Seminars in Oncology Nursing最新文献

{"title":"Why Cancer Care Systems are Insufficient for People with Disabilities? A Middle Eastern Perspective","authors":"Mohammad Amin Akbarzadeh ,&nbsp;Hossein Jabbari Beyrami ,&nbsp;Alireza Rahimi-Mamaghani ,&nbsp;Mohammad-Salar Hosseini","doi":"10.1016/j.soncn.2025.151881","DOIUrl":"10.1016/j.soncn.2025.151881","url":null,"abstract":"<div><h3>Background</h3><div>Cancer care systems in the Middle East face significant challenges, with people with disabilities experiencing compounded barriers to accessing equitable care, leading to suboptimal outcomes for this vulnerable population. Despite advancements in oncology, the unique needs of this population remain insufficiently addressed within the region's healthcare systems. We discuss the present drawbacks and challenges in the Middle Eastern cancer care systems for people with disability, providing practical recommendations to improve the quality of care for this vulnerable population.</div></div><div><h3>Methods</h3><div>Based on the current literature, policy documents, and expert opinions, a critical discussion is presented in this article, adopting a conceptual framework from the Model of Healthcare Disparities and Disability.</div></div><div><h3>Results</h3><div>Key findings were categorized into environmental factors, personal factors, and healthcare access issues. Widespread inadequacies in healthcare accessibility were recorded, including physical barriers in healthcare infrastructure, limited availability of disability-sensitive services, and lack of training in disability-sensitive care for healthcare professionals in region's most countries. Personal factors, such as low health literacy and sociocultural stigmas surrounding both disability and cancer further affect access to care, probably more significantly in women. Environmental factors, such as financial difficulties, compounded by the lack of targeted subsidies for cancer patients with disabilities, double the burden from policy and data gaps, preventing effective implementation of inclusive healthcare strategies.</div></div><div><h3>Conclusions</h3><div>Addressing barriers to cancer care for people with disabilities in the Middle East requires a coordinated, multisectoral approach. Recommendations include policy reforms to enforce accessibility standards, investments in inclusive infrastructure, expansion of financial support mechanisms, and integration of disability-sensitive training into medical education.</div></div><div><h3>Implications for Nursing Practice</h3><div>To provide equitable cancer care, nurses must adopt a disability-sensitive approach emphasizing personalized, compassionate, and culturally aware practices. This requires specialized training in understanding the unique needs of patients with physical, sensory, or cognitive impairments, as well as the integration of assistive technologies and effective communication strategies into daily care routines. Nurses should also advocate for accessibility within healthcare institutions of the Middle East, identifying and addressing structural gaps affecting access to care for patients with disabilities.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151881"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Screening Practices Among Women in Low- and Middle-Income Countries: A Perspective from Vietnam","authors":"Quynh Trang Pham ,&nbsp;Huyen My Hac ,&nbsp;Hai Yen Dang ,&nbsp;Chun Fan Lee ,&nbsp;Cannas Kwok ,&nbsp;Thi Cuc Le ,&nbsp;Thuy Linh Duong","doi":"10.1016/j.soncn.2025.151880","DOIUrl":"10.1016/j.soncn.2025.151880","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the breast cancer screening status of women residing in a rural community in Vietnam and factors associated with their breast cancer screening behavior.</div></div><div><h3>Methods</h3><div>A cross-sectional design was employed among 498 Vietnamese women aged 20 to 84 years by completing a self-administered Vietnamese version of the Breast Cancer Screening Beliefs Questionnaire (BCSBQ). To assess the effect of demographic variables on the likelihood of women adhering to recommended screening practices, multivariable logistic regression analyses were conducted.</div></div><div><h3>Results</h3><div>The majority of participants (68.5%) had heard of breast self-examination (BSE), while about one third had heard of clinical breast examination (CBE) and mammograms (38.6% and 29.7%, respectively). Only 18.8% performed BSE monthly and 22.4% had practiced CBE, among those, only 20.5% of women within the targeted age group had annual CBE. None of women within the targeted age group reported they had a mammogram biennial. Education level was the determining factor for participating in CBE.</div></div><div><h3>Conclusions</h3><div>Our study reveals that actual participation in these practices remains low. It is crucial to enhance awareness of mammography and gain a comprehensive understanding of the barriers affecting women's participation in screening practices.</div></div><div><h3>Implications for Nursing Practice</h3><div>This study underscores the need for targeted nursing intervention to address critical barriers to early breast cancer early detection, which contribute to improve access to timely treatment for rural Vietnamese women.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151880"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of the \"Art\" in Precision Health Symptom Science Research.","authors":"Christine Miaskowski, Sara Colomer-Lahiguera, Yvette P Conley, Susan Dorsey, Marilyn J Hammer, Carolyn Harris, Marques Shek Nam Ng, Michele Pelter, Nancy Redeker, Susan Wesmiller","doi":"10.1016/j.soncn.2025.151906","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151906","url":null,"abstract":"<p><strong>Objectives: </strong>The purposes of this paper are to provide a historical perspective on precision health symptom science research; discuss current \"conundrums\" in precision health symptom science research, including gaps in knowledge and opportunities for growth; and highlight potential challenges that could impede the advancement of precision health symptom science research. The paper concludes with critical directions and recommendations for future research.</p><p><strong>Methods: </strong>A narrative review of the literature on symptoms and symptom burden, across common medical conditions (ie, cancer, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, human immunodeficiency virus, type 2 diabetes mellitus, was conducted to provide information on salient topics associated with precision health symptom science research.</p><p><strong>Results: </strong>This paper provides an overview of the field of precision health symptom science research. Some of the conundrums discussed include measurement of single and multiple symptoms; interindividual variability in persons' symptom experiences; the concept of \"time\" in the evaluation of symptoms; advantages and disadvantages of various analytic approaches; and the collection of \"meaningful\" data. Practical research examples and suggestions are included to guide the development and conduct of future studies.</p><p><strong>Conclusions: </strong>The paper summarizes potential challenges and opportunities in precision health symptom science research. The final section of the paper provides a summary of critical directions and recommendations for future research.</p><p><strong>Implications for nursing practice: </strong>Precision health symptom science is a relatively young field of scientific inquiry. However, the future of precision health symptom science research is both exciting and challenging. Knowledge gained in this field will result in the identification of risk factors for a higher symptom burden and the development and testing of personalized interventions to prevent and/or treat symptoms across one or more acute or chronic medical conditions.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151906"},"PeriodicalIF":2.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of a Musical Starry Sky Projector on Fatigue, Sleep, and Quality of Life in Pediatric Oncology Patients: A Randomized Controlled Trial.","authors":"Remziye Semerci Şahin, Tuba Eren, Aycan Kucukkaya, Polat Goktas, Gülcan Avci, Filiz Savran","doi":"10.1016/j.soncn.2025.151911","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151911","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the effect of an Ocean Wave and LED Starry Sky Projector on fatigue, sleep, and quality of life (QoL) in pediatric oncology patients.</p><p><strong>Methods: </strong>This randomized controlled trial included 60 pediatric oncology patients aged 8 to 18 years who were newly diagnosed with cancer and undergoing chemotherapy. Participants were randomly allocated into two groups: intervention (n = 30) and control (n = 30). The intervention group received standard care plus nightly exposure to an Ocean Wave and LED Starry Sky Projector for 30 minutes before sleep, over a period of 1 week. The control group received standard care only. Data were collected using the Adolescent Information Form, Pediatric Quality of Life Scale, Visual Sleep Scale, and Fatigue Intensity Scale. Fatigue and sleep quality were assessed daily, while QoL was evaluated on the first and seventh days.</p><p><strong>Results: </strong>The descriptive characteristics of children in the intervention and control groups were found to be homogeneously distributed. Although no statistically significant difference was observed in sleep quality between the groups on the first day (P > .05), significant differences favoring the intervention group were found from the second to the seventh day (P < .05). Similarly, no significant differences were found in fatigue levels between the two groups throughout the week (P > .05). There was no statistically significant difference in the mean scores of the \"Pediatric Quality of Life Scale\" between the groups (P > .05).</p><p><strong>Conclusions: </strong>This study found that the ocean wave and LED starry sky projector significantly improved sleep quality over time in pediatric oncology patients but had no significant effect on fatigue or QoL.</p><p><strong>Implications for nursing practice: </strong>Nurses can use musical projectors as a noninvasive, cost-effective tool to improve sleep quality in pediatric oncology patients during treatment.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151911"},"PeriodicalIF":2.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncology Advanced Practice Nurses' Memorable Patient Care Experiences: A Qualitative Analysis.","authors":"Abigail G Cohen, Vanessa Battista, Judith Paice, Betty R Ferrell","doi":"10.1016/j.soncn.2025.151910","DOIUrl":"10.1016/j.soncn.2025.151910","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to describe oncology advanced practice nurses' (APRNs) experiences caring for memorable patients, the meaning derived from patients' experiences and the influence patients have had on their careers. This study builds on work describing the meaning of oncology nursing practice.</p><p><strong>Methods/results: </strong>Oncology APRNs (N=66) participating in an NCI funded ELNEC course responded to 3 open-ended prompts/questions: (1) Share a story about a memorable patient, (2) Why do you think the memory of this patient is meaningful to you? (3) How do you think caring for this patient has influenced your nursing career? A thematic, qualitative analysis of their responses identified several key themes including: (1) Lessons learned: Usually profound, occasionally resulting in career altering impact. (2) Admiration: Admiration for patients' kindness, grace, strength, hope and courage through terminal illness. (3) Delivery of high-quality palliative care: The foundation for deep connections and mutually beneficial relationships between APRNs and patients. (4) Challenges: Clinical scenarios involving APRNs feeling like they failed; staff distress, trauma, or grief.</p><p><strong>Conclusions: </strong>Oncology nurses described early nursing career experiences of patients as the greatest teachers and shared invaluable and transformative lessons learned about what it means to be human in the face of serious illness.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151910"},"PeriodicalIF":2.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste Alterations in Pediatric Oncology Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.","authors":"Eyşan Hanzade Savaş, Aylin Akça Sümengen, Ayşe Ay, Münevver Erkul, İlçim Ercan Koyuncu, Gökçe Naz Çakır, Remziye Semerci","doi":"10.1016/j.soncn.2025.151909","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151909","url":null,"abstract":"<p><strong>Background and aim: </strong>Taste alterations are common yet often overlooked side effects in pediatric oncology patients undergoing hematopoietic stem cell transplantation (HSCT), impacting nutrition and quality of life. This systematic review and meta-analysis aimed to synthesize evidence on the prevalence, characteristics, and treatment phase-specific changes in taste perception among these patients.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across 6 academic databases-PubMed, Cochrane Library, MEDLINE (via Ovid), Scopus, Web of Science, and CINAHL-covering publications up to February 13, 2025. Data extraction and quality appraisal were independently performed by 2 reviewers using the QualSyst tool (The Standardized Quality Assessment Criteria for Evaluating Primary Research Articles from Various Fields) for quantitative studies. This systematic review was registered in PROSPERO (ID: CRD42025646761) and conducted by the PRISMA guidelines.</p><p><strong>Results: </strong>The included studies involved 1,403 pediatric patients aged 0.4-29.9 years. Taste alterations were prevalent, particularly during the early post-transplant phases, with symptoms including dysgeusia, changes in taste thresholds, and reduced sensitivity to sweet and salty tastes. The meta-analysis revealed an event rate of 0.457 (95% CI: 0.330-0.590), which was not statistically significant (P = .529).</p><p><strong>Conclusion: </strong>Taste alterations are frequent in pediatric HSCT patients, varying by treatment phase and assessment method. Early identification and management strategies are essential to mitigate their impact on nutrition and quality of life. Further research is needed to standardize assessment tools and intervention strategies.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151909"},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of an Electronic Patient-Reported Outcomes-Based Model of Care to Monitor Symptoms Related to Cancer Treatment with Immune Checkpoint Inhibitors: Results from the IePRO Randomized Controlled Trial.","authors":"André Manuel da Silva Lopes, Stellio Giacomini, Ambily Ulahannan, Celia Darnac, Sebastien Bugeia, Garance Gutknecht, Sara Colomer-Lahiguera, Gilliosa Spurrier-Bernard, Sofiya Latifyan, Alfredo Addeo, Olivier Michielin, Manuela Eicher","doi":"10.1016/j.soncn.2025.151903","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151903","url":null,"abstract":"<p><strong>Objectives: </strong>This study analyzed the acceptability of an electronic patient-reported outcomes measures-based model of care (IePRO MoC) and the usability of its complementary ePROM mobile app to monitor and manage symptoms related to immune checkpoint inhibitors. In this MoC, symptoms reported by patients treated at an outpatient clinic were reviewed by oncology triage nurses who provided symptom management interventions by telephone.</p><p><strong>Methods: </strong>As part of a larger intervention trial (ClinicalTrials.gov.NCT05530187) we conducted an abductive, semantic thematic analysis through semistructured interviews of patients participating in the intervention arm. Acceptability was deduced from Sekhon et al's (2017) Theoretical Framework of Acceptability completed with inductively generated themes. Usability analysis was guided by the mHealth App Usability Questionnaire's domains by Zhoul et al (2019).</p><p><strong>Results: </strong>A total of 17 interviews were performed. The IePRO MoC was reported to be an acceptable intervention. Patients expressed feeling safe and empowered due to continuous monitoring and timely support from nurses. Personalized support motivated patients to use the MoC throughout treatment. Some questioned the predefined response options of the app, and the standardized approach regarding notifications and monitoring requirements. Despite high app usability, some expressed discomfort from being frequently reminded of their illness and being confronted with questions about their sexuality and other intimate themes.</p><p><strong>Conclusions: </strong>The feedback loop between patients and nurses facilitated the acceptability of the IePRO MoC. The app's usability further facilitated adherence to the MoC. A more personalized approach regarding the frequency of assessments and the way symptoms are conveyed is recommended to decrease discomfort and support the implementation of similar MoCs in the future.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151903"},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Remote Symptom Monitoring, Person-Centered Analytics, and Artificial Intelligence to Advance Precision Health Symptom Science in Oncology.","authors":"Rachel A Pozzar","doi":"10.1016/j.soncn.2025.151901","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151901","url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the relevance of remote symptom monitoring, person-centered statistical analyses, and artificial intelligence to precision health symptom science in oncology; and propose ways in which these three approaches can be integrated to further advance the field.</p><p><strong>Methods: </strong>The following commentary was adapted from a talk delivered at the Symptom Science Experts Meeting in October 2023 at the University of Lausanne, Switzerland. The commentary and talk were informed by an informal review of recent literature in precision health oncology symptom science.</p><p><strong>Results: </strong>Several remote symptom monitoring interventions have demonstrated potential to reduce disease- and treatment-related symptom burden and improve health outcomes in patients with cancer. Data collected passively by wearable and sensor technologies are also being used to characterize patients' health status. Person-centered statistical analyses have identified interindividual variability in the symptom experiences of patients with cancer. Together with artificial intelligence-based approaches, these analyses have identified factors associated with relatively adverse symptom experiences. Future directions for the field include integrating these approaches to optimize clinical resource allocation, tailor symptom management in real-time, and advance scientific knowledge of the symptom experience.</p><p><strong>Conclusions: </strong>Integrating remote symptom monitoring, person-centered statistical analyses and artificial intelligence may provide deeper insights into how patients with cancer experience symptoms.</p><p><strong>Implications for nursing practice: </strong>Findings from research that uses remote symptom monitoring, person-centered statistical analyses, and artificial intelligence may enhance clinicians' ability to deliver personalized symptom management interventions.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151901"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Level and Difficulties with Financial Burden in Multiple Myeloma Patients and Caregivers: A Dyadic Qualitative Study.","authors":"YoungJu Park, Sooyeon Kim, Nayeon Kim, Jeong Hyun Park, Garam Bang, Danbee Kang, Sang Eun Yoon, Kihyun Kim, Juhee Cho, Seok Jin Kim","doi":"10.1016/j.soncn.2025.151848","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151848","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the multifaceted financial burden experienced by patients with multiple myeloma (MM) and their caregivers, focusing on direct and indirect costs, as well as variability and discordance in perceived financial burdens.</p><p><strong>Methods: </strong>A dyadic qualitative study was conducted with 40 patient-caregiver pairs recruited from a tertiary hospital in Seoul, Korea. Semistructured interviews were used to explore participants' experiences with financial burden, and thematic analysis was performed to identify key themes. Quantitative analyses were also conducted to examine clinical and sociodemographic data.</p><p><strong>Results: </strong>A total of 80 participants (41 patients and 39 caregivers) were enrolled. Patients had a median age of 70 years, with a median time since diagnosis of 24 months. Financial burdens were categorized into direct medical and nonmedical costs, as well as indirect costs such as income loss. Variability in financial burden was influenced by factors such as patient age, disease state, and financial stability. Caregivers, particularly adult children, reported a broader perspective on the long-term financial impact, while patients focused on immediate costs. Discordance in perceived burden was evident in over 75% of dyads, with caregivers often perceiving a heavier burden than patients.</p><p><strong>Conclusions: </strong>The financial burden of MM is complex and evolves over time, with notable differences between patient and caregiver perceptions. Caregivers bear significant nonmedical and indirect costs, while patients emphasize immediate financial concerns. These findings highlight the need for family-wide financial counseling and support to address the evolving nature of financial toxicity throughout the disease journey.</p><p><strong>Implications for nursing practice: </strong>Nurses play a vital role in addressing the financial burdens of MM patients and caregivers. They should facilitate open communication to align expectations, provide financial counseling, and advocate for family-centered care. By supporting tailored interventions and resource access, nurses can help reduce financial burden, improving the overall well-being of patients and their families.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151848"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Biomarkers in Precision Health Symptom Science-Opportunities and Challenges.","authors":"Carolyn S Harris, Yvette P Conley, Jinbing Bai, Marilyn J Hammer","doi":"10.1016/j.soncn.2025.151886","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151886","url":null,"abstract":"<p><strong>Objectives: </strong>Precision health symptom science applies person-centered approaches to elucidate interindividual differences in patients' symptom experiences and incorporates omics methods with social, societal, and environmental determinants of health to develop symptom management strategies. By filling scientific gaps related to patients' symptom experiences and their underlying mechanisms, interventions can be developed to improve quality of life and outcomes. The purposes of this article are to describe symptom phenotype development; review analytical approaches to identify a symptom phenotype; and discuss common and emerging methods for biomarker discovery and their implications in precision health symptom science.</p><p><strong>Methods: </strong>Peer-reviewed research studies, review articles, and scientific expertise were synthesized to provide a broad overview of several methods of biomarker discovery and their implications for precision health symptom science.</p><p><strong>Results: </strong>Approaches to symptom phenotype development and analytical methods for phenotype identification were reviewed. Common (ie, genomic, epigenomic, transcriptomic, proteomic, metabolomic, microbiome) and emerging (ie, polygenic risk scores, microRNA, epigenetic clocks, allostatic load, wearables) methods for biomarker discovery were described. Each method provides unique information to improve our understanding of the complex biological processes that underlie symptoms and may be used for risk prediction, screening, surveillance, and treatment response.</p><p><strong>Conclusions: </strong>While the exemplar approaches to conducting precision health symptom science were shared through an oncology lens, they are generalizable across acute and chronic conditions.</p><p><strong>Implications for nursing practice: </strong>Symptom biomarker identification is inherently complex and the methods for biomarker collection, processing, measurement, and analysis are continually evolving. Therefore, symptom scientists need to form transdisciplinary teams with experts in omics methodologies and bioinformatics. Despite the challenges, symptom scientists are well suited to lead the way in precision health symptom science to reduce symptom burden and improve quality of life among patients with various chronic conditions.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151886"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}