Seminars in Oncology Nursing最新文献

{"title":"Different Level and Difficulties with Financial Burden in Multiple Myeloma Patients and Caregivers: A Dyadic Qualitative Study","authors":"YoungJu Park ,&nbsp;Sooyeon Kim ,&nbsp;Nayeon Kim ,&nbsp;Jeong Hyun Park ,&nbsp;Garam Bang ,&nbsp;Danbee Kang ,&nbsp;Sang Eun Yoon ,&nbsp;Kihyun Kim ,&nbsp;Juhee Cho ,&nbsp;Seok Jin Kim","doi":"10.1016/j.soncn.2025.151848","DOIUrl":"10.1016/j.soncn.2025.151848","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to explore the multifaceted financial burden experienced by patients with multiple myeloma (MM) and their caregivers, focusing on direct and indirect costs, as well as variability and discordance in perceived financial burdens.</div></div><div><h3>Methods</h3><div>A dyadic qualitative study was conducted with 40 patient-caregiver pairs recruited from a tertiary hospital in Seoul, Korea. Semistructured interviews were used to explore participants' experiences with financial burden, and thematic analysis was performed to identify key themes. Quantitative analyses were also conducted to examine clinical and sociodemographic data.</div></div><div><h3>Results</h3><div>A total of 80 participants (41 patients and 39 caregivers) were enrolled. Patients had a median age of 70 years, with a median time since diagnosis of 24 months. Financial burdens were categorized into direct medical and nonmedical costs, as well as indirect costs such as income loss. Variability in financial burden was influenced by factors such as patient age, disease state, and financial stability. Caregivers, particularly adult children, reported a broader perspective on the long-term financial impact, while patients focused on immediate costs. Discordance in perceived burden was evident in over 75% of dyads, with caregivers often perceiving a heavier burden than patients.</div></div><div><h3>Conclusions</h3><div>The financial burden of MM is complex and evolves over time, with notable differences between patient and caregiver perceptions. Caregivers bear significant nonmedical and indirect costs, while patients emphasize immediate financial concerns. These findings highlight the need for family-wide financial counseling and support to address the evolving nature of financial toxicity throughout the disease journey.</div></div><div><h3>Implications for Nursing Practice</h3><div>Nurses play a vital role in addressing the financial burdens of MM patients and caregivers. They should facilitate open communication to align expectations, provide financial counseling, and advocate for family-centered care. By supporting tailored interventions and resource access, nurses can help reduce financial burden, improving the overall well-being of patients and their families.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 4","pages":"Article 151848"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of an Electronic Patient-Reported Outcomes-Based Model of Care to Monitor Symptoms Related to Cancer Treatment with Immune Checkpoint Inhibitors: Results from the IePRO Randomized Controlled Trial","authors":"André Manuel da Silva Lopes ,&nbsp;Stellio Giacomini ,&nbsp;Ambily Ulahannan ,&nbsp;Celia Darnac ,&nbsp;Sebastien Bugeia ,&nbsp;Garance Gutknecht ,&nbsp;Sara Colomer-Lahiguera ,&nbsp;Gilliosa Spurrier-Bernard ,&nbsp;Sofiya Latifyan ,&nbsp;Alfredo Addeo ,&nbsp;Olivier Michielin ,&nbsp;Manuela Eicher","doi":"10.1016/j.soncn.2025.151903","DOIUrl":"10.1016/j.soncn.2025.151903","url":null,"abstract":"<div><h3>Objectives</h3><div>This study analyzed the acceptability of an electronic patient-reported outcomes measures-based model of care (IePRO MoC) and the usability of its complementary ePROM mobile app to monitor and manage symptoms related to immune checkpoint inhibitors. In this MoC, symptoms reported by patients treated at an outpatient clinic were reviewed by oncology triage nurses who provided symptom management interventions by telephone.</div></div><div><h3>Methods</h3><div>As part of a larger intervention trial (ClinicalTrials.gov.NCT05530187) we conducted an abductive, semantic thematic analysis through semistructured interviews of patients participating in the intervention arm. Acceptability was deduced from Sekhon et al’s (2017) Theoretical Framework of Acceptability completed with inductively generated themes. Usability analysis was guided by the mHealth App Usability Questionnaire’s domains by Zhoul et al (2019).</div></div><div><h3>Results</h3><div>A total of 17 interviews were performed. The IePRO MoC was reported to be an acceptable intervention. Patients expressed feeling safe and empowered due to continuous monitoring and timely support from nurses. Personalized support motivated patients to use the MoC throughout treatment. Some questioned the predefined response options of the app, and the standardized approach regarding notifications and monitoring requirements. Despite high app usability, some expressed discomfort from being frequently reminded of their illness and being confronted with questions about their sexuality and other intimate themes.</div></div><div><h3>Conclusions</h3><div>The feedback loop between patients and nurses facilitated the acceptability of the IePRO MoC. The app’s usability further facilitated adherence to the MoC. A more personalized approach regarding the frequency of assessments and the way symptoms are conveyed is recommended to decrease discomfort and support the implementation of similar MoCs in the future.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 4","pages":"Article 151903"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste Alterations in Pediatric Oncology Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis","authors":"Eyşan Hanzade Savaş ,&nbsp;Aylin Akça Sümengen ,&nbsp;Ayşe Ay ,&nbsp;Münevver Erkul ,&nbsp;İlçim Ercan Koyuncu ,&nbsp;Gökçe Naz Çakır ,&nbsp;Remziye Semerci","doi":"10.1016/j.soncn.2025.151909","DOIUrl":"10.1016/j.soncn.2025.151909","url":null,"abstract":"<div><h3>Background and Aim</h3><div><span>Taste alterations are common yet often overlooked side effects<span> in pediatric oncology patients undergoing </span></span>hematopoietic stem cell transplantation<span><span> (HSCT), impacting nutrition and quality of life. This </span>systematic review<span> and meta-analysis aimed to synthesize evidence on the prevalence, characteristics, and treatment phase-specific changes in taste perception among these patients.</span></span></div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across 6 academic databases—PubMed, Cochrane Library, MEDLINE (via Ovid), Scopus, Web of Science, and CINAHL—covering publications up to February 13, 2025. Data extraction and quality appraisal were independently performed by 2 reviewers using the QualSyst tool (The Standardized Quality Assessment Criteria for Evaluating Primary Research Articles from Various Fields) for quantitative studies. This systematic review was registered in PROSPERO (ID: CRD42025646761) and conducted by the PRISMA guidelines.</div></div><div><h3>Results</h3><div><span><span>The included studies involved 1,403 pediatric patients aged 0.4-29.9 years. Taste alterations were prevalent, particularly during the early post-transplant phases, with symptoms including dysgeusia, changes in </span>taste thresholds, and reduced sensitivity to sweet and salty tastes. The meta-analysis revealed an event rate of 0.457 (95% CI: 0.330-0.590), which was not statistically significant (</span><em>P = .</em>529).</div></div><div><h3>Conclusion</h3><div>Taste alterations are frequent in pediatric HSCT patients, varying by treatment phase and assessment method. Early identification and management strategies are essential to mitigate their impact on nutrition and quality of life. Further research is needed to standardize assessment tools and intervention strategies.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 4","pages":"Article 151909"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“It Is Kind of Invisible Work”: Lived Experiences of Informal Caregivers of People with a Brain Tumor","authors":"Anna Zanotto ,&nbsp;Chris McVittie ,&nbsp;Karen Goodall ,&nbsp;Marion Ellison","doi":"10.1016/j.soncn.2025.151938","DOIUrl":"10.1016/j.soncn.2025.151938","url":null,"abstract":"<div><h3>Objectives</h3><div>Primary brain tumor presents symptoms related to both cancer and neurological condition. Due to unique characteristics and related care demands, neuro-oncology family caregivers experience different challenges compared to family members of other cancer survivors. The purpose of this study was to understand the informal caregivers’ lived experiences of coping, support needs, and changes in relationships while caring for family member or friend with a brain tumor.</div></div><div><h3>Methods</h3><div>In-depth interviews were conducted with 10 informal caregivers of people diagnosed with a primary brain tumor. The mean age of participants was 45 years (range 19-68 years), and 90% of participants were female (<em>n</em> = 9). Time since diagnosis of the family member ranged from 1 month to 13 years (mean = 4 years). Interviews were transcribed verbatim and analyzed using Interpretative Phenomenological Analysis.</div></div><div><h3>Results</h3><div>Five interrelated themes were identified following the analysis: (1) Exhaustion and all-consuming role, (2) experiencing rupture and loss, (3) togetherness and isolation, (4) navigating healthcare and lack of support, and (5) anticipating grief. There was an overarching sense of loneliness, loss on multiple levels, and feeling invisible in their caregiving role.</div></div><div><h3>Conclusion</h3><div>Neuro-oncology caregiving was described as an extremely challenging and lonely experience. The current findings support calls for healthcare services redesign which would provide family-based cancer care.</div></div><div><h3>Implications for Nursing Practice</h3><div>Findings highlight the importance of involving informal caregivers of persons with a brain tumor in the treatment process and their important role be acknowledged.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 4","pages":"Article 151938"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring and Responding to What Matters in Patient Reported Outcomes: The What and the Why","authors":"Doris Howell","doi":"10.1016/j.soncn.2025.151942","DOIUrl":"10.1016/j.soncn.2025.151942","url":null,"abstract":"<div><h3>Objectives</h3><div>To discuss challenges in Patient Reported Outcome Symptom Screening in routine cancer care and the importance of personalized symptom management and patient involvement in care.</div></div><div><h3>Methods</h3><div>In this paper, the extant literature on routine symptom screening and monitoring in cancer care using Patient-Reported Outcome Measures is examined. This paper expands on ideas from a presentation given at the inaugural meeting of the Global Alliance for Symptom Science in Lausanne Switzerland, 2023. Ongoing challenges in measuring and responding effectively to “what matters” in routine screening to reduce symptom burden and quality of life is discussed.</div></div><div><h3>Results</h3><div>This paper provides a discussion based on key literature to identify key challenges that must be addressed for symptom screening to reduce symptom burden and improve quality of life and potential solutions as follows: (1) measuring what matters from the perspective of the person, (2) responding effectively to screening data from the lens of person-centered care, (3) measuring meaningful symptom improvement and health outcomes from the perspective of patients, and (4) engaging patients (and families) in self-management as co-contributors of symptom and health outcomes.</div></div><div><h3>Conclusion</h3><div>Patient reported outcomes can improve personalized symptom care, however a quality response to symptom data is essential.</div></div><div><h3>Implications for Nurses</h3><div>Nurses have long been identified as the cornerstone to effective symptom management; and they play a vital role in promoting a person-centered approach to PROs data and responding to ‘what matters’ to the person in the context of their daily life. Upskilling of nurses in self-management health coaching will be critical to building patient capacity as co-contributors to health outcomes.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 4","pages":"Article 151942"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods of Teaching Nurses Intravenous Systemic Anticancer Therapy Administration: A Scoping Review.","authors":"Michelle O'Dowd, Siobhan O'Dowd, Geraldine Austin, Orlaith Hernon, Caitríona Duggan, Peter J Carr","doi":"10.1016/j.soncn.2025.151953","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151953","url":null,"abstract":"<p><strong>Objectives: </strong>The safe administration of intravenous (IV) systemic anticancer therapy (SACT) is a specialized and complex skill due to potential exposure to chemotoxic agents. Inadvertent exposure among millions receiving IV SACT annually may harm both patients and nurses. Identifying the literature's scope and gaps in teaching this clinical treatment is essential. The objective of this scoping review was to identify published literature on educational methods for teaching nurses the safe administration of IV SACT.</p><p><strong>Methods: </strong>We conducted a JBI-guided scoping review. With a research librarian's assistance, we searched CINAHL, Embase (OVID), Medline (OVID), SCOPUS, and Google Scholar for grey literature. We included studies published between 2010-2023, in the English language, that examined or reported methods of teaching nurses to administer IV SACT safely. Extracted data was presented narratively using the patterns, advances, gaps, evidence for practice and research recommendations (PAGER) framework.</p><p><strong>Results: </strong>Of 6,820 studies retrieved, 3,725 were screened, resulting in 222 full-text reviews with 20 included for data extraction. Four patterns emerged: education and training methods, interdisciplinary collaboration, global differences, and lack of long-term follow-up and re-validation of educational strategies employed. Teaching methods vary from traditional lectures and clinical practice to simulation, virtual reality, and smartphone applications. However, research, particularly in Europe, is limited, with no European studies cited in the literature.</p><p><strong>Conclusions: </strong>The absence of randomized controlled trials on simulation-based IV SACT training presents an opportunity to improve oncology nursing education and inform evidence-based practice globally.</p><p><strong>Implications for nursing practice: </strong>More interventional research is required, including meta-analyses and studies on emerging technologies such as simulation and artificial intelligence, to improve patient and provider safety. Such research could enhance patient safety by bridging the gap between clinical practice and skills training.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151953"},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding the Right Time to Discuss Advance Care Planning with Myeloma Patients and Their Carers: An Opportunity for Nursing.","authors":"Emma Matthews, Kate Montague-Hellen, Joanne Bird","doi":"10.1016/j.soncn.2025.151913","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151913","url":null,"abstract":"<p><strong>Purpose: </strong>People with multiple myeloma are living longer with an incurable disease due to improved treatments. Despite advance care planning (ACP) and palliative care's focus on improving symptom management and quality of life, there remains a perception among patients and clinicians that palliative care is only for end-of-life care, leading to uncertainty around when to introduce these conversations. This study examines the lived experiences of myeloma patients and their carers, exploring their views as to when and how they would like to commence meaningful conversations around palliative and end-of-life care.</p><p><strong>Methods: </strong>Semistructured online interviews were conducted with multiple myeloma patients and their carers (N = 15). Verbatim transcriptions were analyzed using inductive thematic analysis.</p><p><strong>Results: </strong>From 10 patient and 5 carer interviews, three themes were identified: responsibility, receptivity, and resources. ACP had either not been discussed or would not have been discussed had the patient or carer themself not initiated the discussion. Responsibility for initiating ACP conversations rested with both health care professionals and patients. There was no one, \"right time\" to do this, though diagnosis should be avoided. Conversations depended on resources, whether human, organizational, community, or charities, to facilitate effective ACP.</p><p><strong>Conclusions: </strong>ACP conversations with myeloma patients are often delayed. Patients and carers believe it is the responsibility of health care professionals to initiate them at the right time. A period of adjustment is required after diagnosis, but there is no single \"right time,\" reflecting the heterogeneity of individual needs.</p><p><strong>Implications for nursing practice: </strong>Nurses across all settings should be open and receptive to ACP conversations at all points along the myeloma trajectory. Nurses should normalize the initiation of ACP conversations early in the disease trajectory to promote, and remove barriers to, integrated palliative care. Hematology nurses should work collaboratively with palliative care nurses to support early symptom management for myeloma patients.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151913"},"PeriodicalIF":2.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning to Live With and Beyond Hematological Cancer: A Narrative Study for a Comprehensive Patient Perspective.","authors":"Karine Bilodeau, Cynthia Henriksen, Camila Aloisio Alves, Pegah Torabi, Lynda Piché, Jacinthe Pepin, Virginia Lee, Marie-France Vachon, Nathalie Folch, Marie-Pascale Pomey, Nicolas Fernandez","doi":"10.1016/j.soncn.2025.151952","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151952","url":null,"abstract":"<p><strong>Purpose: </strong>The aim is to describe and conceptualize the lived experiences of people learning to live with and beyond hematological cancer throughout the cancer trajectory.</p><p><strong>Method: </strong>This study used a narrative qualitative methodology to explore the experiences and experiential learning processes of people living with and beyond hematological cancer throughout their cancer care trajectory. Participants were recruited via a Canadian patient advocacy organization, and data were collected via remote semi-structured interviews, which were transcribed into first-person narratives and validated by participants. Data were analyzed using a hybrid inductive/deductive content analysis framework based on an educational biography reconstruction analysis approach.</p><p><strong>Results: </strong>Twelve participants described their experiences during the hematological cancer care trajectory. These were conceptualized into 4 phases. The first phase, characterized as \"Loss and Disruption,\" occurs during the time of the first symptoms and diagnosis. Next, we present the second phase, characterized by \"Putting One's Life on Hold\" during treatment. Then, we describe the third phase, characterized by \"Rediscovery and Personal Development,\" which occurs at the end of treatment. The fourth phase, \"Starting Over, Drawing from Experience\" represents the experience of recurrence of cancer that is common in hemato-oncology.</p><p><strong>Conclusions: </strong>This study highlights how the hematological cancer care trajectory influenced the process of learning to live with the disease. This experiential learning is closely tied to the different stages of the care trajectory, its key events, and the various individuals involved. These results will assist oncology nurses in developing sensitivity through a deeper understanding of each patient's unique journey and experiential learning.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151952"},"PeriodicalIF":2.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Survivor Concerns Scale for Gynecological Cancer: Turkish Validity and Reliability Study.","authors":"Gonul Kurt, Hamide Arslan Tarus, Neriman Yükseltürk Şimşek","doi":"10.1016/j.soncn.2025.151954","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151954","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to adapt the Assessment of Survivor Concern Scale to Turkish and test its validity and reliability in gynecological cancer survivors.</p><p><strong>Methods: </strong>This methodological study was conducted with 76 gynecological cancer survivors. During the adaptation phase of the Assessment of Survivor Concern Scale, the scale was first translated into Turkish and then culturally adapted. Next, the construct validity of the scale was evaluated by confirmatory factor analysis. The reliability of the scale was tested using Cronbach's alpha internal consistency coefficient, item-total score correlation coefficients, and intraclass correlation coefficients.</p><p><strong>Results: </strong>It was determined that the Assessment of Survivor Concern Scale consisted of five items and two subscales. In the confirmatory factor analysis, the fit index values of the scale showed a good fit in general. The Cronbach's alpha internal consistency coefficient of the scale was found to be 0.83, its intraclass correlation coefficients of the scale were above 0.70, and its item-total score correlation coefficients varied between 0.53 and 0.72.</p><p><strong>Conclusion: </strong>The Turkish version of the Assessment of Survivor Concern Scale is a valid and reliable instrument for assessing the worry levels of gynecological cancer survivors.</p><p><strong>Implications for nursing practice: </strong>Assessment of Survivor Concern Scale can help assess worry levels in survivors of gynecological cancers. This makes it possible to identify survivors with high worry levels and provide them with personalized counseling and psychosocial support.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151954"},"PeriodicalIF":2.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Immune Effector Cell-Associated Neurotoxicity Syndrome in Adults with Hematological Malignancies Undergoing Chimeric Antigen Receptor T-Cell Therapy: A Systematic Review.","authors":"Silvia Belloni, Chiara Giacon, Arianna Magon, Daniele Girardi, Marco Alfredo Arcidiacono, Greta Ghizzardi, Gianluca Conte, Rosario Caruso, Cristina Arrigoni","doi":"10.1016/j.soncn.2025.151944","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151944","url":null,"abstract":"<p><strong>Objectives: </strong>We systematically appraised studies investigating factors associated with ICANS development after CAR-T cell therapies in adults with hematological malignancies and estimated ICANS prevalence.</p><p><strong>Method: </strong>We conducted a systematic review (SR) in 4 databases following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for studies published from 2010 to December 2024. We estimated ICANS prevalence with exact binomial and score test-based 95% confidence intervals. We applied the Freeman-Tukey double arcsine transformation to stabilize variances within random-effects models using the Metaprop command in Stata.</p><p><strong>Results: </strong>Sixteen studies (14 retrospective, n = 135, and 2 prospective, n = 300) were included in this SR. The sample comprised adults with various hematological malignancies who received anti-CD19 anti-BCMA. Some clinical factors seem to be associated with ICANS incidence and severity. In retrospective studies, the pooled prevalence was 41% (95% CI: 31%-51%) for all grades of ICANS and 20% (95% CI: 13%-28%) for grade ≥3 ICANS. In prospective studies, the pooled prevalence was 51% (95% CI: 45%-56%).</p><p><strong>Conclusions: </strong>Approximately half of hematological patients undergoing CAR T therapy develop ICANS. Although some factors may contribute to the development of ICANS, limited studies and samples, the retrospective nature of the majority of studies, and the discordance among the results preclude certain risk factors conclusions.</p><p><strong>Implications for nursing practice: </strong>Nurses play a pivotal role in post-treatment monitoring in the early detection and management of ICANS, given their direct and continuous patient interaction. Increasing nurses' awareness of potential risk factors for ICANS can enhance their vigilance and effectiveness in managing this condition.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151944"},"PeriodicalIF":2.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}