A comparison of porcine anti-human T lymphocyte immunoglobulin, rabbit-ATG for GVHD prophylaxis and without ATG in matched sibling donor transplantation

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Current Research in Translational Medicine Pub Date : 2025-01-01 DOI:10.1016/j.retram.2025.103501

Shiyuan Zhou , Chao Ma , Danping Zhou , Qian Zhu , Wenjuan Zhu , Jing Li , Depei Wu , Xiao Ma , Xiaojin Wu

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引用次数: 0

Abstract

Introduction

Research on anti-lymphocyte globulins other than rabbit anti-thymocyte globulin (r-ATG) in prevention of graft-versus-host-disease (GVHD) following HLA-matched siblings hematopoietic stem cell transplantation (MSD-HSCT) is limited. The objective of this study is to investigate the distinct impacts of porcine anti-human T lymphocyte immunoglobulin (p-ATG) and r-ATG on outcomes of MSD-HSCT in patients with hematologic malignancies.

Patients and methods

This retrospective analysis enrolled 373 consecutive patients who underwent MSD-HSCT from January 2019 to October 2023. 135 patients received r-ATG (5mg/kg) and 51 received p-ATG (30mg/kg) for GVHD prophylaxis. 187 did not receive r-ATG or p-ATG.

Results

Despite early deaths, no engraftment failure occurred. In the r-ATG group, neutrophil engraftment was observed earlier, while platelet engraftment was delayed compared to other groups. Both r-ATG and p-ATG group showed protective effect on chronic graft-versus-host disease (cGVHD) (13.9 % and 29.6 % respectively vs. 43.0 % of control group at 2 years post HSCT), whereas only the r-ATG group displayed a decreased acute GVHD (aGVHD) rate (24.9 % vs. 39.8 % of control group at day 100 post HSCT). GVHD-free and relapse-free survival (GRFS) were found superior in both r-ATG and p-ATG groups (63.4 % and 56.8 % respectively vs. 37.0 % of control group at 2 years post HSCT). R-ATG was identified as an independent protective factor for aGVHD, cGVHD and GRFS in multivariate analysis.

Conclusions

Our study further confirmed the role of ATG in MSD-HSCT for improving the outcomes. No evidence supported substituting r-ATG with p-ATG in achieving these effects in the study.

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来源期刊

Current Research in Translational Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

7.00

自引率

4.90%

发文量

审稿时长

45 days

期刊介绍： Current Research in Translational Medicine is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of hematology, immunology, infectiology, hematopoietic cell transplantation, and cellular and gene therapy. The journal considers for publication English-language editorials, original articles, reviews, and short reports including case-reports. Contributions are intended to draw attention to experimental medicine and translational research. Current Research in Translational Medicine periodically publishes thematic issues and is indexed in all major international databases (2017 Impact Factor is 1.9). Core areas covered in Current Research in Translational Medicine are: Hematology, Immunology, Infectiology, Hematopoietic, Cell Transplantation, Cellular and Gene Therapy.