Current Research in Translational Medicine最新文献

{"title":"Clinical image: A new category of articles in current research in translational medicine","authors":"Tamim Alsuliman","doi":"10.1016/j.retram.2024.103462","DOIUrl":"10.1016/j.retram.2024.103462","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 3","pages":"Article 103462"},"PeriodicalIF":3.2,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141772079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitfalls in definitions on respiratory viruses and particularities of Adenovirus infection in hematopoietic cell transplantation patients: Recommendations from the EBMT practice harmonization and guidelines committee","authors":"José Luis Piñana ,&nbsp;Simone Cesaro ,&nbsp;Malgorzata Mikulska ,&nbsp;Paul E. Verweij ,&nbsp;Anne Bergeron ,&nbsp;Dionysios Neofytos ,&nbsp;Jan Styczynski ,&nbsp;Isabel Sánchez-Ortega ,&nbsp;Raffaella Greco ,&nbsp;Francesco Onida ,&nbsp;Ibrahim Yakoub-Agha ,&nbsp;Dina Averbuch ,&nbsp;Rafael de la Cámara ,&nbsp;Per Ljungman","doi":"10.1016/j.retram.2024.103461","DOIUrl":"10.1016/j.retram.2024.103461","url":null,"abstract":"<div><p>In 2023, the EBMT Practice harmonization and Guidelines Committee partnered with the EBMT Infection Diseases Working Party (IDWP) to undertake the task of delivering best practice recommendations, aiming to harmonize by expert consensus, the already existing definitions and future epidemiological and clinical studies among centers of the EBMT network. To attain this objective, a group of experts in the field was convened. The workgroup identified and discussed some critical aspects in definitions of community-acquired respiratory viruses (CARV) and adenovirus (ADV) infections in recipient of hematopoietic cell transplant (HCT). The methodology involved literature review and expert consensus. For CARV, expert consensus focused on defining infection severity, infection duration, and establishing criteria for lower respiratory tract disease (LRTD). For ADV, the expert consensus focused on surveillance methods and the definitions of ADV infection, certainty levels of disease, response to treatment, and attributable mortality. This consensus workshop provided indications to EBMT community aimed at facilitating data collection and consistency in the EBMT registry for respiratory viral infectious complications.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 3","pages":"Article 103461"},"PeriodicalIF":3.2,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452318624000242/pdfft?md5=796a9d025f81cfdf1a3fc56236e60f79&pid=1-s2.0-S2452318624000242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants of dectin-1 and their antifungal immunity impact in hematologic malignancies: A comprehensive systematic review","authors":"Mojtaba Aghaei ,&nbsp;Reyhane Khademi ,&nbsp;Mohammad Ali Jalali Far ,&nbsp;Seyed Sobhan Bahreiny ,&nbsp;Amir Hossein Mahdizade ,&nbsp;Nasrin Amirrajab","doi":"10.1016/j.retram.2024.103460","DOIUrl":"10.1016/j.retram.2024.103460","url":null,"abstract":"<div><h3>Background</h3><p>Fungal infections pose a significant threat to individuals with hematologic malignancies due to compromised immune systems. Dectin-1, a pivotal pattern recognition receptor, plays a central role in antifungal immune responses. Understanding its genetic variants' impact is crucial for advancing personalized therapeutic approaches.</p></div><div><h3>Methods</h3><p>Employing systematic review methods, studies were meticulously selected and assessed for relevance. Data extraction encompassed Dectin-1 genetic variants, antifungal immune responses, and disease outcomes.</p></div><div><h3>Results</h3><p>Findings unveiled a complex relationship between Dectin-1 genetic variants and antifungal immunity in hematologic malignancies. Variable associations emerged, influencing susceptibility to fungal infections and disease prognosis. Moreover, implications for treatment outcomes were explored, suggesting potential avenues for tailored interventions.</p></div><div><h3>Conclusions</h3><p>This systematic review underscores the need for further investigation into the precise influence of Dectin-1 genetic variants on antifungal immunity and disease progression in hematologic malignancies. Insights gained could pave the way for personalized therapeutic strategies, optimizing infection prevention and malignancy management. By delving into the intricate connections between genetic nuances, immune responses, and clinical trajectories, this review contributes to the ongoing discourse surrounding hematologic malignancies, fungal infections, and their multifaceted interplay.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 4","pages":"Article 103460"},"PeriodicalIF":3.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive hemophagocytic lymphohistiocytosis: Epidemiological, clinico-biological and etiological profile","authors":"Fatma Abida ,&nbsp;Raida Ben Salah ,&nbsp;Mourad Chaari ,&nbsp;Makram Koubaa ,&nbsp;Mounir Ben Jemaa ,&nbsp;Henda Elleuch ,&nbsp;Zouheir Bahloul","doi":"10.1016/j.retram.2024.103459","DOIUrl":"10.1016/j.retram.2024.103459","url":null,"abstract":"<div><p>Hemophagocytic lymphohistiocytosis (HLH) is an hyperinflammatory state resulting from increased secretion of proinflammatory cytokines, which are responsible for clinical, biological and cytological manifestations.</p></div><div><h3>Objective</h3><p>The aim of our study is to describe the epidemiological, clinical, biological, etiological and evolutionary profile of HLH in Tunisia.</p></div><div><h3>Methods</h3><p>A retrospective study that involved patients, with images of hemophagocytosis in myelograms analyzed at the laboratory of biological hematology of the University Hospital \"Hédi-Chaker\" of Sfax-Tunisia, followed at these departments: hematology, internal medicine, department of infectious-diseases and department of gastroenterology, (June2017- May2021). First, we identified all patients with hemophagocytosis images. Secondly, we selected the patients who fulfilled the diagnostic criteria of the HLH-2004-score.</p></div><div><h3>Results</h3><p>Nineteen patients were included in this study. Nine men and 10 women with a mean age of 37.95 years. Fever was present in all patients. Organomegaly was described in 74% of cases. The most frequent cytopenia was anemia (100%). Hypertriglyceridemia was noted in 79% of cases and hyperferritinemia (&gt; 500 ng/mL) was ubiquitous. In myelogram, 68% of patients had slides showing numerous or very numerous images of hemophagocytosis. The infectious pathology was the most common cause of HLH (42%). No cause was found in 10% of cases. The corticosteroid therapy at a dose of 1 mg/kg/day was prescribed in 89% of our patients. The overall evolution was favorable in 58% of cases. The mortality was not associated with the causal pathology (p=0.218).</p></div><div><h3>Conclusion</h3><p>Secondary HLH is likely to be under-recognized, which contributes to its high morbidity and mortality. Early recognition is crucial for any reasonable attempt at curative therapy.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 4","pages":"Article 103459"},"PeriodicalIF":3.2,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pluronic F127 composite hydrogel for the repair of contraction suppressed full-thickness skin wounds in a rabbit model","authors":"Khan Sharun ,&nbsp;S. Amitha Banu ,&nbsp;Merlin Mamachan ,&nbsp;Athira Subash ,&nbsp;Mathesh Karikalan ,&nbsp;Obli Rajendran Vinodhkumar ,&nbsp;K.M. Manjusha ,&nbsp;Rohit Kumar ,&nbsp;A.G. Telang ,&nbsp;Kuldeep Dhama ,&nbsp;A.M. Pawde ,&nbsp;Swapan Kumar Maiti ,&nbsp;Amarpal","doi":"10.1016/j.retram.2024.103458","DOIUrl":"10.1016/j.retram.2024.103458","url":null,"abstract":"<div><p>Hydrogels are commonly used as carriers for cell delivery due to their similarities to the extracellular matrix. A contraction-suppressed full-thickness wound model was used to evaluate the therapeutic potential of Pluronic F127 (PF127) hydrogel loaded with adipose-derived stromal vascular fraction (AdSVF), mesenchymal stem cells (AdMSC), and conditioned media (AdMSC-CM) for the repair of wounds in a rabbit model. The experimental study was conducted on forty-eight healthy adult New Zealand white rabbits randomly divided into eight groups with six animals each and treated with AdSVF, AdMSC, and AdMSC-CM as an injectable or topical preparation. The healing potential of different adipose-derived cell-based and cell-free therapeutics was evaluated based on percentage wound healing, period of epithelialization, epidermal thickness, scar evaluation, histopathology analysis, histochemical evaluation, immunohistochemistry (collagen type I), and hydroxyproline assay by comparing with the positive and negative control. Collagen density analysis using different staining methods, immunohistochemistry, and hydroxyproline assay consistently showed that delivering AdMSC and AdMSC-CM in PF127 hydrogel enhanced epithelialization, collagen production, and organization, contributing to improved tissue strength and quality. Even though allogeneic AdSVF was found to promote wound healing in rabbits, it has a lower potential than AdMSC and AdMSC-CM. The wound healing potential of AdMSC and AdMSC-CM was enhanced when loaded in PF127 hydrogel and applied topically. Even though wounds treated with AdMSC outperformed AdMSC-CM, a significant difference in the healing quality was not observed in most instances, indicating almost similar therapeutic potential. The findings indicate that the wound healing potential of AdMSC and AdMSC-CM was enhanced when loaded in PF127 hydrogel and applied topically. These treatments promoted collagen production, tissue organization, and epidermal regeneration, ultimately improving overall healing outcomes.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 4","pages":"Article 103458"},"PeriodicalIF":3.2,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Bone mineral density, osteopenia, osteoporosis, and fracture risk in patients with atopic dermatitis: A systematic review and meta-analysis”","authors":"Jia Wang ,&nbsp;Juelan Ye ,&nbsp;Linyin Yan ,&nbsp;Chunbiao Wu ,&nbsp;Wei Wei ,&nbsp;Ju Wang ,&nbsp;Ting Ye ,&nbsp;Jianru Xiao","doi":"10.1016/j.retram.2024.103457","DOIUrl":"https://doi.org/10.1016/j.retram.2024.103457","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 4","pages":"Article 103457"},"PeriodicalIF":4.1,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Carbamazepine-induced thrombocytopenia complicated with severe skin reactions","authors":"Fengping Peng ,&nbsp;Shaoxue Ding ,&nbsp;Jing Guan ,&nbsp;Rong Fu","doi":"10.1016/j.retram.2024.103456","DOIUrl":"10.1016/j.retram.2024.103456","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 3","pages":"Article 103456"},"PeriodicalIF":4.1,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation","authors":"Gentiana Elena Trotta ,&nbsp;Giulia Ciangola ,&nbsp;Ilaria Cerroni ,&nbsp;Valeria Mezzanotte ,&nbsp;Andrea Nunzi ,&nbsp;Lucia Anemona ,&nbsp;Luca Savino ,&nbsp;Gottardo De Angelis ,&nbsp;Benedetta Mariotti ,&nbsp;Fabrizio Bonanni ,&nbsp;Elisa Meddi ,&nbsp;Annagiulia Zizzari ,&nbsp;Vito Mario Rapisarda ,&nbsp;Ilaria Mangione ,&nbsp;Antonio Bruno ,&nbsp;Maria Cantonetti ,&nbsp;Adriano Venditti ,&nbsp;Raffaella Cerretti","doi":"10.1016/j.retram.2024.103452","DOIUrl":"10.1016/j.retram.2024.103452","url":null,"abstract":"<div><p>Sézary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. Allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graft-versus-host disease (GvHD) remain a clinical challenge. Mogamulizumab, a humanized anti-CC chemokine receptor 4 (CCR4) antibody, is sometimes used as a bridge to transplantation, but its potential interactions with allo-HCT are unclear. This report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. The patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. However, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient's death. This case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. Further research is required to fully understand the interaction between mogamulizumab and allo-HCT and to determine whether it is an optimal approach as a bridge to transplant therapy. This paradigmatic case suggests the need of personalizing transplant strategies by selecting appropriate conditioning therapy and GvHD prophylaxis to minimize potential toxicity.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 3","pages":"Article 103452"},"PeriodicalIF":4.1,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140785934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate level is an independent predictor of mortality in patients with hematologic malignancy receiving urgent chemotherapy in intensive care unit","authors":"Sukriye Miray Kilincer Bozgul ,&nbsp;Ilkce Akgun Kurtulmus ,&nbsp;Ajda Gunes ,&nbsp;Gorkem Koymen ,&nbsp;Devrim Bozkurt ,&nbsp;Zehra Tuba Karaman ,&nbsp;Karya Islamoglu ,&nbsp;Baris Ozkilic ,&nbsp;Burcu Barutcuoglu ,&nbsp;Fatma Feriha Cilli ,&nbsp;Nur Akad Soyer","doi":"10.1016/j.retram.2024.103451","DOIUrl":"https://doi.org/10.1016/j.retram.2024.103451","url":null,"abstract":"<div><h3>Background</h3><p>Intensive care unit (ICU) survival of cancer patients has improved. Urgent chemotherapy has become feasible in critically ill patients with specific organ dysfunction due to hematological malignancies.</p></div><div><h3>Objective</h3><p>The aim of the study was to assess ICU mortality rates and the factors associated with mortality in patients with hematologic malignancies receiving urgent chemotherapy in the ICU.</p></div><div><h3>Methods</h3><p>We retrospectively included all patients admitted to the ICU who received chemotherapy due to hematologic malignancy in 2012–2022.</p></div><div><h3>Results</h3><p>Of the 129 patients undergoing chemotherapy in the ICU, 50 (38.7 %) died during the ICU follow-up. The following conditions were significantly more common among nonsurvivors: presence of infection at the time of ICU admission (<em>p</em> &lt; 0.001), the requirement for mechanical ventilation during ICU stay (<em>p</em> &lt; 0.001), the need for noninvasive mechanical ventilation during ICU stay (<em>p</em> = 0.014), vasopressor support (<em>p</em> &lt; 0.001), and sepsis (<em>p</em> &lt; 0.001). Logistic regression analysis revealed that among laboratory parameters on ICU admission, lactate (<em>p</em> = 0.008), albumin (<em>p</em> = 0.022), C-reactive protein (<em>p</em> = 0.046), baseline sequential organ failure assessment (SOFA) score (<em>p</em> &lt; 0.001), newly developed heart failure (<em>p</em> = 0.006), and the requirement for vasopressor agents during ICU stay (<em>p</em> &lt; 0.001) significantly influenced the risk of mortality in the univariate analysis. The multivariate analysis revealed lactate levels (<em>p</em> = 0.047) on ICU admission as an independent predictor of mortality.</p></div><div><h3>Conclusion</h3><p>The development of heart failure and lactate levels on admission were the main predictors of mortality. Additionally, higher SOFA scores revealed that illness severity was closely associated with mortality. Future studies should focus on strategies to further reduce these risks and achieve the best outcomes for these patients.</p></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 4","pages":"Article 103451"},"PeriodicalIF":4.1,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological manifestations as a first sign of Erdheim-Chester Disease: A case report","authors":"Ahmad Ali Basha ,&nbsp;Mesk Al-Hammadi ,&nbsp;Zora Marjanovic ,&nbsp;Reyes Maria Martin-Rojas ,&nbsp;Tamim Alsuliman","doi":"10.1016/j.retram.2024.103450","DOIUrl":"https://doi.org/10.1016/j.retram.2024.103450","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"72 2","pages":"Article 103450"},"PeriodicalIF":4.1,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140644376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}