-2023-0055

Juliana Marques Sá, Sara de Campos Lopes, Maria Joana Santos, Marta Alves, Adriana De Sousa Lages

{"title":"Multiple basal infusion rates in open-loop insulin delivery systems: is there a metabolic benefit?","authors":"Juliana Marques Sá, Sara de Campos Lopes, Maria Joana Santos, Marta Alves, Adriana De Sousa Lages","doi":"10.20945/2359-4292-2023-0055","DOIUrl":"10.20945/2359-4292-2023-0055","url":null,"abstract":"Objective: To evaluate glycemic control according to the number of daily basal rates (BRs) in type 1 diabetes patients using continuous subcutaneous insulin infusion (CSII).Subjects and methods: Cross-sectional study of patients treated with an open-loop CSII for at least 6 months and using a flash glucose monitoring system. Patients were divided into 2 groups: group 1 (G1) and group 2 (G2), with ≤4 and >4 BRs/24h, respectively. The groups were compared regarding HbA1c, time in range (TIR), time above range (TAR), time below range (TBR), glucose management indicator (GMI), glucose variability and data related to hypoglycemia. Regression models were performed.Results: The study included 99 patients (n = 55 in G1; n = 44 in G2). Median (Interquartile range) overall age was 30 (17) years, with 19.5 (48) and 51 (77) months of CSII use, respectively. The median number of different BRs was 3 (2) for G1 and 6 (2) for G2. There were no differences concerning age, sex, educational stage, weight, and insulin analog used. G2 had longer disease duration, longer CSII use, and higher total basal daily dose/kg. No significant differences regarding HbA1c, median glucose, GMI, TIR, TAR, and CV were found. G2 patients had more hypoglycemia, more asymptomatic hypoglycemia, and higher TBR. After adjusting for potential confounders, G1 maintained a lower risk of asymptomatic hypoglycemia.Conclusion: Programming open-loop CSII devices with more than 4 BRs does not improve metabolic control. Additionally, it seems to be a risk factor for hypoglycemia and was an independent predictor for asymptomatic hypoglycemia.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e230055"},"PeriodicalIF":1.7,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CircSEMA6A upregulates PRRG4 by targeting MiR-520h and recruiting ELAVL1 to affect cell invasion and migration in papillary thyroid carcinoma. CircSEMA6A 通过靶向 MiR-520h 和招募 ELAVL1 上调 PRRG4，从而影响甲状腺乳头状癌细胞的侵袭和迁移。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-23 DOI: 10.20945/2359-4292-2021-0541

Yachao Liu, Yunchao Xin, Xiaoling Shang, Zedong Tian, Gang Xue

{"title":"CircSEMA6A upregulates PRRG4 by targeting MiR-520h and recruiting ELAVL1 to affect cell invasion and migration in papillary thyroid carcinoma.","authors":"Yachao Liu, Yunchao Xin, Xiaoling Shang, Zedong Tian, Gang Xue","doi":"10.20945/2359-4292-2021-0541","DOIUrl":"10.20945/2359-4292-2021-0541","url":null,"abstract":"Objective: As the most prevalent type of thyroid malignancy, papillary thyroid carcinoma (PTC) accounts for over 80% of all thyroid cancers. Circular RNAs (circRNAs) have been found to regulate multiple cancers, including PTC.Materials and methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were used to analyse RNA and protein levels. Fluorescence in situ hybridization (FISH) was used to detect the distribution of the target genes. Functional experiments and animal experiments were implemented to analyse the biological functions of target genes in vitro and in vivo. Luciferase reporter, RNA pulldown, RNA binding protein immunoprecipitation (RIP) and mRNA stability assays were used to probe the underlying mechanisms.Results: CircSEMA6Awas found to be upregulated in PTC tissues and cells, and its circular structure was verified. CircSEMA6A promotes PTC cell migration and invasion. Moreover, circSEMA6A functions as a competing endogenous RNA (ceRNA) to upregulate proline rich and Gla domain 4 (PRRG4) expression by sponging microRNA-520h (miR-520h). CircSEMA6A recruits ELAV1 to stabilize PRRG4 mRNA and drives PTC progression via PRRG4.Conclusion: CircSEMA6A upregulates PRRG4 by targeting miR-520h and recruiting ELAVL1 to affect the invasion and migration of PTC cells, offering insight into the molecular mechanisms of PTC.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e210541"},"PeriodicalIF":1.7,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics. 大型多结节性甲状腺肿中 DICER1 变体的流行情况：甲状腺功能、临床和影像学特征。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-08 DOI: 10.20945/2359-4292-2023-0030

Lara Judith Cabral Miranda, Débora L S Danilovic, Felipe Augusto Brasileiro Vanderlei, Marcos Roberto Tavares, Nicolau Lima Neto, Rosalinda Yossie Asato de Camargo, Suemi Marui

{"title":"Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics.","authors":"Lara Judith Cabral Miranda, Débora L S Danilovic, Felipe Augusto Brasileiro Vanderlei, Marcos Roberto Tavares, Nicolau Lima Neto, Rosalinda Yossie Asato de Camargo, Suemi Marui","doi":"10.20945/2359-4292-2023-0030","DOIUrl":"10.20945/2359-4292-2023-0030","url":null,"abstract":"Objective: Mutations in DICER1 are found in differentiated thyroid carcinoma (DTC) and in multinodular goiter (MNG) at a younger age with other tumors, which characterizes DICER1 syndrome. DICER1 is one driver to DTC; however, it is also found in benign nodules. We speculated that patients with mutations in DICER1 may present long-lasting MNG. Our aim was to investigate the frequency of DICER1 variants in patients with MNG.Subjects and methods: Patients who submitted to total thyroidectomy due to large MNG with symptoms were evaluated. DICER1 hotspots were sequenced from thyroid nodule samples. To confirm somatic mutation, DNA from peripheral blood was also analyzed.Results: Among 715 patients, 154 were evaluated with 56.2 ± 12.3 years old (28-79) and the thyroid volume was 115.7 ± 108 mL (16.2-730). We found 11% with six DICER1 variations in a homo or heterozygous state. Only rs12018992 was a somatic DICER1 variant. All remaining variants were synonymous and likely benign, according to the ClinVar database. The rs12018992 was previously described in an adolescent with DTC, measuring 13 mm. There were no significant differences according to gender, familial history of goiter, age, thyroid volume, TSH and TI-RADS classification between DICER1 carriers. Free T4 were lower in patients with DICER1 polymorphisms (13.77 ± 1.8 vs. 15.44 ± 2.4 pmol/L, p = 0.008), regardless of TSH levels.Conclusion: We conclude that germline DICER1 variants can be found in 11% of large goiters but no second-hit somatic mutation was found. DICER1 is one driver to thyroid lesion and a second-hit event seems unnecessary in the MNG development.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e230030"},"PeriodicalIF":1.7,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronotype of pregnant women with diabetes mellitus: what is the relationship with maternal and fetal outcomes? 糖尿病孕妇的时间型：与母体和胎儿的结局有什么关系？

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-02 DOI: 10.20945/2359-4292-2023-0071

Johnnatas Lopes, Julio Martinez Santos, Guilherme Ribeiro, Matheus Queiroz, Jorge Fernando Pereira Silva

引用次数: 0

Eveningness and preeclampsia in gestational diabetes - a response to the letter "Chronotype of pregnant women with diabetes mellitus: what is the relationship with maternal and fetal outcomes". 妊娠糖尿病患者的均匀性和先兆子痫--回应 "糖尿病孕妇的时间型：与母体和胎儿结局的关系 "一文。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-02-02 DOI: 10.20945/2359-4292-2023-0141

Cristina Figueiredo Sampaio Facanha, Victória Sudário Alencar, Paula Soares Machado, Rejane Belchior Lima Macêdo, Pedro Felipe Carvalhedo de Bruin, Adriana Costa E Forti, Thaine Mirla Rocha, Veralice Meireles Sales de Bruin

引用次数: 0

Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children. 青春期前儿童血浆瘦素/脂联素比率与胰岛素抵抗指数之间的关系

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2024-01-29 DOI: 10.20945/2359-4292-2022-0353

Carolina Bravo, Verónica Mericq, Ana Pereira, Camila Corvalán, Hugo E Tobar, José Patricio Miranda, José Luis Santos

{"title":"Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children.","authors":"Carolina Bravo, Verónica Mericq, Ana Pereira, Camila Corvalán, Hugo E Tobar, José Patricio Miranda, José Luis Santos","doi":"10.20945/2359-4292-2022-0353","DOIUrl":"10.20945/2359-4292-2022-0353","url":null,"abstract":"Objective: To assess the association between leptin/adiponectin ratio (LAR) and insulin resistance surrogates in prepubertal children.Materials and methods: Study based on data from the Growth and Obesity Chilean Cohort Study (GOCS) involving 968 Chilean prepubertal children. Plasma insulin, leptin, and adiponectin were determined by immunoassays. Several common insulin resistance surrogates were calculated, including the homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride/HDL cholesterol index, triglyceride-glucose (TyG) index, and the TyG index corrected for body mass index (BMI; TyG-BMI) and waist circumference (WC; TyG-WC). Associations among variables were assessed using multiple linear and logistic regression analysis.Results: There was a significant direct association between plasma leptin and LAR with BMI z-score but no association between plasma adiponectin and adiposity. After adjustments for sex and age, LAR was significantly associated with all insulin resistance surrogates (which were categorized using the 75th percentile as the cutoff point), with the TyG-WC index emerging as the surrogate with the highest magnitude of association (odds ratio [OR] 2.44, 95% confidence interval [CI] 2.05-2.9). After additional adjustment for BMI z-score, only the association between LAR and TyG-WC remained significant (OR 1.64, 95% CI 1.27-2.12).Conclusion: Plasma leptin and LAR were strongly associated with several common insulin resistance surrogates in prepubertal children, most notably with the TyG-WC index. Associations between LAR and insulin resistance indexes were mainly driven by the effect of plasma leptin, which is also directly associated with increased adiposity.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e220353"},"PeriodicalIF":1.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline PRKACA amplification-associated primary pigmented nodular adrenocortical disease: a case report and literature review. 种系PRKACA扩增相关的原发性色素结节性肾上腺皮质疾病1例报告及文献复习

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2023-11-17 DOI: 10.20945/2359-4292-2022-0491

Wang-Rong Yang, Xing-Huan Liang, Ying-Fen Qin, Hai-Yan Yang, Shu-Zhan He, Zhen-Xing Huang, Yu-Ping Liu, Zuo-Jie Luo

{"title":"Germline PRKACA amplification-associated primary pigmented nodular adrenocortical disease: a case report and literature review.","authors":"Wang-Rong Yang, Xing-Huan Liang, Ying-Fen Qin, Hai-Yan Yang, Shu-Zhan He, Zhen-Xing Huang, Yu-Ping Liu, Zuo-Jie Luo","doi":"10.20945/2359-4292-2022-0491","DOIUrl":"10.20945/2359-4292-2022-0491","url":null,"abstract":"Primary pigmented nodular adrenocortical disease (PPNAD) is a rare adrenocorticotropin hormone (ACTH)-independent Cushing's syndrome (CS). Pediatric patients with PPNAD typically have unusual skin lesions and slow growth with unknown causes. We present a case of a female Chinese patient with PPNAD caused by the germline PRKACA gene copy number gain of chromosome 19. The patient initially presented with kidney stones, short stature, and obesity. After further testing, it was discovered that the patient had diabetes, mild hypertension, low bone mass, a low ACTH level, and hypercortisolemia, and neither the low-dose or high-dose dexamethasone suppression test was able to inhibit hematuric cortisol, which paradoxically increased. PPNAD was pathologically diagnosed after unilateral adrenalectomy. Chromosome microarrays and whole exon sequencing analyses of the peripheral blood, as well as testing of sectioned adrenal tissue, showed a rise in the copy number of the duplication-containing PRKACA gene on chromosome 19p13.13p13.12, a de novo but not heritable gene defect that causes disease. The clinical signs and symptoms supported the diagnosis of Carney complex (CNC). One significant mechanism of CNC pathogenesis may be the rise in germline PRKACA copy number of chromosome 19. When assessing PPNAD patients for CNC, the possibility of PRKACA gene amplification should be considered. The effect of PRKACA gene amplification on the clinical manifestations of CNC needs to be confirmed by more cases.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e220491"},"PeriodicalIF":1.7,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness. 颅咽管瘤患者的生活质量评估及整体健康受损危险因素的识别。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2023-11-17 DOI: 10.20945/2359-4292-2023-0001

Ben Lin, Shiyuan Xiang, Jiajun Chen, Yu Jing, Zhao Ye, Yichao Zhang, Xiaoyun Cao, Zhiwen Yin, Nidan Qiao, Xiang Zhou

{"title":"Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness.","authors":"Ben Lin, Shiyuan Xiang, Jiajun Chen, Yu Jing, Zhao Ye, Yichao Zhang, Xiaoyun Cao, Zhiwen Yin, Nidan Qiao, Xiang Zhou","doi":"10.20945/2359-4292-2023-0001","DOIUrl":"10.20945/2359-4292-2023-0001","url":null,"abstract":"Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices.Subjects and methods: We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Questionnaire Depression (PHQ9) and Pittsburgh Sleep Quality Index to prospectively evaluated their QoL. Parameters of QoL along with clinical indices were compared among sub-groups divided according to Puget classification. Correlation analyses and regression analyses were performed to detect influential determinants to self-reported wellness.Results: Patients presented impaired QoL compared with general population (p < 0.001), as assessed by SF-36. Correlation analyses indicated the detrimental influence resulting from central diabetes insipidus (CDI). Multivariate linear regression unveiled the adverse effect of CDI on Mental Component Summary (coefficient = -13.869, p= 0.007), GAD7 total score (coefficient = 2.072, p = 0.049) as well as PHQ9 total score (coefficient = 3.721, p = 0.001). Multivariate logistic regression verified CDI as a risk factor of developing depressive symptoms (OR = 6.160, p = 0.001).Conclusion: QoL of patients with craniopharyngioma was remarkably compromised before operation. CDI exerted detrimental influences on patients' QoL and it might serve as a marker for early identification of patients at risk of depression.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e230001"},"PeriodicalIF":1.7,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience. 促性腺激素分泌和促甲状腺激素分泌垂体腺瘤:单中心经验。

IF 1.7 4区医学

Archives of Endocrinology Metabolism Pub Date : 2023-11-17 DOI: 10.20945/2359-4292-2023-0072

Manjiri Karlekar, Chakra Diwaker, Vijaya Sarathi, Anurag Lila, Anima Sharma, Saba Samad Memon, Virendra Patil, Tushar Bandgar

{"title":"Gonadotropin-secreting and thyrotropin-secreting pituitary adenomas: A single-center experience.","authors":"Manjiri Karlekar, Chakra Diwaker, Vijaya Sarathi, Anurag Lila, Anima Sharma, Saba Samad Memon, Virendra Patil, Tushar Bandgar","doi":"10.20945/2359-4292-2023-0072","DOIUrl":"10.20945/2359-4292-2023-0072","url":null,"abstract":"Objective: Data regarding rare FPAs from India, a resource limited setting, are limited. We describe a case series of rare FPAs from a single center in western India.Materials and methods: This was a retrospective case record review of patients diagnosed between January 2010 and July 2022. The diagnosis was based on biochemical(inappropriately elevated serum FSH/LH) and pathologic (positive immunostaining for FSH/LH) features in patients with FGA, and elevated serum thyroid hormones and normal/elevated TSH in patients with TSHomas.Results: We identified 11 patients with a total of six FGAs (median age 43.5 years, five men, one FGA cosecreting TSH, median largest dimension 40 mm, range 33-60 mm) and six TSHomas (median age 34.5 years, four women, two TSHomas cosecreting GH, median largest dimension 42.5 mm, range 13-60 mm). Symptoms of sellar mass effects led to pituitary imaging in most patients with FGA. Patients with TSHomas had symptoms of excess hormone secretion (GH/TSH) or sellar mass effects. The TSHomas that cosecreted GH/FSH were larger than those secreting only TSH. Transsphenoidal resection was the most common first-line therapy but significant residual disease was frequent (3 out of 6 FGAs and 4 out of 5 TSHomas).Conclusion: This is the first and second case series of FGAs and TSHomas, respectively, from India. In this study, TSHomas presented at younger age, were larger andhad low surgical cure rates.","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"68 ","pages":"e230072"},"PeriodicalIF":1.7,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10916838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0