Current Research in Translational Medicine最新文献

{"title":"Adolescent and young adult patients with ‘Philadelphia negative’ myeloproliferative neoplasms: a real world, UK tertiary-centre study","authors":"Dipal Mehta,&nbsp;Holly Theaker,&nbsp;Hugo Ferreira,&nbsp;Syeda Ahmed,&nbsp;Aisha Roble,&nbsp;Emma Shambrook,&nbsp;Jonathan Lambert,&nbsp;Andrew Wilson,&nbsp;Donal P McLornan,&nbsp;Samah Alimam","doi":"10.1016/j.retram.2025.103530","DOIUrl":"10.1016/j.retram.2025.103530","url":null,"abstract":"<div><div>Increasing numbers of adolescent and young adult (AYA) patients are diagnosed with myeloproliferative neoplasms (MPNs). Management strategies are often extrapolated from older MPN cohorts and frequently fail to address specific needs. Through retrospective description of 107 AYA patients registered at a UK specialist centre, we identify unique clinicopathological features compared with older patients, including lower incidence of <em>JAK2</em> V617F and additional non-driver mutations, and a reduced rate of transformation. Despite these favourable disease characteristics, we demonstrate significant rates of venous thrombosis (&gt;14 %). This data highlights areas of unmet clinical need and calls for tailored management approaches for AYA MPN patients.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103530"},"PeriodicalIF":3.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green solvent-based synthesis of diclofenac diethylamine-loaded PCL nanoparticles for sustained drug delivery","authors":"Soolafa Al Soliman ,&nbsp;Zaki Ali Ajji ,&nbsp;Antoun Al-Laham","doi":"10.1016/j.retram.2025.103529","DOIUrl":"10.1016/j.retram.2025.103529","url":null,"abstract":"<div><h3>Background</h3><div>Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumor properties; however, its clinical application is limited by systemic toxicity. Encapsulation in biodegradable polymeric nanoparticles offers a strategy to enhance therapeutic efficacy while minimizing adverse effects. Nevertheless, the use of toxic organic solvents in nanoparticle fabrication remains a significant challenge.</div></div><div><h3>Objective</h3><div>This study aimed to develop and characterize diclofenac diethylamine-loaded polycaprolactone (PCL) nanoparticles using green solvents and to compare two preparation methods-emulsification solvent evaporation/extraction and spontaneous emulsification solvent diffusion-for producing diclofenac-loaded nanoparticles with potential applications in tumor therapy.</div></div><div><h3>Methods</h3><div>Diclofenac diethylamine-loaded PCL nanoparticles were prepared using both methods, employing a novel green solvent system. The nanoparticles were characterized in terms of size, polydispersity index (PDI), zeta potential, morphology, and encapsulation efficiency. In vitro drug release profiles were evaluated and fitted to kinetic models.</div></div><div><h3>Results</h3><div>The developed diclofenac diethylamine-loaded PCL nanoparticles exhibited a mean diameter below 200 nm, a monodisperse population, and a negative surface charge. Both preparation methods achieved high encapsulation efficiency and prolonged, diffusion-controlled drug release. The spontaneous solvent diffusion method provided slightly better control over particle size.</div></div><div><h3>Conclusion</h3><div>These nanoparticles are well-suited for cancer therapy, offering sustained drug release, enhanced safety due to the use of green solvents, and robust physicochemical stability. The findings support their potential as an innovative, effective, and safe delivery system for antitumoral applications.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103529"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CC486 as a safe and effective bridge to transplant in MDS-del5q with transfusion-dependent anemia following lenalidomide relapse: A case report","authors":"G. Scorpio ,&nbsp;A. Francesio ,&nbsp;S. Piemontese ,&nbsp;A. Acerbis ,&nbsp;S. Mastaglio ,&nbsp;F. Giglio ,&nbsp;G.M. Bergonzi ,&nbsp;L. Lazzari ,&nbsp;A. Ruggeri ,&nbsp;A. Bruno ,&nbsp;S. Marktel ,&nbsp;M.T. Lupo-Stanghellini ,&nbsp;A. Assanelli ,&nbsp;M. Bernardi ,&nbsp;L. Vago ,&nbsp;F. Ciceri ,&nbsp;E. Diral","doi":"10.1016/j.retram.2025.103528","DOIUrl":"10.1016/j.retram.2025.103528","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103528"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunobiological functions and therapeutic applications of interleukin-17 family in cancer","authors":"Nasrin Mansuri ,&nbsp;Asma'a H. Mohamed ,&nbsp;Marya Ahsan ,&nbsp;Sana Abdul-Jabbar Ali ,&nbsp;Mohammed Ansar Qureshi ,&nbsp;Waleed A Aldhaaban ,&nbsp;Ayaz Khurram Mallick ,&nbsp;Muataz Elsiddig Dafaalla Mohammed ,&nbsp;Fuzail Ahmad ,&nbsp;Irshad Ahmad ,&nbsp;Mohammad Chand Jamali ,&nbsp;Alaa Shafie","doi":"10.1016/j.retram.2025.103527","DOIUrl":"10.1016/j.retram.2025.103527","url":null,"abstract":"<div><div>Interleukin-17 (IL-17) family cytokines play a pivotal role in immune responses and inflammatory processes, significantly impacting various physiological and pathological conditions. This review explores the immunobiological functions of IL-17, focusing on its diverse cellular sources, including T helper 17 (Th17) cells, γδ T cells, innate lymphoid cells (ILCs), neutrophils, and natural killer T (NKT) cells, and signaling pathways. Special attention is given to IL-17 involvement in cancer, where it exhibits both pro-tumorigenic and anti-tumorigenic effects, influencing tumor proliferation, angiogenesis, metastasis, and drug resistance through various signaling cascades such as JAK/STAT, NF-κB, and PI3K/AKT. Understanding these mechanisms highlights IL-17 as a potential therapeutic target for modulating immune responses and improving cancer treatments.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103527"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Alzheimer's disease prediction using random forest: A novel framework combining backward feature elimination and ant colony optimization","authors":"Afeez A. Soladoye ,&nbsp;Nicholas Aderinto ,&nbsp;Bolaji A. Omodunbi ,&nbsp;Adebimpe O. Esan ,&nbsp;Ibrahim A. Adeyanju ,&nbsp;David B. Olawade","doi":"10.1016/j.retram.2025.103526","DOIUrl":"10.1016/j.retram.2025.103526","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) represents a significant global health challenge due to its increasing prevalence and the limitations of current diagnostic approaches. Early detection is crucial as pathological changes occur 10-15 years before clinical symptoms manifest, yet current diagnostic methods typically identify the disease at moderate to advanced stages. Machine learning techniques offer promising solutions for early prediction, but face challenges related to feature selection and hyperparameter optimization.</div></div><div><h3>Objective</h3><div>To develop an enhanced predictive model for Alzheimer's disease by integrating advanced feature selection techniques with nature-inspired hyperparameter optimization for Random Forest classifiers while ensuring robust validation and statistical significance testing.</div></div><div><h3>Methods</h3><div>This study employed three feature selection techniques (Whale Optimization Algorithm, Artificial Bee Colony, and Backward Elimination Feature Selection) and two hyperparameter optimization algorithms (Artificial Ant Colony Optimization and Bald Eagle Search) to improve Random Forest model performance. A dataset comprising 2,149 instances with 34 features was preprocessed using MinMax normalization and Synthetic Minority Oversampling Technique (SMOTE) applied only to training data to prevent data leakage. Statistical significance testing using McNemar's test was conducted to compare model performances. Model performance was evaluated using accuracy, precision, recall, F1-score, and AUC with confidence intervals calculated using bootstrap sampling.</div></div><div><h3>Results</h3><div>The combination of Backward Elimination Feature Selection with Artificial Ant Colony Optimization achieved the highest performance (95% accuracy ± 1.2%, 95% precision ± 1.1%, 94% recall ± 1.3%, 95% F1-score ± 1.0%, 98% AUC ± 0.8%), outperforming other methodological combinations and conventional machine learning algorithms with statistically significant improvements (p &lt; 0.001). This approach identified 26 significant features associated with Alzheimer's disease. Additionally, nature-inspired optimization algorithms demonstrated substantial computational efficiency advantages over empirical approaches (18 minutes versus 133 minutes).</div></div><div><h3>Conclusion</h3><div>The integration of advanced feature selection with nature-inspired hyperparameter optimization enhances Alzheimer's disease prediction accuracy while improving computational efficiency. However, external validation on independent datasets and prospective clinical studies are needed to establish real-world utility. This methodological framework offers promising applications for early diagnosis and intervention planning, with potential extensions to other complex medical prediction tasks.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103526"},"PeriodicalIF":3.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of pre- and post-transplant concentrations of citrulline, zonulin, and calprotectin in children undergoing allogeneic hematopoietic cell transplantation","authors":"Pejman Rohani ,&nbsp;Faezeh Tejareh ,&nbsp;Amir Ali Hamidieh ,&nbsp;Maryam Behfar ,&nbsp;Mohammad Hassan Sohouli","doi":"10.1016/j.retram.2025.103525","DOIUrl":"10.1016/j.retram.2025.103525","url":null,"abstract":"<div><h3>Background</h3><div>Allogeneic hematopoietic cell transplantation (allo-HCT) is a life-saving treatment for pediatric patients but is often associated with severe gastrointestinal complications. Identifying reliable biomarkers of gut integrity and inflammation is crucial for early detection and management of these issues. This study evaluates pre- and post-transplant levels of citrulline, zonulin, and calprotectin in pediatric allo-HCT patients.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted on 100 pediatric patients at the Children’s Hospital from 2023 to 2025. Citrulline, zonulin, and calprotectin levels were measured at baseline (pre-transplant), 3 months, and 6 months post-transplant.</div></div><div><h3>Results</h3><div>Calprotectin and zonulin levels peaked at 3 months post-transplant (calprotectin: 123 ± 40 µg/g, <em>p</em> &lt; 0.001; zonulin: 90.69 ± 20.32 ng/mL, <em>p</em> = 0.001) and declined by 6 months (calprotectin: 90.05 ± 30.27 µg/g; zonulin: 70.74 ± 15.38 ng/mL). Citrulline levels decreased from 25.49 ± 8.22 µM at baseline to 20.39 ± 5.52 µM at 6 months (<em>p</em> = 0.004). Elevated calprotectin and zonulin levels were strongly associated with severe GVHD (Grade III-IV: calprotectin 153.25 ± 51.81 µg/g, <em>p</em> = 0.001; zonulin 110.05 ± 25.33 ng/mL, <em>p</em> = 0.002) and higher grades of diarrhea and mucositis. Patients with obesity (BMI &gt; 30) had significantly higher biomarker levels. Multiple hospital readmissions were also associated with elevated biomarker levels (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Citrulline, zonulin, and calprotectin are promising biomarkers for assessing GI toxicity and inflammation in pediatric allo-HCT recipients. Their levels correlate with the severity of post-transplant complications, nutritional status, and clinical outcomes.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103525"},"PeriodicalIF":3.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections in VEXAS syndrome: a systematic review of the literature","authors":"Syed B Ali ,&nbsp;Carmelo Gurnari","doi":"10.1016/j.retram.2025.103524","DOIUrl":"10.1016/j.retram.2025.103524","url":null,"abstract":"<div><div>Vacuolation, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a multisystem disease for which chronic immunosuppression is needed. Opportunistic infections are common; however, a clear prophylaxis regimen is not defined.</div><div>A systematic review of the literature was undertaken. Six publications with 123 patients were evaluated. Of 86 patients with demographic data; most were males (<em>n</em> = 85, 98.8 %) and median age was 73 years. <em>UBA1</em> mutational status was reported in 80 patients: p.Met41Thr (<em>n</em> = 43, 53.8 %), p.Met41Val (<em>n</em> = 17, 21.3 %) and p.Met41Leu (<em>n</em> = 12, 15.0 %) were most common. In these patients, 48 (60 %) had underlying myelodysplastic syndrome.</div><div>Many of the patients had multiple hospitalizations. Infections were reported as follows: COVID19 (<em>n</em> = 20), Pneumocystis <em>jiroveci</em> pneumonia (PJP) (<em>n</em> = 16), nontuberculous mycobacterium (NTM) species (<em>n</em> = 16), <em>Enterobacteriaceae</em> species (<em>n</em> = 14), <em>Legionella</em> species (<em>n</em> = 13), Varicella Zoster virus (<em>n</em> = 11) and Herpes Simplex Virus (<em>n</em> = 8) infections, respectively.</div><div>Daily prednisolone dose was at, or greater than 10 mg and overall median long term steroid treatment duration was 3.1 years. Notably, for NTM the median daily prednisolone dose was 12.5 mg. Median prednisolone dosing for PJP was only reported in one of the publications, comprising six patients, at 17 mg per day. Where data was available, 45 of the 95 patients (47.3 %) were deceased at last follow-up. Of the 45 deaths, 32 (71.1 %) were attributed to the intercurrent infection.</div><div>In summary, opportunistic infections are commonly reported in VEXAS syndrome. Prophylaxis for such infections remains paramount but no clear consensus on recommendations exists, highlighting the need for prospective studies. Moreover, furthering our understanding of pathophysiology of VEXAS syndrome and impairment in both innate and humoral immunity may clarify its contribution to infections in addition to high background immunosuppressive therapies.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 4","pages":"Article 103524"},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic hematopoietic stem cell transplantation in 18 patients with atypical inherited bone marrow failure syndromes: Efficacy and long-term outcomes","authors":"Yimin Wang,&nbsp;Jing Wang,&nbsp;Qianqian Xiao,&nbsp;Xiaolin Yu,&nbsp;Xiaochen Song,&nbsp;Wenjun Li,&nbsp;Lei Deng,&nbsp;Yixi Hou,&nbsp;Fang Zhou","doi":"10.1016/j.retram.2025.103519","DOIUrl":"10.1016/j.retram.2025.103519","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 3","pages":"Article 103519"},"PeriodicalIF":3.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthracycline and arsenic trioxide-based regimens for the treatment of acute promyelocytic leukemia: thiamine levels monitoring importance","authors":"Reda Garidi,&nbsp;Hassina Aftisse,&nbsp;Djedjiga Si Tayeb,&nbsp;Chahrazad Benchchouk,&nbsp;Nadia Sari Hassoun,&nbsp;Assia Alem,&nbsp;Tamim Alsuliman","doi":"10.1016/j.retram.2025.103520","DOIUrl":"10.1016/j.retram.2025.103520","url":null,"abstract":"","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 3","pages":"Article 103520"},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus HLA antigen load as a new potential predictive factor after haploidentical stem cell transplantation","authors":"Antonio Milano ,&nbsp;Jacopo Mariotti ,&nbsp;Pietro Crivello ,&nbsp;Giulia Di Maggio ,&nbsp;Giorgia Cornacchini ,&nbsp;Giuliana Lando ,&nbsp;Silvano Rossini ,&nbsp;Marialuisa Lavitrano ,&nbsp;Stefania Bramanti ,&nbsp;Roberto Crocchiolo","doi":"10.1016/j.retram.2025.103518","DOIUrl":"10.1016/j.retram.2025.103518","url":null,"abstract":"<div><div>Among the complications occurring after allogeneic hematopoietic stem cell transplantation (HSCT), infection by human Cytomegalovirus (CMV) represents one of the most relevant in terms of morbidity/mortality and specific management is required by either monitoring viral load and administer anti-CMV therapies. Due to the physiological role of the Human Leucocyte Antigen (HLA) system in presenting foreign antigens to the adaptive immune system to enhance viral clearance, we measured here the HLA antigen load for two immunodominant CMV peptides and correlate with transplant outcome in 238 consecutive adult patients undergoing haploidentical HSCT at a single center.</div><div>Interestingly, a higher class I antigen load (i.e. above the median) for protein IE1 correlated with an inferior absolute incidence of CMV infection; moreover, a statistically significant correlation with lower non-relapse mortality and higher overall survival was observed (HR: 0.32, 0.12–0.84, <em>p</em> = 0.02; 0.34 (0.17–0.69, <em>p</em> = 0.003; respectively), with a protective effect in patients with high antigen load values.</div><div>Despite additional research is needed, our exploratory data support the role of the HLA polymorphism on CMV infection and survival after HSCT. The introduction of CMV antigen load as a new potential predictive factor might contribute to further define the post-transplant risk on an individualised basis.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"73 3","pages":"Article 103518"},"PeriodicalIF":3.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}